A study in mice suggests that transplanted brown fat can reduce type 2 diabetes risk factors after a heart attack by dampening gene activation linked to negative effects. The transplantation method could help researchers understand the mechanisms behind this protective effect and potentially lead to therapeutic applications.
Scientists have developed a new method using CRISPR-Cas9 to target specific fat cells, reducing the time and cost of genetic discovery in obesity research. The technique allows researchers to study genes in brown adipose tissue, which plays a crucial role in regulating body temperature.
A new research project, SYSTAM CHINA-SEACS, aims to develop systemic solutions to tackle both undernutrition and overweight, obesity or diet-related NCDs. The study will be piloted in the Chinese city of Fang Cheng Gang and has the potential to improve the health and living conditions of billions of people.
Researchers found that flavanols activate brown adipose tissue, causing it to burn calories and produce heat. Long-term consumption of flavanols increased the levels of heat-related proteins in mice, suggesting a potential therapeutic effect against obesity-related diseases.
Metabolic disorders, such as inflammation and insulin resistance, are key elements in the development of anxiodepressive disorders in obese individuals. Diet high in sugar and saturated fats leads to these changes in the brain, increasing the risk of depression and anxiety.
A study by University of New South Wales has found that one in five future thyroid cancers in Australia is attributable to current levels of overweight and obesity. The prevalence of obesity has doubled in the last two decades, with 75% of Australian men and 60% of women being overweight or obese.
A study found that obesity is associated with severe COVID-19 outcomes, including hospital admission or death. Additionally, accelerated immunosenescence may be a key mechanism explaining the relationship between obesity and T2DM in severe COVID-19. Vaccination effectiveness may also be impacted by metabolic disorders.
A University of Gothenburg study found that bariatric surgery lowers cancer risk by 60% in obese patients with type 2 diabetes, particularly those achieving and maintaining normal glucose control. The research highlights the importance of glucose control in preventing cancer in this high-risk population.
A study by the CDC found a strong association between obesity and diabetes, both of which are widespread in the U.S., and severe COVID-19 disease. In South Carolina, chronic diseases disproportionately affect Black communities, increasing their risk of developing severe COVID-19.
Researchers found that high avocado consumption led to reduced caloric energy intake, lower dairy and meat consumption, and improved fiber and nutrient intake. However, unexpected decreases in calcium and certain minerals were also observed.
Researchers at HKU have identified a naturally occurring flavone as a potential drug for obesity treatment. The study found that obesity damages skeletal muscle metabolism by reducing brain-derived neurotrophic factor (BDNF) levels, leading to impaired mitochondrial function and insulin resistance.
Researchers found that video-based, telehealth-delivered exercise and weight loss programs improved pain and function in people with knee osteoarthritis and overweight or obesity. The intervention with dietary component led to substantial weight loss and additional benefits.
Researchers at UConn Health have discovered that eliminating senescent cells in human fat tissue can alleviate signs of diabetes and improve insulin sensitivity. The study suggests that clearing away these dysfunctional cells could lead to game-changing new treatments for Type 2 diabetes.
Researchers from the University of Tsukuba found that lifestyle factors such as smoking, alcohol consumption, and sedentary behavior significantly increase the risk of developing metabolic syndrome in non-obese individuals. Similar risk factors were identified for both obese and lean individuals, highlighting the importance of healthy ...
Researchers have discovered a protein called CPEB4 that plays a key role in diet-induced obesity. Blocking CPEB4 expression in mice protected them from weight gain, inflammation, and improved their microbiome health. The findings could lead to new treatments for diet-induced obesity and its associated cancer risks.
A clinical trial found that long-term weight loss was similar for those who received 5:2 diet or standard weight management advice, with 18% and 15% of participants losing at least five per cent of their body weight. However, the 5:2 diet group was more likely to recommend the intervention to others or continue with it.
A research team has identified a subset of cerebellar neurons that signal satiation after eating, leading to reduced food intake in mice. The findings suggest a novel target for therapies that could curb overeating and obesity.
Research suggests that using mirrors can decrease anxiety and body dissatisfaction in individuals with obesity. This mirror-based intervention aims to promote self-assessment and reflection, leading to behavioral changes.
A recent study analyzed over 18,000 reported adverse events from patients taking various anti-obesity medications. The study found that 4.9% of reported events were fatal, with 35% requiring hospitalization. Further research and monitoring are needed to address the safety concerns surrounding these medications.
A study analyzing data from 109 COVID-19 patients found that obesity is the key factor associated with endothelial dysfunction, a condition increasing heart attack and stroke risk. The results suggest an 17% higher cardiovascular risk for obese patients compared to those of normal weight.
Research suggests that obesity triggers inflammation, leading to an increase in myeloid-derived suppressor cells, which break down bone tissue. This can result in gum disease and tooth loss. The study found a significant link between high-fat diets and increased osteoclasts and alveolar bone destruction.
A study by West Virginia University researcher Sunil Sharma found that rural COVID patients who end up in an intensive care unit are more likely to die within 30 days compared to their urban counterparts. The researchers also discovered that rural patients with COVID-linked ARDS have a higher mortality rate, even when controlling for d...
A major Finnish–Norwegian study found that obesity does not lower the risk of subarachnoid haemorrhage, as smoking habits are a significant factor in the condition. The study analyzed over 200,000 individuals and comprehensively considered confounding factors.
A Johns Hopkins-led study found that leptin cancels out the effects of Tamoxifen, making it ineffective for obese patients with breast cancer. Researchers suggest that interventions targeting leptin or Med1 may improve Tamoxifen's success in this group.
Research suggests COVID-19 pandemic has adverse effects on women's menstrual cycles due to stress and sleep disturbance. Women are experiencing increased rates of depression, anxiety, and poor sleep.
A new study identifies four novel obesity genes and predicts a fifth, using a platform of fat fruit flies. The research found that these genes are involved in a neuronal signaling pathway that increases fat levels.
An 8-country study finds that obesity will contribute 3.6% of a nation's GDP by 2060, with total costs projected to double in Spain and increase 19-fold in India. Reducing obesity prevalence could cut average annual costs by 5-13%.
A study found that cardiopulmonary exercise testing is highly applicable for early detection of respiratory disorders in obese individuals. The test assesses physiological responses to exercise and identifies potential issues before symptoms appear.
A study at the University of Turku found that brain function regulating satiety and appetite is altered before obesity develops, with family background risk factors contributing to these changes. The findings suggest the brain and central nervous system are key targets for treating obesity.
A study published in Nature Communications identified C-terminal binding protein 2 (CtBP2) as a global regulator of metabolism that balances sugar and fat levels in the liver. CtBP2 is crucial for controlling glucose and lipid balance, making it a promising drug target for treating symptoms associated with obesity.
Researchers found that around 5% of patients with type 2 diabetes in Scotland are in remission, suggesting a need for updated guidelines to support clinicians. Individuals in remission tend to be older and have lower blood sugar levels at diagnosis, and often achieve remission after weight loss since their diagnosis
Researchers at UT Southwestern Medical Center have identified a method to safely replicate the weight-loss benefits of a plant compound, celastrol. By deleting a specific protein in brain cells, they were able to mimic the effects of celastrol, resulting in mice losing 7% of their body weight without experiencing harmful side effects.
New research from the University of South Australia finds that the 5:2 diet is just as effective as a continuous energy-restricted diet in achieving weight loss and preventing type 2 diabetes in women with a previous diagnosis of gestational diabetes. The study suggests that this diet offers greater choice and flexibility for women loo...
Researchers at the University of Pennsylvania found that mice with altered internal clocks gained more weight, had higher blood sugar, and fattier livers when fed high-fat and sugar diets. However, adjusting their environment to match their internal clock corrected these outcomes.
A recent study by the University of California - San Diego team discovered that glycogen regulates and promotes fat metabolism, helping to balance energy intake and expenditure. The research suggests modulating glycogen metabolism in fat cells could provide new approaches for weight loss and improved metabolic health.
A study of 75 FIFO shift workers found significant sleep loss and reduced alertness, with up to 60% at risk of developing sleep disorders. The research highlights the need for companies to reassess roster designs to ensure adequate rest and provide education on good sleep health practices.
Researchers found that moderate potato consumption among adolescent girls did not increase the risk of overweight or high blood pressure, and may even be associated with improved nutrient intakes. The study suggests that potatoes can be a part of a healthy diet pattern, particularly when consumed in moderation.
Research from the University of Cincinnati reveals that female fat tissue contains more mitochondria, providing protection against obesity and metabolic diseases. The study suggests a link between mitochondrial gene Ndufv2 and lower incidence of complications such as diabetes and high cholesterol.
A new study suggests that newborns who get more sleep and wake up less throughout the night are less likely to be overweight in infancy. Researchers found a 26% decrease in infant obesity risks with just one additional hour of sleep.
Researchers aim to generate a model of brain-fat communication system to regulate metabolism during environmental challenges. The study uses cutting-edge techniques like immunolabeling-enabled imaging to identify new components of neural circuits controlling brown and white fat tissues.
A VCU study found that people with advanced liver scarring caused by obesity and diabetes are dying from liver disease, underscoring the need for new treatments. The research provides a roadmap for future therapies to prevent liver transplants and save lives.
A meta-analysis of pooled estimates found that healthcare professionals exhibit implicit weight bias, but the extent and nature of this bias are mixed. The study highlights the importance of addressing weight bias in healthcare settings to improve patient care and outcomes.
About 42% of U.S. adults are considered clinically obese due to increased risk of health conditions such as diabetes and heart disease. New weight-loss drugs like Wegovy (semaglutide) show promise in safely aiding weight loss, but long-term side effects and sustainability remain concerns.
A study of 9,739 adults found that those with stable overweight and obesity had elevated cardiac troponin I levels, a marker of subclinical heart injury. Long-standing obesity is associated with injurious effects on cardiac health before symptoms occur.
A recent study found that fitness apps utilizing illness- and death-related messages are more effective in motivating users than those focusing on social stigma, obesity, or financial costs. The research discovered a significant relationship between these messaging types and self-regulatory beliefs and outcome expectations.
A recent study from the Okinawa Institute of Science and Technology Graduate University identified a crucial protein linked to increased appetite and obesity in mice. The researchers found that mice lacking this protein, XRN1, exhibited leptin resistance, leading to insatiable hunger and weight gain.
Researchers found that regular cycles of a fasting-mimicking diet in mice helped counteract the negative effects of a high-fat, high-calorie diet. The study suggests that this diet may have potential as 'medicine' to prevent obesity and heart disease.
A study by University of Gothenburg found that people with obesity were overrepresented among adults in Sweden receiving intensive care for COVID-19, with a 50% increase in mortality risk compared to normal-weight individuals. Obesity also boosted the risk of ICU stays lasting more than 14 days.
An 18-year study found a significant increase in ultra-processed food consumption among US adults, contributing to obesity and chronic diseases. The study recommends policies to reduce ultra-processed food intake, such as revised dietary guidelines and taxes.
Researchers identify key neurons and signaling pathway regulating female activity before ovulation. Discoveries could lead to new treatments for menopause that sidestep estrogen and reactivates the circuit with CRISPRa technology.
The study provides a unique genomic blueprint for understanding the complex mechanisms linking obesity with comorbidities like type 2 diabetes and cardiovascular diseases. The Ossabaw pig's genome is highly relevant to humans, making it an ideal model for studying human obesity.
A large Swedish cohort study found that obese patients (BMI >35 kg/m2) were twice as likely to experience a prolonged ICU stay or die from COVID-19. The study also showed that obesity is an independent risk factor for severe outcomes, suggesting closer monitoring for individuals with obesity hospitalized for COVID-19.
A clinical trial found that a green Mediterranean diet rich in leafy greens like Mankai and green tea can elevate fasting ghrelin levels, reducing belly fat and improving insulin sensitivity. This approach may also have additional cardiometabolic benefits.
Researchers from The Stuber Lab discovered that certain neurons in the brain light up in obese mice, preventing signals that indicate satiety. The study found that these neurons communicate with regions involved in depression and motivation, suggesting a link between eating disorders and addiction.
A review of 25 studies on intermittent fasting found that all forms produced mild to moderate weight loss, similar to traditional calorie-restrictive diets. Intermittent fasting regimens also showed benefits in decreasing blood pressure and insulin resistance, and improving appetite regulation.
Researchers found that eating high-fibre whole grain rye products resulted in greater weight loss and body fat reduction compared to refined wheat alternatives. The study, involving 242 participants, suggests that rye's unique fibre content may contribute to its weight-loss benefits.
A study found that Medicaid expansion led to a 31% increase in bariatric surgery access for lower-income white adults. However, this benefit did not extend to Hispanic and Black adults, highlighting ongoing disparities in healthcare access.
Researchers found a chemical inhibitor of PDE9 stimulates cells to burn more fat in mice, reducing obesity and fatty liver. The study's findings suggest the experimental drug may be effective in treating severe obesity and improving heart function.
Scientists at Karolinska Institutet have discovered a carbohydrate called mannose as a biomarker for severe COVID-19 disease severity. The study found that glycolysis and glutaminolysis play a crucial role in SARS-CoV-2's spread and growth, providing potential new therapeutic strategies.
A new study found that ketone supplements enhanced blood flow to the brain and improved aspects of cognitive function, such as working memory and processing speed, in adults with obesity. This suggests that ketone supplements may be a novel therapeutic strategy for protecting and improving brain health in people with obesity.