Articles tagged with Obesity
Researchers found that total knee replacement is a cost-effective treatment option for patients with severe knee osteoarthritis and extreme obesity. The procedure leads to substantial increases in quality-adjusted life expectancy for these patients.
A cost-effectiveness analysis found that total knee replacement surgery is a viable option for patients with extreme obesity and end-stage osteoarthritis, offering significant improvements in quality-adjusted life expectancy. The study concluded that TKR leads to substantial benefits in these patients, outweighing potential complications.
A recent study presented at ENDO 2021 found that women with polycystic ovarian syndrome (PCOS) who are obese have a more than three-fold increased risk of developing type 2 diabetes during their lifetime. The risk was not observed in normal-weight women with PCOS.
A study published in The Endocrine Society's annual meeting found that genetic risk factors for PCOS are associated with obesity, diabetes, cardiovascular disease, and male-pattern baldness in men. This suggests that at least some cases of PCOS may be caused by biological mechanisms common to both men and women.
Semaglutide treatment leads to reduced excess body fat and increased lean body mass in adults with obesity. The medication has the potential to reduce the risk of heart disease, diabetes, and stroke by improving body composition. The STEP 1 trial found that semaglutide significantly improved body weight loss and reduced visceral fat.
A recent study found that hospitalized COVID-19 patients with obesity have a significantly higher rate of ICU admissions and longer duration of ICU stay. Individuals with severe obesity were twice as likely to require ICU care, while the risk of death was not significantly higher in those with obesity.
A new study from the University of Bath found that the sugar tax in Catalonia, Spain led to a modest reduction in calorie intake, with households cutting purchases of high-sugar beverages and increasing lower-sugar options. The average reduction was only 2.2% and spread out over 3.7 calories per month.
A pooled data analysis of 31 clinical trials found that wearable fitness trackers and step counters significantly helped people with weight-related health conditions lose weight. Those using research-grade step counters/accelerometers lost an average of 4.4 kg, while commercial fitness trackers produced a 3 kg loss.
A new study of UK Biobank participants found slow walkers have over twice the risk of contracting a severe version of COVID-19 and are almost four times more likely to die from the virus. The analysis examined body mass index (BMI) and self-reported walking pace with the risk of contracting severe COVID-19 and COVID-19 mortality.
A study found lifestyle interventions reduced cardiovascular harm and optimized benefits for 85% of participants. However, it increased the risk of major cardiovascular events in those with poor blood sugar control, suggesting alternative options like glucose-lowering drugs may be necessary.
A study found that family members of patients following the Mediterranean diet-based PREDIMED-Plus program experienced significant weight loss, averaging almost 4 kg over two years. Improved dietary habits were also observed, with family members showing increased commitment to the Mediterranean diet.
Women with a history of hypertensive disorders of pregnancy (HDPs) have a greater risk of premature mortality, including cardiovascular disease (CVD)-related deaths. A new study found that GHTN and preeclampsia were associated with a 42% increase in premature mortality, while women with HDP had an over two-fold higher risk of premature...
Higher obesity rates in Black, Indigenous and People of Color (BIPOC) can be attributed to systemic racism, according to a new perspective article. The authors offer a 10-point strategy to study and solve the public health issues responsible for this disparity.
Researchers found that participants with obesity and food insecurity lost less weight than their food-secure counterparts over a 24-month period, despite following an intensive lifestyle-based intervention. The study highlights the need for weight loss approaches that address both obesity and food insecurity.
A high-fat diet is associated with increased risk of late-onset colorectal cancer, particularly in obese female mice. The study reveals that excess body weight leads to tumor growth through inflammation, insulin-like growth factor release, and polarization of macrophages.
A new study published in The Lancet found that patients with type 2 diabetes treated with Semaglutide achieved significant weight loss and improved blood glucose control. Two-thirds of patients lost at least 5% of their body weight, while over a quarter lost more than 15%.
A recent international study found that semaglutide, an injectable medication, is effective in reducing weight and treating obesity in patients with Type 2 diabetes. The study showed significant weight loss results, with over 25% of participants achieving a 10% or greater weight loss.
Researchers discovered five proteins associated with neutrophil activation that can predict severe COVID-19 outcomes. These biomarkers are elevated in patients who later require ICU admission or die from the virus.
A team of researchers has identified genes linked to both high body fat and protection from negative health impacts of obesity. The findings shed new light on the biology behind this disconnect, offering potential targets for therapies that lower diabetes and heart disease risk.
A randomized clinical trial examines the effectiveness of subcutaneous semaglutide as an adjunct to intensive behavioral therapy for weight management. Semaglutide was found to lead to greater weight loss and improved body mass index compared to placebo in adults with overweight or obesity.
A systematic review of randomized controlled studies found that digital self-monitoring using digital health tools was associated with significant weight loss. Digital tools, including apps, wearables, and websites, were used to track behaviors such as diet and physical activity.
A research team has discovered a metabolic footprint associated with the perception of satiety, revealing that higher concentrations of glycine and linoleic acid are linked to increased satiety. The study involved 140 volunteers with overweight and obesity, showing that certain metabolites in the blood can predict postprandial satiety.
A recent study suggests that targeting a specific protein called eIF4E can reduce weight gain in mice fed a high-fat diet. The researchers found that these mice stored less fat and had improved liver health compared to their counterparts. Additionally, the modified mice showed enhanced lipid metabolism, allowing them to burn more fat.
Research found that morning exercise was associated with higher risks of developing coronary heart disease in men, while midday exercise had lower cardiorespiratory fitness levels. The study suggests that timing of physical activity may play a role in cardiovascular health outcomes for individuals with type 2 diabetes.
A recent study published in Social Psychology and Personality Science found that women with abdominal fat are more stigmatized than those with gluteofemoral fat. The research team also discovered that body shape plays a significant role in driving fat stigma, regardless of weight or ethnicity.
Researchers found a significant link between prolonged sedentary time and decreased ability to focus on tasks despite distractions. Adults with obesity or overweight who spent more time sitting for extended periods showed poorer performance on executive function tests.
Researchers used a novel 3D microscopy technique to study crownlike structures in adipose tissue, finding they are actually concentric spheres surrounding an empty core. This discovery may lead to new treatments for obesity-related diseases like type 2 diabetes and cardiovascular disorders.
A UTEP professor's study discovered a specific area of the brain linked to recollection and desire for food, which could inhibit overeating. The research found that regulating this brain region reduced animal subjects' consumption of treats.
A genetic study found that increased Polynesian ancestry is linked to a higher risk of obesity, Type-2 diabetes, and heart failure in Native Hawaiians. The study suggests both genetic and lifestyle factors contribute to these disease risks.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that Chinese adults are more likely to face high blood pressure and other health risks as a result of higher body mass index (BMI) and waist circumference. The research analyzed data from over 126,000 participants and discovered that C...
Researchers have discovered a new target for developing a drug treatment for obesity and type 2 diabetes. Glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via a receptor in the brain, according to a recent study published in Cell Metabolism.
A new drug, semaglutide, has been shown to cut body weight by 20% in a major global study involving over 1,900 participants. The study, published in the New England Journal of Medicine, found that three quarters of people who received the drug lost more than 10% of their body weight.
A recent study published in the Journal of the American Heart Association found that obesity contributes to up to half of new Type 2 diabetes cases annually in the United States. The research suggests that reducing obesity could prevent or delay the onset of type 2 diabetes, with public health efforts supporting healthy lifestyles pote...
A recent study published in BMC Public Health found that obesity and excess body fat likely accounted for more deaths than smoking among older adults, but still contributed to more deaths among younger adults. The analysis also suggests that gender played a role in the contributions of these factors to estimated deaths.
A new research program, led by health coaches at primary care clinics, has shown that lifestyle interventions can significantly improve heart disease risk factors. Participants experienced lower blood sugar levels, increased good cholesterol, and improved overall cardiometabolic risk scores.
A study found that bariatric surgery leads to greater weight loss in patients with a heightened perception of sweetness and lower hedonic hunger. Changes in sweet intensity perception were associated with the magnitude of weight loss, while pleasantness had no correlation.
A recent study found that nearly half of patients with obesity reported using recreational drugs and alcohol during the pandemic. Those with anxiety or depression were more likely to increase their substance use, highlighting the need for targeted interventions.
A study published in Obesity Reviews found that people are unaware of the calorie content of alcoholic drinks and support labelling. However, most studies were low-quality and did not find a significant impact on consumption levels.
A new study suggests that starting adulthood with a normal weight and gradually gaining pounds later in life can increase the probability of survival. In contrast, those who start as obese or stay at an unhealthy weight throughout their lives tend to have the lowest survival rates.
A pilot study of time restricted eating found that participants lost an average of 3.5kg over 12 weeks with almost 60% adhering to the plan at three months. The researchers suggest this weight loss approach could be a viable option for those struggling with obesity.
A University of Alberta study finds that weight loss before knee replacement surgery does not lead to better outcomes for patients with advanced knee osteoarthritis. The research calls into question the use of body mass index (BMI) as a determinant of patient outcomes, highlighting the need to reconsider recommendations about BMI.
Research reveals captive Asian elephants carry less body fat than average humans, with females averaging 2-25% body fat and males carrying slightly less. The study suggests that activity levels may be key to maintaining elephant health, contradicting traditional notions of obesity.
A recent study from the University of Pennsylvania School of Nursing analyzed various dietary approaches and clinical trials to better understand how to optimize adherence and subsequent weight reduction. The findings suggest that there is not convincing evidence that one diet is universally easier to adhere to than another, highlighti...
Research found that physical activity does not undo the negative effects of excess body weight on heart health. Even among those who are active, being overweight or obese increases cardiovascular risk.
A recent study published in Nature Reviews Endocrinology highlights the interconnection between obesity, impaired metabolic health, and COVID-19 severity. The research found that obesity, visceral fatness, and impaired metabolic health are significant risk factors for a more severe course of COVID-19.
Researchers at Swansea University found a six-fold increase in brain pressure disorder cases among women between 2003 and 2017. Obesity rates in Wales rose significantly during this period, and women from deprived areas had a higher risk of developing the condition, independent of body mass index.
A new study found a six-fold increase in idiopathic intracranial hypertension cases over 15 years, corresponding with rising obesity rates and low socioeconomic status in women. Treatment is often weight loss, while surgery may be required in rare cases.
Researchers studied 18 men's livers after a day of eating and drinking, finding some responded by increasing fat storage while others reduced it. The study suggests that high carbohydrate consumption may protect the liver, contradicting typical associations with alcohol.
A large observational study published in Diabetologia found that obesity is associated with a higher risk of microvascular complications in people with type 2 diabetes. The study suggests that maintaining a healthy body mass index (BMI) before and after a diabetes diagnosis can help prevent these complications. Furthermore, the researc...
A new study by Lund University researchers found that half of young people treated for severe obesity have neuropsychiatric problems, with two-thirds experiencing mental health issues. The study also revealed that symptoms of ADHD and autism are often misdiagnosed in teenagers with severe obesity.
A Finnish study of 332 children aged 7-11 found that aerobic fitness is not linked to motor skills when body composition is considered. The study suggests that even unfit kids can have good motor skills and high levels of physical activity are crucial for development.
Researchers used obese Yucatan mini pigs to study airway flow during sleep apnea episodes. The study found naturally occurring sleep apnea in the pigs and that MRI scans can be used to gain new insights into airflow dynamics, with a 25% increase in airflow velocity through narrowest regions.
Researchers will investigate genetic factors linking obesity and estrogen-containing birth control pills to stroke risk, aiming to identify drug targets for prevention or reduction.
A new study confirms that treatment with Bimagrumab is safe and effective for treating excess adiposity and metabolic disturbances in adult patients with obesity and type 2 diabetes. The medication achieved a nearly 21% decrease in body fat and a 6.5% reduction in body weight, along with a gain of lean mass.
Researchers at Texas A&M University have designed a centimeter-sized wireless device that stimulates the endings of the vagus nerve to induce feelings of fullness. The device is controlled externally via radio frequency and has the potential to be used in conjunction with other devices to manipulate nerve endings throughout the gastroi...
New research from Johns Hopkins Medicine has uncovered that greater obesity seems to make muscle contraction much weaker in this very common form of heart failure. The study found that in patients with severe obesity, the force response to high calcium was reduced by 40%, suggesting that obesity is the key factor.
A study of 52,000 participants found that those with detectable brown fat were less likely to suffer cardiac and metabolic conditions. Brown fat burns energy, and its presence was linked to lower risk of hypertension, congestive heart failure, and coronary artery disease.
Scientists at UT Southwestern Medical Center have discovered a type of cell responsible for triggering chronic inflammation in fat tissue. The study found that these cells, called fibro-inflammatory progenitors (FIPs), produce signals that encourage inflammation when exposed to high-fat diets.
Researchers found that a protein called Cx43 allows stress signals from one liver cell to spread to neighboring cells, causing dysfunction. Mice with deleted Cx43 were protected from insulin resistance, glucose intolerance, and non-alcoholic fatty liver disease.
A new study suggests that COVID-19 patients with obesity have poor outcomes, but this is not due to increased inflammation. Instead, respiratory issues and other factors may play a role. The researchers found that patients with obesity had lower inflammatory markers on hospital days, which could contribute to their poor clinical outcomes.