Articles tagged with Inflammatory Disorders
Researchers identified VEXAS, a severe inflammatory disease caused by UBA1 gene mutations, revealing devastating consequences. The genome-first approach helped uncover the link between disparate diagnoses in patients with undiagnosed inflammatory conditions.
A team of scientists at the University of Toronto has discovered the mechanism linking periodontal disease to other inflammatory conditions. The study found that neutrophil immune cell activity is the key factor connecting gum disease to heart disease, cancer, and other inflammatory conditions.
MIT researchers developed a new technique to recapture lost information from single-cell RNA-sequencing, enabling the extraction of 10 times more data per cell. This breakthrough helps identify subtle differences between healthy and dysfunctional cells, with potential applications in disease diagnosis and treatment.
Researchers at UC San Diego report that Kawasaki disease clusters have distinct demographic and clinical features, suggesting different triggers and genetic susceptibilities. The study's findings support the idea that KD is not a single homogenous disease, but rather a complex condition with multiple causes.
Research found that changes in cell populations and circulating inflammatory proteins are already partly present in older healthy individuals. The study identified markers that explain the high susceptibility of older individuals to severe COVID-19 and inform efforts to prevent and treat the disease.
Researchers have mapped the immune response in children with a rare and life-threatening inflammatory syndrome associated with COVID-19. The study found that the condition differs from Kawasaki disease and severe acute COVID-19, with distinct patterns of immune cell populations, inflammatory cytokines, and autoantibodies.
Adding corticosteroids to standard intravenous immunoglobulin treatment for high-risk Kawasaki disease patients can boost initial response and prevent complications. The combination approach reduced the need for a second course of therapy by 35% and the risk of coronary artery abnormalities by 47%.
Researchers discovered neuromedin B, a nervous system protein, prevents overactive immune responses and damaging inflammation in diseases like asthma, allergies, and COPD. The study provides hope for possible treatments using NMB to treat inflammatory diseases.
A study published in PLOS ONE found that captive black rhinoceroses have higher iron levels, inflammation, and oxidative stress compared to white rhinoceroses. This suggests a link between iron accumulation and the development of diseases like organ failure.
Researchers pinpointed a single gene biomarker, nitride oxide synthase 2 (NOS2), to distinguish between atopic dermatitis and psoriasis with 100% accuracy using adhesive tape strips. The study identifies distinct immune response markers for each disease.
A study found that type 1 interferon deficiency is a biomarker for patients at risk of severe COVID-19. Low levels of type 1 interferon in plasma precede clinical worsening and are characteristic of each stage of the disease, suggesting it could identify a high-risk population.
Scientists discovered that Staphylococcus epidermidis interacts with the immune system to promote wound healing and prevent inflammation. The study's findings may lead to therapies for conditions like atopic dermatitis and inflammatory bowel diseases, affecting millions worldwide.
A new study published in PNAS reveals that low levels of the cytokine IL-38 are associated with increased inflammation in the amygdala of children with autism spectrum disorder. This suggests that targeting IL-38 may represent a promising therapeutic strategy for treating autism.
Walter and Eliza Hall Institute researchers used advanced imaging to visualize MLKL's role in necroptosis, a form of cell death triggered by inflammation. They found that inherited variants of MLKL are connected to human inflammatory diseases and have been subject to evolutionary pressures.
The Pew Scholars Program in Biomedical Sciences supports early-career researchers with four-year funding for foundational research. This year's class of 22 scholars tackles complex questions in biomedicine, including aging differences between males and females, inflammatory disease trajectories, and temperature regulation mechanisms.
NHGRI researchers have identified genetic mutations associated with PFAPA syndrome, a periodic fever disorder that affects only children. The study reveals commonalities with other inflammatory conditions, including Behçet's disease and canker sores, and highlights the potential for new treatments and diagnostic tools.
Researchers are investigating the use of intravenous immunoglobulin (IVIG) to treat COVID-19 patients experiencing respiratory failure. Preliminary data show promise in preventing mechanical ventilation and improving outcomes for critically ill patients.
A new study finds that e-cigarettes cause a proinflammatory response in the oral microbiome, coating commensal bacteria with slime and disrupting healthy colonization. The glycerol/glycol vehicle in e-cigarettes appears to drive these changes, according to researchers who analyzed bacterial genes in plaque samples from e-cigarette users.
Castleman Disease patients experience a cytokine storm that can cause fever, organ failure, and death. Researchers identified Type-I Interferons as highly active during flares and the JAK pathway as a critical mediator of the immune system's hyper-response.
A new project led by Murdoch Children's Research Institute has received a $525,000 grant to analyze lung samples from healthy and unwell children to describe lung inflammation in childhood disorders such as asthma and bronchiectasis. The study aims to inform strategies for improving clinical care and pulmonary health throughout life.
MIT biological engineers develop a multitissue model of the colon and liver, revealing how different tissues contribute to inflammatory diseases. The study finds that metabolic byproducts generated by bacteria play an important role in exacerbating inflammation.
A new study suggests that a diet rich in sugar increases the risk of both dental cavities and gum inflammation. Healthy eating habits should be prioritized to avoid expensive treatments.
Researchers have identified chronic inflammation as the primary driver of accelerated aging, leading to a range of diseases including Alzheimer's, atherosclerosis and cancer. This discovery opens up new avenues for early diagnosis, prevention and treatment of these conditions.
Researchers discovered an alternate mechanism by which the molecule RIPK1 triggers cell death in infected or damaged cells. The finding breaks existing dogma that RIPK1 kinase activity is required for cell death and holds promise for treating inflammatory diseases and cancer.
Researchers develop a new approach to alter intestinal microbiota and vaccinate against chronic inflammatory diseases, including inflammatory bowel diseases and obesity. Targeted immunization against bacterial flagellin has been shown to beneficially alter the composition and function of the intestinal microbiota.
A study published in EMBO Molecular Medicine suggests that blocking the protease MT1-MMP could protect the vasculature in the inflamed gut and reduce severity of colitis. The research found that inhibiting this protease could have potential clinical implications, including identifying biomarkers for mild IBD.
Researchers describe how ancestral origins impact the likelihood of developing immune-related diseases, including Crohn's disease and cardiovascular diseases. The human immune system is evolving depending on a person's location or lifestyle, leading to new diseases emerging as our lifespans increase.
A research team at Trinity College Dublin has discovered that PKM2 is a central 'on' switch for immune cells involved in psoriasis and multiple sclerosis. Interfering with PKM2 blocks these cells and limits inflammation, offering new potential treatments for these diseases.
A new study has discovered four subtypes of primary Sjögren's syndrome, a chronic inflammatory disease affecting the body's fluid production. This finding offers hope for personalized treatment and improved quality of life for patients.
Blood vessels play a significant role in chronic inflammatory bowel diseases, with highly permeable vessels found in patients. The researchers identified interferon-γ as the cause of this malfunction and discovered that inhibiting vessel permeability slows down disease progression.
A study of postmortem brain tissue found increased expression of IL-18 and IL-37 in children with Autism Spectrum Disorder (ASD), suggesting these cytokines may inhibit microglia-driven inflammation and represent a potential therapeutic candidate for ASD.
Researchers propose that teenage acne is a naturally occurring, inflammatory state caused by the sudden change in skin microbiota composition and increased sebum production during adolescence. This hypothesis challenges conventional thinking and may explain special clinical characteristics of acne.
A subset of immune cells from PID patients exhibit increased cellular respiration, leading to inflammation and autoimmunity. Researchers successfully administered a targeted treatment with fewer side effects.
A study published in Cell found that intermittent fasting reduces the release of pro-inflammatory cells called monocytes, which can cause serious tissue damage. Fasting also leads to these cells going into a less inflammatory state.
Researchers estimate that over 72 per 100,000 people in the US are affected by prurigo nodularis, a skin disease characterized by itchy bumps. The study also found associations with other conditions, including HIV, kidney disease, and mental health disorders.
A randomized clinical trial compared a technology-enhanced community health nursing intervention to standard care for female adolescents and young adults with pelvic inflammatory disease. The study found that the tech-enhanced intervention may offer improved medication adherence and treatment outcomes.
A team of researchers has developed a method to establish multicellular human liver organoids that show liver tissue characteristics down to the gene and protein scale. The livers were triggered with liver diseases, such as steatohepatitis, and showed increased levels of fibrosis indicators.
A study has characterised two distinct populations of gut immune cells, which could help scientists develop treatments targeting inflammation while preserving healthy gut function. The 'good' cell population helps keep the gut lining healthy, while the 'bad' cells cause excessive inflammation and are associated with inflammatory diseases.
Scientists have made a breakthrough in understanding how macrophage cells respond to certain bacteria, potentially leading to new treatments for Crohn's Disease. The study found that different types of macrophages exhibit distinct molecular mechanisms when switching off their pro-inflammatory behavior.
Researchers developed a new type of nuclear medicine scan that quickly and precisely diagnoses inflammation in IBD using monoclonal antibodies directed against specific innate immune cell markers. The immuno-PET scan has high potential for theranostic diagnosis and precision treatment of IBD and other inflammatory diseases.
Researchers from University of Bristol and others found that GP inflammatory marker tests are not sensitive enough to rule out serious underlying conditions. The studies also revealed high rates of false positive results leading to unnecessary consultations and referrals.
A new study suggests that chronic inflammation disrupts the brain's dopamine system, leading to motivational impairments in depression, schizophrenia, and other disorders. The researchers developed a computational method to test their theory, which may yield insights into treating cases of depression and behavioral disorders.
A new study from the Australian National University found that spending half an hour a day outside in the sun can lower the risk of inflammatory bowel disease (IBD) by almost 20%, including Crohn's Disease and ulcerative colitis. Short periods of sun exposure also showed significant benefits.
A study published in Human Molecular Genetics reveals that DNA mutations trigger an inflammatory response, leading to cell death and progressive neurological damage. The discovery may lead to effective treatments using existing anti-inflammatory drugs.
Two studies found a significant association between psoriasis and an increased risk of mental health disorders, including depression and anxiety, in Denmark and South Korea. The research highlights the importance of addressing the mental health needs of individuals with chronic skin conditions like psoriasis.
A team of researchers from Trinity College Dublin has discovered that SARM plays an important role in the immune response and regulates inflammation. The study suggests that targeting SARM could provide a new option for treating diseases such as diabetes, cancer, and Alzheimer
A new $1.8 million grant will aid in developing personalized treatments for Crohn's disease through the use of a gut-on-a-chip system, which mimics human gut structure and function. The goal is to uncover triggers and develop more effective therapies, ultimately improving health outcomes.
Researchers identify five classes of early immune-system programming, linking childhood experiences to chronic inflammatory diseases and psychiatric disorders in adulthood. The study found that children with resilient immune systems were better protected against both conditions.
Researchers at the George Washington University found dermcidin, an antimicrobial peptide, is downregulated in hidradenitis suppurativa skin, suggesting its role in disease pathogenesis. The study suggests multiple biological pathways are disrupted in HS, warranting further investigation into new therapeutic options.
Chen Dong has made seminal contributions to the field of CD4 T cell subsets, including the discovery of Th17 lineage cells and T follicular helper cells. His research has improved our understanding of human diseases and led to novel treatments, such as antagonizing Th17 cell function for autoimmune diseases.
Scientists at Joslin Diabetes Center discovered a group of 17 inflammatory proteins associated with diabetic kidney disease progression. These Kidney Risk Inflammatory Signature (KRIS) proteins, including TNF receptors, are indicative of systemic inflammation and may serve as drug targets to prevent and treat end-stage renal disease.
Researchers used advanced PET/MRI technology to analyze inflammatory processes in arteries of individuals with atherosclerotic plaques. The study found that inflammation is present at early stages of atherosclerosis, particularly in regions without developed plaques.
A study published in PNAS shows that an enzyme inhibitor reduces inflammation in the brains of mice born to mothers with maternal immune activation, reversing cognitive and social interaction deficiencies. The findings suggest a potential new treatment approach for neurodevelopmental disorders such as autism and schizophrenia.
Scientists at Institut Pasteur and Inserm have found that an immune response generated when solid food is introduced in mice prevents inflammatory disorders. The reaction involves regulatory T cells and balances the immune system, leading to lower susceptibility to allergies, colitis, autoimmune diseases, and cancer.
A research team identified molecular and genetic mechanisms allowing bats to host multiple viral pathogens without suffering diseases. Bats have a unique ability to limit inflammation, which may be key to their long lifespans and virus reservoir status.
A new study found that multiple sclerosis patients with food allergies experienced a higher rate of disease activity and increased likelihood of new lesions compared to those without food allergies. The association highlights the potential role of the gut in MS immune dysregulation.
Studies presented at the Crohn's & Colitis Congress highlight the need for improved diagnosis in IBD patients, which can lead to delayed treatment and increased complications. New biomarkers, such as a blood-based prognostic biomarker, are being developed to predict disease course and personalize therapy.
Researchers at University of Freiburg discover new immune cells that promote multiple sclerosis development, creating an immune cell atlas for the brain. Chronic activation of these cells may explain why the brain is chronically attacked in MS patients.
Researchers at FAU have identified TRM cells as a key player in inducing acute inflammatory episodes in bowel diseases, leading to flare-ups and tissue damage. Patients with high proportions of these cells are more likely to experience severe symptoms.
A study published in the British Journal of Dermatology found that an investigational nonsteroidal topical cream, PAC-14028, improved clinical symptoms and signs in adults with mild to moderate atopic dermatitis. The cream blocks a specific ion channel involved in pain perception and inflammation.