Articles tagged with Renal Failure
A recent study by John Gill and colleagues found that the age of a live donor between 18 to 64 years has minimal effect on the survival of transplanted kidneys. This finding suggests that patients over 39 years old may benefit from participating in living donor paired exchange programs or kidney swaps.
Patients with kidney failure have relatively poor physical health. Frequent dialysis does not significantly improve their overall physical capacity compared to conventional dialysis, but it can provide improved quality of life.
Researchers at Mount Sinai School of Medicine have identified HIPK2 as a crucial regulator protein in kidney fibrosis, leading to improved conditions when eliminated or inhibited. The study provides a new therapeutic target for the treatment of kidney failure, affecting millions of Americans.
A study published by the American Society of Nephrology found that 10% of patients with chronic kidney disease did not experience progressive kidney dysfunction, and 3% demonstrated improved kidney function. The study suggests that some cases of CKD may be reversible, providing hope for patients with this condition.
Most Medicare beneficiaries with kidney failure (64%) participate in Part D coverage, with 72% receiving financial assistance. Those without assistance often opt for more expensive plans due to the need for intensive medication therapy.
Home-based dialysis treatments for kidney failure are gaining popularity worldwide, particularly in developing countries. The study found a significant increase in peritoneal dialysis patients in these regions, driven by lower costs and easier access to care.
Upper GI bleeding is common and serious in dialysis patients, with rates 10 times higher than in the general population. The condition can lead to early deaths and substantial negative effects on kidney function.
Research from Michigan Medicine shows a 15% increase in post-liver transplant kidney failure among recipients since the implementation of Model of End Stage Liver Disease (MELD) allocation. Modifiable risk factors identified include African American race, hepatitis C, and pre-transplant diabetes.
A recent JAMA commentary suggests vitamin B therapy can still lower stroke risk, particularly in patients with good renal function. However, the authors argue that clinical trials overlooked the role of vitamin B12 and renal failure, which can affect treatment efficacy.
Children of minority races are less likely to get kidney transplants before they need dialysis, and blacks with no health insurance face a higher risk of death while waiting for a transplant. Certain racial groups have lower rates of preemptive transplantation and are more likely to die than others
Two studies agree that diabetics with kidney failure shouldn't lower their blood glucose levels as much as those without kidney failure, suggesting a different optimal range. Hemoglobin A1C levels between 7% and 8% were found to be associated with the lowest risk of death for these patients.
Researchers found that blocking arginase-2 activity prevents kidney failure in diabetic mice, offering a new therapeutic approach for diabetic nephropathy. The study also suggests that this inhibition may protect against albuminuria and cardiovascular problems.
A promising new drug to protect the kidneys has failed to benefit diabetes patients with kidney disease. The study, which enrolled 1,248 patients, found that sulodexide did not prevent kidney failure or reduce urinary protein excretion in patients with type 2 diabetes and kidney disease.
New research reveals that APOL1 gene variants are a major risk factor for two forms of kidney disease, with African Americans having a significantly higher risk due to genetic predisposition. Early screening and treatment could potentially safeguard against kidney failure and early death for millions of individuals.
A recent study found that using a lower dose of contrast media (60 milliliters) in 320 detector row CT scans resulted in sufficient enhancement in over 96% of coronary segments. Larger patients with higher body mass indexes showed improved results, supporting the use of this lower dose protocol.
A new study found that African Americans are more likely to develop kidney failure due to high levels of protein in the urine. The study analyzed data from 27,911 individuals and found that African Americans were four times more likely to develop kidney failure than whites.
A natural language processing-based approach outperformed traditional administrative data codes in detecting postoperative surgical complications. The study found the new method correctly identified 82% of acute renal failure cases, while also being highly specific for diagnoses like pneumonia and sepsis.
Researchers found that intravenous fluids can lower the odds of developing severe kidney failure in children infected with E. coli O157:H7, a common cause of pediatric kidney failure. The study suggests that early fluid administration may protect kidneys and reduce the need for dialysis.
A Canadian study found Aboriginal children with kidney failure were less likely to receive a kidney transplant compared to white children. The study revealed that Aboriginal children had more immune-mediated kidney diseases and shorter waiting times on dialysis before transplantation, leading to lower rates of successful transplants.
Researchers from Mount Sinai School of Medicine have found that a ketogenic diet may reverse impaired kidney function in people with Type 1 and Type 2 diabetes. The study, published in PLoS ONE, also identified previously unreported genes associated with diabetes-related kidney failure whose expression was reversed by the diet.
A prediction model that includes data on measures of several routinely obtained laboratory tests accurately predicted the short-term risk of kidney failure for patients with moderate to severe chronic kidney disease. The researchers used demographic, clinical, and laboratory data from over 7,000 patients with CKD stages 3 to 5.
A recent study found that using acute kidney injury (AKIN) criteria in hospitalized cirrhotic patients can predict outcomes and improve diagnosis. The AKIN criteria is more sensitive than current definitions, considering a ≥50% increase in serum creatinine within 48 hours as renal failure. This may lead to better management of health s...
A study published in CMAJ found that elderly patients taking combination ACE inhibitors and ARBs had a higher risk of kidney failure and death. The researchers observed that most patients stopped the combination therapy within three months due to low blood pressure.
A study of over 5 million Medicare beneficiaries found that hospital regions with a higher frequency of diagnoses have a lower case-fatality rate for chronic conditions. The analysis suggested that increased diagnosis frequency leads to better patient outcomes.
Kidney failure affects nearly half a million US individuals, with 48% being 60 years or older. Elderly patients are now more likely to receive a kidney transplant due to increased access to organs from living and deceased donors, as well as improved survival rates while waiting.
A recent study published in Cell Metabolism has identified podocytes as a crucial factor in the development of kidney failure in diabetes. The researchers found that these cells become less responsive to insulin, leading to similar kidney disease symptoms in mice with normal blood sugar levels.
Researchers have discovered that growth hormone controls skeletal muscle development through IGF-1, whereas its effect on nutrient uptake is independent of IGF-1. In contrast, aldosterone promotes vascular injury by inducing expression of the protein PGF in mouse and human blood vessel walls.
A study of 24,875 dialysis patients found that sustained extremes in blood sugar levels increased the risk of dying prematurely. Individualized hemoglobin A1c targets may be more appropriate than a one-size-fits-all approach for diabetic patients with kidney failure.
A new study suggests that genetic variations in the APOL1 gene are responsible for population disparities in kidney failure, particularly among persons of African and Hispanic heritage. The findings highlight the importance of identifying genetic mutations associated with increased risk of chronic kidney disease.
A study found pronounced regional differences in treatment practices for older adults with kidney failure, including decisions on starting or stopping dialysis. Higher-spending regions tend to have more intensive care, but patients don't necessarily fare better.
Researchers at TGen discovered a genetic biomarker with significant association to kidney failure in American Indians in Arizona. The study found evidence of some lesser associations between kidney failure and four other markers, all linked to the SUCNR1 gene.
Gastrointestinal symptoms are common in peritoneal dialysis patients, with a history of corticosteroid therapy and daily pill intake positively correlated to GI symptoms. Residual renal function is negatively correlated to GI symptoms, suggesting its role in predicting complications.
Researchers at Indiana University School of Medicine successfully treated acute kidney injury in laboratory experiments using genetically reprogrammed cells producing a protein that aids kidney development. The treatment, administered intravenously, showed significant improvements in kidney function and reduced physical damage.
The American Thoracic Society has published a joint statement on renal failure in ICU patients, highlighting the need for better prevention, diagnosis, and treatment strategies. The statement emphasizes the importance of fluid management, biomarkers, and evidence-based practices to reduce mortality and morbidity.
Scientists discovered that Lupus patients lack or have blocked DNase-1, an enzyme degrading NETs, leading to their accumulation in the kidneys. This impairs NET degradation, increasing kidney failure risk. A new test based on this finding may enable early diagnosis and treatment.
A study by Henry Ford Hospital found that heart failure patients developing kidney failure after LVAD surgery experience significantly decreased survival rates and prolonged hospitalizations. The researchers suggest improving patient selection and reducing cardio-pulmonary bypass time to mitigate the risk of kidney failure.
Early recognition and prevention of chronic kidney disease (CKD) are vital for all settings. CKD is associated with increased cardiovascular risk, even at mild reductions in glomerular filtration rate. Implementing interventions can reduce cardiovascular events or progression to kidney failure.
A study published in the New England Journal of Medicine found that dialysis for nursing home seniors does not improve functional capacity and may even worsen quality of life. Researchers call for individualized approaches to treatment, considering patients' goals and prognostic information.
A new study reveals that kidneys recovered from deceased donors with acute renal failure can function just as well as those from healthy donors, opening up a significant expansion of the donor kidney pool. This could lead to an additional 1,000 kidneys or more per year being made available to patients waiting for a transplant.
A $10.25 million study will investigate the causes of kidney failure and the need for dialysis in patients with nephrotic syndrome. The research network will focus on understanding the mechanisms behind minimal change disease, focal and segmental glomerulosclerosis, and membranous nephropathy.
Researchers discovered a link between the anti-aging gene klotho and reduced high blood pressure, reversing kidney damage. The study shows that increasing klotho expression can lower blood pressure for at least 12 weeks and potentially prevent hypertension.
Three cases of patients with liver injury and renal failure have been reported due to steroid-enriched dietary supplements. Researchers warn that even low doses of anabolic steroids can cause severe health consequences.
Researchers at MCG report breakthrough in treating acute renal failure by blocking mitochondrial fragmentation caused by vascular obstruction, trauma, chemotherapy, and toxins. This can prevent kidney cells from committing suicide and lead to acute renal failure.
A recent study by Marcello Tonelli and colleagues found no correlation between remote or rural residence and increased time to kidney transplantation in the US. The likelihood of receiving a transplant from a deceased or living donor was similar among patients dwelling farther away, suggesting disparities may not be solely due to location
Patients with mild to severe kidney dysfunction require lower warfarin doses and closer monitoring due to increased bleeding risk. Warfarin dose is significantly affected by kidney function, even after accounting for genetics.
Researchers identified variations in the MYH9 gene strongly associated with FSGS and HIV-associated FSGS among African-Americans, with a risk 300-500% higher than whites. The findings shed light on common genetic pathways to prevent kidney disease progression.
The Lancet Editorial emphasizes the importance of independent medical assessment for hunger strikers and criticizes the lack of emphasis on impartial advice and care. Force feeding is deemed unacceptable in clinical management, and prisoners or detainees are entitled to highest clinical standards worldwide.
A new study suggests that monitoring fibroblast growth factor 23 (FGF-23) levels can provide crucial information for the treatment of kidney failure patients. Elevated FGF-23 levels have been linked to a significantly increased risk of death among dialysis patients, even when phosphate levels are normal.
Researchers have discovered a new kidney protein, NGAL, that can diagnose sudden kidney failure days sooner than current tests. A simple urine test for NGAL can help emergency department physicians accurately diagnose kidney failure and make evidence-based treatment decisions.
A study funded by the National Institutes of Health found that reducing early blockages in bloodsstream access does not increase the likelihood that the access will function adequately for long-term treatments. Fistulas are the preferred type of access since they clot less often, experience fewer infections, and are less costly.
A new study found that an iso-osmolar X-ray dye did not reduce the risk of kidney damage during percutaneous coronary intervention (PCI) in patients with chronic renal failure. The study compared two types of contrast medium and found no significant difference in rates of kidney injury or need for dialysis.
Researchers at Albert Einstein College of Medicine found that aberrant Notch signaling plays a role in diabetic nephropathy and focal segmental glomerulosclerosis, two major causes of end-stage renal disease. They discovered that gamma secretase inhibitors can protect against kidney disease, sparking hope for new treatment options.
A study of acute kidney failure treatments found that intermittent hemodialysis and continuous kidney replacement therapy have similar clinical outcomes. No significant difference was seen in the risk of death or chronic dialysis treatment between the two therapies.
A wearable haemodialysis device has delivered promising results in a pilot trial, with patients reporting improved quality of life and no adverse cardiovascular changes. The device has the potential to become a practical means of delivering extended and more frequent dialysis to patients with end-stage kidney failure.
The estimated prevalence of chronic kidney disease in US adults has increased from 10% to 13%, driven by rising diabetes and hypertension rates. The prevalence of earlier stages of CKD accounts for most individuals with the condition, highlighting the need for cardiovascular risk factor management.
Recent studies have linked widely used osteoporosis drugs and bowel prep solutions to kidney damage. Nephrologists must be aware of these emerging causes of kidney problems and take steps to prevent them.
Researchers have identified a gene, GLIS2, that protects against a serious kidney disease called nephronopthisis. Mutations in this gene cause the disease, which leads to kidney degeneration and failure.
Researchers at Mayo Clinic have successfully developed a protocol for performing coronary angiography on the same day as elective valve surgery, reducing the need for separate hospital visits and improving patient outcomes. The study, which evaluated 226 consecutive patients, showed that 28.3% had severe coronary artery disease requiri...
A research team has identified a protective gene variant that may help prevent severe kidney failure in people with diabetes. The discovery could lead to novel treatment approaches for susceptible individuals, as well as a new marker for identifying those at increased risk of future kidney disease.
A new analysis of over 5 million hospital discharges found a significant increase in kidney damage after coronary artery bypass surgery, but a decrease in mortality rate. The study suggests that current prevention strategies may not be effective and more research is needed to identify susceptible patients and effective treatments.