Articles tagged with Inflammatory Disorders
Researchers will investigate how loss of protective barrier protein TCPTP contributes to IBD and identify novel molecular pathways. They aim to correct intestinal barrier defects using JAK signaling pathway inhibitors, which are being tested in clinical trials.
Scientists have made a breakthrough in understanding the immune system's molecular mechanisms, providing new foundations for treating various diseases. The study reveals that 'toll-like receptors' play a key role in both protecting against infection and triggering pathological inflammatory responses.
Researchers at Nagoya University have identified a new category of genetic skin diseases characterized by autoinflammatory responses. These conditions reflect an uncontrolled primitive immune response that does not depend on external irritants, emphasizing the need for better understanding and effective treatments.
A new study reveals that particle-induced cell death depends on multiple redundant cathepsins, which can be blocked by inhibiting or silencing these enzymes in macrophages. The researchers found that several key proinflammatory events induced by sterile particles are blocked, including cell death.
The new technology uses electronically barcoded microparticles to test for biomarkers, bacteria, viruses, air contaminants and more. It aims to enable true labs on chips, smaller than a USB flash drive or an Apple Watch, for real-time health monitoring and diagnosis.
Researchers found chemokines can activate chemokine receptors in different ways, leading to varying responses and chronic inflammation. This discovery may lead to the development of anti-inflammatory drugs targeting specific molecules.
A recent study of 160 participants found that being overweight or obese increases the likelihood of having poor oral health. Patients with obesity were almost 6-times more likely to have severe periodontitis compared to normal-weight individuals.
New research published in the Journal of Leukocyte Biology found that smoking decreases frequencies of MAIT cells in healthy individuals and patients with multiple sclerosis. This discovery sheds light on the effects of smoking on the immune system, potentially revealing pathogenic mechanisms contributing to autoimmune diseases.
A recent study published in eLife provides a deeper understanding of p38α's structure and activation mechanism. The research reveals novel conformations that could be used to uncover new inhibitors, as well as important electrostatic interactions that may allow for alternative activation pathways with increased specificity.
A UC Riverside researcher has received a two-year grant to explore a therapeutic target for IBD patients with TCPTP mutations. The study aims to correct intestinal barrier defects and reduce inflammation in the intestine.
A new report links early life antibiotic use to inflammatory gut diseases in adulthood, finding that altered gut bacteria may increase the likelihood of conditions like IBD, asthma, and multiple sclerosis. The study adds evidence to suggest that modifying gut flora could be a treatment approach for some inflammatory diseases.
Gum disease and tooth loss are linked to a higher risk of death in postmenopausal women, according to new research. The study, which analyzed data from over 57,000 women, found that history of periodontal disease was associated with a 12% higher risk of death from any cause.
Researchers found that adding back beneficial bacteria can help end a cycle of unchecked inflammation, suggesting a new treatment for inflammatory bowel disease. The study suggests targeting the inflammation downstream of NLRP12 with anti-inflammatory drugs or feeding specific beneficial bacteria to potentially lead to treatments.
A new study found that a strain of Saccharomyces cerevisiae can worsen intestinal damage in mouse models of colitis by causing elevated uric acid levels. Blocking this yeast strain may alleviate symptoms of inflammatory bowel disorders in some patients, according to the researchers.
Research using mutant zebrafish models human disease to show that changes in certain gut bacteria can cause intestinal inflammation. Transplanting beneficial bacteria and restoring gut neurons also cured the disease.
Researchers from the University of Turku identified new links between DNA variations and inflammation tracers, suggesting potential new treatments for diseases such as multiple sclerosis and Crohn's disease. The study used a large dataset to investigate the molecular processes underlying inflammatory diseases.
Scientists have identified a genetic variant that doubles an individual's risk of developing ulcerative colitis and uncovered novel genetic associations to IBD risk. The study provides clues on new drug targets for IBD treatment.
A genetic difference in the FADS1 gene affects levels of LDL- and HDL-cholesterol, as well as the risk for allergies, inflammatory diseases, and certain types of cancer. This imbalance is thought to have evolved over time due to changes in human diet.
IUPUI chemists have developed a new molecular binding technique that can shorten or abridge the human and animal drug discovery and development process. The new method, which uses site-selective C-H arylation of primary aliphatic amines, has potential benefits for both the pharmaceutical industry and patients.
Researchers discovered a new signal path in the RAS that influences immune cells, specifically phagocytes, which play a key role in MS development. The Mas receptor's influence on macrophages could provide an anti-inflammatory treatment option for chronic inflammatory diseases.
Researchers used FDG PET-CT to assess anatomical structure and metabolic activity in a patient with GLILD, showing widespread metabolic activity affecting lymph nodes throughout the body. The study reveals that GLILD is a complex, highly metabolically active condition requiring optimal monitoring and treatment timing.
A new study finds that inflammatory marker AGP better predicts mortality than IL-6, offering insights for personalized medicine. Researchers used data from 1997 to 2015 on 6545 adults aged 45-69, revealing the potential for inflammation markers to predict disease risk and death.
Scientists have identified chemical changes in DNA that can be detected in blood samples, paving the way for a simple test to aid diagnosis. The findings could lead to a blood test to screen people who show symptoms of bowel diseases, sparing further tests for those without the signatures.
A team of scientists, led by prof. Savvas Savvides, used integrative structural biology to study how GIF, a protein secreted by the Orf virus, inactivates key cytokines of the host immune system. The research reveals unique strategies that viruses use to counter antiviral responses and highlights great potential for innovative therapies.
Resveratrol, a compound found in red wine and grapes, has been shown to reduce inflammation induced by bacterial pathogens that cause respiratory diseases such as asthma and COPD. The study identified a novel mechanism by which resveratrol suppresses inflammation by upregulating a negative regulator called MyD88 short.
A new study reveals a significant relationship between chronic periodontitis and lacunar infarct, two common diseases affecting the elderly. The study suggests that periodontitis may lead to systemic inflammation, increasing the risk of developing cerebrovascular diseases.
The gut microbiome's impact on brain health and disease is a growing area of research. Dr. David Perlmutter discusses the link between the gut microbiome and conditions like Alzheimer's, ALS, and multiple sclerosis.
Autoinflammatory diseases are characterized by recurrent acute inflammatory episodes due to deregulation of the inflammatory process. Researchers have identified epigenetic alterations in cryopyrin-associated periodic syndromes (CAPS), which could lead to the development of novel biomarkers for diagnosis and treatment.
Scientists at Hokkaido University found that ARL3 facilitates STAT3 transport into the nucleus, regulating gene expression and cell proliferation. This discovery offers promising candidates for novel therapies targeting STAT3-related diseases.
Researchers have discovered a signature of gut bacteria associated with primary sclerosing cholangitis (PSC), a liver disease with no effective treatment. The findings may lead to a novel diagnosis tool and microbiota-based therapies, enabling better identification of PSC patients and personalized treatment approaches.
Non-inflammatory destructive periodontal disease (NIDPD) is a severe destructive periodontal disease marked by generalized gingival recession and periodontal pocket development. The disease's etiology is linked to endogenous opportunistic bacteria, anatomical factors, occlusion pattern, emotional stress, and mouth breathing condition.
A study published in Science has identified a key gene in the development of coeliac disease, found in 95% of non-coding DNA. The gene, 1nc13, regulates inflammatory response and its altered expression is associated with increased levels of pro-inflammatory genes.
Researchers have identified the genetic mutation causing PAAND, a rare inflammatory disease, and found that repurposed anti-arthritis drug anakinra can effectively treat the condition. The treatment was tested on a volunteer from an English family with striking results.
A new study has found a strong link between gum disease and increased rates of cognitive decline in people with early stages of Alzheimer's Disease. Periodontitis at baseline was associated with a six-fold increase in the rate of cognitive decline over a six-month follow-up period.
A large study found that hidradenitis suppurativa is associated with a higher risk of adverse cardiovascular outcomes and death from all causes. Patients with HS were found to have a higher risk of cardiovascular-associated death compared to those with severe psoriasis. The study suggests greater awareness is needed for this association.
A study published in Nature Immunology identified Trabid, a protein regulator, as a key component in regulating interleukin genes and promoting autoimmune inflammation in multiple sclerosis patients. This finding suggests that Trabid may be a potential therapeutic target for treating inflammatory diseases such as MS.
IL-17A and Th17 cells contribute to renal injury, which can lead to permanent scarring in kidneys. Blocking IL-17A/F signaling shows promise as a novel therapy for immune-mediated renal diseases.
Researchers found that vitamin A converts 'angry' immune cells into inflammation suppressors, reducing the severity of necrotizing enterocolitis in mice. This discovery adds to evidence of vitamin A's anti-inflammatory properties and could lead to new treatments for premature infants with severe bowel disease.
A new microfluidic model of the human small airway has been developed to study COPD and asthma, allowing researchers to analyze disease mechanisms, identify biomarkers, and test new drug candidates. The model recapitulates critical features of asthma and COPD with unprecedented fidelity and detail.
Researchers developed molecular prosthetics that can detect complex signals in the immune system to suppress inflammatory responses. The prosthetics were implanted into mice and successfully treated psoriasis, providing a potential early-warning system for prevention.
Researchers at Oxford University are exploring the link between metabolism and inflammation in metabolic diseases, including type 2 diabetes and cardiovascular disease. The projects aim to deliver effective treatments and prevention strategies, addressing a global health problem affecting over 400 million people worldwide.
Researchers have developed fallopian tube organoids to study female genital diseases such as infertility, inflammatory disease, and ovarian cancer. These hollow spheres can culture cells from clinical fallopian tube samples, offering a new avenue for investigating disease mechanisms and developing therapies.
Researchers at the University of Alberta have discovered a potential new pathway for treating multiple sclerosis by suppressing granzyme B, an enzyme that damages nerve cells. By inhibiting granzyme B with serpina3n, they found significant reduction in MS symptoms in human cells and pre-clinical models.
Researchers at Australian National University and Genentech have identified a gene, Gasdermin-D, that triggers the inflammatory condition leading to sepsis. The discovery could lead to new treatments for this deadly disease, which kills an estimated one million people in the US each year.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a mechanism by which secreted proteins age and turnover, shedding light on health and disease. The discovery highlights the importance of N-glycan remodeling and lectin recognition in regulating protein abundance.
Researchers at Umeå University have discovered a molecular switch called MYSM1 that can suppress an overactive immune response and prevent inflammation. The study found that MYSM1 accumulates outside the nucleus during infection or inflammation, disrupting signaling molecules involved in activating pattern-recognition receptors.
A large study published in The BMJ found that women who underwent hysteroscopic sterilization using the Essure device had a significantly higher risk of reoperation following complications. The study analyzed data from over 8,000 and 44,000 women who underwent laparoscopic sterilization.
A Georgia State University researcher is investigating the impact of emulsifiers on gut microbiota, leading to chronic inflammatory diseases and metabolic syndrome. The study aims to determine how emulsifiers alter the intestinal tract's relationship with beneficial bacteria.
A new study found that a Mediterranean-type diet high in monounsaturated fats and low in saturated fats decreased the inflammatory response, compared to diets high or low in palmitic acid. The research suggests that dietary fats may play a key role in obesity-related diseases.
Researchers at Georgia State University developed a vaccine containing virus-like nanoparticles that induces long-term protection against RSV. The study found that mice vaccinated with these particles showed no severe pulmonary disease and lower levels of inflammatory markers after infection.
Researchers at Case Western Reserve University used stereomicroscopy to create detailed 3D images of mouse models of IBD, revealing distinct patterns related to health and disease. The findings suggest two mouse models most closely resembling human forms of the illness.
Researchers discovered a molecular mechanism that contributes to age-related macular degeneration due to excessive iron accumulation in retinal cells. Excessive iron impairs the processing of inflammatory RNAs, leading to inflammasome-mediated cell death.
Researchers discovered a control switch for the unfolded protein response (UPR), a cellular stress relief mechanism involved in various diseases. The UPR pathway can trigger cell death if stress is not resolved, but the discovery of this control switch may open new drug development avenues to prevent excessive cell death.
Researchers have developed a new drug-like molecule called WEHI-345 that binds to and inhibits a key immune signalling protein, preventing the release of inflammatory cytokines. The molecule showed promise in preventing the progression of multiple sclerosis in 50% of cases.
Researchers at Yale University found a compound produced by the body during dieting or fasting can block an immune system part involved in several inflammatory disorders. The compound BHB directly inhibits NLRP3, driving inflammation in diseases like autoimmune disorders, type 2 diabetes, and Alzheimer
Researchers have discovered two new drug compounds that target endometriosis by interacting with estrogen receptors, reducing inflammation and tissue growth. The compounds, OBHS and CLI, showed promising results in mouse models and human cell cultures, offering a potential new approach to treating the disorder.
Resistin, an immune protein found in human serum, instigates an inappropriate inflammatory response to worm infections, impairing clearance. Targeting this pathway with drugs or antibodies could lead to new therapeutic strategies for worm infections and associated pathology.
Researchers at UCLA and J. Craig Venter Institute discovered a signaling interaction between TM7x and Actinomyces odontolyticus, which causes mucosal inflammation. The study sheds light on the biological importance of TM7x and its potential roles in chronic diseases.
Researchers at the Walter and Eliza Hall Institute discovered that inflammatory skin diseases such as psoriasis are linked to abnormal apoptosis, while necroptosis is associated with systemic inflammation. This finding could lead to the development of new treatments for these conditions.
Researchers discovered that lamin-B protein plays a key role in suppressing immune responses in aging fruit flies, leading to chronic inflammation and gut hyperplasia. The findings have implications for understanding age-related immunosenescence in humans.