Research on obesity, its causes, and its treatment. Covers GLP-1 weight-loss drugs, diet, metabolic health, treatment guidelines, and obesity in children.
A recent study by the University of Georgia found a slower uptake of Medicaid enrollment among low-income obese individuals compared to non-obese counterparts. The study revealed a 5.6% increase in coverage for obese individuals versus 7.4% for non-obese individuals.
A new study from the University of Gothenburg finds that weighted vests can lead to a reduction in body weight and fat mass, particularly when wearing heavy weights, while maintaining muscle mass. The researchers suggest that this is due to a built-in energy balance system that endeavors to keep body weight constant.
A study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that short-term cold exposure increased energy expenditure and improved fatty acid profiles in individuals with active brown fat. People with brown fat burned 15% more calories than those without, highlighting the organ's potential as a ta...
Researchers found that high-fat diets caused impaired cognitive function in obese rats, affecting their mental exhaustion. The study, published in The FASEB Journal, suggests a link between excess weight and compromised cognitive abilities.
Researchers unveil the structure of a key protein in human metabolism, which could lead to better obesity treatments. The study found that calcium ions play a crucial role in the protein's function, opening new paths for developing targeted pharmaceuticals.
Researchers from IKBFU, Moscow, and Kiev investigate the effects of deuterium on adipose tissue differentiation in an in vitro model. They found that varying deuterium concentrations can influence the formation of brown/beige or white adipocytes.
Researchers discovered that nociceptin neurons in the hypothalamus of mice promote consumption of high-fat food. Removing these neurons from the brain eliminated overeating in mice.
Researchers found that Orujo Olive Oil significantly reduced obesity in mice by 30%, while also decreasing body fat, hepatic inflammation and improving insulin sensitivity. The study highlights the biological value of orujo oil as a functional food with great therapeutic potential against metabolic disorders.
A new study published in PLOS Biology found that excess weight can cause poor sleep in worms, not the other way around. Researchers genetically modified worms to lose their ability to sleep and observed a severe drop in energy levels, suggesting that sleep is an attempt to conserve energy.
A new study found that the effective population size of the first Samoans was small, ranging from 700 to 3,400 people, with population growth starting around 1,000 years ago. The research highlights the importance of population history and size in understanding health conditions such as obesity and diabetes.
Research published in Diabetologia found that obesity increases type 2 diabetes risk by at least 6 times, even among those with low genetic risk. The study highlights the importance of weight management and healthy lifestyle in preventing type 2 diabetes across all genetic risk groups.
Researchers discovered a synthetic gold-based compound that inhibits adipogenesis and reduces key metabolites, potentially treating obesity. The D-AuNPs showed nontoxicity to cells at high concentrations, offering a new avenue for obesity medicine.
A study published by The Endocrine Society highlights shared disease pathways between COVID-19 and type 2 diabetes, requiring new approaches in treatment for hospitalized patients. Commonly used diabetes medications may pose risks in severe coronavirus infections.
A large observational study of over 33,000 women found that those born by cesarean section were at higher risk of developing obesity and type 2 diabetes in adulthood. The study, published in JAMA Network Open, controlled for various factors and found a significant association between cesarean births and increased risk of these conditions.
A study of 519,513 UK adults found a significant correlation between depression and obesity. Antidepressant prescriptions also increased with rising weight, highlighting the need for tailored guidance.
A larger thigh circumference may be associated with lower blood pressure and a reduced risk of heart disease in people with obesity. Thigh circumference could potentially be used as an indicator for earlier detection and prevention of high blood pressure and related complications.
Two studies from Boston University School of Public Health found that patients with higher BMIs were up to 158% more likely to use prescription opioids long-term. Osteoarthritis, other joint disorders, and back pain accounted for most opioid prescriptions linked to obesity.
A new study published by Oxford University Press USA found that mat Pilates training significantly reduces arterial stiffness and blood pressure in young obese women with elevated blood pressure. The study, which included 12 weeks of mat Pilates training, also found a decrease in body fatness.
A new study published in the Journal of the Endocrine Society found that people with very poor fitness at the beginning of a behavioral weight loss program lose less weight in the long term. Adults with poor or better fitness lost nearly twice as much weight over 18 months compared to those with very poor fitness.
A survey of resident physicians found that most felt uncomfortable managing obesity despite its increasing prevalence. The study highlights the need for improved education in obesity management to improve patient care.
Researchers found that bariatric surgery significantly decreased liver enzymes, Fatty Liver Index, and BARD score in patients with NAFLD. Gastric bypass was associated with the greatest reduction in liver damage.
An animal study found that coconut oil consumption reduces cholesterol and blood glucose levels, and fatty liver disease in obese female mini-pigs. The study suggests that coconut oil may be used to treat metabolic syndrome, particularly in women with obesity.
Patients with superobesity are more prone to regain weight after bariatric surgery due to unconscious food cravings and attentional bias. Research found that pre-conscious and conscious attentional biases play a significant role in weight regain, suggesting that cognitive processes similar to addiction may be present in morbid obesity.
Researchers have discovered a molecular accelerator of leptin action in the brain called Sh2b1, which promotes the stimulation of the sympathetic nervous system and activates brown fat. This activation increases energy expenditure and protects against obesity and metabolic disease.
A new study links pregnant women's PFAS exposure to their granddaughters' increased obesity risk. The research found that higher levels of PFAS in grandmothers were associated with a greater risk of obesity in granddaughters, even when controlling for other factors.
Studies confirm that breast reduction surgery significantly improves physical health, including pain levels and physical function, as well as mental wellbeing. Women of all shapes and sizes benefit from the surgery, including overweight or obese individuals who were previously barred from the procedure.
Researchers from Kumamoto University found that Melinjo seed extract activates the beneficial hormone adiponectin, improving obesity and diabetes. The study discovered individual genotype differences affect efficacy.
A new study reveals that sugar-rich diets can lead to early death, but not due to obesity. The researchers found that the build-up of uric acid is a key factor in this process. By providing flies with access to water, they were able to prevent the accumulation of uric acid and subsequent shortened survival.
A nationwide study found that bariatric surgery significantly reduces the risk of heart attacks and strokes among obese patients. The surgery was associated with a 60% lower rate of fatal and non-fatal heart attacks and stroke, as well as significant weight loss and improved type 2 diabetes management.
Researchers at Max Delbrück Center have identified protein EHD2 as a key regulator of fatty acid uptake in fat cells. The study found that people with normal weight produce more EHD2 than those who are overweight, suggesting a correlation between EHD2 levels and fat metabolism.
A large Kaiser Permanente study found that patients who underwent bariatric surgery maintained significantly more weight loss at 5 years compared to those who did not have surgery. Gastric bypass surgery showed better results than sleeve gastrectomy, with fewer participants regaining weight.
A ketogenic diet reduced liver fat content and improved insulin resistance in overweight participants. The diet also increased hydrolysis of triglycerides and promoted ketogenesis, suggesting a possible mechanism for reversing nonalcoholic fatty liver disease.
Researchers found that gastric bypass surgery alters both fecal and mucosal microbiomes, leading to improved metabolic outcomes. The study suggests manipulating the gut microbiome could be a potential alternative to surgery for sustained weight loss.
Researchers found that weight-loss surgery increased colorectal cancer risk by 20% and mortality rates among obese patients, highlighting the need for post-operative surveillance.
A new study published in Environment International links poor air quality to changes in the human gut microbiome, increasing the risk of obesity and diabetes. Young adults exposed to higher levels of ozone showed less microbial diversity and more species associated with obesity and disease.
Researchers developed a computer program analyzing molecules in blood plasma to identify individuals at risk of becoming overweight and developing obesity-related diseases. The test is 90% accurate in detecting whether the subject will gain weight without intervention, also predicting diabetes and other health risks.
Obesity increases levels of peroxynitrite-making enzymes in tiny cell membranes, silencing TRPV4 and lowering calcium entry. This leads to increased blood pressure. Targeting peroxynitrite or enzymes that make it may be an effective way to treat high blood pressure in obesity.
A study by Université Laval researchers suggests that bacteria may play a role in the development of type 2 diabetes in individuals with severe obesity. The researchers found distinct bacterial signatures in diabetics' blood, liver, and fat deposits compared to non-diabetics.
A Mayo Clinic-led study reveals that rapid fat degradation occurs in acute pancreatitis, triggered by PNLIP enzyme, and worsens disease outcomes. Obesity exacerbates pancreatitis risk, while unsaturated fats increase organ failure risk.
Scientists at CNRS have discovered that triglycerides interact with certain neurons in the brain's reward circuit, reducing their excitability and strengthening reward-seeking behavior. The study also found a correlation between blood triglyceride levels and brain activity in response to food odors.
Research suggests that middle-aged individuals who walk the most steps per day have a significantly lower risk of developing diabetes and high blood pressure. Women in particular see a substantial reduction in obesity risk, with the highest step count linked to a 61% lower likelihood.
A recent survey-based study of health professionals from 68 countries found that inadequate treatment services for obesity are prevalent globally. Lack of clear care pathways, high costs, and stigma are among the factors attributed to the shortage of effective treatments.
A £500,000 NIHR grant will be used to investigate the effectiveness of NHS-funded obesity treatment programmes in the UK. The project, BE:COME, aims to determine which components of these programmes contribute to weight loss and identify the best combination for different groups of people.
A new preclinical study reveals how liraglutide, an FDA-approved obesity drug, interacts with the brain's 'energy balance' system to reduce hunger and promote weight loss. The study identified a distinct group of neurons in the brainstem that play a key role in mediating these effects.
A study published in Journal of Internal Medicine found that weight loss surgery, especially gastric bypass, increases the long-term risk of bone fractures. The rate was highest among patients who underwent gastric bypass, with a 2.58-times higher fracture risk compared to non-surgical obesity care and other bariatric surgery methods.
The PCORnet Bariatric Study's findings provide a more complete picture of the comparative benefits and risks of Roux-en-Y gastric bypass and sleeve gastrectomy. Patients with severe obesity can now make informed decisions about weight-loss surgery based on individual circumstances and preferences.
Visceral fat generates high levels of interleukin-1 beta, over-activating microglia and promoting chronic inflammation. This leads to impaired cognitive function, including difficulties with navigation and learning and memory.
Over 100 medical and scientific organisations pledge to end weight stigma, citing evidence that stigma causes physical and psychological harm. The group calls for policies to prevent weight-based discrimination in healthcare, education, and the workplace.
A molecule found in oranges, called nobiletin, has been shown to drastically reduce obesity in mice by reducing insulin resistance and blood fats. Researchers are now exploring its potential as a treatment for human obesity and related diseases, including heart disease and diabetes.
A new study finds that obesity promotes the virulence of the influenza virus by impairing interferon defense responses and allowing for viral diversity. This correlation may explain why yearly influenza vaccines are needed, as obese individuals shed more virus and have delayed antiviral responses.
A leading health psychologist argues that negative attitudes towards weight gain affect patient treatment quality. Research shows that obesity is a complex condition with multiple causes, and using positive language can help promote understanding.
A new technology developed at Purdue University has shown promise in treating obesity and diabetes by converting bad fat into good fat. The Adipo Therapeutics team is seeking additional funding to further develop their technology and submit it to the FDA.
A 20-year study found that mid-life weight gain accelerates the natural decline in lung capacity with aging, while weight loss slows it down. Maintaining a healthy weight is crucial to stave off serious respiratory illness and extend life expectancy.
A new study published by the American Psychological Association found that adolescents who are bullied about their weight or body shape may be more likely to use alcohol or marijuana. The link between appearance-related teasing and substance use was strongest among overweight girls, raising special concerns about this group.
Researchers at Utah State University developed a novel sensing optical imaging nanoprobe to track cellular events leading to obesity. The probes enable researchers to monitor multiple surface receptors on individual cells, providing an unprecedented view of cellular surface activity.
A new study analyzed weight changes and their impact on lung function over a 20-year period, finding that moderate or high weight gain accelerates decline. Weight loss attenuates lung function decline in obese individuals, while maintaining low weight is crucial for preventing chronic respiratory diseases.
A multi-site study found that intensive behavioral therapy (IBT) combined with liraglutide 3.0 mg produced clinically-meaningful weight loss in patients with obesity, resulting in improvements in quality of life and cardiometabolic risk factors. The treatment approach appears to have complementary mechanisms of action.
A new disease classification system for obesity is proposed by researchers, replacing the current BMI-based diagnosis. The ABCD system has four domains: pathophysiology, body mass index classification, complications, and complication severity. This new framework aims to provide a more nuanced understanding of obesity as a chronic disease.
A new study reveals half of young Australian women experience sexually-related personal distress, with 20.6% experiencing at least one female sexual dysfunction. Low self-image and psychotropic medication are major contributors to these issues.
A new study from the University of Gothenburg shows that bariatric surgery is as effective for individuals who developed obesity early in life as it is for those who developed it later. The study found no difference in weight loss or obesity-related complications between the two groups.