Articles tagged with Skin Cancer
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Researchers discovered a genetic mutation in the DOCK8 gene that accounts for combined immunodeficiency, a previously undefined primary immune deficiency disease. This discovery provides a more accurate diagnosis for individuals with this rare condition and sheds light on its causes.
Recent research on five common cancers shows lifestyle interventions can prevent cancers, reduce risk factors, and counsel patients for lower cancer risk. Changes in diet, exercise, smoking habits, and UV radiation exposure can decrease cancer incidence.
Researchers identified two proteins, C/EBPα and β, that control the transition from stem cell to skin cell development in mice. Mice lacking these proteins had defective skin formation and died shortly after birth. The study sheds light on the mechanisms involved in skin cancer and other epithelial cancers.
A new study reveals that vitamin C helps promote wound healing and protects skin cells from DNA damage, a finding with great relevance to the cosmetics industry. The research also suggests that vitamin C can help remove DNA damage caused by free radicals, leading to potential advances in skin regeneration and cancer prevention.
A Phase I clinical study found that GDC-0449 inhibited the Hedgehog signaling pathway in patients with advanced basal cell skin cancers, with half showing tumor regression. Another patient with medulloblastoma showed significant tumor shrinkage and improvement in symptoms.
Researchers from Thomas Jefferson University developed a prodrug that could potentially reduce or avoid skin toxicity associated with EGFR-inhibiting cancer drugs. The prodrug is designed to preferentially bind to tumor tissue, reducing side effects. By targeting the tumor site, the prodrug can minimize damage to normal tissues.
Scientists identify defective immunity in skin as a key factor in skin aging and age-related health problems. The study reveals that older people's skin tissue fails to attract T-cells, leading to reduced immunity and increased risk of infections and cancer.
A new study found that people's bodies handle arsenic differently, with some individuals excreting up to 95% of ingested arsenic, while others store it in their bodies, posing a risk to health. The research suggests that existing standards for evaluating human health risks from arsenic may need to be reassessed.
Scientists found that primary cilia can either suppress or promote basal cell carcinoma, a type of skin cancer. Removing primary cilia from skin cancer cells blocks tumor growth, while boosting cilia function boosts tumor growth.
Researchers at Ohio State University found that a virus discovered in a rare form of skin cancer was also present in people with the second most common type of skin cancer. The virus had a mutation that enabled it to integrate into host DNA, raising questions about its potential role in causing squamous cell carcinoma.
Researchers engineered mice with a persistent wound-like skin condition to study tumor growth. The study found that chronic skin wounds promote skin tumors by secreting molecules that activate dermal cells and increase inflammation. Notch1 signaling plays a critical role in this process, suggesting potential complications for drug design.
Researchers successfully treated basal cell carcinoma with a non-toxic radioactive patch, showing minimal scarring and no toxicity. The treatment delivered beta radiation to the cancer site, effectively eradicating the malignant cells.
Researchers found that applying a chemotherapy medication to the face reduced actinic keratoses by 87% and improved signs of aging. The treatment also showed promise in addressing photo-aging, with patients reporting improved skin appearance and willingness to undergo therapy again.
Researchers found actinic keratoses can lead to squamous cell carcinoma and basal cell carcinoma, with two-thirds of patients tracing their cancers back to the lesions. The study also showed that actinic keratoses come and go, making prevention crucial.
A study found that Asian Americans who adopted more aspects of Western culture were more likely to engage in sun exposure behaviors, such as deliberate sunbathing and getting more sun on weekends. This association may lead to increased risk of skin cancer among this population.
A Stanford University School of Medicine survey finds that Asian Americans living in California are adopting unhealthy sun-exposure behaviors as they become more westernized. The study highlights the need for increased skin-health awareness among primary care physicians and people of Asian ancestry.
A Montana State University master's graduate is working with doctors at Vanderbilt Medical Center to build a handheld laser microscope that can detect skin cancer more accurately. The device uses laser light to form an image of the skin's cellular structure and compare it to a database of known cancers.
Researchers have developed hollow gold nanospheres that target and destroy melanoma cells using near-infrared light, showing eight times more damage to skin tumors than solid gold nanoparticles.
A new study describes how telomere dysfunction in skin cells can lead to increased skin cancer risk and pigmentation. Limiting the activity of a tumor suppressor protein, p53, restores cell regeneration but also advances skin cancer progression.
A study found that sun-safe pool policies are associated with improved sun safety behaviors among outdoor staff, leading to fewer reported sunburns. The program also promotes healthy sun protection habits and creates a work environment conducive to developing these habits.
Researchers found that blocking macrophage migration inhibitory factor (MIF) protein activity can reduce the incidence and severity of skin cancer tumors in mice. The study suggests a link between MIF and chronic inflammation, which precedes skin cancer development after long-term sun exposure.
A study of 170 military personnel who were evacuated from combat zones found that 34% were diagnosed with dermatitis or general skin inflammation. The study highlights the importance of identifying individuals with chronic skin conditions before deployment to reduce evacuations and improve combat effectiveness.
Research suggests that blocking RHAMM expression can selectively induce fat cell generation, replacing lost cells in the aging process and reducing deposits of unhealthy visceral fat. This technique could provide a non-surgical approach for wrinkle reduction and skin normalization.
Researchers at the University of East Anglia have identified a compound that blocks pigment cell movement, potentially preventing skin cancer. The study uses Xenopus Laevis tadpoles as a model organism due to their genetic similarity to humans.
A new UNC study found that the circadian clock influences a cell's repair machinery, which can affect the potency of cancer drugs. By targeting the daily oscillations of this enzyme system, researchers believe clinicians can maximize treatment effectiveness and minimize side effects.
Researchers found a potential new cancer risk and path for testing treatments for people with Fanconi anemia. Restoring the FA pathway reverses irregular cell growth in HPV-positive cells and may reduce cancer risk.
A study found that beachgoers who intended to tan and used the least amount of sunscreen were at higher risk of skin cancer. The researchers identified three groups with distinct characteristics and sun protection behaviors, highlighting the need for targeted interventions to reduce UV radiation exposure.
A new Cornell study found a strong relationship between allergies and cancer in tissues exposed to environmental factors, such as eczema, hives, and hay fever. Allergies linked to these conditions were most strongly associated with lower rates of cancers in exposed tissues.
Researchers found that IKKalpha acts as a sentry to monitor and regulate keratinocyte proliferation, preventing the development of squamous cell carcinomas. Deleting IKKalpha induced cancer in mouse models by activating the epidermal growth factor receptor pathway.
A study by Fox Chase Cancer Center found 27% of college students exhibit symptoms of tanning dependence, similar to substance addictions. Thinness and cigarette smoking are linked to higher rates of tanning dependence, suggesting potential avenues for prevention.
Researchers found a significant association between ACE inhibitor and ARB use and reduced incidence of basal cell carcinoma and squamous cell cancers in U.S. veterans. The study revealed a 39% relative reduction in basal cell cancer and 33% relative reduction in squamous cell cancers among users compared to non-users.
Researchers have identified a unique 'odor profile' for skin cancer using advanced chromatography techniques. The discovery could lead to a rapid, non-invasive diagnostic test that detects skin cancer before symptoms appear.
Researchers at Monell Chemical Senses Center have discovered a unique scent associated with basal cell carcinoma, the most common form of skin cancer. By analyzing volatile organic compounds in the air above skin lesions, they found distinct profiles that could potentially be used to screen for and diagnose skin cancers at early stages.
A new probe that uses light to detect skin cancer has received more funding for clinical trials. The device, called a 'clinical spectrometer,' can take measurements and identify cancerous cells within seconds.
A mouse study reveals that sex-specific growth hormone secretion patterns mediate gender-associated differences in susceptibility to diseases caused by inappropriate thrombosis. Additionally, research identifies the protein FGF9 as a key player in prostate cancer progression to osteoblastic bone metastases.
A new research study published in the FASEB Journal reveals that UVB light is more likely to cause DNA damage and lead to skin cancer than UVA light. This finding has significant implications for public health officials and government regulatory agencies, who can now use this information to develop more effective sunscreen products.
A new study from the University of Minnesota has identified a key receptor molecule involved in the development of sun-induced skin cancer. Researchers found that UV light triggers this molecule to change state, allowing it to interact with cannabinoid compounds found in marijuana, leading to an increased risk of skin cancer.
A new delivery technique using skin flaps and gene therapy reduces tumor volume by 79% in rats. The treatment allows for the production of therapeutic proteins directly at the tumor site, avoiding liver damage caused by traditional intravenous administration.
A study published in the EMBO Journal reveals that distinct signaling pathways between neighboring cells regulate cell division. Notch and Wnt/Wingless pathways control proliferation through gene effectors dMyc and bantam, which instruct E2F to activate the cell division machinery.
A restricted-calorie diet inhibited the development of precancerous growths in skin cancer, while an obesity-inducing diet activated pathways contributing to cancer growth and development.
A new breed of targeted cancer drugs is attacking specific proteins in cancer cells, but also causes devastating dermatologic side effects. The Cancer Skin Care Program at Northwestern University provides specially formulated lotions and drugs to help patients preserve their dignity and quality of life.
Researchers from Boston University School of Medicine found that previtamin D3 production varies depending on skin type and weather conditions. Vitamin D deficiency is common worldwide, with increased risk of cancers and autoimmune diseases associated with higher altitudes.
A new robotic surgery technique called transoral robotic surgery (TORS) has been shown to be effective in removing tonsil cancer with minimal complications and improved patient outcomes. In a study of 27 patients, surgeons successfully removed all cancerous tissues in 93% of cases, with an average surgery time of one hour and 43 minutes.
Researchers found that eating veggies, gardening, and being physically active can reduce lung cancer risk in smokers and non-smokers. Additionally, a study suggests men are more prone to developing skin cancers due to differences in antioxidant levels and DNA repair capacity.
Researchers discovered a promising new agent, CP-31398, that restores mutant p53 tumor suppressor function and inhibits skin cancer growth in mice exposed to UVB light. The findings suggest potential for this approach as a sunscreen component for preventing and treating UV light-induced skin cancers.
A new study published in JCI Journal has found that CP-31398, a compound that binds to mutant forms of the p53 protein, can prevent and treat UV light–induced skin cancers in mice. The study also demonstrated that CP-31398 increased p53 function in human skin cancer cells expressing a mutant form of p53.
A team of scientists has developed a tissue-engineered, organotypic 3D culture system of esophageal squamous cell cancer, revealing the genetic mutations and tumor microenvironment driving the disease. The model also highlights the critical role of stromal fibroblasts in cancer progression.
A team of Johns Hopkins scientists found that topical application of broccoli sprout-derived extract can protect human skin against UV radiation-induced damage. The extract works by boosting protective enzymes in cells, providing long-lasting protection even after the extract is removed from the skin.
A study published in the American Journal of Clinical Nutrition found that folic acid supplements can dramatically lower blood arsenic levels by up to 14 percent. Folate deficiency is common in Bangladesh, where the study was conducted, and supplementation enhanced detoxification of arsenic.
Researchers at UVA Health System discovered how cells protect themselves from DNA damage caused by UV rays, involving an unexpected connection between proteins. The study reveals part of a pathway inside human cells that regulates when and how cells repair damage to their DNA.
Researchers have developed a protocol for generating mice with squamous cell carcinoma, allowing them to study the disease in a controlled environment. The method involves injecting mice with DMBA and TPA, leading to tumor formation and enabling scientists to examine the role of the immune system in susceptibility to skin cancer.
Researchers have discovered that sulforaphane can prevent severe blistering and skin breakage associated with the rare genetic disease EBS. The study, funded by various organizations, found marked improvement in treated mice, suggesting a potential therapeutic for this condition.
A Rutgers study found that moderate caffeine intake combined with exercise can protect against UVB radiation-induced skin damage. Apoptosis rates increased by 95% in caffeine drinkers, 120% in exercisers, and nearly 400% in those who drank and exercised.
Researchers at the University of Texas M.D. Anderson Cancer Center discovered that a protein called IKK-alpha protects an important cell defense mechanism from silencing in skin cancers. The protein prevents DNA methylation, which normally silences the checkpoint gene 14-3-3-sigma.
Researchers found a substantial rise in cutaneous T-cell lymphoma cases over three decades, with highest rates in San Francisco and lowest in Iowa. The disease disproportionately affects men, Blacks, and those living in affluent areas.
A study published in the Journal of the National Cancer Institute found that nearly 80% of Kaposi sarcoma tumors arose independently from multiple cells. This challenges the traditional understanding of cancer origins, suggesting that Kaposi sarcoma is not a true metastatic cancer.
Research reveals that p53 gene mutations can trigger skin cancer, particularly squamous cell carcinoma (SCC), by accelerating malignant progression and sensitizing skin cells to tumor formation. Inflammation also plays a critical role in SCC development, with the chemokine receptor D6 acting as a key regulator.
Researchers have discovered a natural body lipid that signals cells to normalize growth and maturation. The finding, published in The Journal of Investigative Dermatology, shows that bypassing the signaling pathway restores normal differentiation of skin cells in diseases like psoriasis.
Researchers found that a specific enzyme, ATM, plays a crucial role in shutting down transcription near sites of DNA damage, ensuring repair in an undisturbed environment. This discovery could lead to a better understanding of genetic aberrations and cancer development in individuals with ATM deficiency.
Researchers discovered that caspase-14 plays a crucial role in maintaining the skin's balance of moisture and protecting against UVB radiation. The protein helps to regulate the processing of a key protein involved in skin structure, which can explain dehydration.