Articles tagged with Renal Failure
A study validated kidney failure risk equations developed in a Canadian population across 30 countries, showing accurate predictions for patients with chronic kidney disease. The recalibrated equations improved calibration in non-North American cohorts, enabling clinicians to inform treatment decisions and patient communication.
Consuming a beverage rich in cocoa flavanols improves blood vessel function and reduces diastolic blood pressure in patients with kidney failure. Individuals with failing kidneys are at increased risk of developing heart problems, but diet-based therapeutic approaches to counteract cardiovascular disease are limited.
Researchers found that paying attention to results of a simple blood test can help predict the likelihood of patients experiencing kidney failure or death. The studies emphasize the importance of monitoring measures of kidney function over time to inform treatment decisions.
Researchers aim to conduct clinical trials on implantable, engineered organs in this decade. The device mimics human kidney functions and has shown encouraging early studies.
Rates of kidney failure caused by multiple myeloma have declined over the past decade, with a 20% reduction from 2001-2002 to 2009-2010. ESRD patients with multiple myeloma are also living longer and experiencing a decline in mortality within 3 years after initiating dialysis.
Researchers at Mayo Clinic have discovered a specific protein in the blood that can serve as an early indicator of end-stage renal disease and death in people with hypertension. This finding may enable doctors to intervene more effectively, potentially improving patients' quality and quantity of life.
Researchers at Boston University School of Medicine have discovered a new protein, TMIGD1, that protects kidney epithelial cells from injury. Increasing expression of this protein can reduce cell death and potentially prevent kidney failure. The findings could lead to the development of therapeutic agents that target these cells.
Researchers found that mortality rates vary significantly according to kidney disease subtype, suggesting that treatment plans should be tailored towards disease-specific risks. The study analyzed data from 84,301 patients and showed significant differences in survival rates among those with different subtypes of glomerulonephritis.
Researchers identified high blood pressure, protein loss, and anemia as predictors of disease worsening in children with mild to moderate CKD. Intervening on these modifiable risk factors may change the long-term course of the disease, preventing kidney failure and delaying dialysis or transplantation.
A new study reveals that at least 2.3 million people may have died prematurely from kidney failure in 2010 due to lack of access to life-saving treatment. The researchers predict that the number of patients needing dialysis or transplantation will more than double to 5.4 million by 2030.
A study published in the Journal of the American Society of Nephrology suggests that a diet high in animal proteins, especially red meat, can increase the risk of developing kidney failure in people with chronic kidney disease. Conversely, consuming diets rich in fruits and vegetables may protect kidney function.
Patients with chronic kidney disease who consume high acid diets are 3-times more likely to develop kidney failure than those on low acid diets. A diet rich in fruits and vegetables can help protect kidneys.
A simple 5-variable model accurately predicts most cases of kidney failure in socially disadvantaged individuals with moderate or advanced chronic kidney disease. The model can help guide approaches to reduce socioeconomic disparities in kidney disease care.
Researchers have discovered ferroptosis, a regulated form of necrosis that occurs in various pathological conditions. Ferroptosis inhibitors, such as Liproxstatin-1, offer novel therapeutic opportunities to mitigate diseases previously thought to be untreatable.
A study found that recent policy changes did not create racial disparities in the management of anemia and mineral metabolism among dialysis patients. The analysis of 7384 patients at 132 facilities showed similar trends in laboratory measures and management practices for different races.
A recent study published in Journal of the American Society of Nephrology found that CKD patients who experience multiple heart failure hospitalizations are at a higher risk of developing kidney failure. The study's findings suggest that coordinated care between specialists is crucial in managing these patients.
An analysis from University of Pittsburgh School of Medicine suggests acute hemodialysis may not decrease mortality in people with sudden kidney failure. The study found that patients who received acute hemodialysis had a nearly twice the risk of death compared to those who did not receive treatment.
Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected diseases sharing common risk factors and causes. The NIH study suggests that patients with either condition should be monitored for the other, as pre-existing CKD increases the odds of AKI by 10 times and vice versa.
A recent study found that young black adults with kidney failure living in poor neighborhoods are nearly twice as likely to die while still young compared to whites. The reasons for this difference are not well understood, but the researchers suggest that socioeconomic factors may play a role.
A study found that more frequent face-to-face physician visits after hospital discharge can reduce kidney failure patient readmissions by 3.5%, resulting in significant cost savings. Nearly 400,000 people in the US are on dialysis, highlighting the importance of this intervention.
A recent study found that individuals with diabetes who experience major depressive symptoms are at a significantly higher risk of developing kidney failure. In contrast, minor depressive symptoms were not found to have a significant association with kidney disease development.
A new study suggests that Medicaid expansion among low-income nonelderly adults can help prevent kidney failure and improve access to kidney disease care. States with broader Medicaid coverage have lower incidences of kidney failure and smaller insurance-related gaps in access to kidney disease care.
Researchers discovered abnormal molecular signaling pathways that promote chronic kidney disease progression, targeting endothelial mitochondrial oxidative stress and glomerular filtration barrier. New therapeutic targets may prevent or reverse disease, providing hope for millions of Americans affected by kidney disease.
A study by Mayo Clinic researchers found that patients who had troublesome teeth extracted before heart surgery were at a higher risk of poor outcomes, including death. The study suggested that physicians should evaluate each patient individually to weigh the benefits and risks of tooth extraction before cardiac surgery.
A study published by the American Society of Nephrology found that intensive dialysis treatments in pregnant women with kidney failure lead to higher live birth rates, with fewer complications. Infants born to these mothers tend to be healthier at birth when their mothers receive more frequent and longer dialysis sessions.
A new Johns Hopkins research reveals that kidney failure is much less prevalent in living kidney donors than in the general population. The study found a lifetime rate of kidney failure in donors to be 90 per 10,000, compared to 326 per 10,000 in non-donors.
Researchers have found that certain cells contribute to kidney function decline by causing destructive scarring, making them attractive targets for treatments. An additional but limited reserve of mature and functional filter cells is present at birth, which can be preserved and protected through pharmacological strategies.
African Americans with APOL1 gene variant experience faster chronic kidney disease progression and increased risk of kidney failure compared to those without the variant. The study found that APOL1 risk variants increase CKD progression in African Americans, regardless of their diabetes status.
Studies suggest that consuming more fruits and vegetables can counteract the negative effects of dietary acid on kidney health. Research found that individuals with hypertensive nephropathy who received extra fruits and vegetables or an oral alkaline medication experienced preserved kidney health, while those with high dietary acid lev...
A new study links preeclampsia during pregnancy to a higher risk of developing kidney failure. Researchers analyzed data from Olmsted County, MN and found that individuals with preeclampsia were more likely to develop kidney failure later in life, but this association was attenuated when diabetes and hypertension were considered.
A recent study has found that the APOL1 gene variant is independently associated with a more aggressive course of disease, particularly in African-Americans. The variant is linked to twice the rate of CKD progression and loss of kidney function in those with chronic kidney disease.
Genetic variants in the APOL1 gene increase the risk of kidney disease progression and end-stage renal disease in African Americans. Approximately 1 in 10 blacks possess high-risk variants, which speed up kidney disease progression and substantially increase the risk of developing kidney failure.
Loyola researchers found that zoledronic acid's kidney failure and calcium deficiency risks are extremely rare. The study of 237 patients showed a slight decline in calcium levels after the first infusion, but this effect is transient and only significant for those with normal vitamin D levels.
A genetic variant on chromosome 2 is strongly linked with kidney failure in diabetic women, but not in men. Diabetic women with the risk variant had a nearly two-fold increased risk of developing kidney failure compared to those without it.
A risk score calculation developed by Brigham and Women's Hospital researchers can help doctors predict which patients with rhabdomyolysis are at risk for severe kidney failure or death. The model uses routine clinical variables to identify patients who may benefit from different treatment options.
A new definition of chronic kidney disease labels over 1 in 8 adults as having the disease, but low rates of kidney failure suggest many may never progress to severe disease. Experts argue that this is evidence of overdiagnosis and call for greater scrutiny and public awareness.
A study analyzing data from 1000 black and white patients with kidney disease found that black patients experienced a faster progression to kidney failure. The disparity was predominantly present in patients with diabetes and those who excreted greater amounts of protein, indicating more advanced kidney dysfunction.
A recent study published in the Canadian Medical Association Journal found that current use of fluoroquinolone antibiotics increases the risk of acute kidney injury by two-fold. The risk was highest with ciprofloxacin and moxifloxacin, and concurrent use with renin-angiotensin-system blockers further increased the risk.
A study found that individuals with chronic kidney disease who have a heart-healthy lifestyle are less likely to develop kidney failure. Those with four ideal factors for life's simple 7 tool had nearly half their risk cut, while those with five ideal factors didn't develop kidney failure.
A study of 1.2 million dialysis patients found Hispanics lived the longest, followed by Blacks, with Whites having the shortest survival time. The disparity may be due to differences in health status before kidney failure.
A study of over 404,000 dialysis patients found significant racial and geographic disparities in kidney care. Black patients received less pre-end-stage renal disease (ESRD) care than their white counterparts, particularly in rural and large-metro counties.
A new study identifies a link between carbamylated albumin protein and increased risk of heart disease in kidney dialysis patients. Researchers found that measuring carbamylated albumin may help doctors monitor dialysis patients and identify those at risk of cardiac complications.
A study found that certain gene mutations increase the risk of developing aHUS and affect patient prognosis after diagnosis. Screening for these mutations may help diagnose and treat affected individuals.
A technique that removes additional toxins during dialysis decreased kidney failure patients' risk of dying from any cause by 30% over three years, with lower risks of heart-related causes and infections. The study's findings suggest OL-HDF may indeed prolong kidney failure patients' lives compared to conventional hemodialysis.
Researchers at UCSF and Kaiser Permanente have found that atrial fibrillation significantly increases the risk of end-stage renal disease among patients with chronic kidney disease. The study involved over 206,000 adults and showed that those who developed atrial fibrillation were 67% more likely to progress to kidney failure.
Residence in areas with higher average household income was linked with improved survival for both Black and White kidney failure patients. However, in White patients, income inequality was associated with mortality, while in Black patients exclusively, residence in highly segregated areas was associated with increased mortality.
Researchers at Monash University used advanced microscopy techniques to visualize the movements of white blood cells in healthy and diseased kidneys. They found that leukocytes are constantly circulating through and patrolling blood vessels within healthy kidneys, but become agitated during disease, causing inflammation and kidney damage.
A study found that disordered mineral metabolism worsens with progressive chronic kidney disease and is linked to a higher risk of kidney failure among African Americans. Measuring mineral metabolites may be a useful way to determine CKD patient prognosis, while targeting these metabolites could help slow disease progression.
African Americans experience faster progression of chronic kidney disease in later stages compared to other races. Screening for microalbuminuria is cost-effective for African Americans with diabetes or hypertension, improving care and reducing kidney failure risk.
A study found that open heart surgery is safer than angioplasty for dialysis patients with blocked arteries surrounding the heart, with five-year survival rates over 90% without kidney disease but dismal in kidney failure patients. Heart disease is a leading cause of death in kidney failure patients, affecting 30-60%.
A study reveals that kidney failure patients have less of the sugar coating on their blood vessels, leading to high levels of its constituents in the blood. This damage may contribute to their increased risk of heart problems.
A simple six-question quiz can identify kidney dialysis patients at high risk of death, with those needing assistance with basic activities being more than three times more likely to die. The study, published in the Journal of the American Geriatrics Society, found that over 600,000 people in the US are on dialysis due to kidney failure.
UCI researchers found that chronic kidney disease changes the composition of intestinal bacterial microbes, leading to uremic toxins and nutritional abnormalities. Study leader Dr. N.D. Vaziri suggests improving gut microbes through diet and dialysis may improve patient well-being.
Researchers found that individuals with a history of kidney stones are more susceptible to developing serious kidney problems and kidney failure, particularly women under 50. The study's results highlight the importance of screening for risk factors in patients with a history of kidney stones.
A study estimates that approximately 1 in 93 men and 1 in 133 women of middle age may develop kidney failure in their lifetime. People with reduced kidney function face a higher risk, with men facing a 7.51% chance and women a 3.21%.
A study published in JAMA Network found that older adults are at a significantly higher risk of developing untreated kidney failure, with rates increasing with age. The study suggests that the incidence of advanced kidney disease in the elderly may be substantially underestimated by rates of treated kidney failure alone.
Homeless individuals with chronic kidney disease are more likely to develop depression, substance abuse, and kidney failure. They also overuse emergency medical services, leading to increased public costs. Research highlights the need for better healthcare access and support services for homeless patients.
Researchers found that pre-operative aspirin therapy can halve the risk of post-operative acute kidney failure. The study involved 3,219 patients and showed a significant decrease in incidence of acute renal failure with aspirin use.
Researchers genetically modified kidney cells to produce a protein that promotes cell growth and regeneration. The transplanted cells engrafted themselves into damaged kidneys, resulting in improved function and limited physical damage. This breakthrough has significant implications for the treatment of human kidney failure.
Researchers found excess protein in urine dipstick tests predicted renal failure in 55% of sepsis patients. The test is widely available and inexpensive, providing early diagnosis of renal failure.