Articles tagged with Obesity
Researchers at Max Delbrück Center have identified protein EHD2 as a key regulator of fatty acid uptake in fat cells. The study found that people with normal weight produce more EHD2 than those who are overweight, suggesting a correlation between EHD2 levels and fat metabolism.
A large Kaiser Permanente study found that patients who underwent bariatric surgery maintained significantly more weight loss at 5 years compared to those who did not have surgery. Gastric bypass surgery showed better results than sleeve gastrectomy, with fewer participants regaining weight.
A ketogenic diet reduced liver fat content and improved insulin resistance in overweight participants. The diet also increased hydrolysis of triglycerides and promoted ketogenesis, suggesting a possible mechanism for reversing nonalcoholic fatty liver disease.
Researchers found that gastric bypass surgery alters both fecal and mucosal microbiomes, leading to improved metabolic outcomes. The study suggests manipulating the gut microbiome could be a potential alternative to surgery for sustained weight loss.
Researchers found that weight-loss surgery increased colorectal cancer risk by 20% and mortality rates among obese patients, highlighting the need for post-operative surveillance.
A new study published in Environment International links poor air quality to changes in the human gut microbiome, increasing the risk of obesity and diabetes. Young adults exposed to higher levels of ozone showed less microbial diversity and more species associated with obesity and disease.
Researchers developed a computer program analyzing molecules in blood plasma to identify individuals at risk of becoming overweight and developing obesity-related diseases. The test is 90% accurate in detecting whether the subject will gain weight without intervention, also predicting diabetes and other health risks.
Obesity increases levels of peroxynitrite-making enzymes in tiny cell membranes, silencing TRPV4 and lowering calcium entry. This leads to increased blood pressure. Targeting peroxynitrite or enzymes that make it may be an effective way to treat high blood pressure in obesity.
A study by Université Laval researchers suggests that bacteria may play a role in the development of type 2 diabetes in individuals with severe obesity. The researchers found distinct bacterial signatures in diabetics' blood, liver, and fat deposits compared to non-diabetics.
A Mayo Clinic-led study reveals that rapid fat degradation occurs in acute pancreatitis, triggered by PNLIP enzyme, and worsens disease outcomes. Obesity exacerbates pancreatitis risk, while unsaturated fats increase organ failure risk.
Scientists at CNRS have discovered that triglycerides interact with certain neurons in the brain's reward circuit, reducing their excitability and strengthening reward-seeking behavior. The study also found a correlation between blood triglyceride levels and brain activity in response to food odors.
Research suggests that middle-aged individuals who walk the most steps per day have a significantly lower risk of developing diabetes and high blood pressure. Women in particular see a substantial reduction in obesity risk, with the highest step count linked to a 61% lower likelihood.
A recent survey-based study of health professionals from 68 countries found that inadequate treatment services for obesity are prevalent globally. Lack of clear care pathways, high costs, and stigma are among the factors attributed to the shortage of effective treatments.
A £500,000 NIHR grant will be used to investigate the effectiveness of NHS-funded obesity treatment programmes in the UK. The project, BE:COME, aims to determine which components of these programmes contribute to weight loss and identify the best combination for different groups of people.
A new preclinical study reveals how liraglutide, an FDA-approved obesity drug, interacts with the brain's 'energy balance' system to reduce hunger and promote weight loss. The study identified a distinct group of neurons in the brainstem that play a key role in mediating these effects.
A study published in Journal of Internal Medicine found that weight loss surgery, especially gastric bypass, increases the long-term risk of bone fractures. The rate was highest among patients who underwent gastric bypass, with a 2.58-times higher fracture risk compared to non-surgical obesity care and other bariatric surgery methods.
The PCORnet Bariatric Study's findings provide a more complete picture of the comparative benefits and risks of Roux-en-Y gastric bypass and sleeve gastrectomy. Patients with severe obesity can now make informed decisions about weight-loss surgery based on individual circumstances and preferences.
Visceral fat generates high levels of interleukin-1 beta, over-activating microglia and promoting chronic inflammation. This leads to impaired cognitive function, including difficulties with navigation and learning and memory.
Over 100 medical and scientific organisations pledge to end weight stigma, citing evidence that stigma causes physical and psychological harm. The group calls for policies to prevent weight-based discrimination in healthcare, education, and the workplace.
A molecule found in oranges, called nobiletin, has been shown to drastically reduce obesity in mice by reducing insulin resistance and blood fats. Researchers are now exploring its potential as a treatment for human obesity and related diseases, including heart disease and diabetes.
A new study finds that obesity promotes the virulence of the influenza virus by impairing interferon defense responses and allowing for viral diversity. This correlation may explain why yearly influenza vaccines are needed, as obese individuals shed more virus and have delayed antiviral responses.
A leading health psychologist argues that negative attitudes towards weight gain affect patient treatment quality. Research shows that obesity is a complex condition with multiple causes, and using positive language can help promote understanding.
A new technology developed at Purdue University has shown promise in treating obesity and diabetes by converting bad fat into good fat. The Adipo Therapeutics team is seeking additional funding to further develop their technology and submit it to the FDA.
A 20-year study found that mid-life weight gain accelerates the natural decline in lung capacity with aging, while weight loss slows it down. Maintaining a healthy weight is crucial to stave off serious respiratory illness and extend life expectancy.
A new study published by the American Psychological Association found that adolescents who are bullied about their weight or body shape may be more likely to use alcohol or marijuana. The link between appearance-related teasing and substance use was strongest among overweight girls, raising special concerns about this group.
Researchers at Utah State University developed a novel sensing optical imaging nanoprobe to track cellular events leading to obesity. The probes enable researchers to monitor multiple surface receptors on individual cells, providing an unprecedented view of cellular surface activity.
A new study analyzed weight changes and their impact on lung function over a 20-year period, finding that moderate or high weight gain accelerates decline. Weight loss attenuates lung function decline in obese individuals, while maintaining low weight is crucial for preventing chronic respiratory diseases.
A multi-site study found that intensive behavioral therapy (IBT) combined with liraglutide 3.0 mg produced clinically-meaningful weight loss in patients with obesity, resulting in improvements in quality of life and cardiometabolic risk factors. The treatment approach appears to have complementary mechanisms of action.
A new disease classification system for obesity is proposed by researchers, replacing the current BMI-based diagnosis. The ABCD system has four domains: pathophysiology, body mass index classification, complications, and complication severity. This new framework aims to provide a more nuanced understanding of obesity as a chronic disease.
A new study reveals half of young Australian women experience sexually-related personal distress, with 20.6% experiencing at least one female sexual dysfunction. Low self-image and psychotropic medication are major contributors to these issues.
A new study from the University of Gothenburg shows that bariatric surgery is as effective for individuals who developed obesity early in life as it is for those who developed it later. The study found no difference in weight loss or obesity-related complications between the two groups.
A new study shows that intensive behavioral therapy from dietitians is an effective way for older Americans to lose weight. The study found that patients who received dietitian-provided therapy lost an average of 2.66 lbs, while those in the control group gained weight.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that eating a large breakfast instead of a large dinner creates twice as high diet-induced thermogenesis. This process measures how well metabolism is working, and can differ depending on mealtime.
Research published in the Journal of the American Heart Association found that longer sitting times were associated with higher levels of heart disease risk among overweight and obese post-menopausal women. The study revealed a strong negative link between sitting time and insulin resistance, particularly among Hispanic women.
A study of young African American adults found that high blood pressure, diabetes, and obesity contribute to a higher stroke risk. Improved nutrition and healthy eating habits can help mitigate this risk by increasing stroke awareness among this group.
A new study by researchers at the University of Washington found that increases in minimum wages had no overall effect on the health of working-age people. However, they did find a mix of negative and positive effects associated with the health of certain subgroups, including increased obesity rates among working-age people of color.
A University of New Mexico Health Sciences Center-led research team has discovered a cancer-fighting compound that also reduces fat in obese mice. The team found that the compound, G-1, increases energy expenditure and targets brown fat cells, leading to weight loss and improved diabetes symptoms.
A study of 677 participants found higher abdominal fat was associated with lower scores on memory and language tasks. Visceral adiposity may impact cognitive decline in older patients with diabetes, emphasizing the importance of targeted interventions.
A new AI method combines incomplete medical datasets to spot causal relationships, allowing researchers to analyze expensive or difficult-to-run trials. The algorithm uses quantum cryptography-inspired principles to determine the most disordered variable as the cause.
Researchers at the University of Illinois found that tasting or consuming sucralose can affect blood glucose and insulin levels, even in healthy individuals. The study suggests that sweetness should be consumed in moderation regardless of calories.
The 2020 OMA Obesity Algorithm offers updated resources for clinicians, including clickable links to podcasts and lectures by obesity experts. The Algorithm is based on scientific evidence and aims to improve patient outcomes through individualized treatment approaches.
The American Heart Association's 2030 Impact Goals aim to increase healthy life expectancy globally, with targets of 67 years by 2030. Despite positive trends in cardiovascular health, the US faces challenges such as obesity and inadequate physical activity among youth.
A study published in Radiology found that weight loss surgery improves breathing issues in obese patients by reducing air trapping and tracheal collapse. CT scans revealed structural changes to the lung and trachea after surgery, which correlate with improved symptoms and reduced inflammation.
Weight loss surgery significantly reduced hypertension, heart failure, and early death risks in a UK study. Patients who underwent gastric bypass surgery had lower cardiovascular disease risk compared to those receiving routine care.
A new Cal Poly study found that building healthy dietary, self-monitoring and psychological coping strategies are key to maintaining weight loss. People who reported losing an average of 50 pounds and keeping it off for over three years used more frequent strategies like setting daily food intake goals and recording what was eaten each...
Researchers found that dietary disinhibition was associated with 5-year longitudinal weight gain in obesity-prone individuals. Additionally, breastfeeding duration and timing of solids introduction significantly impacted BMI trajectories in early childhood.
A University of Barcelona study found that irregular eating schedules during weekends, known as eating jet lag, may contribute to increased body mass index (BMI) and obesity. Researchers suggest that maintaining regular eating and sleeping schedules can help prevent weight gain.
A large study of over 22,000 patients after a first heart attack found that abdominal obesity is independently associated with fatal and non-fatal heart attacks and strokes. Waist circumference was a stronger marker of recurrent events than overall obesity in men, while women had a U-shaped relationship between waist circumference and ...
Researchers found a neuron in mice that can suppress appetite without causing nausea, potentially leading to new treatment options for obesity. The study discovered that activating this CALCR neuron increases food intake and contributes to obesity, while deactivating it decreases food intake and body weight.
Researchers found soybean oil causes genetic changes in the brain, affecting obesity, diabetes, and neurological conditions. The study discovered 100 genes not functioning correctly, including a gene that produces oxytocin, leading to potential ramifications for brain function and diseases.
A specialized Lung Rescue Team at Massachusetts General Hospital has significantly reduced mortality rates in patients with obesity and acute respiratory failure compared to standard treatment. By individualized treatment, the team has cut the risk of death by half for up to a year.
Researchers at Stockholm University discovered engineered silica particles can reduce food efficiency, leading to lower weight gain and improved metabolic profiles in mice. The study suggests these particles could be used to treat obesity and diabetes in humans.
Blocking a cellular receptor called AHR prevents and reverses obesity in mice by inhibiting key genes involved in fat metabolism. Researchers at Dartmouth's Norris Cotton Cancer Center found that the drug NF, which blocks AHR, can not only prevent but also reverse obesity in study mice.
Researchers have discovered that blocking the iRhom2 protein increases energy consumption in fat depots, protecting against fat accumulation and inflammation. The study found no deleterious side effects, suggesting iRhom2 blocking may be a promising treatment for obesity.
Yale researchers identify O-GlcNAc transferase enzyme as key regulator of fat droplet doorman, which controls cellular access for nutrients and lipids. Mice lacking the enzyme exhibit reduced fat cell size and improved lipid burning, while overexpression triggers obesity by increasing carbohydrate intake.
A study published in JAMA Cardiology found that a person's BMI measurement from 25 years ago is a better predictor of their current BMI than a polygenic risk score. The researchers analyzed data from over 2,500 young adults and found that baseline BMI explained 52.3% of BMI variation over time.
Researchers conducted the largest study on weight loss surgery in a Chinese population with obesity and type 2 diabetes. Surgery provided substantial effects on weight, blood sugar, and cholesterol over five years, with restrictive surgeries being slightly more effective in diabetes remission.
A nationwide Danish study found that overweight and obesity were associated with a 12% higher risk of several common cancers. The study included 20,706 cancers among 313,321 adults diagnosed with overweight and obesity compared to expected cancers in the general population.
Half of women with heart failure do not receive adequate treatment due to the underlying cause being unrelated to a heart attack, leading to progressive stiffening of the heart. Obesity and high blood pressure are significant risk factors for this type of heart failure in women.
A review article published by George Washington University researcher Leigh A. Frame found a strong correlation between processed food consumption and the rising obesity epidemic in the US. The study suggests that limiting ultra-processed foods and increasing whole grain, fruit, and vegetable intake can help combat weight gain.