Articles tagged with Obesity
The ASMBS Foundation announced PatientPartner as a premier sponsor of its monthly giving program, AWARE. The partnership aims to raise funds for obesity research and increase access to metabolic and bariatric surgery, a proven effective treatment for severe obesity.
A new study published in Stroke found that adolescents with higher body mass index (BMI) are at a significantly higher risk of first ischemic stroke as adults. The study, which analyzed data from over 1.9 million participants, also found that even those with high-normal BMI had a higher stroke risk compared to those with low-normal BMI.
Researchers found that obesity-related cancer deaths improved at a slower rate than non-obesity related cancer deaths, with declines of 2.29% and .83%, respectively. Obesity contributes to both cancer risk and heart disease risk, but the study suggests that maintaining a healthy weight can improve overall health.
Researchers discovered that a gene called melanocortin 4 (Mc4r) plays a key role in weight gain associated with risperidone. A new drug approved for genetic obesity treatment, when combined with risperidone, prevents weight gain while maintaining therapeutic effect.
Patients who underwent bariatric surgery ten years ago reported that their eating habits and appetite remained affected, with reduced cravings for unhealthy foods. However, they also described struggling to manage their lives, including supporting overweight children, due to ongoing guilt and self-blame.
A new study found that semaglutide, an obesity drug, supresses appetite and food cravings, reducing energy intake in individuals with obesity. The study showed a 35% lower energy intake during a meal where participants could eat as much as they liked.
A new study found that semaglutide causes similar weight loss in patients aged under 40, 40-60 years, and 60 years and over. The treatment also showed a more pronounced effect on body composition in younger patients.
Researchers found that semaglutide treatment leads to significant weight loss across various patient groups, including those with different ages, sexes, and body weights. Female participants and those with lower starting body weights achieved the most substantial weight losses.
A new study has found a reduced risk of eye cataracts associated with obesity surgery. Patients who underwent weight loss through bariatric surgery showed a lower incidence of cataract compared to those who did not have surgery, especially when performed before age 60.
A phase 1 study found that combining cagrilintide, a long-acting amylin analogue, with semaglutide led to greater weight loss compared to semaglutide alone. The combination was well-tolerated and showed an acceptable safety profile.
A study found that obese people with an evening chronotype, characterized by later waking and peak activity, have a significantly higher risk of developing type 2 diabetes and cardiovascular disease. This increased risk is independent of sleep quality, age, gender, and body mass index.
Researchers found blocking a receptor of neuropeptide Y increases fat metabolism and prevents weight gain in obese individuals. The treatment, BIBO3304, targets peripheral tissues without affecting the brain, offering a potentially safer alternative to current medications.
A virtual weight-management support group during lockdown resulted in clinically meaningful weight loss for 27% of participants, associated with reduced risk of diabetes and other chronic conditions. Average weight loss was 7.4lbs or 3.5% of body weight.
A new study published in The Lancet Diabetes & Endocrinology found that BMI cut-offs used by the World Health Organization and UK's National Institute for Health and Care Excellence are not suitable for adults from Black Asian and Minority Ethnic backgrounds. The research, which included over 1.5 million people, shows that these groups...
A study from the University of Surrey found that 67% of UK adults are overweight or obese, with time-restricted feeding showing potential to combat obesity. More than 400 participants believed they could reduce their 'feeding window' by three hours if associated health benefits were clear.
Research reveals that as body mass index (BMI) increases, the risk of testing positive for SARS-CoV-2 also rises, especially among overweight and obese patients. The study analyzed data from over 26,000 patients tested for COVID-19 at a major medical center in Israel and found significant associations between BMI and viral infection risk.
Research shows that abdominal obesity is a stronger predictor of severe COVID-19 symptoms, as measured by chest X-ray results. Patients with waist circumference above normal limits had significantly higher X-ray scores and were at 75% increased risk of worse outcomes.
A study published in the International Journal of Obesity found that men prenatally exposed to the Dutch famine of 1944-45 were 30% more likely to be overweight with a BMI of 25 or over at age 19. The researchers speculate that changes in DNA methylation may contribute to this increased risk.
Research finds inflammasomes play a role in inflammation and intestinal barrier integrity. Obesity-associated colon cancer is linked to increased gene expression levels of certain proteins, including NLRP3 and IL1B.
A new metric called 'A Body Shape Index' (ABSI) measures obesity by considering age, sex, weight, height, and waist circumference. ABSI was linked to increased risks for liver, lung, and bowel cancers, while high ABSI combined with BMI increased cancer risk for seven types of cancer.
A study of over 400,000 UK adults found that higher BMI, body fat, and larger waist and hips pose similar risks for developing 10 common cancers. The researchers estimated that excess weight could be responsible for around 40% of endometrial and uterine cancer cases.
A global review of 121 randomised trials involving nearly 10,000 adults found herbal and dietary supplements show statistically greater weight loss but not enough to benefit health. The authors call for more research into long-term safety due to lack of clinical evidence supporting their effectiveness.
A study found that women who conceive within 12 months of bariatric surgery are at a higher risk of adverse outcomes in pregnancy, including lower gestational age and neonatal birth weights. Inadequate gestational weight gain was also linked to increased preterm births.
A study by Uppsala University found that bullying is a greater risk factor than overweight for developing depressive symptoms in both girls and boys. However, boys' mental health is more affected if they suffer from obesity, with a five-fold higher risk of having depressive symptoms in 2015 compared to normal-weight boys.
A recent study found that obesity, particularly class II and III, is associated with a higher risk of death, severe pneumonia, and intubation in both men and women with COVID-19. However, the association was stronger in men than women, suggesting that obesity may be a more significant risk factor for death from COVID-19 in men.
A new study by University of Copenhagen researchers reveals the key to maintaining long-term weight loss in people with obesity. Combining moderate-intensity exercise with appetite-inhibiting medication yields significant health benefits, including reduced blood sugar levels, improved fitness ratings, and muscle mass preservation.
A study published in Women's Health found that the pandemic significantly increased stress levels among mothers with preschoolers, leading to reduced sleep, physical activity, and a higher risk for obesity and poor health. The researchers recommend providing reliable childcare options and support systems to help mothers balance work an...
A new study suggests that inhibiting GKN1, a stomach-specific protein, can lead to significant weight loss and reduced body fat in mice. The researchers found that models without GKN1 had improved metabolism and resistance to weight gain on high-fat diets.
Intellihealth, a medical obesity treatment platform co-founded by Dr. Katherine Saunders, was selected as the first winner of the Women at Weill investment competition. The company's software platform Evolve generates personalized treatment plans for patients and is integrated with Epic, a widely-used electronic health record system.
A new study reveals that higher body mass index (BMI) is associated with worse survival in early breast cancer patients but improved survival in advanced disease. The 'obesity paradox' highlights the need to understand the biological basis of obesity impacts on breast cancer diagnosis and treatment.
A recent study found that obesity and a high-salt diet are bigger risks for females, who are more sensitive to salt and have naturally higher levels of hormones like leptin and aldosterone. This can lead to increased blood pressure and cardiovascular disease in young women.
A diet high in pro-inflammatory foods may be associated with increased odds of developing testosterone deficiency among men. Men who consume refined carbohydrates and sugar, as well as polyunsaturated fats, are more likely to experience low libido, decreased energy, and depression.
Researchers identified two dietary patterns associated with an increased risk of cardiovascular disease and death in middle-age. The first pattern includes high intakes of chocolate, confectionary, butter, and white bread, while the second is characterized by high sugar-sweetened beverages, fruit juice, and preserves.
International research found that obese and overweight COVID-19 patients require more oxygen and invasive ventilation, but show no increased risk of death. Chronic inflammation and shortness of breath are linked to increased severity in these patients.
A new study published in Scientific Reports reveals that underweight and overweight women are significantly more likely to experience recurrent miscarriages due to their abnormal Body Mass Index. The research highlights the importance of weight management in reducing the risk of repeated pregnancy losses.
Researchers at CNIO discover that digoxin, a drug used for heart diseases, reduces inflammation and leads to significant weight loss in obese mice. The study identifies IL-17A as a causal factor of obesity, suggesting a potential therapeutic option for treating the inflammatory disease.
Scientists have discovered how a unique molecular switch in the brain causes feelings of fullness and may help develop improved anti-obesity drugs. The melanocortin receptor 4 is activated by setmelanotide, which binds to its binding pocket and enhances binding with calcium ions.
A study of 264,230 individuals found that UK adults who are overweight or obese retain their weight over time, associated with an increased risk of health complications and death. The researchers also found greater levels of socioeconomic deprivation linked to increasing severity of obesity.
A study by Penn State researchers found that supplementing high-fat-fed mice with cocoa powder reduced the severity of their liver disease and improved markers of oxidative stress. The researchers suggest that similar benefits may be achieved in humans through dietary changes, but caution against overconsumption.
Researchers suggest reducing food waste in various settings, including schools, homes, and restaurants, while promoting healthy nutrition. Strategies include implementing behavioral cues, reusing leftovers, and developing cooking education curricula for low-income households.
A study published in Nature Metabolism reveals that vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced energy-burning brown fat cells. This finding could lead to the development of new therapies targeting obesity and metabolic disorders by increasing overall energy expenditure.
Researchers found obesity reduces mitochondrial function in fat tissue, leading to proinflammatory state and increased risk of diseases like diabetes and liver disease. Muscle tissue also shows decreased mitochondrial function, but to a lesser extent.
A study published in the Journal of Endocrinology found an association between higher body weight and greater menstrual blood loss, potentially due to delayed womb lining repair. The research used a combined approach of human and mouse studies, suggesting obesity may contribute to heavier periods through increased inflammation.
A University of Gothenburg study found a significant increase in heart failure and stroke cases among men under 40 in Sweden, attributed to rising obesity rates and declining physical fitness. The study monitored over 1.2 million men for 20 years, revealing a sharp decline in heart attacks despite increasing obesity.
A recent study published in Nutrients investigated the influence of exercise on food intake. The results showed that physical activity increased the amount and urgency of food consumption, particularly after exercise. This finding highlights the importance of considering post-exercise eating habits for optimal weight loss.
The American Gastroenterological Association has released new clinical guidelines recommending the use of intragastric balloons for patients with obesity who have not been able to lose weight with traditional strategies. The treatment is most successful when combined with lifestyle modifications and pharmacological agents, and can be u...
A study published in Radiology found that chest CT scans can assess body composition and predict mortality risk in people with chronic obstructive pulmonary disease (COPD). Higher intermuscular fat was linked to higher mortality rates, while subcutaneous adipose tissue was associated with lower risks.
A new study by UBC Sauder School of Business found that people with obesity tend to be more responsive to food marketing, but when their weight drops significantly, so does their responsiveness. After significant weight loss, people become less responsive to marketing, making it more sustainable to remain at a lower body mass index.
Researchers discover adolescent adipose tissue differs from adult white fat in terms of precursor cell properties. Modulating Asc-1 function may help obese patients maintain a healthy metabolism and delay obesity treatment.
Research at Joslin Diabetes Center found that exercise in pregnancy boosts SOD3, a protein linked to glucose metabolism, and improves metabolic health in offspring. Vitamin D also plays a critical role in this process.
A study published in eLife found that selenium supplementation protects against diet-induced obesity in mice, reducing levels of energy-regulating hormones IGF-1 and leptin. The researchers also observed increased healthspan in yeast grown under selenium-supplemented conditions.
A long-term study published in PLOS ONE found that bariatric surgery does not increase the risk of colorectal cancer in obese individuals. After a median follow-up period of 22 years, there were 57 cases of colorectal cancer in the surgery group and 67 in the control group, suggesting no association between the two.
Researchers found that total knee replacement is a cost-effective treatment option for patients with severe knee osteoarthritis and extreme obesity. The procedure leads to substantial increases in quality-adjusted life expectancy for these patients.
A cost-effectiveness analysis found that total knee replacement surgery is a viable option for patients with extreme obesity and end-stage osteoarthritis, offering significant improvements in quality-adjusted life expectancy. The study concluded that TKR leads to substantial benefits in these patients, outweighing potential complications.
A recent study presented at ENDO 2021 found that women with polycystic ovarian syndrome (PCOS) who are obese have a more than three-fold increased risk of developing type 2 diabetes during their lifetime. The risk was not observed in normal-weight women with PCOS.
A study published in The Endocrine Society's annual meeting found that genetic risk factors for PCOS are associated with obesity, diabetes, cardiovascular disease, and male-pattern baldness in men. This suggests that at least some cases of PCOS may be caused by biological mechanisms common to both men and women.
Semaglutide treatment leads to reduced excess body fat and increased lean body mass in adults with obesity. The medication has the potential to reduce the risk of heart disease, diabetes, and stroke by improving body composition. The STEP 1 trial found that semaglutide significantly improved body weight loss and reduced visceral fat.
A recent study found that hospitalized COVID-19 patients with obesity have a significantly higher rate of ICU admissions and longer duration of ICU stay. Individuals with severe obesity were twice as likely to require ICU care, while the risk of death was not significantly higher in those with obesity.
A new study from the University of Bath found that the sugar tax in Catalonia, Spain led to a modest reduction in calorie intake, with households cutting purchases of high-sugar beverages and increasing lower-sugar options. The average reduction was only 2.2% and spread out over 3.7 calories per month.
A pooled data analysis of 31 clinical trials found that wearable fitness trackers and step counters significantly helped people with weight-related health conditions lose weight. Those using research-grade step counters/accelerometers lost an average of 4.4 kg, while commercial fitness trackers produced a 3 kg loss.