Articles tagged with Skin Cancer
Researchers at Northwestern University have developed a novel gene regulation technology that can selectively target disease-causing genes in skin cells. The treatment uses spherical arrangements of nucleic acids to penetrate the skin and deliver therapeutics, offering new hope for life-saving therapies for skin cancers and other skin ...
Researchers found associations between certain types of cutaneous human papillomavirus (HPV) and squamous cell carcinoma (SCC). The study investigated five HPV genera and found significant associations between HPV 10 in genus alpha and SCC, as well as beta HPV types 5, 8, 17, and 24.
Researchers at H. Lee Moffitt Cancer Center found a synergy between sun exposure and cutaneous HPV infection in developing non-melanoma skin cancers like basal cell carcinoma and squamous cell carcinoma. People with low melanin production, such as those with light skin, are more susceptible to these risks.
A new ACS video series provides an overview of the chemistry behind sunscreens, explaining how they protect against UV rays. The video also offers pointers on shopping for effective sunscreen products, highlighting the importance of SPF numbers in choosing the right product.
A population-based study has found that high levels of ultraviolet radiation at birth, sun-sensitive skin type, and a history of skin cancer decreased the risk of pancreatic cancer. Participants born in areas with high UV radiation had a 24% lower risk compared to those born in low UV areas.
A meta-analysis and review of medical literature found a clear association between smoking and an increased risk of cutaneous squamous cell carcinoma. The study, which included data from 11 countries, showed a 52% significant increase in odds for current or ever smokers.
A customized patch treatment for basal cell carcinoma has shown an 80% cure rate without surgery or major radiation therapy. The phosphorus-32 skin patch delivers a fragmented dose of radiation to cancerous lesions, killing facial tumors in patients with facial basal cell carcinoma.
A phase II clinical study shows that vismodegib can dramatically shrink basal cell skin cancers and prevent new ones in patients with basal cell nevus syndrome, a rare genetic condition. The treatment offers an alternative to surgical removal, but side effects remain a consideration.
Lt. Col. Dore Gilbert, a California-based dermatologist, received the Members Making a Difference award for his service in the U.S. Army Reserve providing skin cancer screenings and supporting patients undergoing chemotherapy and radiation treatments.
A new study found that early childhood neglect may increase the risk of adult skin cancer recurrence, particularly in individuals who have experienced severe stress. The research suggests that early life experiences can affect immune response, making people more susceptible to certain types of cancers.
A new study suggests that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin can decrease the risk of squamous cell carcinoma and malignant melanoma. The findings indicate a potential cancer-protective effect of NSAID use, which should be considered when discussing benefits and harms.
Rutgers scientists found that surgical removal of abdominal fat from obese mice fed a high-fat diet reduces UV-induced skin cancer risk. The study suggests that removing original fat tissue may reduce the biochemical properties of new fat tissue, leading to less harmful cancer risks.
A study published in Cancer Research found that RalA and RalB proteins are associated with aggressive cancer characteristics in human tumors. The signature of genes changed by these proteins predicts poor outcomes. Removing these proteins from cancer cells may stop the genetic changes that cause aggressive cancer.
Young people are at risk of severe skin damage from autumn UV levels, which can lead to cancer-causing skin aging and wrinkles. Researchers used a unique non-invasive UV camera to measure the relationship between lifetime sun exposure and skin cancer risk.
The American College of Physicians recommends screening women for intimate partner violence in healthcare settings to discuss IPV with clinicians. Physician counseling also increases sun-protective behaviors among patients at greatest risk for skin cancer, particularly children and young adults with fair skin.
Two scientists, Elaine Fuchs and Howard Green, have been awarded the March of Dimes Prize in Developmental Biology for their groundbreaking research on skin stem cells and inherited skin disorders. Their work has saved thousands of lives and holds promise for new therapies for baldness and other diseases.
A study of Medicare data reveals that surgical treatment for nonmelanoma skin cancer has increased substantially since 2001, primarily due to the growing use of Mohs micrographic surgery (MMS). MMS was more likely performed on lesions on the lip and eyelid, and its use varied by age and region.
Researchers found EPR to be 30-46% better at identifying nonmelanoma skin cancer cases compared to claims data. The study suggests using EPR as an alternative for effectively tracking these cases, potentially improving disease burden estimates.
A UK study provides insight into the relationship between manganese superoxide dismutase (MnSOD) and cancer progression. The research found that MnSOD expression was suppressed early in skin carcinogenesis but increased at late stages, highlighting its role as a p53-regulated gene.
A new study found that transplant patients with head and neck cancer are more likely to be non-smokers and non-drinkers, and less likely to survive past one year of diagnosis. The risk for developing head and neck cancer is small, but the study highlights the need for regular screenings and aggressive treatment.
Researchers have discovered that a leukemia drug called Campath can effectively treat L-CTCL without increasing the risk of infections. The treatment targets only circulating cancerous T-cells, while sparing tissue-resident T-cells that provide frontline immune protection.
Researchers found that blocking the mutated BRAF protein in melanoma cells sets off a cellular cascade in other skin cells with pre-disposing mutations, leading to accelerated development of skin squamous cell carcinomas. The study provides molecular insight into this side effect and suggests strategies to prevent secondary tumors.
Researchers found that imiquimod converts plasmacytoid DCs into tumor-killing effector cells, clearing tumors in a mouse model of melanoma. This discovery has implications for antitumor therapies targeting both skin cancers and other types.
The collaboration aims to build on Professor Susann Schweiger's discovery of the mechanism controlling disease-causing protein production. The project seeks to prevent toxic protein buildup in the brain and potentially provide a treatment for Huntington's Disease.
Researchers found a strong association between smoking and squamous cell carcinoma in women, with increased risk seen with higher cigarette consumption. Smoking history was more strongly linked to SCC in women than men, with a four-fold increase in those who had smoked for 20 years or more.
Male mice have lower catalase activity, leading to higher oxidative stress and increased susceptibility to UVB-induced skin damage. Women may have natural antioxidant protection that reduces their risk of developing skin cancer.
Certain IBD patients may have an increased risk of nonmelanoma skin cancer, particularly those on thiopurine immunosuppressants. Researchers emphasize the need for dermatologic screening and sun protection in these patients.
Researchers at Monash University discovered a gene that helps protect against squamous cell carcinoma, the most common form of skin cancer. The absence of this gene is a profound driver of SCC tumours, leading to unchecked cell growth and cancer.
A new study suggests a possible link between radon exposure and non-melanoma skin cancer in the southwest region of England. The research found a correlation between areas with high radon concentrations and squamous cell carcinoma cases.
Researchers found a strong association between tanning bed use and an increased risk for three common skin cancers: basal cell carcinoma, squamous cell carcinoma, and melanoma. The study tracked 73,494 nurses who used tanning beds during high school and college, finding that more frequent exposure led to higher risks.
Researchers found that morning UV exposure increases skin cancer risk by 500% compared to afternoon exposure. The study's findings imply that restricting sunbathing or tanning booth visits to morning hours could help prevent skin cancer in humans.
Researchers found that an antiparasitic agent used to treat African sleeping sickness may provide long-term protection against nonmelanoma skin cancers. The study, conducted on 209 participants, showed a reduced incidence of skin cancers among those who took the drug for five years compared to those who received a placebo.
Research reveals VEGF's crucial role in regulating skin cancer stem cells, which are key to sustaining tumor growth. The study also identifies Neuropilin 1 as a critical receptor in this process, highlighting new targets for cancer therapy.
A UNC-led study shows that patients with high-risk non-melanoma skin carcinomas of the head and neck may benefit from concomitant radiotherapy and chemotherapy, achieving better outcomes compared to radiation alone. The study provides preliminary data on the feasibility of combining chemotherapy with radiotherapy.
Researchers have discovered how the Merkel cell carcinoma virus operates, offering a potential new approach to treating this rare and aggressive skin cancer. The study found that the virus can cause abnormal cell growth even after removing key interaction sites with heat-shock proteins.
A new study found that plerixafor, a drug already approved for bone marrow transplants, corrects panleukopenia in patients with WHIM syndrome. This targeted therapy may provide a more effective treatment for this rare immune deficiency.
A new Rutgers study found that applying caffeine directly to the skin may help prevent damaging UV light from causing skin cancer. The study, which involved genetically modifying mice with diminished ATR enzyme, showed that the modified mice developed fewer tumors and had reduced risk of invasive tumors compared to unmodified mice.
A study of 3,223 participants found that higher vitamin D levels were associated with an increased risk of nonmelanoma skin cancer (NMSC), particularly in cases not exposed to UV radiation. Despite this association, the relationship between vitamin D and NMSC remains complex due to inconsistent evidence.
Researchers at the University of Pittsburgh Cancer Institute have identified the small tumor protein (sT) as the oncoprotein that triggers Merkel Cell Carcinoma (MCC), a rare but deadly skin cancer. The discovery could improve diagnosis and understanding of MCC, potentially shedding light on other cancers.
A study published in Cancer Research found that PTEN helps remove DNA damage caused by UVB radiation, a risk factor for non-melanoma skin cancer. Increasing PTEN activity through supplements or pharmaceuticals may prevent skin cancer.
Researchers found a sub-group of cutaneous human papillomaviruses (beta HPV types) associated with skin carcinogenesis in a novel experimental animal model. Chronic skin UV irradiation promoted the formation of skin lesions resembling squamous cell carcinoma precursor lesions, closely mimicking human observations.
A study of 210 organ transplant recipients with previous SCC found that BetaPV infection is extremely common, with concordant presence of DNA and antibodies increasing the risk for SCC skin cancer. The findings may lead to novel preventative or therapeutic interventions for immunosuppressed individuals.
A new study found that heart transplant patients are more likely to develop skin cancers, including cutaneous squamous cell carcinoma and melanoma. The incidence increased post-transplant by up to 30-fold, highlighting the need for improved patient education and screening.
A new study by UCSF researchers reveals that complex mutations in genes like TP53 occur earlier in skin and ovarian cancers than previously thought. The findings could help doctors develop new diagnostics for early cancer detection.
Researchers at UofL removed microRNA 21 from mice and found reduced skin tumor formation compared to control groups. The study suggests that miR-21 plays a role in cancer growth and that its removal increases the body's own tumor-suppressing ability.
AIDS-related cancer, Kaposi's sarcoma, is a frequent harbinger of HIV, with FSU scientist Dr. Fanxiu Zhu leading research on the human herpesvirus 8 (HHV-8) to develop targeted therapies. His work focuses on viral proteins, including ORF45, which plays a crucial role in infection and immune evasion.
Researchers at Brigham and Women's Hospital discovered a novel mechanism of action for fluorinated glucosamine, which blocks the synthesis of key carbohydrate structures linked to skin inflammation and cancer progression. This finding has significant implications for developing new treatments against these conditions.
Researchers at Fred Hutchinson Cancer Center have discovered a new drug target for squamous cell carcinoma, the second most common form of skin cancer. The protein alpha-catenin acts as a tumor suppressor and regulates cell proliferation by controlling Yap1 activity in cancer cells.
A 'gatekeeper' protein called C/EBP alpha plays a crucial role in preventing DNA damage and skin cancer. Its absence is linked to human skin cancers, including breast and colon cancer, and may also play a role in tumor suppression.
A Cochrane Systematic Review of randomized controlled clinical trials found no protective effect against non-melanoma skin cancer and prostate cancer. Researchers also noted potential toxic effects from long-term selenium intake.
A phase 3 trial found subcutaneous administration of bortezomib to be as effective as intravenous delivery, but with a better safety profile and lower rates of peripheral neuropathy. Subcutaneous injection could provide an easy home-based treatment option at reduced cost.
Squamous cell cancers can arise from hair follicle stem cells, which were found to be more prone to developing tumors. Researchers hope this discovery will lead to specific therapies targeting cancer initiation, potentially preventing the disease before it starts.
Researchers have developed a new technique using light-sensitive molecules and antibodies to target tumour blood vessels, starving cancer cells of oxygen and nutrients. The treatment was shown to completely eradicate some models of skin cancer in clinical trials.
Researchers at LSU Health Sciences Center have identified a protein called c-MYC oncoprotein that enables cancer cells to resist DNA-damaging agents like cisplatin. The study suggests that inhibiting this protein may provide a novel strategy for cancer therapy in combination with DNA-damaging agents.
Researchers have discovered the genetic fault behind a rare skin cancer that spontaneously heals after growing rapidly. The faulty TGFBR1 gene leads to unusual behavior in these self-healing squamous epithelioma tumors, which may help predict clinical effects of targeted therapies.
A new 'molecular switch' regulates epidermal stem cells, controlling skin growth and development. The study provides clues to new treatments for squamous cell carcinoma and burn patients.
A recent study published in JNCI found that shift work may be associated with a reduced risk of skin cancer in women. The researchers analyzed data from the Nurses' Health Study and discovered that rotating night shifts were linked to a lower risk of skin cancer, particularly melanoma. Darker-haired women had the lowest risk.
Sharing educational materials with kidney transplant recipients increased their likelihood of performing self-examinations and detecting skin cancers, according to a randomized controlled trial. The intervention also improved knowledge and attitudes towards skin cancer risk, leading to more follow-up appointments with dermatologists.
Researchers have developed a new method for imaging below the skin's surface using a liquid lens setup. This technology provides unprecedented images of tissue up to 1 millimeter deep, allowing for simpler and less invasive detection of skin lesions.
Researchers at Cold Spring Harbor Laboratory have identified a new role for the sister gene of p53, p63, in skin cancer and stem cell biology. The study reveals that increased activity of Ras combined with overly exuberant activity of ΔNp63α stimulates skin stem cells to promote carcinoma development.