Articles tagged with Obesity
Researchers at UT Southwestern Medical Center have identified a method to safely replicate the weight-loss benefits of a plant compound, celastrol. By deleting a specific protein in brain cells, they were able to mimic the effects of celastrol, resulting in mice losing 7% of their body weight without experiencing harmful side effects.
New research from the University of South Australia finds that the 5:2 diet is just as effective as a continuous energy-restricted diet in achieving weight loss and preventing type 2 diabetes in women with a previous diagnosis of gestational diabetes. The study suggests that this diet offers greater choice and flexibility for women loo...
Researchers at the University of Pennsylvania found that mice with altered internal clocks gained more weight, had higher blood sugar, and fattier livers when fed high-fat and sugar diets. However, adjusting their environment to match their internal clock corrected these outcomes.
A recent study by the University of California - San Diego team discovered that glycogen regulates and promotes fat metabolism, helping to balance energy intake and expenditure. The research suggests modulating glycogen metabolism in fat cells could provide new approaches for weight loss and improved metabolic health.
A study of 75 FIFO shift workers found significant sleep loss and reduced alertness, with up to 60% at risk of developing sleep disorders. The research highlights the need for companies to reassess roster designs to ensure adequate rest and provide education on good sleep health practices.
Researchers found that moderate potato consumption among adolescent girls did not increase the risk of overweight or high blood pressure, and may even be associated with improved nutrient intakes. The study suggests that potatoes can be a part of a healthy diet pattern, particularly when consumed in moderation.
Research from the University of Cincinnati reveals that female fat tissue contains more mitochondria, providing protection against obesity and metabolic diseases. The study suggests a link between mitochondrial gene Ndufv2 and lower incidence of complications such as diabetes and high cholesterol.
A new study suggests that newborns who get more sleep and wake up less throughout the night are less likely to be overweight in infancy. Researchers found a 26% decrease in infant obesity risks with just one additional hour of sleep.
Researchers aim to generate a model of brain-fat communication system to regulate metabolism during environmental challenges. The study uses cutting-edge techniques like immunolabeling-enabled imaging to identify new components of neural circuits controlling brown and white fat tissues.
A VCU study found that people with advanced liver scarring caused by obesity and diabetes are dying from liver disease, underscoring the need for new treatments. The research provides a roadmap for future therapies to prevent liver transplants and save lives.
A meta-analysis of pooled estimates found that healthcare professionals exhibit implicit weight bias, but the extent and nature of this bias are mixed. The study highlights the importance of addressing weight bias in healthcare settings to improve patient care and outcomes.
About 42% of U.S. adults are considered clinically obese due to increased risk of health conditions such as diabetes and heart disease. New weight-loss drugs like Wegovy (semaglutide) show promise in safely aiding weight loss, but long-term side effects and sustainability remain concerns.
A study of 9,739 adults found that those with stable overweight and obesity had elevated cardiac troponin I levels, a marker of subclinical heart injury. Long-standing obesity is associated with injurious effects on cardiac health before symptoms occur.
A recent study found that fitness apps utilizing illness- and death-related messages are more effective in motivating users than those focusing on social stigma, obesity, or financial costs. The research discovered a significant relationship between these messaging types and self-regulatory beliefs and outcome expectations.
A recent study from the Okinawa Institute of Science and Technology Graduate University identified a crucial protein linked to increased appetite and obesity in mice. The researchers found that mice lacking this protein, XRN1, exhibited leptin resistance, leading to insatiable hunger and weight gain.
Researchers found that regular cycles of a fasting-mimicking diet in mice helped counteract the negative effects of a high-fat, high-calorie diet. The study suggests that this diet may have potential as 'medicine' to prevent obesity and heart disease.
A study by University of Gothenburg found that people with obesity were overrepresented among adults in Sweden receiving intensive care for COVID-19, with a 50% increase in mortality risk compared to normal-weight individuals. Obesity also boosted the risk of ICU stays lasting more than 14 days.
An 18-year study found a significant increase in ultra-processed food consumption among US adults, contributing to obesity and chronic diseases. The study recommends policies to reduce ultra-processed food intake, such as revised dietary guidelines and taxes.
Researchers identify key neurons and signaling pathway regulating female activity before ovulation. Discoveries could lead to new treatments for menopause that sidestep estrogen and reactivates the circuit with CRISPRa technology.
The study provides a unique genomic blueprint for understanding the complex mechanisms linking obesity with comorbidities like type 2 diabetes and cardiovascular diseases. The Ossabaw pig's genome is highly relevant to humans, making it an ideal model for studying human obesity.
A large Swedish cohort study found that obese patients (BMI >35 kg/m2) were twice as likely to experience a prolonged ICU stay or die from COVID-19. The study also showed that obesity is an independent risk factor for severe outcomes, suggesting closer monitoring for individuals with obesity hospitalized for COVID-19.
A clinical trial found that a green Mediterranean diet rich in leafy greens like Mankai and green tea can elevate fasting ghrelin levels, reducing belly fat and improving insulin sensitivity. This approach may also have additional cardiometabolic benefits.
Researchers from The Stuber Lab discovered that certain neurons in the brain light up in obese mice, preventing signals that indicate satiety. The study found that these neurons communicate with regions involved in depression and motivation, suggesting a link between eating disorders and addiction.
A review of 25 studies on intermittent fasting found that all forms produced mild to moderate weight loss, similar to traditional calorie-restrictive diets. Intermittent fasting regimens also showed benefits in decreasing blood pressure and insulin resistance, and improving appetite regulation.
Researchers found that eating high-fibre whole grain rye products resulted in greater weight loss and body fat reduction compared to refined wheat alternatives. The study, involving 242 participants, suggests that rye's unique fibre content may contribute to its weight-loss benefits.
A study found that Medicaid expansion led to a 31% increase in bariatric surgery access for lower-income white adults. However, this benefit did not extend to Hispanic and Black adults, highlighting ongoing disparities in healthcare access.
Researchers found a chemical inhibitor of PDE9 stimulates cells to burn more fat in mice, reducing obesity and fatty liver. The study's findings suggest the experimental drug may be effective in treating severe obesity and improving heart function.
Scientists at Karolinska Institutet have discovered a carbohydrate called mannose as a biomarker for severe COVID-19 disease severity. The study found that glycolysis and glutaminolysis play a crucial role in SARS-CoV-2's spread and growth, providing potential new therapeutic strategies.
A new study found that ketone supplements enhanced blood flow to the brain and improved aspects of cognitive function, such as working memory and processing speed, in adults with obesity. This suggests that ketone supplements may be a novel therapeutic strategy for protecting and improving brain health in people with obesity.
A multidisciplinary taskforce developed a Clinical Care Pathway for NAFLD/NASH, outlining practical guidance from screening to patient care management. The pathway aims to provide efficient, safe, and value-based care for patients with NAFLD and NASH, highlighting the importance of early interventions and shared decision-making.
A study found that people living with overweight or obesity experience lower levels of care across eight quality markers, including emotional support and fast access. Healthcare professionals often make rude comments about weight, contributing to poor experiences.
Researchers at the University of Virginia Health System have identified 14 genes that can cause and three that can prevent weight gain, offering a promising lead in developing new treatments for obesity. The findings were made using a worm model of obesity and automation to test hundreds of genes.
A new strategy proposes that weight loss of 15% or more should be the main treatment focus for patients with type 2 diabetes, with potential to slow progress and reverse cases. This approach aims to address not just high blood sugar but other obesity-related complications.
A new review concludes that people with type 1 diabetes can manage their weight, but more research is needed to understand the specific needs of this patient group. The review explores strategies such as nutrition education, adjunct therapies like metformin and GLP-1 receptor agonists, and obesity surgery.
A new USC study found that artificial sweeteners like sucralose can trick the brain into feeling hungry, leading to increased calorie consumption. This study, one of the largest to-date on artificial sweeteners, suggests that females and people with obesity may be more sensitive to these sweeteners.
Problem-solving therapy led to short-term changes in the amygdala, a key region for emotion regulation, in individuals with comorbid depression and obesity. The study suggests that neural target changes at two months predicted improved behavioral outcomes after 12 months.
A new study published in the American Journal of Clinical Nutrition found that a low-carb diet with high saturated fat levels produced better cardiovascular and metabolic profiles than a low-fat diet. The low-carb diet improved blood lipid profiles, increased adiponectin, and reduced lipoprotein(a), a risk factor for heart disease.
Glyscend Therapeutics has initiated a phase 1 clinical trial in Australia investigating an oral polymer therapy that improves glucose homeostasis with weight loss in nonclinical models. The therapy targets mechanisms underlying bariatric surgery and aims to replicate its benefits without the need for surgery.
A recent US study found that major weight loss can reverse most cardiovascular risks associated with obesity. The study analyzed data from over 20,000 adults and found that the risk of high blood pressure and dyslipidemia was similar in those who lost weight and those who never had obesity.
Researchers analyzed data from nearly 3 million adults and found that those with 'metabolically healthy obesity' had a higher risk of developing heart failure and atrial fibrillation. However, they were not at increased risk for heart attacks, strokes, or cardiovascular deaths.
A study of over 19,000 bariatric surgery patients found men are five times as likely to die within 30 days after the procedure compared to women. Men's long-term mortality is also almost three times higher due to comorbidities such as cardiovascular disease and type 2 diabetes.
A Cleveland Clinic-led research team found that statistically overweight children who followed a healthy eating pattern significantly improved weight and reduced various cardiovascular disease risks. The study also showed improvements in blood pressure, total cholesterol, and low-density lipoprotein levels.
A recent study published in Nature found that a high-fat diet or genetic obesity can deplete hair follicle stem cells, leading to hair thinning and loss. The researchers discovered that inflammation signals block hair follicle regeneration, ultimately resulting in loss of hair follicles.
A new study suggests that failing to meet sleep recommendations can lead to higher intake of non-meal calories, including carbohydrates, added sugar, fats, and caffeine. Adults who don't get enough sleep tend to make poorer snacking choices, such as reaching for salty snacks and sweets.
Increasing physical activity and improving fitness are superior to weight loss in reducing mortality risk and treating obesity-related health conditions. Employing a weight-neutral approach also reduces the risks associated with yo-yo dieting.
A study by the University of the Basque Country analyzed the nutritional profile and level of processing of food products sold in vending machines. The results show that 48.6% of the products were classified as low-quality, while 73.8% were ultra-processed.
A study found that psychological factors and social determinants of health, such as race, education, and food security, influence a patient's likelihood of undergoing bariatric surgery. Patients with depression, anxiety, lower education, and SNAP benefits were less likely to receive surgery.
Researchers found that modest weight loss was achieved through financial incentives and environmental changes, but participants felt more guidance would have helped. The study suggests that ongoing support and personalized coaching could lead to better weight loss outcomes.
A study at 19 workplace cafeterias found that reducing portion sizes and replacing high-calorie food with lower-calorie options led to a 4.8% reduction in calories purchased per day. This simple intervention could contribute towards tackling obesity, particularly in deprived areas where access to healthy foods is limited.
The energy balance model fails to explain the biological causes of weight gain, whereas the carbohydrate-insulin model identifies excessive consumption of rapidly digestible carbohydrates as a key contributor to obesity. This perspective argues for a shift in focus from calorie restriction to dietary pattern change.
A new study by Oregon State University finds that xanthohumol improves glucose metabolism in mice only when the gut microbiota is present. The researchers discovered that three specific bacteria, Akkermansia muciniphila, Parabacteroides goldsteinii and Alistipes finegoldii, are responsible for XN's health benefits.
A recent study published in Scientific Reports found that individuals with inflexible metabolisms exhibit higher carbohydrate oxidation rates at night, indicating a reduced ability to burn fat during sleep. This discovery has the potential for practical use in disease prevention and early intervention.
A study of Finnish adults with overweight found that higher sleep-time parasympathetic activity is associated with healthier diets and lower alcohol consumption. Those with a good stress balance reported better diet quality, fibre intake, and self-control.
A new study found that non-Hispanic Black and Mexican American adults are diagnosed with type 2 diabetes at an average age of 46-47 years old, four to seven years earlier than non-Hispanic white adults. Preventive measures such as nutrition counseling and physical-activity programs can prevent or delay the onset of diabetes.
Researchers have found that blocking DHPS, an enzyme necessary for activating elF5A, can reduce inflammation and improve glucose control in mice. The study suggests macrophages play a key role in inflammation in obesity, and targeting this pathway may be a promising approach to treating the condition.
Researchers found that high-fat diets disrupt the body clock's satiety control, leading to overeating and obesity in rats. The study suggests that restoring the proper functioning of the body clock may help tackle obesity.
A new study found that young adults aged 18 to 24 are four times more likely to become overweight or develop obesity over the next 10 years than those aged 65 to 74. The study suggests that age is the most important sociodemographic factor for BMI change, and that targeted interventions for young adults may be necessary to prevent obes...
A controlled trial found that consuming an avocado daily for 12 weeks reduced visceral abdominal fat and the ratio of visceral to subcutaneous fat in female participants. The benefits were primarily seen in females, with no impact on glucose tolerance or male participants.
A new study from NYU Langone Health found that losing weight and managing excess body fat can significantly reduce the risk of lung disease in firefighters exposed to toxic substances on 9/11. The study analyzed 20 years of data from over 5,700 first responders and identified five key factors that predict lung disease.
A recent study discovered a connection between the brain's opioid system and food craving triggered by external stimuli. The researchers found that individuals with fewer opioid receptors were more likely to overeat in response to appetizing food, suggesting the opioid system as a potential target for anti-obesity drugs.