Articles tagged with Inflammatory Disorders
Researchers have identified the genetic mutation causing PAAND, a rare inflammatory disease, and found that repurposed anti-arthritis drug anakinra can effectively treat the condition. The treatment was tested on a volunteer from an English family with striking results.
A new study has found a strong link between gum disease and increased rates of cognitive decline in people with early stages of Alzheimer's Disease. Periodontitis at baseline was associated with a six-fold increase in the rate of cognitive decline over a six-month follow-up period.
A large study found that hidradenitis suppurativa is associated with a higher risk of adverse cardiovascular outcomes and death from all causes. Patients with HS were found to have a higher risk of cardiovascular-associated death compared to those with severe psoriasis. The study suggests greater awareness is needed for this association.
A study published in Nature Immunology identified Trabid, a protein regulator, as a key component in regulating interleukin genes and promoting autoimmune inflammation in multiple sclerosis patients. This finding suggests that Trabid may be a potential therapeutic target for treating inflammatory diseases such as MS.
IL-17A and Th17 cells contribute to renal injury, which can lead to permanent scarring in kidneys. Blocking IL-17A/F signaling shows promise as a novel therapy for immune-mediated renal diseases.
Researchers found that vitamin A converts 'angry' immune cells into inflammation suppressors, reducing the severity of necrotizing enterocolitis in mice. This discovery adds to evidence of vitamin A's anti-inflammatory properties and could lead to new treatments for premature infants with severe bowel disease.
A new microfluidic model of the human small airway has been developed to study COPD and asthma, allowing researchers to analyze disease mechanisms, identify biomarkers, and test new drug candidates. The model recapitulates critical features of asthma and COPD with unprecedented fidelity and detail.
Researchers developed molecular prosthetics that can detect complex signals in the immune system to suppress inflammatory responses. The prosthetics were implanted into mice and successfully treated psoriasis, providing a potential early-warning system for prevention.
Researchers at Oxford University are exploring the link between metabolism and inflammation in metabolic diseases, including type 2 diabetes and cardiovascular disease. The projects aim to deliver effective treatments and prevention strategies, addressing a global health problem affecting over 400 million people worldwide.
Researchers have developed fallopian tube organoids to study female genital diseases such as infertility, inflammatory disease, and ovarian cancer. These hollow spheres can culture cells from clinical fallopian tube samples, offering a new avenue for investigating disease mechanisms and developing therapies.
Researchers at the University of Alberta have discovered a potential new pathway for treating multiple sclerosis by suppressing granzyme B, an enzyme that damages nerve cells. By inhibiting granzyme B with serpina3n, they found significant reduction in MS symptoms in human cells and pre-clinical models.
Researchers at Australian National University and Genentech have identified a gene, Gasdermin-D, that triggers the inflammatory condition leading to sepsis. The discovery could lead to new treatments for this deadly disease, which kills an estimated one million people in the US each year.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a mechanism by which secreted proteins age and turnover, shedding light on health and disease. The discovery highlights the importance of N-glycan remodeling and lectin recognition in regulating protein abundance.
Researchers at Umeå University have discovered a molecular switch called MYSM1 that can suppress an overactive immune response and prevent inflammation. The study found that MYSM1 accumulates outside the nucleus during infection or inflammation, disrupting signaling molecules involved in activating pattern-recognition receptors.
A large study published in The BMJ found that women who underwent hysteroscopic sterilization using the Essure device had a significantly higher risk of reoperation following complications. The study analyzed data from over 8,000 and 44,000 women who underwent laparoscopic sterilization.
A Georgia State University researcher is investigating the impact of emulsifiers on gut microbiota, leading to chronic inflammatory diseases and metabolic syndrome. The study aims to determine how emulsifiers alter the intestinal tract's relationship with beneficial bacteria.
A new study found that a Mediterranean-type diet high in monounsaturated fats and low in saturated fats decreased the inflammatory response, compared to diets high or low in palmitic acid. The research suggests that dietary fats may play a key role in obesity-related diseases.
Researchers at Georgia State University developed a vaccine containing virus-like nanoparticles that induces long-term protection against RSV. The study found that mice vaccinated with these particles showed no severe pulmonary disease and lower levels of inflammatory markers after infection.
Researchers at Case Western Reserve University used stereomicroscopy to create detailed 3D images of mouse models of IBD, revealing distinct patterns related to health and disease. The findings suggest two mouse models most closely resembling human forms of the illness.
Researchers discovered a molecular mechanism that contributes to age-related macular degeneration due to excessive iron accumulation in retinal cells. Excessive iron impairs the processing of inflammatory RNAs, leading to inflammasome-mediated cell death.
Researchers discovered a control switch for the unfolded protein response (UPR), a cellular stress relief mechanism involved in various diseases. The UPR pathway can trigger cell death if stress is not resolved, but the discovery of this control switch may open new drug development avenues to prevent excessive cell death.
Researchers have developed a new drug-like molecule called WEHI-345 that binds to and inhibits a key immune signalling protein, preventing the release of inflammatory cytokines. The molecule showed promise in preventing the progression of multiple sclerosis in 50% of cases.
Researchers at Yale University found a compound produced by the body during dieting or fasting can block an immune system part involved in several inflammatory disorders. The compound BHB directly inhibits NLRP3, driving inflammation in diseases like autoimmune disorders, type 2 diabetes, and Alzheimer
Researchers have discovered two new drug compounds that target endometriosis by interacting with estrogen receptors, reducing inflammation and tissue growth. The compounds, OBHS and CLI, showed promising results in mouse models and human cell cultures, offering a potential new approach to treating the disorder.
Resistin, an immune protein found in human serum, instigates an inappropriate inflammatory response to worm infections, impairing clearance. Targeting this pathway with drugs or antibodies could lead to new therapeutic strategies for worm infections and associated pathology.
Researchers at UCLA and J. Craig Venter Institute discovered a signaling interaction between TM7x and Actinomyces odontolyticus, which causes mucosal inflammation. The study sheds light on the biological importance of TM7x and its potential roles in chronic diseases.
Researchers at the Walter and Eliza Hall Institute discovered that inflammatory skin diseases such as psoriasis are linked to abnormal apoptosis, while necroptosis is associated with systemic inflammation. This finding could lead to the development of new treatments for these conditions.
Researchers discovered that lamin-B protein plays a key role in suppressing immune responses in aging fruit flies, leading to chronic inflammation and gut hyperplasia. The findings have implications for understanding age-related immunosenescence in humans.
Researchers found that gut-derived bacterial products penetrate the gut barrier and induce inflammatory responses in alcohol-dependent patients. This leads to increased cravings for alcohol, with some but not all altered inflammatory processes recovered after detoxification.
A new Review article explores the potential to target IL-27-activated mechanisms in diseases such as multiple sclerosis and Crohn's disease. The cytokine's dual anti-inflammatory and proinflammatory activities suggest it could be a significant determinant of inflammatory responses.
A study published in JAMA Neurology found that immunosuppressant MMF treatment significantly reduced relapse rates and improved disability scores in patients with neuromyelitis optica spectrum disorder (NMOSD). The results suggest MMF may be an effective treatment option for preventing attacks and resulting disabilities in these patients.
Researchers at Lund University discovered inflammation and changes in the intestinal barrier function early in MS, indicating a potential link to disease progression. The study suggests that damage to the intestinal barrier may prevent the body from ending an autoimmune reaction, leading to chronic diseases like MS.
Researchers have discovered a link between genetic factors and the development of early-onset ulcerative colitis. The study's findings suggest that phosphatase and tensin homologue (PTEN) may play a role in helping the disease develop, and that altering the gut microbiome could be a key to prevention.
New research at Rockefeller University reveals how IELs develop to protect the intestinal epithelium, a critical interface between the gut and body. Understanding this pathway may lead to new insights into inflammatory diseases of the gut and cancer.
A new study published in Clinical Gastroenterology and Hepatology found that thiopurine therapy for inflammatory bowel disease (IBD) may increase the risk of myeloid disorders, including acute myeloid leukemia. The study analyzed data from over 19,000 IBD patients and found a seven-fold increased risk among those taking thiopurines.
A new study published in the Journal of Leukocyte Biology suggests that modulation of B cells may effectively treat and/or prevent periodontitis symptoms related to type 2 diabetes. Researchers used a mouse model to demonstrate the B cell-response's viability as a target for pharmacological intervention.
A new review argues that most intestinal parasite infections have no negative impact in well-nourished people with low overall parasite loads. In some cases, parasite infections could activate the immune system and prevent disorders caused by inflammation of the intestines.
New research from the Monell Center reveals that believing an odor is harmful can lead to increased airway inflammation in asthmatics. Airway inflammation remained elevated 24 hours later, making asthmatics more sensitive to other triggers.
Scientists have identified genetic markers associated with eosinophilic esophagitis (EoE), an inflammatory disease characterized by high levels of immune cells in the esophagus. The study found that several genes are involved in EoE development, which can cause difficulty eating and is often associated with food allergies.
Researchers at Helmholtz Munich have created a diagnostic procedure that uses only two genes to reliably differentiate between psoriasis and eczema. The new test is expected to pave the way for personalized medicine in chronic inflammatory skin diseases, reducing the need for expensive treatments.
Researchers discovered that a biochemical cascade in the bone marrow microenvironment leads to inflammation and disruption of normal blood formation, resulting in potentially deadly disorders. By targeting this inflammatory reaction, potential new strategies for treating these diseases may be developed.
Researchers have unraveled the mechanism of necroptosis, a type of cell death linked to various diseases. Understanding this process enables the development of targeted medications to block or stimulate necroptosis, potentially treating chronic and acute inflammatory and degenerative diseases.
A recent study suggests that chronic disruption of circadian rhythms may contribute to inflammatory bowel disease and other harmful conditions. Consuming a high-fat, high-sugar diet can worsen the effects of circadian rhythm disruption on intestinal flora.
Researchers discovered disease-causing bacteria in medieval dental plaque similar to those causing periodontal disease in humans today. The study sheds light on the long-term relationship between humans and their resident microbes.
A study published in The Journal of Immunology found that Interleukin 21 (IL-21) contributes to fatal inflammatory disease, particularly when another cytokine is deficient. Removing IL-21 can greatly subdue the inflammatory response and may help people with chronic inflammation due to defective T cell regulation.
Researchers found that epsilon toxin from Clostridium perfringens kills brain's myelin-producing cells and targets other cells associated with MS inflammation. The toxin may be responsible for triggering MS in genetically susceptible individuals.
Scientists have found that macrophages invade the diabetic pancreas, producing cytokines that contribute to insulin-producing beta cells' elimination. This discovery may lead to development of tailor-made anti-inflammatory therapies to reduce type 2 diabetes burden.
Scientists have found a molecular mechanism behind aging that can be reversed using a compound that restores communication between mitochondria and the nucleus. This breakthrough may lead to new treatments for age-related diseases such as cancer, type 2 diabetes, and inflammatory disorders.
Researchers found no evidence of an association between iron levels and the risk of atherosclerosis, contradicting a long-held hypothesis. The study's findings carry important implications for patients with chronic kidney disease or anemia related to inflammatory disorders.
Three researchers at the Walter and Eliza Hall Institute have been awarded ARC Future Fellowships to study how the body controls errant immune cells causing type 1 diabetes and coeliac disease. They aim to develop new treatments using cell signalling pathways and targeted vaccines or drugs.
Researchers found that disrupting the circadian clock in mice increases susceptibility to inflammatory disease by controlling the development of key immune cells called interleukin-17-producing CD4+ T helper cells. This discovery could lead to new ways to regulate the immune response and prevent autoimmune diseases.
The University of Minnesota College of Veterinary Medicine has uncovered the role of ORMDL3 in asthma, linking it to inflammatory cell recruitment and airway inflammation. The study found that silencing or over-expressing ORMDL3 in eosinophils reduces inflammation by decreasing integrin expression.
The American Academy of Periodontology urges pregnant women to prioritize periodontal health to minimize risks of adverse pregnancy outcomes. Regular dental cleanings and monitoring can help prevent premature birth or low-birth weight babies.
A study by Michigan Medicine researchers has identified five genes that play a major role in the development of Takayasu arteritis, a debilitating disease causing inflammation and damage to major blood vessels. The findings may lead to new therapeutic targets for this under-studied condition.
Dr. Ken Cadwell has been recognized with the 2013 ICAAC Young Investigator Award for his exceptional research in infectious diseases and pathogenesis, with findings already having a profound impact on the fields of immunity.
Researchers identified a network of genes involved in inflammatory response driving Late Onset Alzheimer's Disease (LOAD), providing new understanding of key pathways and genes. The study suggests targeting the TREM2-TYROBP pathway as potential therapies for LOAD.
A study published in The Journal of Immunology found that inhibiting a group of proteins can decrease inflammatory responses associated with diseases like obesity, type 2 diabetes, cancer, and sepsis. This suggests that targeting these proteins could be a potential treatment for various diseases.
A Monash Institute of Medical Research team has identified a protein called Interferon epsilon (IFNe) that protects females against infections, including STIs. The discovery could lead to new therapeutic opportunities and boost protective immunity.
Researchers have identified novel gene variants linked to Behçet's disease, a chronic condition causing painful ulcers and brain inflammation. The study also reveals multiple independent genetic risk regions within the HLA region, which could lead to better understanding and treatment options for this devastating illness.
Research suggests that being overweight is a risk factor for gum disease, which can lead to chronic inflammation and other health issues. Daily brushing, flossing, and professional cleanings are essential for preventing gum disease and maintaining good oral health.