Articles tagged with Inflammatory Disorders
A study has identified a new gene that may play a key role in the development of pediatric-onset inflammatory bowel disease. The gene, TNFRSF6B, is involved in regulating inflammation and its activity has been linked to the severity of the disease.
Anemia of chronic disease could be an adaptive response to inflammatory illness, rather than a disorder. Researchers suggest treating mild to moderate cases to avoid increased mortality from treatment.
An international team of researchers has identified 21 new genetic risk factors for Crohn's disease, building on earlier studies that linked the disorder to disruptions in autophagy and immune system response. The findings, published in Nature Genetics, may lead to novel therapies and prevention strategies.
Researchers at the University of Bonn discovered that oregano's active ingredient beta-caryophyllin inhibits inflammation and may help treat osteoporosis, arteriosclerosis, and chronic disorders like Crohn's disease. The substance targets cannabinoid-CB2 receptors, providing a non-intoxicating alternative to existing treatments.
Research shows that people with temporal arteritis, an inflammatory artery disease, are three times more likely to experience blindness due to swollen arteries restricting blood flow. The disease is often accompanied by symptoms like headaches and jaw soreness, and if left untreated can lead to severe vision loss or stroke.
Researchers discovered a new family of genetic mutations involved in inflammatory intestinal diseases, including coeliac disease and Crohn's disease. The study found common origins for the two diseases and identified eight new areas with genes controlling immune responses.
Researchers found that combined immunosuppression therapy was more effective than conventional treatment in inducing remission and reducing corticosteroid use in patients with newly diagnosed Crohn's disease. The study showed that early intensive treatment could lead to better outcomes, with higher remission rates at weeks 26 and 52.
The new Chlamydia rapid test detects infection in over 4 out of 5 infected women, even without symptoms. The test can provide results in under 30 minutes and is up to twice as accurate as current tests.
Researchers used PET/CT to diagnose and stage inflammatory breast cancer, detecting disease earlier than traditional methods. The study achieved a 95% accuracy rate in identifying cancerous areas and involved 41 women with the aggressive form of breast cancer.
A study found that valsartan reduces Alzheimer's disease-like symptoms in mice by lowering brain beta-amyloid protein levels. A new virotherapeutic also shows promise in treating cancer by selectively targeting cancer cells.
A study found that high blood levels of C-reactive protein, a substance linked to inflammation, are associated with an increased risk for age-related macular degeneration. The research suggests that reducing C-reactive protein levels may potentially decrease the risk of AMD.
A study published by the American Society for Gastrointestinal Endoscopy found that capsule endoscopy identified Crohn's disease recurrence in 62% of patients, compared to 25% with colonoscopy. This led to changes in therapy for more than half of the patients studied.
A study found that childhood vaccination for the rubella virus may have eliminated an inflammatory eye disease from the U.S.-born population. The vaccine was implemented in 1969, and subsequent reductions in Fuchs heterochromic iridocyclitis (FHI) cases were observed, especially among foreign-born patients.
The Lancet proposes adding chronic systemic inflammatory syndrome to COPD diagnosis to address frequent comorbidities and improve patient care. Patients with COPD often die from non-respiratory disorders such as cardiovascular disease or cancer.
Researchers found that chronic stress intensifies inflammation and increases risk of developing central nervous system infections and diseases like multiple sclerosis. Interventions that block stress-induced IL-6 can prevent worsening of disease symptoms, suggesting a potential therapy for vulnerable populations.
A new therapy, certolizumab pegol, has been found to be effective in easing symptoms of patients with active Crohn's disease. The treatment was shown to improve clinical symptoms in both short-term and long-term maintenance therapies, offering a potential new option for managing the condition.
A study has identified a new genetic risk factor for coeliac disease, which lacks a protective DNA sequence in the interleukin-2 and interleukin-21 gene region. This discovery could pave the way towards improved diagnostics and treatments for the condition.
A new study demonstrates the value of PET/CT in diagnosing and monitoring Crohn's disease, offering a non-invasive alternative to invasive endoscopy. The scan can accurately identify active disease and detect severe lesions, reducing the need for costly and side-effect-ridden treatments.
Researchers have discovered that consuming popcorn may lower the risk of diverticulitis by 28% in individuals with diverticular disease. A randomized clinical trial also found rosiglitazone to be an effective treatment for mild-to-moderately active ulcerative colitis.
A study at the University of Pittsburgh School of Medicine found that green tea's catechins protected normal and cancerous bladder cells from inflammation. The findings suggest herbal supplements from green tea could be a treatment option for various bladder conditions.
Research found that prenatal toxicity is associated with immunological damage leading to chronic diseases such as asthma, cancer, and autoimmunity. The study identified several substances, including herbal and fungal chemicals, that may help restore inflammatory cell regulation.
A study by Mayo Clinic found that adalimumab is an effective treatment for adults with Crohn’s disease who do not respond to infliximab therapy. The therapy was shown to achieve remission in 21% of patients and improve symptoms in 52%.
Researchers have discovered a new genetic locus associated with an increased risk of developing Crohn's disease, a chronic inflammatory disorder. The study, published in PLOS Genetics, found that a specific region on chromosome 5 is linked to the disease.
Researchers identify three genetic variants associated with an increased risk of Crohn's disease, including PHOX2B, NCF4, and ATG16L1. These discoveries offer new insights into the biological pathways underlying the disease and may lead to more effective therapies.
Inflammatory myopathies and coeliac disease may be linked, with a gluten-free diet potentially improving inclusion-body myositis symptoms. Researchers explore immunopathogenic mechanisms and genetic substrates to confirm findings.
Researchers found that increased HO-1 expression and carbon monoxide administration protect mice from MS. Mice lacking HO-1 develop more severe disease, but administering carbon monoxide reverses symptoms in already affected mice.
Researchers at UCSD found fibrosis and remodeling in pediatric EE patients similar to airway remodeling in asthma. These changes increase blood vessel adhesion molecules, leading to inflammation in the esophagus.
Researchers have discovered a genetic risk factor for inflammatory bowel disease (IBD) that may confer protection against Crohn's disease and ulcerative colitis. The study highlights a major inflammatory pathway and identifies potential targets for therapies, including the manipulation of IL-23 pathway.
The study identified two genes linked to Crohn's disease: Nod2 and IL-23R. This discovery may lead to improved diagnosis and targeted drug therapies for patients with Crohn's disease.
Researchers have developed a new oral enzyme therapy that allows celiacs to safely consume low-to-moderate levels of gluten. The therapy, which involves the use of EP-B2 and PEP enzymes, has shown promise in breaking down gluten proteins and preventing inflammation.
Research suggests that pregnant women with periodontitis have higher CRP levels, which may contribute to preeclampsia and preterm delivery. The study's findings support previous research linking periodontal disease and inflammation with adverse pregnancy outcomes.
Scientists from Université Laval found that red wine polyphenols significantly modulate inflammatory components released by macrophages in response to bacterial stimuli. These anti-oxidant properties could be useful in preventing and treating inflammatory periodontal diseases as well as other disorders involving free radicals.
Researchers found that Crohn's disease patients produce lower quantities of neutrophils and inflammatory mediators in response to trauma, leading to delayed blood flow and persistence of bacteria. Treatment with Viagra corrected abnormally low blood flow, suggesting a potential role for the drug in treating the disease.
Researchers uncover first molecular insight into eosinophilic esophagitis by identifying genetic program distinguishing it from other forms of esophagitis. The study reveals eotaxin-3 as a key gene contributing to the disease, offering new potential for diagnosis and therapy.
A recent study published in American Journal of Roentgenology found that CT enteroclysis can detect complications like fistulas, abscesses, and tumors superior to conventional enteroclysis. This imaging method also detects minimal mucosal changes, a sign of early stage Crohn's disease, with no disadvantages.
Scientists discovered that interleukin-6 increases in TM patients' cerebrospinal fluid and is linked to tissue injury. Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXR phosphorylation. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea.
Researchers at Johns Hopkins found elevated IL-6 levels correlate with tissue injury and clinical disability in Transverse Myelitis (TM) patients. Elevated IL-6 levels are necessary and sufficient to mediate neural injury, dependent on nitric oxide.
Researchers discovered that around 3% of the bowel's surface area is covered in a glue-like substance that plugs gaps in healthy tissue. This finding may lead to new treatments for inflammatory bowel disease and explain the development of colon cancer.
A comprehensive analysis of gene expression revealed that 650 genes differ between normal individuals and patients with ulcerative colitis or Crohn disease. Down-regulation, rather than up-regulation, was the prevailing pattern found in both diseases.
A study analyzing over 180,000 breast cancer cases found that inflammatory breast carcinoma (IBC) accounts for about 2% of all breast cancers. Women diagnosed with IBC tend to be younger and have poorer survival rates compared to other types of breast cancer.
Researchers at USC College of Letters, Arts and Sciences have found a link between early exposure to inflammatory diseases like gum disease and an increased risk of Alzheimer's. The study, which analyzed data from the Swedish Twin Registry, suggests that chronic gum disease may be a preventable risk factor for Alzheimer's, adding to th...
A new study by Dr. Jane Dimmitt Champion and her team found that minority adolescent women with a history of sexual/physical abuse are at higher risk of pelvic inflammatory disease and HIV/STDs. With better screening, these health problems could be decreased.
A recent study published in PLoS Medicine found that oats can cause intolerance in some patients with celiac disease, triggering a similar molecular reaction as wheat, barley, or rye. This means that not all patients with celiac disease may be able to safely include oats in their diet.
Eosinophilic esophagitis (EE) is a rapidly rising disorder characterized by severely elevated levels of eosinophils in the esophagus, leading to vomiting and difficulty swallowing. The disease has a familial pattern suggesting genetic or environmental factors, warranting further study.
Max Planck researchers discovered that the body's own cannabinoid receptor acts as a protective system against colon inflammation. The study found that mutant mice lacking this receptor are more prone to inflammatory responses, but treatment with cannabinoids can alleviate inflammation in wild-type animals.
Researchers at PTC Therapeutics have discovered a new biochemical pathway that controls cell growth modulation. This finding has significant implications for the development of therapeutics targeting cancer cells, which rely on deregulated translation to grow uncontrollably.
The study, published in Pharmacological Reviews, reveals that activation of certain melanocortin receptors can modulate the inflammatory process, reducing major molecules involved. This discovery has implications for treating localized and systemic inflammatory disorders, including organ transplantation and chronic inflammatory diseases.
A new study by McGill University researchers has identified phospholipase A2 (cPLA2) as a key enzyme that triggers multiple sclerosis-like disease in an animal model. Treatment with a chemical inhibitor of this enzyme results in a marked reduction in the onset and severity of the disease.
Researchers investigate targeting pericytes and endothelial cells with kinase inhibitors to treat cancer and autoimmune diseases. PDX1 levels also play a crucial role in islet survival and diabetes development, while Factor H's anti-inflammatory properties are explored for hemolytic uremic syndrome treatment.
Research suggests that irritable bowel syndrome is a discrete collection of organic bowel diseases, characterized by morphological, psychological, and physiological changes. Treatment options, including cognitive behavioral therapy and tricyclic antidepressants, show promise in managing symptoms.
Researchers found strong connection between common IL-1 gene variations and elevated CRP levels, a protein marker of inflammation. The study's findings may help physicians identify patients at risk earlier and monitor disease progression.
Researchers have discovered a link between keratinocyte growth factor (KGF) concentrations and protection against bronchopulmonary dysplasia (BPD) in premature infants. Additionally, a new pH test offers a simple method to evaluate airway inflammation in diseases such as asthma and COPD.
A synthetic form of bacterial DNA has been shown to reduce the harmful effects of Inflammatory Bowel Disease (IBD) in mice while enhancing the immune system. The study's findings suggest that IBD patients may be able to take an oral form of this compound once a week to prevent flare-up periods typical of the disease.
The Emory study uses the COGNIShunt device to drain off toxins from the cerebrospinal fluid, a potential breakthrough in treating Alzheimer's disease. The 18-month trial aims to assess the effectiveness of the treatment and its impact on patients' symptoms.
The Vienna centre of excellence in biomedicine is researching into the genetic causes of chronic inflammatory diseases, such as rheumatism and arteriosclerosis. The centre brings together leading university institutes, pharmaceutical companies, and start-ups to achieve rapid transfers of research results from the laboratory to patients.
A new study found that screening all young women under 30 for Chlamydia trachomatis infection is the most efficient way to identify infected women, reducing infertility and costly medical complications. The test is cost-effective due to its high sensitivity, identifying more infections.