Articles tagged with Obesity
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Researchers found a key driver of nutrient absorption synchronization with Earth's day-night light cycle, linking it to weight gain. The commensal bacteria program the metabolic rhythms by activating protein histone deacetylase 3 (HDAC3), which enhances fat absorption.
Researchers have discovered that a lipid produced by brown adipose tissue, called 12-HEPE, helps reduce blood sugar levels in obese mice. The study found that 12-HEPE promotes glucose uptake into both skeletal muscle and brown adipose tissue, leading to improved glucose tolerance.
A new mouse study shows that disrupting the daily routine of gut microbes in mice increases the risk for metabolic dysfunction and obesity. The findings suggest a link between microbiota damage and human obesity, particularly in modern environments with antibiotics or long-distance jet travel.
Scientists have identified a signaling channel in the carotid body that links obesity to high blood pressure, paving the way for potential new treatments. Blocking this molecule can effectively lower blood pressure in obese mice.
Researchers at the University of Würzburg are developing a new therapy approach using virtual reality avatars to combat obesity. The avatars aim to provide a realistic body image, promoting acceptance and self-reflection in patients struggling with the condition.
A new tool kit provides real-world guidelines for counseling weight loss in primary care settings, offering a 21-session treatment manual modeled on the schedule of visits recommended by CMS. This approach has shown favorable weight losses of 5.4% at 6 months and 6.1% at 1 year.
A large-scale implementation of an enhanced recovery program (ERP) reduced rates of extended hospitalization for bariatric surgery patients by nearly half. The protocol, known as ENERGY, improved patient outcomes through measures such as minimizing fluid overload and implementing opioid-sparing pain management strategies.
Increasing nut consumption by half a serving a day may help stave off gradual weight gain, according to researchers. Substituting unhealthy foods with nuts was associated with lower risk of obesity and weight gain.
The Obesity Society has released a new evidence-based treatment protocol for intensive behavioral therapy (IBT) to treat obesity in primary care settings. The MODEL-IBT program provides 14 visits in the first 24 weeks, with 7 additional monthly visits through week 52.
A new study found that fat mass index is associated with a higher risk of cardiovascular events in people with type 2 diabetes. Researchers analyzed data from the ACCORD study and found that participants with higher fat mass were at increased risk, while lean body mass did not provide protection.
A new study from the University of Copenhagen found that overweight dog owners are more likely to have obese dogs, with a correlation between treats used for training and comfort. The study also reveals that castration triples the risk of being heavy or obese in male dogs.
Researchers discovered that inhibiting tanycytic TSPO increases energy expenditure and decreases appetite in high-fat diet-induced obese mice. This finding suggests a potential therapeutic strategy for treating metabolic diseases like obesity.
A new study published in Alimentary Pharmacology & Therapeutics found a strong association between obesity and chronic diarrhea, independent of dietary, lifestyle, or medical factors. Obesity was 60% more likely to cause chronic diarrhea compared to normal weight individuals.
A study published in Heliyon found that early life experiences shape individuals' beliefs about themselves and the world, contributing to chronic obesity and frequent bingeing. Schema therapy model can help address these underlying issues by identifying and changing maladaptive schemas and coping modes.
A UK study found that the proportion of younger adults diagnosed with type 2 diabetes has increased since the start of the century. Younger cases have a more aggressive metabolic profile, including higher BMI, blood glucose levels, and cholesterol levels. This trend is associated with a higher risk of cardiovascular disease and mortality.
Forager-farmers in Bolivian lowlands experience changes in body mass and diet over nine years, with increased use of cooking oil contributing to weight gain. Despite remarkable cardiovascular health, the Tsimane' population faces health challenges associated with high-calorie foods.
A new study found that obesity increases the risk of type 2 diabetes by 5.8-fold, while genetic predisposition and unfavorable lifestyle factors contribute less to the risk, but still play a role in its development. Lifestyle interventions can help delay the onset of T2D among high-risk subjects.
High levels of progesterone enable increased mineralocorticoid receptor expression, leading to blood vessel damage in young females with obesity. The study found that removing or blocking progesterone and aldosterone receptors can prevent blood vessel dysfunction.
Researchers at SDSU examine the role of sensory experience in shaping healthy food choices, finding that associating healthy foods with pleasure can increase interest in purchasing or eating them. Time and money are identified as primary barriers to accessing healthy foods.
A new study found that Japanese-American adults with a normal body mass index have a significantly higher risk of developing diabetes compared to their non-Hispanic white counterparts. The study revealed that younger respondents, never smokers, and those with higher education levels were less likely to have diabetes.
Researchers from Trinity College Dublin isolated a family of proteins linked to better control of blood sugar levels in type 2 diabetes patients. These IL-36 cytokines alter the intestinal microbiome, potentially mitigating insulin resistance and glucose build-up.
A recent Yale study found that high-fat diets stimulate hypothalamic inflammation, leading to changes in microglial cells and regulating energy homeostasis. The research suggests a neurological mechanism controlling food intake, with potential implications for obesity and diseases like Alzheimer's.
A large cohort study found that obesity is consistently associated with a greater burden of symptoms and experiences of distress among patients with breast or prostate cancer. Among patients with colon cancer, significant symptoms and distress were observed regardless of weight, suggesting alternative factors at play.
Researchers at U of M Medical School have discovered a new mechanism that could help treat obesity. The team found critical mutations in molecules implicated in obesity and diabetes, suggesting a possible therapeutic approach to human disease.
A study published by Cleveland Clinic shows that weight-loss surgery is associated with a lower risk of death and major adverse cardiovascular events than usual medical care. Patients who underwent surgery also had better diabetes control, used fewer medications, and lost more weight.
A mouse study found that exercise prior to and during pregnancy restores tissues in the body, improving blood sugar levels and lowering the risk of long-term health problems. The researchers suggest that an active lifestyle is crucial when planning pregnancy.
A new study finds that waist size, not overall obesity, is a significant predictor of coronary artery disease in postmenopausal women. The study, published in Menopause, found no association between body mass index and obstructive cardiovascular disease.
A new study finds that excess body fat increases the risk of depression, with a 17% higher probability for every ten kilograms of extra weight. The study suggests that psychological consequences of being overweight or obese drive this increased risk, rather than biological effects.
A new study at Binghamton University reveals that obesity is connected to a weaker response to taste. Researchers found that obese rats showed smaller and less responsive taste reactions compared to lean rats.
Researchers at Rutgers University have found that brown fat can filter and remove branched-chain amino acids (BCAAs) from the blood, which are linked to diabetes and obesity. The study suggests that environmental factors such as cold temperatures or spicy foods may be able to control BCAA uptake by brown fat.
Researchers discovered a connection between high-fat diets and insulin resistance through gut bacteria, specifically the protein IgA produced by B cells in the gut. A high fat diet weakens the gut immune system, leading to inflammation and worsening blood sugar levels.
A new study published in the Journal of Clinical Investigation reveals a previously unknown gut-brain connection that plays a key role in obesity caused by overeating. The research found that increased levels of gastric inhibitory polypeptide (GIP) in the gut inhibit the action of leptin, leading to weight gain.
A proof of concept study uses an 'obesity simulation suit' to teach medical students about obesity and uncover their prejudices. The results show that nearly two-thirds of medical students found the suit realistic, but also harbored more negative attitudes towards obesity than teachers or patients.
Research finds heart disease and stroke mortality rates are barely declining or increasing in 12 high-income countries since 2000. Obesity levels may be a significant contributor to the slowdown.
The American Thoracic Society has published a clinical guideline on the evaluation and management of obesity hypoventilation syndrome (OHS), a breathing disorder affecting obese individuals. The guideline aims to improve early recognition and effective treatment, reducing morbidity and mortality.
A new study has established the strongest evidence yet of a causal relationship between obesity and various serious conditions. The research analyzed data from the UK Biobank to assess associations between body mass index (BMI) and disease outcomes in 337,536 people.
A study of 18,424 Han Chinese adults found that regular jogging and other exercises like mountain climbing and yoga reduce BMI in individuals predisposed to obesity. These findings suggest that genetics are not destiny and that exercise can help mitigate genetic effects on obesity.
A new study found that people with obesity experience higher levels of initial taste perception and greater satisfaction from food compared to those with normal weight. This difference in taste perception may lead to increased food consumption among individuals with obesity, contributing to their higher caloric intake.
A recent study from the Rudd Center for Food Policy and Obesity found that weight stigma in men is associated with harmful health consequences, including depressive symptoms and dieting behaviors. Men who experienced or internalized weight stigma had higher rates of binge eating and lower self-rated health.
A recent study found that university students who used their smartphones for five or more hours a day had a 43% increased risk of obesity. This prolonged cell phone use was associated with decreased physical activity and unhealthy lifestyle habits, including consuming sugary drinks and fast food.
A new study reveals that T follicular helper cells shield mice from obesity by promoting IgA antibody production, which suppresses lipid absorption. This discovery highlights the immune system's role in regulating the gut microbiome and offers potential for novel treatments against metabolic diseases.
A computer-simulated study suggests that standard solid food feeding guides from hospitals and baby-formula makers may not provide accurate recommendations for infants. Following these guidelines can lead to overweight infants as early as 9-11 months old, with the Similac guide producing the healthiest results.
Researchers at University of Utah Health identified a specific class of gut bacteria called Clostridia that prevents mice from becoming obese. Giving these microbes back to mice with an impaired immune system allows them to stay slim, suggesting a potential therapeutic approach for humans.
A new study has filled gaps in knowledge on weight loss experiences for minority groups with type 2 diabetes. Researchers found that tailoring interventions to individual needs, including behavioral strategies and meal replacement use, can improve health outcomes among African Americans and Hispanics with the condition.
A study published by the American Academy of Neurology found that having a higher BMI and bigger waistline in the 60s is associated with greater signs of brain aging. This can lead to accelerated brain thinning, which is tied to an increased risk of Alzheimer's disease.
A study of nearly 157,000 postmenopausal women found those with normal weight and high abdominal fat had a higher risk of death compared to their counterparts with no central obesity. The findings highlight the importance of considering body shape and fat distribution in addition to BMI for obesity prevention.
A study published in Neurology found that having a bigger waistline and high BMI in the 60s is associated with greater signs of brain aging. The study suggests that obesity accelerates brain aging, which can increase the risk of Alzheimer's disease by at least a decade.
Researchers found that meal timing strategies like eTRF lower hunger hormone levels and improve metabolic flexibility, while also increasing fat-burning. The study suggests that these strategies may be more effective than previous research on improving metabolic health.
A study published in JAMA Network Open found that women with normal weight but high waist circumference were 31% more likely to die from cardiovascular disease and obesity-related cancer. Waist size is a forgotten factor in defining obesity, and its inclusion could lead to better risk evaluation and intervention programs.
A recent study published in The FASEB Journal explored the potential of SIRT6 to protect the heart from developing diabetic cardiomyopathy. Researchers found that SIRT6 over-expression can prevent the development of obesity and cardiomyopathy under conditions of excess nutrition.
Obesity experts argue that it should be recognized as a chronic disease due to its strong biological influence and severe complications. They believe this approach can help reduce stigma and discrimination, but critics caution that labeling obesity as a disease may not lead to better outcomes for individuals or society.
A new study published in PLOS ONE found that spaying or neutering large-breed dogs can lead to a higher risk of obesity and nontraumatic orthopedic injuries. Dogs spayed or neutered before 6 months of age were at a significantly greater risk of sustaining these injuries.
Researchers identified a molecular mechanism that may be contributing to the global obesity epidemic. The study found that a protein called RAGE on the surface of fat cells can block fat burning when stressed, leading to weight gain. Removing RAGE from fat cells reduced weight gain in mice fed a high-fat diet.
A study by Clemson researchers found that the Cyp2b gene is associated with obesity and fatty liver disease in male mice, regardless of diet. The discovery suggests that enzymes involved in detoxification may play a role beyond diet and exercise in weight management and metabolic health.
Patients with Type 1 diabetes who are obese often face denied pancreas transplantation due to high infection risks. However, robotic pancreas transplantation has shown promising results, reducing blood loss and surgical complications while improving patient outcomes.
A new study by Massachusetts General Hospital found that labeling food choices with simple 'traffic-light' symbols reduced the number of calories purchased by employees in the hospital cafeteria. The intervention was associated with a sustained reduction in calories over two years, with estimated weight loss ranging from 1-2 kg per year.
A biomedical scientist is studying how the body's cannabis-like molecules affect feeding behavior and contribute to obesity. The research aims to identify novel therapeutic strategies for safely treating obesity and related metabolic disorders, which are currently lacking reliable options.
A UTSA professor is designing a novel protein blocker to inhibit the activity of P450 8B1, a human enzyme linked to bad cholesterol and obesity. The breakthrough aims to fight rising obesity rates and related health issues like high blood pressure and strokes.
Researchers suggest that strengthening muscles, rather than losing fat, may be a better way to protect against weight-related health risks like diabetes and cardiovascular disease. Muscle health is linked to metabolic function, insulin sensitivity, and glucose uptake, making it a potential indicator of overall health.
A study led by Dr. Stephanie Kullmann found that exercise improves brain function in overweight and obese individuals by normalizing brain functions important for metabolism and increasing regional blood flow in areas of the brain dependent on dopamine. Participants also reported improvements in mood and executive function.