Articles tagged with Inflammatory Disorders
Researchers found that gut-derived bacterial products penetrate the gut barrier and induce inflammatory responses in alcohol-dependent patients. This leads to increased cravings for alcohol, with some but not all altered inflammatory processes recovered after detoxification.
A new Review article explores the potential to target IL-27-activated mechanisms in diseases such as multiple sclerosis and Crohn's disease. The cytokine's dual anti-inflammatory and proinflammatory activities suggest it could be a significant determinant of inflammatory responses.
A study published in JAMA Neurology found that immunosuppressant MMF treatment significantly reduced relapse rates and improved disability scores in patients with neuromyelitis optica spectrum disorder (NMOSD). The results suggest MMF may be an effective treatment option for preventing attacks and resulting disabilities in these patients.
Researchers at Lund University discovered inflammation and changes in the intestinal barrier function early in MS, indicating a potential link to disease progression. The study suggests that damage to the intestinal barrier may prevent the body from ending an autoimmune reaction, leading to chronic diseases like MS.
Researchers have discovered a link between genetic factors and the development of early-onset ulcerative colitis. The study's findings suggest that phosphatase and tensin homologue (PTEN) may play a role in helping the disease develop, and that altering the gut microbiome could be a key to prevention.
New research at Rockefeller University reveals how IELs develop to protect the intestinal epithelium, a critical interface between the gut and body. Understanding this pathway may lead to new insights into inflammatory diseases of the gut and cancer.
A new study published in Clinical Gastroenterology and Hepatology found that thiopurine therapy for inflammatory bowel disease (IBD) may increase the risk of myeloid disorders, including acute myeloid leukemia. The study analyzed data from over 19,000 IBD patients and found a seven-fold increased risk among those taking thiopurines.
A new study published in the Journal of Leukocyte Biology suggests that modulation of B cells may effectively treat and/or prevent periodontitis symptoms related to type 2 diabetes. Researchers used a mouse model to demonstrate the B cell-response's viability as a target for pharmacological intervention.
A new review argues that most intestinal parasite infections have no negative impact in well-nourished people with low overall parasite loads. In some cases, parasite infections could activate the immune system and prevent disorders caused by inflammation of the intestines.
New research from the Monell Center reveals that believing an odor is harmful can lead to increased airway inflammation in asthmatics. Airway inflammation remained elevated 24 hours later, making asthmatics more sensitive to other triggers.
Scientists have identified genetic markers associated with eosinophilic esophagitis (EoE), an inflammatory disease characterized by high levels of immune cells in the esophagus. The study found that several genes are involved in EoE development, which can cause difficulty eating and is often associated with food allergies.
Researchers at Helmholtz Munich have created a diagnostic procedure that uses only two genes to reliably differentiate between psoriasis and eczema. The new test is expected to pave the way for personalized medicine in chronic inflammatory skin diseases, reducing the need for expensive treatments.
Researchers discovered that a biochemical cascade in the bone marrow microenvironment leads to inflammation and disruption of normal blood formation, resulting in potentially deadly disorders. By targeting this inflammatory reaction, potential new strategies for treating these diseases may be developed.
Researchers have unraveled the mechanism of necroptosis, a type of cell death linked to various diseases. Understanding this process enables the development of targeted medications to block or stimulate necroptosis, potentially treating chronic and acute inflammatory and degenerative diseases.
A recent study suggests that chronic disruption of circadian rhythms may contribute to inflammatory bowel disease and other harmful conditions. Consuming a high-fat, high-sugar diet can worsen the effects of circadian rhythm disruption on intestinal flora.
Researchers discovered disease-causing bacteria in medieval dental plaque similar to those causing periodontal disease in humans today. The study sheds light on the long-term relationship between humans and their resident microbes.
A study published in The Journal of Immunology found that Interleukin 21 (IL-21) contributes to fatal inflammatory disease, particularly when another cytokine is deficient. Removing IL-21 can greatly subdue the inflammatory response and may help people with chronic inflammation due to defective T cell regulation.
Researchers found that epsilon toxin from Clostridium perfringens kills brain's myelin-producing cells and targets other cells associated with MS inflammation. The toxin may be responsible for triggering MS in genetically susceptible individuals.
Scientists have found that macrophages invade the diabetic pancreas, producing cytokines that contribute to insulin-producing beta cells' elimination. This discovery may lead to development of tailor-made anti-inflammatory therapies to reduce type 2 diabetes burden.
Scientists have found a molecular mechanism behind aging that can be reversed using a compound that restores communication between mitochondria and the nucleus. This breakthrough may lead to new treatments for age-related diseases such as cancer, type 2 diabetes, and inflammatory disorders.
Researchers found no evidence of an association between iron levels and the risk of atherosclerosis, contradicting a long-held hypothesis. The study's findings carry important implications for patients with chronic kidney disease or anemia related to inflammatory disorders.
Three researchers at the Walter and Eliza Hall Institute have been awarded ARC Future Fellowships to study how the body controls errant immune cells causing type 1 diabetes and coeliac disease. They aim to develop new treatments using cell signalling pathways and targeted vaccines or drugs.
Researchers found that disrupting the circadian clock in mice increases susceptibility to inflammatory disease by controlling the development of key immune cells called interleukin-17-producing CD4+ T helper cells. This discovery could lead to new ways to regulate the immune response and prevent autoimmune diseases.
The University of Minnesota College of Veterinary Medicine has uncovered the role of ORMDL3 in asthma, linking it to inflammatory cell recruitment and airway inflammation. The study found that silencing or over-expressing ORMDL3 in eosinophils reduces inflammation by decreasing integrin expression.
The American Academy of Periodontology urges pregnant women to prioritize periodontal health to minimize risks of adverse pregnancy outcomes. Regular dental cleanings and monitoring can help prevent premature birth or low-birth weight babies.
A study by Michigan Medicine researchers has identified five genes that play a major role in the development of Takayasu arteritis, a debilitating disease causing inflammation and damage to major blood vessels. The findings may lead to new therapeutic targets for this under-studied condition.
Dr. Ken Cadwell has been recognized with the 2013 ICAAC Young Investigator Award for his exceptional research in infectious diseases and pathogenesis, with findings already having a profound impact on the fields of immunity.
Researchers identified a network of genes involved in inflammatory response driving Late Onset Alzheimer's Disease (LOAD), providing new understanding of key pathways and genes. The study suggests targeting the TREM2-TYROBP pathway as potential therapies for LOAD.
A study published in The Journal of Immunology found that inhibiting a group of proteins can decrease inflammatory responses associated with diseases like obesity, type 2 diabetes, cancer, and sepsis. This suggests that targeting these proteins could be a potential treatment for various diseases.
A Monash Institute of Medical Research team has identified a protein called Interferon epsilon (IFNe) that protects females against infections, including STIs. The discovery could lead to new therapeutic opportunities and boost protective immunity.
Researchers have identified novel gene variants linked to Behçet's disease, a chronic condition causing painful ulcers and brain inflammation. The study also reveals multiple independent genetic risk regions within the HLA region, which could lead to better understanding and treatment options for this devastating illness.
Research suggests that being overweight is a risk factor for gum disease, which can lead to chronic inflammation and other health issues. Daily brushing, flossing, and professional cleanings are essential for preventing gum disease and maintaining good oral health.
Intravenous immune globulin (IVIG) therapy provides anti-inflammatory and immunomodulatory benefits through its diverse antibody content, benefiting patients with autoimmune diseases and potentially expanding to Alzheimer's treatment options.
A new study identifies 71 additional genetic associations for IBD, many linked to immune-related disorders. Researchers found a strong overlap between IBD susceptibility genes and genes responding to mycobacterial infections.
Researchers at UofL School of Dentistry have discovered a way to prevent inflammation and bone loss surrounding teeth by blocking the natural signaling pathway of enzyme GSK3b. This finding has implications for preventing periodontal disease, a chronic inflammatory condition causing tooth loss.
Researchers have discovered a new target for treating acute myeloid leukemia by targeting cyclin-dependent kinase 1 (CDK1), which promotes differentiation of cancer cells. Additionally, inflammation has been found to play a significant role in age-related retinal degeneration.
Researchers use zebrafish to study the biological mechanisms underlying human disorders, including inflammatory bowel disease, doxorubicin-induced heart failure, spinal muscular atrophy, and acute T-cell lymphoblastic leukemia. The models provide valuable insights into causes and potential treatments for these diseases.
Researchers discovered that fungi inhabit the large intestine and play a role in inflammatory diseases like ulcerative colitis. The study identified a protein called Dectin-1, which helps protect against inflammation caused by indigenous fungi.
Researchers found that teenagers living on farms had more diverse skin bacteria and lower allergen sensitivity than urban dwellers. Gammaproteobacteria in the skin microbiota may enhance immune tolerance, suggesting a link between biodiversity loss and inflammatory diseases.
Researchers have identified biosignatures for tuberculosis and sarcoidosis, but a single signature is insufficient to distinguish between the two diseases. A combination of markers is required to accurately diagnose a specific disease, enabling doctors to distinguish between different diseases with similar clinical appearances.
Research suggests that CD36 protein, involved in cellular inflammation, increases harmful effects of LDL cholesterol. Mice infected with gum disease bacteria showed increased fatty plaque accumulation, while those with deleted CD36 gene remained plaque-free.
Researchers investigate gum disease in young and old mice and find a drop in Del-1 levels is associated with increased gum disease. Understanding the effects of Del-1 on the immune system could lead to new treatments or prevention strategies for gum disease.
Scientists at Trinity College Dublin have found that controlling IL-18 levels could prevent the development of wet AMD, a form of blindness. Drs. Sarah Doyle and Matthew Campbell discovered that drusen accumulating in the macula lead to IL-18 production, which acts as an anti-angiogenic factor.
People of African descent may be at risk for cardiovascular disease despite normal triglyceride levels, highlighting a paradox known as the TG paradox. Researchers call for further study and development of new screening guidelines to better identify metabolic syndrome in this population.
Researchers have identified a genetic signature for regulation of IL-13, a key immune hormone involved in allergic reactions. MicroRNA miR-375 is regulated by IL-13 and plays a role in asthma and eosinophilic esophagitis (EoE), a severe food allergy.
Researchers identify 'gatekeeper' ADAM17 involved in regulating immune response and preventing inflammatory skin disease. Reactivation of Notch signaling rescues local skin inflammation and abnormal immune cell proliferation.
A nationwide Danish cohort study suggests women with endometriosis are 50% more likely to develop inflammatory bowel disease, a condition that affects the bowel and causes abdominal pain. The risk persists for over 20 years after diagnosis and is linked to common causes or treatment effects.
Researchers recommend 10 key areas for research, including large cohort studies, interdisciplinary approaches, and the development of new tools and models. Effective public-private partnerships are also essential for advancing understanding of chronic inflammatory diseases.
Patients with moderate to severe psoriasis prioritize treatment location, probability of benefit, and method of delivery over treatment outcome attributes. The study highlights the significance of incorporating patient preferences in shared decision-making to optimize treatment adherence and outcomes.
Patients with recurrent inflammatory spinal cord diseases have significantly lower vitamin D levels compared to those with monophasic disease. The study suggests a common link between low vitamin D levels and immunologic dysregulation in these conditions.
Researchers have identified a type of immune cell, dendritic cells, that plays a protective role in atherosclerosis. The study found that classical dendritic cells help prevent the disease from progressing.
Researchers found that specific microRNAs are up-regulated in obese individuals with healthy periodontium and non-obese subjects with periodontal disease. The study suggests microRNA modulation may play a role in modulating inflammatory pathways within periodontal tissues.
Research suggests that shift work in teenagers may increase the risk of developing multiple sclerosis, a central nervous system autoimmune inflammatory disorder. Disruption of the circadian rhythm and sleep patterns are believed to contribute to this increased risk.
Researchers identify key protein CFH that blocks inflammatory immune response to oxidative stress, found in conditions like atherosclerosis and AMD. The study reveals potential therapeutic target for treating chronic inflammatory diseases.
Researchers have successfully treated severe Crohn's disease with a new cell therapy approach using Type 1 regulatory lymphocytes. The preliminary results indicate improved condition and good tolerability, paving the way for further phase 2b clinical trials.
Research validates Pentraxin-2/SAP as a novel therapeutic approach for treating lung fibrosis, including IPF. PTX-2/SAP potently inhibits TGF-beta1 driven pathologies without affecting growth factor levels.
Researchers found that Porphyromonas gingivalis infection accelerates inflammation and atherosclerosis in the innominate artery of mice, characterized by vessel narrowing and perivascular inflammation. The study provides evidence for a link between periodontal disease and systemic cardiovascular diseases.
Scientists at Virginia Tech have discovered key molecular events in the immune system that contribute to inflammatory bowel disease. The study identifies peroxisome proliferator-activated receptor-gamma as a crucial regulator of inflammation and offers potential targets for repurposed drugs and naturally occurring compounds.
A study found that consuming polyunsaturated fatty acids, particularly DHA and EPA, is associated with a reduced prevalence of periodontitis. The research suggests that dietary therapy using n-3 fatty acids could be a less expensive and safer method for preventing and treating gum disease.
Researchers from Monash University identified interleukin 37 as a key therapy for many inflammatory diseases, including those affecting premature babies. The protein blocks inflammation throughout the body and has been activated by various biological triggers.