Articles tagged with Renal Failure
Researchers have identified ROBO2 as a potential therapeutic target for treating kidney diseases, including glomerular diseases and chronic kidney disease. High ROBO2 protein levels are found in injured kidney models and can lead to reduced podocyte adhesion, making it a promising area of investigation.
Racial and ethnic minorities with kidney failure and atrial fibrillation are less likely to fill prescriptions for blood thinners, resulting in higher stroke rates. Equalizing warfarin distribution could prevent 7-12% of the stroke disparity among minority groups.
A large-scale trial found that reducing steroid dosage and eliminating plasma exchange did not impact long-term survival for ANCA-associated vasculitis patients. Patients who received lower doses of steroids had fewer serious infections compared to those on higher doses.
A new study found that cardiovascular diseases, including heart failure, atrial fibrillation, and coronary heart disease, are each linked with a higher risk of developing kidney failure. Adults hospitalized with heart failure had an 11.4-times higher risk of developing kidney failure than individuals without cardiovascular disease.
Recent advancements in wearable and implantable hemodialysis devices have the potential to revolutionize treatment for patients with kidney failure. These devices aim to provide a more patient-friendly alternative to traditional hemodialysis, allowing patients to lead healthier lives.
A new meta-analysis found that SGLT2 inhibitors can reduce the risk of dialysis, transplantation, or death due to kidney disease by about 30% and also reduce the risk of acute kidney injury. The results are encouraging for people with diabetic kidney disease, offering a new treatment option to halt disease progression.
A new study confirms that SGLT2 inhibitors can prevent loss of kidney function and kidney failure in people with type 2 diabetes, reducing the risk by about 30%. The findings provide further strong support for the key role of SGLT2 inhibition in kidney protection.
A new study published in BMJ Open found that patients with gout are at increased risk of chronic kidney disease and kidney failure. The largest-ever study on the subject used data from over 620,000 patients in the UK health system and found a 29% higher risk of advanced CKD compared to those without gout.
A study found psychiatric illnesses are prevalent in children and adults with kidney failure, with hospitalizations associated with a higher risk of early death. The prevalence of psychiatric diagnoses increased over time across age groups.
A recent analysis reveals that sleeve gastrectomy is safe for patients with kidney failure and obesity. The study found that complication rates were similar between groups, but patients with kidney failure had longer hospital stays.
A recent analysis of US data over 20 years shows that children with kidney failure are being started on dialysis with higher levels of kidney function. Initiating dialysis at these higher levels is linked to lower patient survival, suggesting that asymptomatic children may benefit from delaying treatment.
Researchers developed molecular imaging probes that can track changes in biological processes at the molecular level, detecting acute kidney failure up to 1.5 days earlier than current methods. The probes have high renal clearance efficiency and could be used as non-invasive test strips for urine samples.
A study found that older living kidney donors with hypertension had a higher risk of developing kidney failure within 15 years after donation. However, the absolute risk was relatively low. In contrast, hypertension was not linked to an increased risk of early death among older donors.
A pilot study suggests that patients with chronic kidney disease who wear medical-alert accessories have a lower risk of developing kidney failure. However, there is no significant difference in rates of hospitalization or death between those who wear the accessories and those who do not.
A USask-led research team is developing an artificial portable kidney that can be worn by patients with renal failure, reducing hospital visits and healthcare costs. The team aims to create a highly efficient dialysis membrane that mimics the human kidney's filtering properties.
A landmark clinical trial shows that canagliflozin lowers the risk of kidney failure by 30% in people with Type 2 diabetes and kidney disease. The study also found a significant reduction in cardiovascular events, providing a promising new treatment option for patients at high risk.
A breakthrough treatment has been found to protect against kidney failure and cardiovascular complications in people with diabetes. The study showed a significant reduction in kidney failure and cardiovascular events, such as heart attacks and strokes, by up to 30%.
Patients with kidney failure who undergo lower extremity amputation have prolonged stays in healthcare settings, limited access to hospice services, and a poorer prognosis. These findings highlight the need for improved end-of-life care for this group of seriously ill patients.
A study found that influenza-like illness contributes to more than 1,100 deaths of patients with kidney failure each year in the US. The risk is highest during winter months when seasonal fluctuations occur.
A new study examines dialysis reimbursement policies worldwide, revealing significant disparities in access to care. The research suggests that high-income countries spend more on dialysis but have a lower percentage of healthcare budget allocated to it compared to low- and middle-income countries.
Researchers found that men with chronic kidney disease experience faster disease progression and higher death rates compared to women. The study analyzed over 4,000 participants and discovered a 17% lower risk of end-stage renal disease in women.
Patients with newly diagnosed kidney failure may experience delays in accessing preferred dialysis methods due to lack of insurance coverage. Uninsured patients were less likely to use arteriovenous fistulas or grafts and had a higher risk of dialysis-related infections compared to those with Medicare or Medicaid.
A national sample of 1,084 adults with chronic kidney disease (CKD) found that pro-inflammatory diets increased the risk of developing kidney failure. The study suggests that nutritional interventions focusing on reducing inflammation may help halt CKD progression.
A recent study found that Hispanic kidney disease patients with poor primary care experiences have a higher risk of hospitalization. The study analyzed data from 252 patients and found associations between low communication quality, health promotion, interpersonal treatment, and trust with increased hospitalization risk.
Researchers found that autophagy efficiency declines with age, leading to accumulation of damaged biological structures in the kidneys. They discovered that nutrition restrictions and pharmacological drugs like rapamycin may help tackle this issue.
A recent study published in Clinical Transplantation found that carefully-selected older adults over 60 years old pose minimal risks for living kidney donation. The research suggests that accepting more older donors can expand the donor pool, making a previously perceived high-risk group accessible.
A trained navigator with a degree in social work helped increase access to the transplant waitlist among patients who needed a longer time to get through the transplant evaluation process. Nearly 70,000 US patients have end-stage renal disease and most benefit from kidney transplantation.
A recent study published in International Journal of Obesity found that patients who underwent weight-loss surgery had a significantly lower risk of developing severe chronic kidney disease and kidney failure. The Swedish Obese Subjects (SOS) study followed over 4,000 patients with obesity for more than 20 years and showed that surgica...
A new study reveals that changes in living kidney donation in the US over the last decade have varied by sex, resulting in a widened gap in donation between women and men. The incidence of donation was 44% higher in women after adjusting for differences in age, race, and geographic factors.
A study examining employment trends among patients with kidney failure found that employment was low throughout the study period at 23-24%. Approximately 120,000 adults in the US develop kidney failure each year, a majority of whom undergo dialysis. The probability of employment in kidney failure patients increased slightly over time.
A new tool predicts the likelihood of a child progressing to kidney failure with high accuracy, enabling better planning for transplant. The tool could reduce the need for interim dialysis and increase transplantation rates in children with kidney disease.
Survival rates for individuals with kidney failure have improved significantly over the past 22 years, with decreases observed across all age groups. Improvements in dialysis care, organ transplantation, and clinical practice guidelines may be contributing factors to these advancements.
A major new study has found that commonly used treatments to prevent acute kidney failure after angiogram procedures make no difference to health outcomes. Patients undergoing angiography should instead be treated with saline, which is cheaper and more readily available, say researchers.
A recent analysis has linked proton pump inhibitors (PPIs) to a 33% increased relative risk of chronic kidney disease or kidney failure. The study, published at ASN Kidney Week 2017, suggests that providers should consider the potential risks of PPI therapy in patients.
A study of over 900,000 US veterans found chronic insomnia to be associated with increased risks of early death, rapid kidney function decline, and kidney failure. The study suggests that attention to proper management of chronic insomnia could have long-ranging positive effects on overall health.
Researchers at the University of Louisville discovered a new autoimmune disease that causes kidney failure, dubbed anti-brush border antibody (ABBA) disease. The disease was identified after analyzing biopsied kidney tissue from patients with acute kidney injury, and it affects the nephrons' brush borders by coating them with antibodies.
A study found that young adults with kidney failure have lower quality of life, worse employment prospects, and are less likely to be married or have a partner. Higher education, alcohol abstinence, and smoking status did not differ significantly between those on dialysis and transplantation.
A study found a linear relationship between air pollution levels and the risk of experiencing kidney function decline and developing kidney disease or failure. The results suggest that particulate matter above the EPA's recommended limit is associated with new cases of chronic kidney disease (CKD) and end-stage renal disease (ESRD).
A study found that individuals with chronic kidney disease who experienced high sleep fragmentation were at elevated risk of developing kidney failure. Higher sleep fragmentation and shorter sleep duration were also linked to steeper declines in kidney function over time. Subjectively measured daytime sleepiness was associated with an ...
Research reveals that many patients with chronic kidney disease experience smell loss, which correlates with poorer nutritional status. Treatment with intranasal theophylline has shown promise in improving smell function and reducing markers of malnutrition in a small group of patients.
Researchers developed a risk calculator to estimate long-term risks of developing kidney failure in living kidney donors. The study found that black donors and older male donors were at higher risk, while younger black candidates should be carefully evaluated.
Researchers developed a prognostic tool predicting end-stage renal disease risk in type 1 and 2 diabetes patients. The test uses biomarker values to identify those at high risk, improving the efficiency and cost-effectiveness of clinical trials.
Research finds that individuals with sickle cell trait have a twofold increased risk of developing kidney failure, similar to the APOL1 gene variants. Hemoglobin C trait did not associate with kidney disease or kidney failure. Early screening and aggressive treatment can help mitigate this risk.
A new study found that HIV-infected individuals with kidney failure are less likely to receive a transplant, especially from living donors. The study highlights the need for expanded access to organs for HIV+ patients to address disparities in transplantation.
A study of undocumented immigrants with kidney failure found that lack of access to hemodialysis results in significant physical and psychological distress. The patients also experienced anxiety, work disruption, and family distress due to their life-threatening illness.
A recent study published in the Journal of the American Society of Nephrology found that doubling dialysis hours did not improve overall quality of life for patients with kidney failure. However, some intermediate outcomes improved, such as blood pressure parameters and biochemistry measurements.
A study analyzing data from over 12,000 children reveals racial disparities in kidney transplant survival rates, with black children at higher risk due to reduced access to transplantation. Hispanic children, despite lower access, had a lower risk of death compared to non-Hispanic white children.
Research found that short and poor quality sleep were associated with a lower risk of developing kidney failure, while higher sleep fragmentation increased the risk. Patients who experienced daytime sleepiness also had a higher risk of death during follow-up.
A recent study found that nearly half of kidney failure patients receiving dialysis had advance directives, but only a small minority specifically addressed dialysis management at the end of life. The simple presence or absence of an advance directive is not enough to fully address important aspects of dialysis patients' end-of-life care.
Researchers have discovered a link between constipation and poor kidney health, suggesting that diagnosis and management of constipation may help prevent or treat kidney disease. Individuals with constipation had a 13% higher likelihood of developing chronic kidney disease and a 9% higher likelihood of developing kidney failure compare...
Research found that retained metabolites in the blood are associated with impaired cognitive function in patients with kidney failure. The study suggests that interventions may be necessary to safeguard the mental health of these patients.
A mathematical model of open-heart surgery simulates oxygen levels in rat kidneys, revealing vulnerability to hypoxia during surgery. The study sheds light on the causes of kidney injury and suggests potential strategies for prevention.
Researchers are examining DNA samples from 20,000 people with diabetes to identify genetic factors in diabetic kidney disease. The study aims to develop new tests and treatments to prevent kidney complications and improve patient outcomes.
Research found chronic use of proton pump inhibitors (PPIs) accelerates vascular aging in humans, leading to increased cardiovascular disease, vascular dementia, and renal failure. PPIs like esomeprazole are widely used but not approved for long-term use.
Researchers found that female reproductive hormone cycles are associated with transient increases in enzymes indicative of kidney health. This suggests that women may have an increased resistance to kidney damage due to cyclical changes in sex hormone levels.
Research finds that proton pump inhibitors, widely used for heartburn and ulcers, can lead to kidney function decline, chronic kidney disease, and kidney failure. Long-term use of these medications significantly increases the risk of developing kidney problems.
A new study found that elderly kidney failure patients who chose conservative management had a similar survival rate to those on dialysis. The research suggests that conservative care may be a reasonable option for selected older patients with end-stage renal disease.
A recent study found that African Americans have a higher risk of hypertension, diabetes, and kidney failure compared to whites, even after adjusting for genetic variants. Most blacks with the high-risk APOL1 gene variant experienced similar decline in kidney function as those without the variant.
Researchers have developed a new mouse model that successfully suppresses NF-kappaB signaling, reducing tissue damage and inflammation in the kidneys. This breakthrough could lead to a tailored therapy for patients with ischemic renal failure.
A study validated kidney failure risk equations developed in a Canadian population across 30 countries, showing accurate predictions for patients with chronic kidney disease. The recalibrated equations improved calibration in non-North American cohorts, enabling clinicians to inform treatment decisions and patient communication.