Articles tagged with Inflammatory Disorders
A study has characterised two distinct populations of gut immune cells, which could help scientists develop treatments targeting inflammation while preserving healthy gut function. The 'good' cell population helps keep the gut lining healthy, while the 'bad' cells cause excessive inflammation and are associated with inflammatory diseases.
Researchers developed a new type of nuclear medicine scan that quickly and precisely diagnoses inflammation in IBD using monoclonal antibodies directed against specific innate immune cell markers. The immuno-PET scan has high potential for theranostic diagnosis and precision treatment of IBD and other inflammatory diseases.
Researchers from University of Bristol and others found that GP inflammatory marker tests are not sensitive enough to rule out serious underlying conditions. The studies also revealed high rates of false positive results leading to unnecessary consultations and referrals.
Scientists have made a breakthrough in understanding how macrophage cells respond to certain bacteria, potentially leading to new treatments for Crohn's Disease. The study found that different types of macrophages exhibit distinct molecular mechanisms when switching off their pro-inflammatory behavior.
A new study suggests that chronic inflammation disrupts the brain's dopamine system, leading to motivational impairments in depression, schizophrenia, and other disorders. The researchers developed a computational method to test their theory, which may yield insights into treating cases of depression and behavioral disorders.
A new study from the Australian National University found that spending half an hour a day outside in the sun can lower the risk of inflammatory bowel disease (IBD) by almost 20%, including Crohn's Disease and ulcerative colitis. Short periods of sun exposure also showed significant benefits.
A study published in Human Molecular Genetics reveals that DNA mutations trigger an inflammatory response, leading to cell death and progressive neurological damage. The discovery may lead to effective treatments using existing anti-inflammatory drugs.
Two studies found a significant association between psoriasis and an increased risk of mental health disorders, including depression and anxiety, in Denmark and South Korea. The research highlights the importance of addressing the mental health needs of individuals with chronic skin conditions like psoriasis.
A team of researchers from Trinity College Dublin has discovered that SARM plays an important role in the immune response and regulates inflammation. The study suggests that targeting SARM could provide a new option for treating diseases such as diabetes, cancer, and Alzheimer
A new $1.8 million grant will aid in developing personalized treatments for Crohn's disease through the use of a gut-on-a-chip system, which mimics human gut structure and function. The goal is to uncover triggers and develop more effective therapies, ultimately improving health outcomes.
Researchers identify five classes of early immune-system programming, linking childhood experiences to chronic inflammatory diseases and psychiatric disorders in adulthood. The study found that children with resilient immune systems were better protected against both conditions.
Researchers at the George Washington University found dermcidin, an antimicrobial peptide, is downregulated in hidradenitis suppurativa skin, suggesting its role in disease pathogenesis. The study suggests multiple biological pathways are disrupted in HS, warranting further investigation into new therapeutic options.
Chen Dong has made seminal contributions to the field of CD4 T cell subsets, including the discovery of Th17 lineage cells and T follicular helper cells. His research has improved our understanding of human diseases and led to novel treatments, such as antagonizing Th17 cell function for autoimmune diseases.
Scientists at Joslin Diabetes Center discovered a group of 17 inflammatory proteins associated with diabetic kidney disease progression. These Kidney Risk Inflammatory Signature (KRIS) proteins, including TNF receptors, are indicative of systemic inflammation and may serve as drug targets to prevent and treat end-stage renal disease.
Researchers used advanced PET/MRI technology to analyze inflammatory processes in arteries of individuals with atherosclerotic plaques. The study found that inflammation is present at early stages of atherosclerosis, particularly in regions without developed plaques.
Scientists at Institut Pasteur and Inserm have found that an immune response generated when solid food is introduced in mice prevents inflammatory disorders. The reaction involves regulatory T cells and balances the immune system, leading to lower susceptibility to allergies, colitis, autoimmune diseases, and cancer.
A study published in PNAS shows that an enzyme inhibitor reduces inflammation in the brains of mice born to mothers with maternal immune activation, reversing cognitive and social interaction deficiencies. The findings suggest a potential new treatment approach for neurodevelopmental disorders such as autism and schizophrenia.
A research team identified molecular and genetic mechanisms allowing bats to host multiple viral pathogens without suffering diseases. Bats have a unique ability to limit inflammation, which may be key to their long lifespans and virus reservoir status.
A new study found that multiple sclerosis patients with food allergies experienced a higher rate of disease activity and increased likelihood of new lesions compared to those without food allergies. The association highlights the potential role of the gut in MS immune dysregulation.
Studies presented at the Crohn's & Colitis Congress highlight the need for improved diagnosis in IBD patients, which can lead to delayed treatment and increased complications. New biomarkers, such as a blood-based prognostic biomarker, are being developed to predict disease course and personalize therapy.
Researchers at University of Freiburg discover new immune cells that promote multiple sclerosis development, creating an immune cell atlas for the brain. Chronic activation of these cells may explain why the brain is chronically attacked in MS patients.
Researchers at FAU have identified TRM cells as a key player in inducing acute inflammatory episodes in bowel diseases, leading to flare-ups and tissue damage. Patients with high proportions of these cells are more likely to experience severe symptoms.
A study published in the British Journal of Dermatology found that an investigational nonsteroidal topical cream, PAC-14028, improved clinical symptoms and signs in adults with mild to moderate atopic dermatitis. The cream blocks a specific ion channel involved in pain perception and inflammation.
A recent study published in JAMA Dermatology found a significant association between eczema and suicidal thoughts or attempts. The research, analyzing data from over 310,000 patients with eczema and 4.4 million without, suggests individuals with eczema are more likely to experience suicidal thoughts and attempts compared to those without.
Researchers have found evidence of multiple environmental triggers for Kawasaki Disease, with clusters associated with distinct atmospheric patterns and warmer conditions in Southern California. Gene expression analysis revealed distinct groups of patients based on their gene expression pattern, suggesting varying causes for the disease.
A study of 1,278 adults found that atopic dermatitis affects 7.3% of the population, with 6.6 million cases being moderate-to-severe. The condition can significantly impact quality of life and may change over time, highlighting the need for innovative therapies.
Researchers found corticosteroids, biologics, and immunosuppressive agents to be effective for treating urticarial vasculitis. Antihistamines and other anti-inflammatory drugs were ineffective, contrary to common practice.
Researchers at Tel Aviv University have developed a new platform that uses biology and nanotechnology to carry mRNA directly to target cells. The system demonstrates safe and effective passage of therapies for treating various diseases, including cancer and inflammatory disorders.
Targeting immune checkpoints in microglia may reduce neuroinflammation in neurodegenerative diseases. Dysregulation of these checkpoints is linked to diseases such as Alzheimer's, Parkinson's, and ALS.
Consuming caffeine from coffee, but not tea or soda, was associated with a decreased risk of rosacea. This observational study found that four servings or more of caffeinated coffee per day were linked to the lowest risk of rosacea.
The Journal of the American Medical Association highlights the growing field of geroscience, which seeks to understand and address the biological mechanisms underlying aging. Researchers from the American Federation for Aging Research are leading the way in this area, exploring therapeutic interventions and extending healthspan.
Researchers have discovered a protein called RNF5 that drives intestinal inflammation in inflammatory bowel disease (IBD). High levels of S100A8, another protein regulated by RNF5, are linked to disease severity and may serve as a potential diagnostic marker.
Research found that STAT3 is constitutively activated in CAEBV-infected T- or NK-cells, promoting cell survival and inflammation. Ruxolitinib inhibition blocks survival and reduces pro-inflammatory cytokine production, suggesting a potential therapeutic target for this fatal disorder.
A new study led by the University of Pennsylvania School of Medicine finds that aspirin desensitization can also alleviate alcohol-induced allergies in patients with Aspirin Exacerbated Respiratory Disease (AERD). Following treatment, 86.5% of patients reported they could drink alcohol without experiencing symptoms.
Researchers discover a causal relationship between inflammatory responses in aging nerves and degenerative aging processes. The team found that reducing macrophage activity improves nerve structure and function, increasing mobility and quality of life for those affected by age-related muscle weakness.
Research published in Endocrine Connections found that individuals with type-1 diabetes and depression have higher galectin-3 levels, a protein involved in inflammatory immune responses. Elevated galectin-3 levels were also linked to an increased risk of inflammatory disorders such as Alzheimer's disease and cardiovascular disease.
Weizmann Institute of Science researchers found a natural defense mechanism that prompts the body to alleviate intestinal inflammation. Boosting signals in certain cells, such as those making up the inner lining of the gut, may help treat inflammatory bowel diseases and potentially even colon cancer.
A study at Osaka University has identified Sema6D as a crucial protein in the activation of macrophages that protect against inflammatory disorders. The research found that Sema6D plays a key role in the metabolic reprogramming necessary for M2-type macrophages to function properly, highlighting its potential as a therapeutic target.
A new guideline from the American Academy of Neurology suggests that starting MS drugs early may be better than letting the disease run its course. Disease-modifying therapies can alter or change the course of MS, reducing relapses and slowing disease progression.
Researchers identified key molecular drivers in calcific aortic valve disease, including cells from the lamina fibrosa layer with high propensity to calcify. A precise omics-level molecular atlas of the aortic valve reveals potential therapeutic targets for developing pharmacological therapy.
Researchers at Osaka University have found that the double deletion of tetraspanins CD9 and CD81 in mice causes progressive aging and shortened lifespan. The study reveals that CD9/CD81 DKO mice develop an accelerated aging syndrome, with symptoms including emphysema, osteoporosis, and skin and muscle atrophy.
Research reveals inflammatory airway disease (IAD) is common among racehorses, even those without respiratory signs. The study of 95 deceased racehorses found most had some degree of IAD, suggesting all horses may be exposed to inflammation.
Researchers found that sucralose, a key ingredient in Splenda, promotes gut inflammation in mice with Crohn's-like disease, but has no effect on healthy mice. The study suggests that individuals with pro-inflammatory predispositions may be more susceptible to exacerbation of symptoms.
Scientists have discovered key regulators that control the inflammatory response in chronic diseases such as Crohn's disease and multiple sclerosis. The NOD2 pathway plays a critical role in detecting bacterial invaders, but faults in its regulation can lead to uncontrolled inflammation.
Researchers found that elevated frequencies of a specific protein-expressing T cell correlate with increased HIV infection risk and more severe disease in women. Existing treatments for inflammatory bowel disease may be repurposed as valuable interventions for HIV.
A new study found that brains of people with Huntington's disease (HD) and Parkinson's disease (PD) show similar responses to a lifetime of neurodegeneration, despite being distinct diseases. Most genes related to immune response and inflammatory pathways are common in both diseases.
An international study discovered five new regions of the genome associated with increased asthma risk, characterized by epigenetic marks on gene enhancers. The genetic variants also show associations with auto-immune diseases and inflammatory component diseases, highlighting the importance of pleiotropy in multifactorial diseases.
Researchers found that repeated low-grade bacterial infections can lead to severe inflammatory disease and potentially life-threatening colitis. The study also identified a link between Salmonella infection and an acquired deficiency of intestinal alkaline phosphatase, which accelerates inflammation.
Researchers at the University of Sydney have discovered unique micro-RNA molecules in the blood that can diagnose multiple sclerosis (MS) and predict its progression. These findings hold promise for developing a definitive diagnostic test, which could lead to earlier treatment and improved outcomes for people with MS.
Researchers at the National University of Singapore have discovered a critical molecular target for sphingosine-1-phosphate production, paving the way for regulating its signalling in circulation. Low levels of S1P have been linked to various immune and vascular diseases, including multiple sclerosis and cardiovascular complications.
Researchers discovered etosis in human blood monocytes, a type of immune cell that can project DNA outside the cell. This process has implications for understanding inflammation and potentially developing new diagnostic tools and therapeutic targets.
Researchers will investigate how loss of protective barrier protein TCPTP contributes to IBD and identify novel molecular pathways. They aim to correct intestinal barrier defects using JAK signaling pathway inhibitors, which are being tested in clinical trials.
Scientists have made a breakthrough in understanding the immune system's molecular mechanisms, providing new foundations for treating various diseases. The study reveals that 'toll-like receptors' play a key role in both protecting against infection and triggering pathological inflammatory responses.
Researchers at Nagoya University have identified a new category of genetic skin diseases characterized by autoinflammatory responses. These conditions reflect an uncontrolled primitive immune response that does not depend on external irritants, emphasizing the need for better understanding and effective treatments.
A new study reveals that particle-induced cell death depends on multiple redundant cathepsins, which can be blocked by inhibiting or silencing these enzymes in macrophages. The researchers found that several key proinflammatory events induced by sterile particles are blocked, including cell death.
The new technology uses electronically barcoded microparticles to test for biomarkers, bacteria, viruses, air contaminants and more. It aims to enable true labs on chips, smaller than a USB flash drive or an Apple Watch, for real-time health monitoring and diagnosis.
Researchers found chemokines can activate chemokine receptors in different ways, leading to varying responses and chronic inflammation. This discovery may lead to the development of anti-inflammatory drugs targeting specific molecules.
A recent study of 160 participants found that being overweight or obese increases the likelihood of having poor oral health. Patients with obesity were almost 6-times more likely to have severe periodontitis compared to normal-weight individuals.
New research published in the Journal of Leukocyte Biology found that smoking decreases frequencies of MAIT cells in healthy individuals and patients with multiple sclerosis. This discovery sheds light on the effects of smoking on the immune system, potentially revealing pathogenic mechanisms contributing to autoimmune diseases.
A recent study published in eLife provides a deeper understanding of p38α's structure and activation mechanism. The research reveals novel conformations that could be used to uncover new inhibitors, as well as important electrostatic interactions that may allow for alternative activation pathways with increased specificity.