Articles tagged with Inflammatory Disorders
Researchers have identified biosignatures for tuberculosis and sarcoidosis, but a single signature is insufficient to distinguish between the two diseases. A combination of markers is required to accurately diagnose a specific disease, enabling doctors to distinguish between different diseases with similar clinical appearances.
Research suggests that CD36 protein, involved in cellular inflammation, increases harmful effects of LDL cholesterol. Mice infected with gum disease bacteria showed increased fatty plaque accumulation, while those with deleted CD36 gene remained plaque-free.
Researchers investigate gum disease in young and old mice and find a drop in Del-1 levels is associated with increased gum disease. Understanding the effects of Del-1 on the immune system could lead to new treatments or prevention strategies for gum disease.
Scientists at Trinity College Dublin have found that controlling IL-18 levels could prevent the development of wet AMD, a form of blindness. Drs. Sarah Doyle and Matthew Campbell discovered that drusen accumulating in the macula lead to IL-18 production, which acts as an anti-angiogenic factor.
People of African descent may be at risk for cardiovascular disease despite normal triglyceride levels, highlighting a paradox known as the TG paradox. Researchers call for further study and development of new screening guidelines to better identify metabolic syndrome in this population.
Researchers have identified a genetic signature for regulation of IL-13, a key immune hormone involved in allergic reactions. MicroRNA miR-375 is regulated by IL-13 and plays a role in asthma and eosinophilic esophagitis (EoE), a severe food allergy.
Researchers identify 'gatekeeper' ADAM17 involved in regulating immune response and preventing inflammatory skin disease. Reactivation of Notch signaling rescues local skin inflammation and abnormal immune cell proliferation.
A nationwide Danish cohort study suggests women with endometriosis are 50% more likely to develop inflammatory bowel disease, a condition that affects the bowel and causes abdominal pain. The risk persists for over 20 years after diagnosis and is linked to common causes or treatment effects.
Researchers recommend 10 key areas for research, including large cohort studies, interdisciplinary approaches, and the development of new tools and models. Effective public-private partnerships are also essential for advancing understanding of chronic inflammatory diseases.
Patients with moderate to severe psoriasis prioritize treatment location, probability of benefit, and method of delivery over treatment outcome attributes. The study highlights the significance of incorporating patient preferences in shared decision-making to optimize treatment adherence and outcomes.
Patients with recurrent inflammatory spinal cord diseases have significantly lower vitamin D levels compared to those with monophasic disease. The study suggests a common link between low vitamin D levels and immunologic dysregulation in these conditions.
Researchers have identified a type of immune cell, dendritic cells, that plays a protective role in atherosclerosis. The study found that classical dendritic cells help prevent the disease from progressing.
Researchers found that specific microRNAs are up-regulated in obese individuals with healthy periodontium and non-obese subjects with periodontal disease. The study suggests microRNA modulation may play a role in modulating inflammatory pathways within periodontal tissues.
Research suggests that shift work in teenagers may increase the risk of developing multiple sclerosis, a central nervous system autoimmune inflammatory disorder. Disruption of the circadian rhythm and sleep patterns are believed to contribute to this increased risk.
Researchers identify key protein CFH that blocks inflammatory immune response to oxidative stress, found in conditions like atherosclerosis and AMD. The study reveals potential therapeutic target for treating chronic inflammatory diseases.
Researchers have successfully treated severe Crohn's disease with a new cell therapy approach using Type 1 regulatory lymphocytes. The preliminary results indicate improved condition and good tolerability, paving the way for further phase 2b clinical trials.
Research validates Pentraxin-2/SAP as a novel therapeutic approach for treating lung fibrosis, including IPF. PTX-2/SAP potently inhibits TGF-beta1 driven pathologies without affecting growth factor levels.
Researchers found that Porphyromonas gingivalis infection accelerates inflammation and atherosclerosis in the innominate artery of mice, characterized by vessel narrowing and perivascular inflammation. The study provides evidence for a link between periodontal disease and systemic cardiovascular diseases.
Scientists at Virginia Tech have discovered key molecular events in the immune system that contribute to inflammatory bowel disease. The study identifies peroxisome proliferator-activated receptor-gamma as a crucial regulator of inflammation and offers potential targets for repurposed drugs and naturally occurring compounds.
A study found that consuming polyunsaturated fatty acids, particularly DHA and EPA, is associated with a reduced prevalence of periodontitis. The research suggests that dietary therapy using n-3 fatty acids could be a less expensive and safer method for preventing and treating gum disease.
Researchers from Monash University identified interleukin 37 as a key therapy for many inflammatory diseases, including those affecting premature babies. The protein blocks inflammation throughout the body and has been activated by various biological triggers.
The 2010 AAO-HNSF Annual Meeting showcased significant research on the connection between allergic disease and rhinosinusitis, with literature highlighting the united airway concept. Robotic thyroidectomy was also discussed, with experts exploring its feasibility, safety, and future adoption.
Researchers have discovered a mechanism to detect bacteria in the womb, opening up new possibilities for preventative treatments. This unique environment relies on a simpler form of immunity called the innate system, as the adaptive response is underdeveloped.
Preliminary research published in Gut suggests that plantain and broccoli fibers may prevent the translocation of E. coli across M-cells, a key stage in Crohn's disease development. The study found that plantain and broccoli fibers reduced E. coli translocation by 45-82%, while leek and apple fibers had no effect.
Researchers have identified key genetic mutations causing Behçet's disease, a vascular condition leading to severe ulcers and skin lesions. The study found three genes associated with the disease, paving the way for new treatments.
The Hebrew University of Jerusalem has been selected to participate in the CREATE program, focusing on cellular and molecular mechanisms of inflammation. The research aims to develop diagnostic/prognostic indicators and novel therapeutics for inflammatory diseases.
Researchers discovered that Lactobacillus reuteri reduces muscle contractions in the gut within minutes of exposure. This bacterium naturally occurs in human breast milk, suggesting a potential treatment for various gut disorders.
The Registry for Eosinophilic Gastrointestinal Disorders (REGID) will help researchers conduct larger studies and accelerate the translation of research into better treatments. The registry aims to improve understanding and treatment of eosinophilic disorders, which affect thousands of US children.
Researchers at OHSU School of Dentistry have discovered that inflammation boosts the production of a protein involved in pain signaling, which could lead to new treatments for craniofacial pain conditions. The findings provide a crucial understanding of the molecular mechanisms underlying trigeminal pain.
Researchers found that some genes have opposing effects on the risk of developing both autoimmune diseases, while others may increase the risk for both. The study suggests a possible genetic switch that could be triggered by specific infectious agents.
Researchers at Cedars-Sinai Medical Center have identified over 30 regions of the genome linked to ulcerative colitis, providing insights into the disease's causes and potential new therapies. This understanding may lead to more effective treatments tailored to individual patients' needs.
Researchers at the University of Colorado Boulder have discovered a novel approach to studying Hemophagocytic Lymphohistiocytosis (HLH), a rare and deadly inflammatory disease. Mice infected with Salmonella bacteria developed symptoms consistent with human secondary HLH, including fever, anemia, and neurological signs.
The Montreal Heart Institute has received $4.8 million in financing to support two research projects focused on genetics and genomic medicine. The projects aim to create diagnostic tests and therapeutic approaches for lactic acidosis and improve the diagnosis and treatment of inflammatory diseases.
Researchers have developed a new technique to restore lost bone and gum tissue following periodontal disease, using layers of cells such as stem cells and gingival fibroblasts. The method has been shown to be successful in laboratory studies and has potential applications in other fields like skin grafts.
A long-term study by Indiana University School of Medicine found that frequent testing and treatment does not reduce the prevalence of chlamydia in urban teenage girls. Despite regular screenings, 84% of repeated infections were reinfections.
A study by researchers at the University of California, San Diego reveals that normal skin bacteria trigger a pathway preventing excessive inflammation after injury. This mechanism involves staphylococcal lipoteichoic acid and Toll-like receptor 3 activation, providing new therapeutic approaches for inflammatory skin diseases.
A new type of T-helper cell, called Th22 cells, has been discovered by researchers from Imperial College London. These cells play a special role in overseeing and coordinating immune cells that cause inflammation in chronic and allergic inflammatory diseases.
A Penn study reveals that thiocyanate, an antioxidant in broccoli and cauliflower, protects lung cells from inflammation damage. The findings suggest a potential therapy for cystic fibrosis, as inadequate thiocyanate levels may worsen inflammatory diseases.
A new study reveals that 65% of patients with chronic rhinosinusitis have used alternative medicine, with women and university-educated individuals more likely to do so. However, only 43% of CAM users inform their doctor about the therapy, highlighting a need for improved communication between clinicians and patients.
Research found a modestly increased risk of death in patients with lesser degrees of celiac disease-related symptoms. The risk was highest in the first year of follow-up, with cardiovascular disease and malignancy being the main causes of death in celiac disease.
Researchers at Case Western Reserve University School of Medicine discovered a novel connection between ITCH and NOD2 genes, which may lead to new treatments for Crohn's disease. The study highlights the potential for individually-tailored therapies for patients with the NOD2 mutation.
Periodontal disease has been linked to an increased risk of cardiovascular disease, with as many as 75% of adults in the US affected by periodontal disease. The study suggests that addressing oral/body inflammatory connection can improve overall health and reduce CVD risks.
A new study links a history of periodontitis to an increased risk of cerebrovascular disease, particularly ischemic stroke, in men. The study found that periodontal bone loss, not current inflammation, was associated with the incidence of cerebrovascular disease.
A new study suggests that measuring serum levels of myeloid-related proteins 8 and 14 can predict disease activity, treatment response, and diagnose FMF in children and adolescents. The study also indicates a potential link between MRP 8/14 biomarkers and detection of subclinical inflammatory activity.
The joint clinical recommendations aim to promote patient health by encouraging collaboration between periodontists and cardiologists. The consensus paper includes guidelines for medical and dental professionals to identify patients at risk of both diseases.
Researchers found that local intestinal inflammation induced DNA damage to lymphocytes in peripheral blood, indicating systemic genetic damage. Chromosome damage was detected in the blood before colitis onset and correlated with disease severity.
A study analyzing the periodontal health of 940 men found that regular green tea drinkers had superior periodontal health than those who consumed less. The antioxidants present in green tea may help reduce inflammation and promote healthy gums and teeth.
Patients with pediatric-onset multiple sclerosis tend to have a higher yearly rate of relapses compared to those diagnosed in adulthood. This discrepancy may suggest greater plasticity and potentially more repair and remyelination in the younger nervous system.
A comprehensive elimination strategy is proposed to significantly block the spread of schistosomiasis, a chronic inflammatory disease affecting over 207 million people worldwide. The approach incorporates supplementary education and sanitation with secondary environmental benefits.
A four-year study of Baltimore inner-city teenage girls diagnosed with pelvic inflammatory disease reveals a high rate of subsequent sexually transmitted infections. Researchers emphasize the need for individually tailored counseling and strict follow-up care to prevent future infections.
Researchers found that stress activates immune cells, which initiate and perpetuate skin diseases. Blocking specific proteins prevented the increase in white blood cells, suggesting a key role for ICAM-1/LFA-1 interactions.
NIAID scientists will present research on various infectious diseases, including noroviruses, Crohn's disease, and antibiotic-resistant infections. The talks aim to advance our understanding of these conditions and develop effective treatments.
Research reveals a common connection between cellular innate immunity and human chronic inflammatory diseases, including atherosclerosis, Type 2 Diabetes, and neurodegenerative diseases. A critical signaling network involving IRAK-1 has been identified as a potential target for diagnosis and treatment.
A study has identified a new gene that may play a key role in the development of pediatric-onset inflammatory bowel disease. The gene, TNFRSF6B, is involved in regulating inflammation and its activity has been linked to the severity of the disease.
Anemia of chronic disease could be an adaptive response to inflammatory illness, rather than a disorder. Researchers suggest treating mild to moderate cases to avoid increased mortality from treatment.
An international team of researchers has identified 21 new genetic risk factors for Crohn's disease, building on earlier studies that linked the disorder to disruptions in autophagy and immune system response. The findings, published in Nature Genetics, may lead to novel therapies and prevention strategies.
Researchers at the University of Bonn discovered that oregano's active ingredient beta-caryophyllin inhibits inflammation and may help treat osteoporosis, arteriosclerosis, and chronic disorders like Crohn's disease. The substance targets cannabinoid-CB2 receptors, providing a non-intoxicating alternative to existing treatments.
Research shows that people with temporal arteritis, an inflammatory artery disease, are three times more likely to experience blindness due to swollen arteries restricting blood flow. The disease is often accompanied by symptoms like headaches and jaw soreness, and if left untreated can lead to severe vision loss or stroke.
Researchers discovered a new family of genetic mutations involved in inflammatory intestinal diseases, including coeliac disease and Crohn's disease. The study found common origins for the two diseases and identified eight new areas with genes controlling immune responses.
Researchers found that combined immunosuppression therapy was more effective than conventional treatment in inducing remission and reducing corticosteroid use in patients with newly diagnosed Crohn's disease. The study showed that early intensive treatment could lead to better outcomes, with higher remission rates at weeks 26 and 52.