Articles tagged with Renal Failure
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Researchers at UAB successfully transplanted genetically modified pig kidneys into a brain-dead human, demonstrating the feasibility of xenotransplantation. The kidneys functioned for 77 hours without immediate rejection, paving the way for potential treatment of thousands suffering from kidney failure.
A clinical trial will harness synthetic chimeric antigen receptor (CAR) T cells to deplete immune B cells and plasma cells producing donor-specific antibodies, aiming to achieve a compatible kidney match for patients with pre-existing antibodies. The NIH-funded study, led by Penn Medicine, intends to begin enrolling patients in 2022.
A large-scale trial found that high-dose intravenous iron therapy reduces heart attacks in patients with kidney failure undergoing dialysis. The study analyzed 2141 patients and reported a significant reduction in type 1 heart attacks, which are often caused by blood clots or blockages.
The new project aims to bridge the gap between complex rare category analysis and state-of-the-art techniques. It will focus on developing explainable methods for detecting defective silicon wafers and severe complications among diabetes patients.
A new study found that the COVID-19 pandemic led to a 30% decline in patients seeking treatment for kidney failure, with Black patients experiencing significantly worse kidney function. The decline was attributed to changes in healthcare delivery and may reflect delays in treatment due to fear of infection or logistical barriers.
The National Kidney Foundation has released a research roadmap to accelerate innovations in treatment and increase understanding of kidney disease. The report calls for increased funding in preclinical science, genetics, health equity, and implementation science to tackle the most vexing challenges in kidney disease.
A study found that patients affected by dialysis facility closures experienced higher rates of hospitalizations (7-9%) and a higher risk of dying within 6 months (8%). The researchers highlight the need for policies to reduce the risk of closures to safeguard patient health.
A serum biomarker, polyubiquitinated phosphatase and tensin homolog (PTEN), was associated with a four-fold higher risk of kidney function decline. This modified form of PTEN was linked to severity of lesions in kidney structure, indicating early manifestations of diabetic kidney disease.
Referral guidelines for nephrology care are shifting towards identifying patients at higher risk of kidney failure. A study using Veterans Health Administration data found that referring patients with a two-year risk of kidney failure above 1% would identify those at highest median risk.
The USPSTF has lowered the recommended starting age of screening for type 2 diabetes from 40 to 35. Screening is now recommended for adults with prediabetes or type 2 diabetes, particularly those aged 35-70 who are overweight or obese. This recommendation aims to detect and treat these conditions earlier.
A study found that 95% of fungal species on Earth remain undescribed, leading to inconsistent regulations and potential health risks. The researchers tested 16 food products labeled as containing 'wild mushrooms' and discovered most consisted of cultivated species, including poisonous varieties.
A recent study found that weight fluctuations are associated with higher risks of cardiovascular-related problems and early death in adults with chronic kidney disease. The study included 84,636 patients with CKD who were listed in a national health screening database in South Korea.
The new allocation system could result in reduced access to kidney transplants and longer wait times for patients in South Carolina. Researchers argue that the current system unintentionally worsens inequities and recommend improving access to transplant care.
Researchers developed a new risk equation using 6 routinely available patient parameters to estimate the risk of CKD patients progressing to ESKD requiring KRT. The 6-variable risk score achieved high predictive performance and good calibration in validation cohorts.
A new score, PROPr, assesses health-related quality of life in patients with kidney failure by considering cognitive function, depression, fatigue, and social roles. The study's findings support the validity of PROPr among patients undergoing hemodialysis or kidney transplants.
A recent study published in CJASN found that patients with kidney failure did not report better experiences with care from more frequent face-to-face visits with kidney specialists. In fact, more frequent visits were linked to slightly lower patient-reported experiences with kidney-related care.
Patients waiting for a kidney transplant who experienced various symptoms had a higher risk of dying while on the waitlist. However, those who underwent transplantation saw an improvement in symptoms, with overall 10% reduction and significant declines in fatigue and itchy skin.
A new study highlights the high risk of kidney failure and cardiovascular complications in patients with primary nephrotic syndrome, particularly those with focal segmental glomerulosclerosis. Adults with this condition are 19.63 times more likely to develop kidney failure over a median follow-up period of 4.5 years.
Researchers analyzed records from two large U.S. databases to examine the relationship between erythropoietin doses and hip fracture rates in patients with kidney failure. They found that fluctuations in EPO doses over time closely tracked average EPO dose used, highlighting a potential increased risk of hip fractures.
A new study estimates the years of employment loss experienced by working-aged adults with kidney failure, finding that most lost time is due to patients' loss of life expectancy. The study analyzed data from patients initiating dialysis in Taiwan and found that men had a higher rate of employment than women.
A new analysis indicates that patients with kidney failure associated with sickle cell disease benefit from kidney transplantation to a similar extent as patients with kidney failure from other causes. Despite this, the sickle cell population is less likely to receive transplants.
A recent study found that enrolling Black patients on the waitlist with slightly better kidney function could reduce racial disparities in transplant access. This approach aims to bridge the gap between Black and white patients' wait times before kidney failure, ultimately promoting greater equality in transplantation.
The study found that racial disparities in kidney transplantation persist despite advances in the field. Blacks are more likely to develop kidney failure but less likely to undergo transplantation, particularly from living donors.
China's kidney disease burden is expected to increase significantly, with an estimated 874,373 patients receiving dialysis by 2025. The study used insurance claims data to estimate the national prevalence of dialysis in China.
A survey of adults with kidney failure reveals that most own mobile devices and have intermediate or advanced mobile health proficiency. The main reasons for using mobile health include making appointments, communicating with healthcare personnel, and obtaining laboratory results.
A recent analysis found limited research evaluating depression screening tools in patients with kidney failure. The most extensively studied tool was the Beck Depression Inventory II (BDI-II), but many studies were small and had shortcomings.
A new study from the University of Cincinnati found that only 5.3% of women with kidney failure on dialysis in the US use contraceptives, increasing the risk of unplanned pregnancies. The study emphasizes the importance of family planning and counseling for this high-risk population.
A new study found that Blacks and Hispanics experience higher rates of kidney failure compared to whites, driven by faster declines in kidney function after chronic kidney disease onset. This disparity can be addressed by slowing the progression of kidney disease in these populations.
A study of 3,503 patients found beta blocker use reduced mortality by 21% among those starting dialysis. This association supports the routine use of beta blockers for heart failure patients initiating dialysis.
Researchers found that diabetes increases autophagy initially, but then decreases it due to the activation of tumor suppressor p53 and microRNA miR-214, leading to hypertrophy, scarring, and inflammation in the kidneys. This discovery offers a potential target for preventing or slowing kidney failure.
A study found that individuals with declining kidney function starting at age 30 performed like those nine years older on certain cognitive tests 20 years later. This suggests that preserving kidney function in young adulthood may be crucial for maintaining thinking skills in midlife.
A new study has found that measuring the ratio of two proteins in deceased donor urine can identify kidneys with a higher probability for successful transplantation and long-term survival. The researchers believe this biomarker could help reduce the number of discarded kidneys and increase the organ donation pool.
A Marshall University researcher has been awarded a $444,000 grant to investigate the role of sodium pump signaling in fat cells and its potential as a treatment for uremic cardiomyopathy. The study aims to reveal more about oxidative stress and its impact on disease progression.
Exposure to high levels of fine particulate air pollution from wildfires is associated with a 4% higher death rate among patients with kidney failure. Patients with kidney failure are particularly susceptible to the effects of wildfire smoke, highlighting the need for research into managing exposure during wildfire episodes.
New research from Marshall University finds that production of peptide NaKtide in fat cells inhibits sodium pump function, preventing the development of cardiomyopathy associated with renal failure. The study also suggests targeting adipocytes may serve as a viable clinical strategy for preventing and treating the condition.
A study published in Clinical Journal of the American Society of Nephrology found that mortality rates are higher for patients with acute kidney injury (AKI) compared to those with kidney failure due to diabetes or other causes. The risk is particularly high for women and minorities.
A new study found that 21% of patients with kidney failure treated with dialysis experience regret, particularly those who choose dialysis due to external pressures. Discussing life expectancy and completing a living will can help mitigate this regret.
Researchers have identified ROBO2 as a potential therapeutic target for treating kidney diseases, including glomerular diseases and chronic kidney disease. High ROBO2 protein levels are found in injured kidney models and can lead to reduced podocyte adhesion, making it a promising area of investigation.
Racial and ethnic minorities with kidney failure and atrial fibrillation are less likely to fill prescriptions for blood thinners, resulting in higher stroke rates. Equalizing warfarin distribution could prevent 7-12% of the stroke disparity among minority groups.
A large-scale trial found that reducing steroid dosage and eliminating plasma exchange did not impact long-term survival for ANCA-associated vasculitis patients. Patients who received lower doses of steroids had fewer serious infections compared to those on higher doses.
A new study found that cardiovascular diseases, including heart failure, atrial fibrillation, and coronary heart disease, are each linked with a higher risk of developing kidney failure. Adults hospitalized with heart failure had an 11.4-times higher risk of developing kidney failure than individuals without cardiovascular disease.
Recent advancements in wearable and implantable hemodialysis devices have the potential to revolutionize treatment for patients with kidney failure. These devices aim to provide a more patient-friendly alternative to traditional hemodialysis, allowing patients to lead healthier lives.
A new meta-analysis found that SGLT2 inhibitors can reduce the risk of dialysis, transplantation, or death due to kidney disease by about 30% and also reduce the risk of acute kidney injury. The results are encouraging for people with diabetic kidney disease, offering a new treatment option to halt disease progression.
A new study confirms that SGLT2 inhibitors can prevent loss of kidney function and kidney failure in people with type 2 diabetes, reducing the risk by about 30%. The findings provide further strong support for the key role of SGLT2 inhibition in kidney protection.
A new study published in BMJ Open found that patients with gout are at increased risk of chronic kidney disease and kidney failure. The largest-ever study on the subject used data from over 620,000 patients in the UK health system and found a 29% higher risk of advanced CKD compared to those without gout.
A study found psychiatric illnesses are prevalent in children and adults with kidney failure, with hospitalizations associated with a higher risk of early death. The prevalence of psychiatric diagnoses increased over time across age groups.
A recent analysis reveals that sleeve gastrectomy is safe for patients with kidney failure and obesity. The study found that complication rates were similar between groups, but patients with kidney failure had longer hospital stays.
A recent analysis of US data over 20 years shows that children with kidney failure are being started on dialysis with higher levels of kidney function. Initiating dialysis at these higher levels is linked to lower patient survival, suggesting that asymptomatic children may benefit from delaying treatment.
Researchers developed molecular imaging probes that can track changes in biological processes at the molecular level, detecting acute kidney failure up to 1.5 days earlier than current methods. The probes have high renal clearance efficiency and could be used as non-invasive test strips for urine samples.
A study found that older living kidney donors with hypertension had a higher risk of developing kidney failure within 15 years after donation. However, the absolute risk was relatively low. In contrast, hypertension was not linked to an increased risk of early death among older donors.
A pilot study suggests that patients with chronic kidney disease who wear medical-alert accessories have a lower risk of developing kidney failure. However, there is no significant difference in rates of hospitalization or death between those who wear the accessories and those who do not.
A USask-led research team is developing an artificial portable kidney that can be worn by patients with renal failure, reducing hospital visits and healthcare costs. The team aims to create a highly efficient dialysis membrane that mimics the human kidney's filtering properties.
A breakthrough treatment has been found to protect against kidney failure and cardiovascular complications in people with diabetes. The study showed a significant reduction in kidney failure and cardiovascular events, such as heart attacks and strokes, by up to 30%.
A landmark clinical trial shows that canagliflozin lowers the risk of kidney failure by 30% in people with Type 2 diabetes and kidney disease. The study also found a significant reduction in cardiovascular events, providing a promising new treatment option for patients at high risk.
Patients with kidney failure who undergo lower extremity amputation have prolonged stays in healthcare settings, limited access to hospice services, and a poorer prognosis. These findings highlight the need for improved end-of-life care for this group of seriously ill patients.
A study found that influenza-like illness contributes to more than 1,100 deaths of patients with kidney failure each year in the US. The risk is highest during winter months when seasonal fluctuations occur.
A new study examines dialysis reimbursement policies worldwide, revealing significant disparities in access to care. The research suggests that high-income countries spend more on dialysis but have a lower percentage of healthcare budget allocated to it compared to low- and middle-income countries.
Researchers found that men with chronic kidney disease experience faster disease progression and higher death rates compared to women. The study analyzed over 4,000 participants and discovered a 17% lower risk of end-stage renal disease in women.
Patients with newly diagnosed kidney failure may experience delays in accessing preferred dialysis methods due to lack of insurance coverage. Uninsured patients were less likely to use arteriovenous fistulas or grafts and had a higher risk of dialysis-related infections compared to those with Medicare or Medicaid.
A national sample of 1,084 adults with chronic kidney disease (CKD) found that pro-inflammatory diets increased the risk of developing kidney failure. The study suggests that nutritional interventions focusing on reducing inflammation may help halt CKD progression.