Articles tagged with Inflammatory Disorders
Researchers at Cedars-Sinai Medical Center have identified over 30 regions of the genome linked to ulcerative colitis, providing insights into the disease's causes and potential new therapies. This understanding may lead to more effective treatments tailored to individual patients' needs.
Researchers at the University of Colorado Boulder have discovered a novel approach to studying Hemophagocytic Lymphohistiocytosis (HLH), a rare and deadly inflammatory disease. Mice infected with Salmonella bacteria developed symptoms consistent with human secondary HLH, including fever, anemia, and neurological signs.
The Montreal Heart Institute has received $4.8 million in financing to support two research projects focused on genetics and genomic medicine. The projects aim to create diagnostic tests and therapeutic approaches for lactic acidosis and improve the diagnosis and treatment of inflammatory diseases.
Researchers have developed a new technique to restore lost bone and gum tissue following periodontal disease, using layers of cells such as stem cells and gingival fibroblasts. The method has been shown to be successful in laboratory studies and has potential applications in other fields like skin grafts.
A long-term study by Indiana University School of Medicine found that frequent testing and treatment does not reduce the prevalence of chlamydia in urban teenage girls. Despite regular screenings, 84% of repeated infections were reinfections.
A study by researchers at the University of California, San Diego reveals that normal skin bacteria trigger a pathway preventing excessive inflammation after injury. This mechanism involves staphylococcal lipoteichoic acid and Toll-like receptor 3 activation, providing new therapeutic approaches for inflammatory skin diseases.
A new type of T-helper cell, called Th22 cells, has been discovered by researchers from Imperial College London. These cells play a special role in overseeing and coordinating immune cells that cause inflammation in chronic and allergic inflammatory diseases.
A Penn study reveals that thiocyanate, an antioxidant in broccoli and cauliflower, protects lung cells from inflammation damage. The findings suggest a potential therapy for cystic fibrosis, as inadequate thiocyanate levels may worsen inflammatory diseases.
A new study reveals that 65% of patients with chronic rhinosinusitis have used alternative medicine, with women and university-educated individuals more likely to do so. However, only 43% of CAM users inform their doctor about the therapy, highlighting a need for improved communication between clinicians and patients.
Research found a modestly increased risk of death in patients with lesser degrees of celiac disease-related symptoms. The risk was highest in the first year of follow-up, with cardiovascular disease and malignancy being the main causes of death in celiac disease.
Periodontal disease has been linked to an increased risk of cardiovascular disease, with as many as 75% of adults in the US affected by periodontal disease. The study suggests that addressing oral/body inflammatory connection can improve overall health and reduce CVD risks.
Researchers at Case Western Reserve University School of Medicine discovered a novel connection between ITCH and NOD2 genes, which may lead to new treatments for Crohn's disease. The study highlights the potential for individually-tailored therapies for patients with the NOD2 mutation.
A new study links a history of periodontitis to an increased risk of cerebrovascular disease, particularly ischemic stroke, in men. The study found that periodontal bone loss, not current inflammation, was associated with the incidence of cerebrovascular disease.
A new study suggests that measuring serum levels of myeloid-related proteins 8 and 14 can predict disease activity, treatment response, and diagnose FMF in children and adolescents. The study also indicates a potential link between MRP 8/14 biomarkers and detection of subclinical inflammatory activity.
The joint clinical recommendations aim to promote patient health by encouraging collaboration between periodontists and cardiologists. The consensus paper includes guidelines for medical and dental professionals to identify patients at risk of both diseases.
Researchers found that local intestinal inflammation induced DNA damage to lymphocytes in peripheral blood, indicating systemic genetic damage. Chromosome damage was detected in the blood before colitis onset and correlated with disease severity.
A study analyzing the periodontal health of 940 men found that regular green tea drinkers had superior periodontal health than those who consumed less. The antioxidants present in green tea may help reduce inflammation and promote healthy gums and teeth.
Patients with pediatric-onset multiple sclerosis tend to have a higher yearly rate of relapses compared to those diagnosed in adulthood. This discrepancy may suggest greater plasticity and potentially more repair and remyelination in the younger nervous system.
A comprehensive elimination strategy is proposed to significantly block the spread of schistosomiasis, a chronic inflammatory disease affecting over 207 million people worldwide. The approach incorporates supplementary education and sanitation with secondary environmental benefits.
A four-year study of Baltimore inner-city teenage girls diagnosed with pelvic inflammatory disease reveals a high rate of subsequent sexually transmitted infections. Researchers emphasize the need for individually tailored counseling and strict follow-up care to prevent future infections.
Researchers found that stress activates immune cells, which initiate and perpetuate skin diseases. Blocking specific proteins prevented the increase in white blood cells, suggesting a key role for ICAM-1/LFA-1 interactions.
NIAID scientists will present research on various infectious diseases, including noroviruses, Crohn's disease, and antibiotic-resistant infections. The talks aim to advance our understanding of these conditions and develop effective treatments.
Research reveals a common connection between cellular innate immunity and human chronic inflammatory diseases, including atherosclerosis, Type 2 Diabetes, and neurodegenerative diseases. A critical signaling network involving IRAK-1 has been identified as a potential target for diagnosis and treatment.
A study has identified a new gene that may play a key role in the development of pediatric-onset inflammatory bowel disease. The gene, TNFRSF6B, is involved in regulating inflammation and its activity has been linked to the severity of the disease.
Anemia of chronic disease could be an adaptive response to inflammatory illness, rather than a disorder. Researchers suggest treating mild to moderate cases to avoid increased mortality from treatment.
An international team of researchers has identified 21 new genetic risk factors for Crohn's disease, building on earlier studies that linked the disorder to disruptions in autophagy and immune system response. The findings, published in Nature Genetics, may lead to novel therapies and prevention strategies.
Researchers at the University of Bonn discovered that oregano's active ingredient beta-caryophyllin inhibits inflammation and may help treat osteoporosis, arteriosclerosis, and chronic disorders like Crohn's disease. The substance targets cannabinoid-CB2 receptors, providing a non-intoxicating alternative to existing treatments.
Research shows that people with temporal arteritis, an inflammatory artery disease, are three times more likely to experience blindness due to swollen arteries restricting blood flow. The disease is often accompanied by symptoms like headaches and jaw soreness, and if left untreated can lead to severe vision loss or stroke.
Researchers discovered a new family of genetic mutations involved in inflammatory intestinal diseases, including coeliac disease and Crohn's disease. The study found common origins for the two diseases and identified eight new areas with genes controlling immune responses.
Researchers found that combined immunosuppression therapy was more effective than conventional treatment in inducing remission and reducing corticosteroid use in patients with newly diagnosed Crohn's disease. The study showed that early intensive treatment could lead to better outcomes, with higher remission rates at weeks 26 and 52.
The new Chlamydia rapid test detects infection in over 4 out of 5 infected women, even without symptoms. The test can provide results in under 30 minutes and is up to twice as accurate as current tests.
Researchers used PET/CT to diagnose and stage inflammatory breast cancer, detecting disease earlier than traditional methods. The study achieved a 95% accuracy rate in identifying cancerous areas and involved 41 women with the aggressive form of breast cancer.
A study found that valsartan reduces Alzheimer's disease-like symptoms in mice by lowering brain beta-amyloid protein levels. A new virotherapeutic also shows promise in treating cancer by selectively targeting cancer cells.
A study found that high blood levels of C-reactive protein, a substance linked to inflammation, are associated with an increased risk for age-related macular degeneration. The research suggests that reducing C-reactive protein levels may potentially decrease the risk of AMD.
A study published by the American Society for Gastrointestinal Endoscopy found that capsule endoscopy identified Crohn's disease recurrence in 62% of patients, compared to 25% with colonoscopy. This led to changes in therapy for more than half of the patients studied.
A study found that childhood vaccination for the rubella virus may have eliminated an inflammatory eye disease from the U.S.-born population. The vaccine was implemented in 1969, and subsequent reductions in Fuchs heterochromic iridocyclitis (FHI) cases were observed, especially among foreign-born patients.
The Lancet proposes adding chronic systemic inflammatory syndrome to COPD diagnosis to address frequent comorbidities and improve patient care. Patients with COPD often die from non-respiratory disorders such as cardiovascular disease or cancer.
Researchers found that chronic stress intensifies inflammation and increases risk of developing central nervous system infections and diseases like multiple sclerosis. Interventions that block stress-induced IL-6 can prevent worsening of disease symptoms, suggesting a potential therapy for vulnerable populations.
A new therapy, certolizumab pegol, has been found to be effective in easing symptoms of patients with active Crohn's disease. The treatment was shown to improve clinical symptoms in both short-term and long-term maintenance therapies, offering a potential new option for managing the condition.
A study has identified a new genetic risk factor for coeliac disease, which lacks a protective DNA sequence in the interleukin-2 and interleukin-21 gene region. This discovery could pave the way towards improved diagnostics and treatments for the condition.
A new study demonstrates the value of PET/CT in diagnosing and monitoring Crohn's disease, offering a non-invasive alternative to invasive endoscopy. The scan can accurately identify active disease and detect severe lesions, reducing the need for costly and side-effect-ridden treatments.
Researchers have discovered that consuming popcorn may lower the risk of diverticulitis by 28% in individuals with diverticular disease. A randomized clinical trial also found rosiglitazone to be an effective treatment for mild-to-moderately active ulcerative colitis.
A study at the University of Pittsburgh School of Medicine found that green tea's catechins protected normal and cancerous bladder cells from inflammation. The findings suggest herbal supplements from green tea could be a treatment option for various bladder conditions.
Research found that prenatal toxicity is associated with immunological damage leading to chronic diseases such as asthma, cancer, and autoimmunity. The study identified several substances, including herbal and fungal chemicals, that may help restore inflammatory cell regulation.
A study by Mayo Clinic found that adalimumab is an effective treatment for adults with Crohn’s disease who do not respond to infliximab therapy. The therapy was shown to achieve remission in 21% of patients and improve symptoms in 52%.
Researchers have discovered a new genetic locus associated with an increased risk of developing Crohn's disease, a chronic inflammatory disorder. The study, published in PLOS Genetics, found that a specific region on chromosome 5 is linked to the disease.
Researchers identify three genetic variants associated with an increased risk of Crohn's disease, including PHOX2B, NCF4, and ATG16L1. These discoveries offer new insights into the biological pathways underlying the disease and may lead to more effective therapies.
Inflammatory myopathies and coeliac disease may be linked, with a gluten-free diet potentially improving inclusion-body myositis symptoms. Researchers explore immunopathogenic mechanisms and genetic substrates to confirm findings.
Researchers found that increased HO-1 expression and carbon monoxide administration protect mice from MS. Mice lacking HO-1 develop more severe disease, but administering carbon monoxide reverses symptoms in already affected mice.
Researchers at UCSD found fibrosis and remodeling in pediatric EE patients similar to airway remodeling in asthma. These changes increase blood vessel adhesion molecules, leading to inflammation in the esophagus.
The study identified two genes linked to Crohn's disease: Nod2 and IL-23R. This discovery may lead to improved diagnosis and targeted drug therapies for patients with Crohn's disease.
Researchers have discovered a genetic risk factor for inflammatory bowel disease (IBD) that may confer protection against Crohn's disease and ulcerative colitis. The study highlights a major inflammatory pathway and identifies potential targets for therapies, including the manipulation of IL-23 pathway.
Researchers have developed a new oral enzyme therapy that allows celiacs to safely consume low-to-moderate levels of gluten. The therapy, which involves the use of EP-B2 and PEP enzymes, has shown promise in breaking down gluten proteins and preventing inflammation.
Research suggests that pregnant women with periodontitis have higher CRP levels, which may contribute to preeclampsia and preterm delivery. The study's findings support previous research linking periodontal disease and inflammation with adverse pregnancy outcomes.
Scientists from Université Laval found that red wine polyphenols significantly modulate inflammatory components released by macrophages in response to bacterial stimuli. These anti-oxidant properties could be useful in preventing and treating inflammatory periodontal diseases as well as other disorders involving free radicals.
Researchers found that Crohn's disease patients produce lower quantities of neutrophils and inflammatory mediators in response to trauma, leading to delayed blood flow and persistence of bacteria. Treatment with Viagra corrected abnormally low blood flow, suggesting a potential role for the drug in treating the disease.
Researchers uncover first molecular insight into eosinophilic esophagitis by identifying genetic program distinguishing it from other forms of esophagitis. The study reveals eotaxin-3 as a key gene contributing to the disease, offering new potential for diagnosis and therapy.
A recent study published in American Journal of Roentgenology found that CT enteroclysis can detect complications like fistulas, abscesses, and tumors superior to conventional enteroclysis. This imaging method also detects minimal mucosal changes, a sign of early stage Crohn's disease, with no disadvantages.
Researchers at Johns Hopkins found elevated IL-6 levels correlate with tissue injury and clinical disability in Transverse Myelitis (TM) patients. Elevated IL-6 levels are necessary and sufficient to mediate neural injury, dependent on nitric oxide.
Scientists discovered that interleukin-6 increases in TM patients' cerebrospinal fluid and is linked to tissue injury. Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXR phosphorylation. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea.