Articles tagged with Renal Failure
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A prediction model that includes data on measures of several routinely obtained laboratory tests accurately predicted the short-term risk of kidney failure for patients with moderate to severe chronic kidney disease. The researchers used demographic, clinical, and laboratory data from over 7,000 patients with CKD stages 3 to 5.
A recent study found that using acute kidney injury (AKIN) criteria in hospitalized cirrhotic patients can predict outcomes and improve diagnosis. The AKIN criteria is more sensitive than current definitions, considering a ≥50% increase in serum creatinine within 48 hours as renal failure. This may lead to better management of health s...
A study published in CMAJ found that elderly patients taking combination ACE inhibitors and ARBs had a higher risk of kidney failure and death. The researchers observed that most patients stopped the combination therapy within three months due to low blood pressure.
A study of over 5 million Medicare beneficiaries found that hospital regions with a higher frequency of diagnoses have a lower case-fatality rate for chronic conditions. The analysis suggested that increased diagnosis frequency leads to better patient outcomes.
Kidney failure affects nearly half a million US individuals, with 48% being 60 years or older. Elderly patients are now more likely to receive a kidney transplant due to increased access to organs from living and deceased donors, as well as improved survival rates while waiting.
A recent study published in Cell Metabolism has identified podocytes as a crucial factor in the development of kidney failure in diabetes. The researchers found that these cells become less responsive to insulin, leading to similar kidney disease symptoms in mice with normal blood sugar levels.
Researchers have discovered that growth hormone controls skeletal muscle development through IGF-1, whereas its effect on nutrient uptake is independent of IGF-1. In contrast, aldosterone promotes vascular injury by inducing expression of the protein PGF in mouse and human blood vessel walls.
A study of 24,875 dialysis patients found that sustained extremes in blood sugar levels increased the risk of dying prematurely. Individualized hemoglobin A1c targets may be more appropriate than a one-size-fits-all approach for diabetic patients with kidney failure.
A new study suggests that genetic variations in the APOL1 gene are responsible for population disparities in kidney failure, particularly among persons of African and Hispanic heritage. The findings highlight the importance of identifying genetic mutations associated with increased risk of chronic kidney disease.
A study found pronounced regional differences in treatment practices for older adults with kidney failure, including decisions on starting or stopping dialysis. Higher-spending regions tend to have more intensive care, but patients don't necessarily fare better.
Researchers at TGen discovered a genetic biomarker with significant association to kidney failure in American Indians in Arizona. The study found evidence of some lesser associations between kidney failure and four other markers, all linked to the SUCNR1 gene.
Gastrointestinal symptoms are common in peritoneal dialysis patients, with a history of corticosteroid therapy and daily pill intake positively correlated to GI symptoms. Residual renal function is negatively correlated to GI symptoms, suggesting its role in predicting complications.
Researchers at Indiana University School of Medicine successfully treated acute kidney injury in laboratory experiments using genetically reprogrammed cells producing a protein that aids kidney development. The treatment, administered intravenously, showed significant improvements in kidney function and reduced physical damage.
The American Thoracic Society has published a joint statement on renal failure in ICU patients, highlighting the need for better prevention, diagnosis, and treatment strategies. The statement emphasizes the importance of fluid management, biomarkers, and evidence-based practices to reduce mortality and morbidity.
Scientists discovered that Lupus patients lack or have blocked DNase-1, an enzyme degrading NETs, leading to their accumulation in the kidneys. This impairs NET degradation, increasing kidney failure risk. A new test based on this finding may enable early diagnosis and treatment.
A study by Henry Ford Hospital found that heart failure patients developing kidney failure after LVAD surgery experience significantly decreased survival rates and prolonged hospitalizations. The researchers suggest improving patient selection and reducing cardio-pulmonary bypass time to mitigate the risk of kidney failure.
Early recognition and prevention of chronic kidney disease (CKD) are vital for all settings. CKD is associated with increased cardiovascular risk, even at mild reductions in glomerular filtration rate. Implementing interventions can reduce cardiovascular events or progression to kidney failure.
A study published in the New England Journal of Medicine found that dialysis for nursing home seniors does not improve functional capacity and may even worsen quality of life. Researchers call for individualized approaches to treatment, considering patients' goals and prognostic information.
A new study reveals that kidneys recovered from deceased donors with acute renal failure can function just as well as those from healthy donors, opening up a significant expansion of the donor kidney pool. This could lead to an additional 1,000 kidneys or more per year being made available to patients waiting for a transplant.
A $10.25 million study will investigate the causes of kidney failure and the need for dialysis in patients with nephrotic syndrome. The research network will focus on understanding the mechanisms behind minimal change disease, focal and segmental glomerulosclerosis, and membranous nephropathy.
Researchers discovered a link between the anti-aging gene klotho and reduced high blood pressure, reversing kidney damage. The study shows that increasing klotho expression can lower blood pressure for at least 12 weeks and potentially prevent hypertension.
Three cases of patients with liver injury and renal failure have been reported due to steroid-enriched dietary supplements. Researchers warn that even low doses of anabolic steroids can cause severe health consequences.
Researchers at MCG report breakthrough in treating acute renal failure by blocking mitochondrial fragmentation caused by vascular obstruction, trauma, chemotherapy, and toxins. This can prevent kidney cells from committing suicide and lead to acute renal failure.
A recent study by Marcello Tonelli and colleagues found no correlation between remote or rural residence and increased time to kidney transplantation in the US. The likelihood of receiving a transplant from a deceased or living donor was similar among patients dwelling farther away, suggesting disparities may not be solely due to location
Patients with mild to severe kidney dysfunction require lower warfarin doses and closer monitoring due to increased bleeding risk. Warfarin dose is significantly affected by kidney function, even after accounting for genetics.
Researchers identified variations in the MYH9 gene strongly associated with FSGS and HIV-associated FSGS among African-Americans, with a risk 300-500% higher than whites. The findings shed light on common genetic pathways to prevent kidney disease progression.
The Lancet Editorial emphasizes the importance of independent medical assessment for hunger strikers and criticizes the lack of emphasis on impartial advice and care. Force feeding is deemed unacceptable in clinical management, and prisoners or detainees are entitled to highest clinical standards worldwide.
A new study suggests that monitoring fibroblast growth factor 23 (FGF-23) levels can provide crucial information for the treatment of kidney failure patients. Elevated FGF-23 levels have been linked to a significantly increased risk of death among dialysis patients, even when phosphate levels are normal.
Researchers have discovered a new kidney protein, NGAL, that can diagnose sudden kidney failure days sooner than current tests. A simple urine test for NGAL can help emergency department physicians accurately diagnose kidney failure and make evidence-based treatment decisions.
A study funded by the National Institutes of Health found that reducing early blockages in bloodsstream access does not increase the likelihood that the access will function adequately for long-term treatments. Fistulas are the preferred type of access since they clot less often, experience fewer infections, and are less costly.
A new study found that an iso-osmolar X-ray dye did not reduce the risk of kidney damage during percutaneous coronary intervention (PCI) in patients with chronic renal failure. The study compared two types of contrast medium and found no significant difference in rates of kidney injury or need for dialysis.
Researchers at Albert Einstein College of Medicine found that aberrant Notch signaling plays a role in diabetic nephropathy and focal segmental glomerulosclerosis, two major causes of end-stage renal disease. They discovered that gamma secretase inhibitors can protect against kidney disease, sparking hope for new treatment options.
A study of acute kidney failure treatments found that intermittent hemodialysis and continuous kidney replacement therapy have similar clinical outcomes. No significant difference was seen in the risk of death or chronic dialysis treatment between the two therapies.
A wearable haemodialysis device has delivered promising results in a pilot trial, with patients reporting improved quality of life and no adverse cardiovascular changes. The device has the potential to become a practical means of delivering extended and more frequent dialysis to patients with end-stage kidney failure.
The estimated prevalence of chronic kidney disease in US adults has increased from 10% to 13%, driven by rising diabetes and hypertension rates. The prevalence of earlier stages of CKD accounts for most individuals with the condition, highlighting the need for cardiovascular risk factor management.
Recent studies have linked widely used osteoporosis drugs and bowel prep solutions to kidney damage. Nephrologists must be aware of these emerging causes of kidney problems and take steps to prevent them.
Researchers have identified a gene, GLIS2, that protects against a serious kidney disease called nephronopthisis. Mutations in this gene cause the disease, which leads to kidney degeneration and failure.
Researchers at Mayo Clinic have successfully developed a protocol for performing coronary angiography on the same day as elective valve surgery, reducing the need for separate hospital visits and improving patient outcomes. The study, which evaluated 226 consecutive patients, showed that 28.3% had severe coronary artery disease requiri...
A research team has identified a protective gene variant that may help prevent severe kidney failure in people with diabetes. The discovery could lead to novel treatment approaches for susceptible individuals, as well as a new marker for identifying those at increased risk of future kidney disease.
A new analysis of over 5 million hospital discharges found a significant increase in kidney damage after coronary artery bypass surgery, but a decrease in mortality rate. The study suggests that current prevention strategies may not be effective and more research is needed to identify susceptible patients and effective treatments.
A study of 5,615 child patients found that age, race, cause of kidney failure, and residual function were associated with short stature. Over one-third of children with kidney disease met the criteria for short stature.
A new diagnostic test using NGAL protein has been shown to predict kidney transplant outcomes, with lower values indicating faster recovery and higher values indicating longer recovery periods. This breakthrough could lead to improved patient care and reduced risk of kidney failure.
A new UCSF study found that obesity is a significant risk factor for kidney failure, with the morbidly obese having up to seven times greater risk than normal-weight individuals. The research, published in Annals of Internal Medicine, suggests that weight loss may be a potential way to reduce kidney failure risk.
Researchers identify thrombospondin (TSP-1) as a potential target for preventing acute kidney failure. Studies in mice show that the protein causes irreversible kidney damage when blood flow is disrupted, but genetically engineered mice lacking TSP-1 are protected from damage.
US kidney failure rates have stabilized over the past two decades, with diabetes and high blood pressure remaining leading causes. Despite progress, racial disparities persist, particularly among African Americans, who continue to experience higher rates of new cases.
A study examining global prevalence of kidney failure among critically ill patients found that septic shock was the most common contributing factor (47.5%). The overall hospital death rate was 60.3%, with dialysis dependence at discharge being 13.8% for survivors.
A large international study found that 6% of critically ill patients develop kidney failure, with 60% dying while hospitalized. Researchers also discovered that 86% of surviving patients do not require dialysis after discharge, providing a clue for treating acute renal failure.
Researchers have found a novel biomarker, neutrophil gelatinase-associated lipocalin (NGAL), that can detect kidney failure in children after cardiac surgery in as little as two hours. This early diagnosis enables timely administration of effective therapeutic measures to prevent further complications.
A new study published in The Lancet identified a biomarker NGAL that can detect kidney failure hours after cardiac surgery, offering hope for earlier diagnosis and treatment. The research found high concentrations of NGAL in urine and blood samples within two hours of surgery, indicating the presence of kidney failure.
Researchers at Columbia University Medical Center discovered a protein called Ngal that can protect mice from renal failure after injection, suggesting its potential as a therapeutic tool. The study also found Ngal to be an effective marker for early diagnosis of kidney failure.
Researchers at MCG Medical Center are studying a bioartificial kidney that can mimic the functions of natural kidneys, reducing mortality rates in ICU patients. The device, developed by Dr. H. David Humes, uses billions of donor kidney cells to filter waste and regulate various bodily processes.
A phase I/II study demonstrates the bioartificial kidney's safety and effectiveness in treating acute renal failure, with six patients surviving over 30 days after treatment. The device uses human adult progenitor/stem cells to filter blood and regulate immune system molecules.
Rosuvastatin, marketed as Crestor, has been linked to a higher incidence of rhabdomyolysis and renal insufficiency compared to other statins. The drug's manufacturer, AstraZeneca, is estimated to be seeking $20 billion in annual sales, making it morally unjustifiable to keep the drug on the market.
Researchers have identified multiple families with a genetic mutation causing gout and kidney failure, developing in teenage years and progressing to end-stage kidney disease by the 40s or 50s. The team hopes to find family members who may be unaware of their condition and develop improved treatment for this rare disease.
Research finds that heavy use of analgesics for at least nine years prior to irreversible kidney failure is associated with anatomic changes of SICK. Over 7% of dialysis patients had SICK, with 33% having overused analgesics preceding dialysis start.
A new study found that 16.5% of non-kidney transplant recipients develop chronic kidney failure, with older age, being a woman, and pre-transplant hepatitis C infection increasing the risk. The risk is higher for those whose kidneys fail after transplant, highlighting the need for better treatment regimens.
Researchers found that 30% of diabetic patients with kidney disease do not exhibit common symptoms like protein in urine and eye disease. The current approach of screening for these symptoms alone is insufficient, and a blood test measuring kidney function directly is recommended.
A study published in Science suggests that proteins normally pass into the kidneys and that kidney disease may result from an inability to draw them back out. Researchers identified at least two patients with kidney disease who lack one copy of CD2AP, a protein critical for kidney function.
Researchers estimate 8 million people in the US have less than half of normal kidney function, a treatable condition. Chronic kidney disease is strongly associated with older age and non-Hispanic whites, raising concerns about minority populations' higher risk of kidney failure
A study published in JAMA found that ICU patients treated with diuretics have a 68% increase in mortality and 77% non-recovery of kidney function. The researchers suggest reassessing diuretic use, particularly for those not responding to treatment, as delays can lead to adverse outcomes.