Articles tagged with Skin Cancer
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Researchers at the University of Pittsburgh Cancer Institute have identified the small tumor protein (sT) as the oncoprotein that triggers Merkel Cell Carcinoma (MCC), a rare but deadly skin cancer. The discovery could improve diagnosis and understanding of MCC, potentially shedding light on other cancers.
A study published in Cancer Research found that PTEN helps remove DNA damage caused by UVB radiation, a risk factor for non-melanoma skin cancer. Increasing PTEN activity through supplements or pharmaceuticals may prevent skin cancer.
Researchers found a sub-group of cutaneous human papillomaviruses (beta HPV types) associated with skin carcinogenesis in a novel experimental animal model. Chronic skin UV irradiation promoted the formation of skin lesions resembling squamous cell carcinoma precursor lesions, closely mimicking human observations.
A study of 210 organ transplant recipients with previous SCC found that BetaPV infection is extremely common, with concordant presence of DNA and antibodies increasing the risk for SCC skin cancer. The findings may lead to novel preventative or therapeutic interventions for immunosuppressed individuals.
A new study found that heart transplant patients are more likely to develop skin cancers, including cutaneous squamous cell carcinoma and melanoma. The incidence increased post-transplant by up to 30-fold, highlighting the need for improved patient education and screening.
A new study by UCSF researchers reveals that complex mutations in genes like TP53 occur earlier in skin and ovarian cancers than previously thought. The findings could help doctors develop new diagnostics for early cancer detection.
Researchers at UofL removed microRNA 21 from mice and found reduced skin tumor formation compared to control groups. The study suggests that miR-21 plays a role in cancer growth and that its removal increases the body's own tumor-suppressing ability.
AIDS-related cancer, Kaposi's sarcoma, is a frequent harbinger of HIV, with FSU scientist Dr. Fanxiu Zhu leading research on the human herpesvirus 8 (HHV-8) to develop targeted therapies. His work focuses on viral proteins, including ORF45, which plays a crucial role in infection and immune evasion.
Researchers at Brigham and Women's Hospital discovered a novel mechanism of action for fluorinated glucosamine, which blocks the synthesis of key carbohydrate structures linked to skin inflammation and cancer progression. This finding has significant implications for developing new treatments against these conditions.
Researchers at Fred Hutchinson Cancer Center have discovered a new drug target for squamous cell carcinoma, the second most common form of skin cancer. The protein alpha-catenin acts as a tumor suppressor and regulates cell proliferation by controlling Yap1 activity in cancer cells.
A 'gatekeeper' protein called C/EBP alpha plays a crucial role in preventing DNA damage and skin cancer. Its absence is linked to human skin cancers, including breast and colon cancer, and may also play a role in tumor suppression.
A Cochrane Systematic Review of randomized controlled clinical trials found no protective effect against non-melanoma skin cancer and prostate cancer. Researchers also noted potential toxic effects from long-term selenium intake.
A phase 3 trial found subcutaneous administration of bortezomib to be as effective as intravenous delivery, but with a better safety profile and lower rates of peripheral neuropathy. Subcutaneous injection could provide an easy home-based treatment option at reduced cost.
Squamous cell cancers can arise from hair follicle stem cells, which were found to be more prone to developing tumors. Researchers hope this discovery will lead to specific therapies targeting cancer initiation, potentially preventing the disease before it starts.
Researchers have developed a new technique using light-sensitive molecules and antibodies to target tumour blood vessels, starving cancer cells of oxygen and nutrients. The treatment was shown to completely eradicate some models of skin cancer in clinical trials.
Researchers at LSU Health Sciences Center have identified a protein called c-MYC oncoprotein that enables cancer cells to resist DNA-damaging agents like cisplatin. The study suggests that inhibiting this protein may provide a novel strategy for cancer therapy in combination with DNA-damaging agents.
Researchers have discovered the genetic fault behind a rare skin cancer that spontaneously heals after growing rapidly. The faulty TGFBR1 gene leads to unusual behavior in these self-healing squamous epithelioma tumors, which may help predict clinical effects of targeted therapies.
A new 'molecular switch' regulates epidermal stem cells, controlling skin growth and development. The study provides clues to new treatments for squamous cell carcinoma and burn patients.
A recent study published in JNCI found that shift work may be associated with a reduced risk of skin cancer in women. The researchers analyzed data from the Nurses' Health Study and discovered that rotating night shifts were linked to a lower risk of skin cancer, particularly melanoma. Darker-haired women had the lowest risk.
Sharing educational materials with kidney transplant recipients increased their likelihood of performing self-examinations and detecting skin cancers, according to a randomized controlled trial. The intervention also improved knowledge and attitudes towards skin cancer risk, leading to more follow-up appointments with dermatologists.
Researchers have developed a new method for imaging below the skin's surface using a liquid lens setup. This technology provides unprecedented images of tissue up to 1 millimeter deep, allowing for simpler and less invasive detection of skin lesions.
Researchers at Cold Spring Harbor Laboratory have identified a new role for the sister gene of p53, p63, in skin cancer and stem cell biology. The study reveals that increased activity of Ras combined with overly exuberant activity of ΔNp63α stimulates skin stem cells to promote carcinoma development.
Michigan State University researchers have developed smart laser technology that can identify molecules in skin cancer without cutting away tissue. This technology, published in Nature Photonics, enables rapid, non-invasive scanning and may help reduce the time required to develop new drugs.
Scientists at the University of East Anglia discovered a rogue gene, WWP2, that attacks and breaks down natural inhibitors preventing cancer cell spreading. Blocking WWP2 boosts these inhibitors, keeping cancer cells dormant.
A rock concert raised £30,000 for cancer research by Photodynamic Therapy (PDT), supporting Dr. Alison Curnow's clinical PDT research team at the Peninsula Medical School and Royal Cornwall Hospital. The funding will enable them to continue their work on this relatively unknown light-activated anti-cancer drug therapy.
Researchers found that UV light activates an enzyme called protein kinase D, which helps skin cancer cells survive and proliferate. This discovery suggests a new target for treating non-melanoma skin cancers, with potential benefits for the millions of people diagnosed annually in the US.
A study published in the Journal of the National Cancer Institute found that celecoxib, a widely used arthritis drug, significantly reduces non-melanoma skin cancers. The medication achieved a 68% reduction in basal cell carcinomas and a 58% reduction in squamous cell carcinomas among high-risk patients.
New research from the University of Alabama at Birmingham suggests that Celebrex may help prevent some non-melanoma skin cancers. The study found that celecoxib was highly effective in preventing cancer development from pre-cancerous actinic keratoses lesions, especially in patients with large numbers of lesions.
A randomized clinical trial found that celecoxib reduced the incidence of new nonmelanoma skin cancers but not precancerous lesions in patients with actinic keratosis. The study suggests that cyclooxygenase inhibitors may provide an additional benefit to sunscreens in preventing these cancers.
Researchers introduce new ways to encourage at-risk groups to visit a dermatologist, using age threshold and payment system. The initiatives aim to improve early diagnosis and treatment, reducing deaths and costs associated with skin cancer.
A Stanford study finds that depletion of protein Perp, which hooks skin cells together, may be an early indicator of skin cancer development. The loss of Perp also promotes cancer by increasing inflammatory molecules and disrupting cell-cell adhesion.
Scientists at UC Irvine have designed a new device using spatial frequency domain imaging to image cancerous lesions and monitor the effectiveness of photodynamic therapy (PDT) for skin cancer. The device, which uses an array of LEDs, can provide detailed images of the biochemistry of tissue, enabling targeted treatment.
A new study found that dieters who slept 8.5 hours per night lost 56% more body fat compared to those who slept 5.5 hours, highlighting the importance of adequate sleep for weight maintenance. Researchers also discovered that sleep restriction increased ghrelin levels, leading to increased hunger and food intake.
Researchers found that individuals with low DNA repair capacity have three times greater likelihood of developing non-melanoma skin cancer compared to those with high DRC. Low DRC levels were strongly associated with non-melanoma skin cancer, regardless of other risk factors.
Researchers have found a gene associated with aggressive skin cancer, INPP5A, which could predict its onset and track its progression. The study suggests that targeting this gene may provide new ways to prevent and treat cutaneous squamous cell carcinoma.
A study found that one in ten US adolescents uses sunless tanning products, which may reduce sunbathing and sunburns among adult women. Another study showed that promoting sunless tanning as an alternative to regular tanning can lead to reduced UV radiation exposure and improved sun safety behaviors.
Researchers at The Hormel Institute have found a link between capsaicin, a common ingredient in chili peppers, and the formation of skin cancer. Topical application of capsaicin induced tumors in mice, with higher and larger tumors forming in those without TRPV1 receptors.
Researchers at Oregon State University have identified adjacent skin cells called 'co-conspirators' that play a key role in the development of melanoma. The study found that these cells send signals to pigment-producing cells, which can either prevent or promote melanoma growth.
Researchers at the University of Texas Health Science Center San Antonio have discovered that certain plant substances can suppress damage that can cause skin cancer. The substances were tested on mice and proved protective even at low doses, with synergistic effects seen when given in combination.
Researchers at Mount Sinai School of Medicine discovered that DNA polymerase eta, an enzyme helping cells replicate despite sun damage, is structured differently in people with XPV. This finding sets the stage for research into therapies to protect XPV patients from skin cancers.
Researchers discovered a chain of molecular events that increase skin cancer risk, enabling doctors to assess genetic risk and develop new sunscreens. The study may lead to genetically tested sunscreens and personalized medicine for individuals carrying MC1R gene changes.
Men who choose radiotherapy over surgery for prostate cancer have a 17% improvement in overall survival rate, with patients refusing treatment having a 51% 10-year survival rate. This study highlights the importance of considering treatment options when diagnosed with prostate cancer.
A Canadian study found that skin cancer rates in Alberta have decreased for men and stabilized for women over a 20-year period. The research suggests that strong skin cancer awareness campaigns may be contributing to this trend, which contrasts with the rising global incidence of skin cancer.
Transplant patients have a significantly increased risk of developing lung cancer after organ transplantation, with the highest rates seen in heart and liver recipients. Researchers found that 0.85% of transplants developed lung cancer over 22 years, with higher incidence rates in smokers.
A significant study found that no single immunosuppressive drug regimen increases the risk of cancer among kidney transplant patients. However, factors such as age and smoking history contribute to increased cancer risk.
Researchers discovered that TRPV3 plays a crucial role in regulating hair growth and skin health. The protein's activation leads to the release of TGF-alpha, which stimulates EGFR, forming a positive signaling loop.
A sun protection intervention program increased hat use at school, but had no effect on self-reported hat use at home or skin pigmentation. The program's success highlights the importance of educating children about sun protection and modeling healthy behavior.
Research at Emory University School of Medicine found that high phosphate diet promotes tumor formation and growth in skin cancer, while restricting phosphate may prevent cancer. The study suggests that altered levels of phosphate could tip the balance of chemical reactions influencing cancer development.
A nurse researcher has settled a common cancer concern by discovering that routine advice on skin care was rooted in myth instead of scientific evidence. Her findings, published in the Clinical Journal of Oncology Nursing, found no evidence to support a four-hour restriction on lotions before radiation therapy.
A recent study by Henry Ford Hospital has found a significant link between elevated vitamin D levels and basal cell carcinoma, the most common form of skin cancer. The researchers discovered that cancerous tissue showed a 10-fold increase in vitamin D enzyme levels and a two-fold increase in protein levels compared to normal skin tissue.
Researchers have developed a new technique using photoacoustics to locate cancer cells in lymph nodes, enabling doctors to make more accurate diagnoses. This technology could help reduce the time and effort required for pathologists to determine if melanoma has spread to the lymphatic system.
According to a study published in Archives of Dermatology, regular use of non-steroidal anti-inflammatory drugs (NSAIDs) is not associated with an increased risk of squamous cell skin cancer. The study found that NSAID users were not at a higher risk for squamous cell carcinoma regardless of duration or dose.
A study found that kidney transplant recipients with high levels of T-regulatory cells and low Natural Killer cells are at a higher risk for skin cancer, which can occur after ten years of immunosuppressive drugs.
Researchers at Loyola Medicine found that sun damage silences protein kinase C gene, allowing cancerous cells to grow and divide unchecked. The study could lead to development of new drugs to shrink tumors.
A study published in Cancer Prevention Research suggests that topical application of celecoxib may prevent basal cell carcinoma. The research found that celecoxib reduced the growth of skin tumors by 50% and tumor burden in patients with a genetic predisposition to the disease.
A study of 312 heart transplant patients found that nearly half developed skin cancer during a 19-year follow-up period. The majority of these cancers were squamous cell carcinomas, with risk factors including age, other types of cancer, and immunosuppressive medication use.
A twin study has identified factors associated with sun damage and skin aging, including smoking and being heavier. The study found that a history of skin cancer and photodamage were highly associated in twin pairs, while sunscreen use was not.
Scientists at the University of Pennsylvania School of Medicine have developed a new model of skin cancer that sheds light on the role of Src kinase and its anti-oncogene counterpart, Srcasm. The study found that Fyn, a member of the Src family of proteins, is a potent oncogene in skin cancer, while Srcasm levels are decreased and acti...
Researchers at Huntsman Cancer Institute have discovered a new treatment for pachyonychia congenita, a rare genetic skin condition, using siRNA. The treatment involves preventing the mutated gene from being expressed while allowing healthy keratin genes to function normally.
A new study found that switching to a newer type of immunosuppressant drug, sirolimus, reduced the rate of skin cancer in kidney transplant patients by 25%. Nearly half of patients stopped treatment due to side effects. The researchers believe this could offer a new option for reducing skin cancer risk in transplant recipients.