Articles tagged with Skin Cancer
The OHSU Knight Cancer Institute awarded $462,656 to 17 projects statewide to address community-identified needs and decrease the impact of cancer on Oregonians. The funded projects focus on preventing tobacco use among youth, increasing colorectal cancer screening, and developing skin cancer prevention programs.
A team of investigators at the University of Calgary has identified potential drug targets for neurocutaneous melanocytosis (NCM), a rare childhood cancer. The study used molecular analysis of patient tumor cells grown in animal models, revealing new insights into the disease's biology and suggesting possible treatments.
Researchers at King's College London identified a mechanism by which bacteria trigger tumour formation in skin damaged wounds. The study highlights the role of bacterial protein flagellin and immune receptor TLR-5 in this process.
A new study reveals SIRT6 can promote the development of skin cancers by increasing inflammation and cell proliferation. Inhibition of SIRT6 expression decreased COX-2 levels and tumor growth in mice.
A QUT study found that more than 50% of outdoor workers rated UV radiation exposure as a major concern. The study developed personalized sun protection action plans, which led to significant increases in workers' behaviors and attitudes towards sun protection.
Researchers discovered that chronic inflammation caused by metal allergy can promote the development of rare and aggressive skin cancers like Marjolin's ulcer. The study suggests that patients with metal implants near the skin may need to be monitored for this type of inflammation.
A genetic mutation caused by ultraviolet light is linked to millions of human skin cancers, according to Stanford researchers. The mutation occurs in the KNSTRN gene and can cause genomic catastrophe, leading to cutaneous squamous cell carcinomas.
Researchers at Loyola University Chicago Stritch School of Medicine discovered that dasatinib causes cancer cells to clump together, preventing metastasis. The drug targets a protein called BCR-ABL found in various malignancies, including breast and skin cancers.
Three plant-derived compounds, caffeic acid, rosmarinic acid, and trans-cinnamic acid, have been found to protect human skin cells from gamma radiation-induced damage during cancer radiotherapy. The compounds reduced reactive oxygen species and DNA damage by up to 40% and 15%, respectively.
A recent study published in JAMA Dermatology found that nearly 36.9% of skin cancer lesions are accompanied by itching, while 28.2% involve pain. Non-melanoma skin cancers are more likely to be associated with itch or pain.
Researchers at the University of Colorado Anschutz Medical Campus found that YouTube is a promising platform for disseminating research in dermatology. The study analyzed 100 videos with over 47 million views, driving 6,325 subscriptions to distinct user pages.
Researchers found that women with breast cancers involving the skin have widely varied survival rates, differing by tumor size and nodal involvement. They recommend adding a new staging category for tumors with skin involvement to accurately reflect a woman's chances of surviving her cancer.
A study published in the Journal of Behavioral Medicine found that fear and worry about skin cancer drive people's use of sunscreen, rather than information about the disease. The researchers suggest that addressing emotions may be crucial for designing effective public health interventions.
Chronic UV radiation stimulates endorphin production, causing physical dependence and addiction-like behavior in mice. This finding could explain why people have an instinctive desire for sunlight despite its health risks. Researchers suggest that a conscious effort to limit sun exposure is needed to mitigate skin cancer risk.
A new analysis found certain cancers are more concentrated in areas with high poverty, while others arise in wealthy regions. Areas with higher poverty have lower cancer incidence and higher mortality than those with lower poverty.
Researchers are studying the role of protein kinase D (PKD1) in non-melanoma skin cell damage and death. The study aims to understand how PKD1 protects skin cells from UV damage and explore ways to reduce its activity for cancer prevention.
Scientists discovered that low levels of RXR protein can cause normal skin cells to transform into cancerous melanoma cells, making it vulnerable to diagnosis. The study's findings may lead to new therapies by stabilizing or stimulating RXR expression.
Researchers analyzed 842 Ohio soil samples, finding all had high levels of arsenic above EPA's screening standard. Natural geological and soil processes are the main cause of these high levels.
Minorties are diagnosed with advanced stage skin cancer and lower survival rates than Caucasians, highlighting the need for increased awareness. Educating minority populations on sun protection guidelines can reduce their risk of developing skin cancer.
Dr. Elaine Fuchs received the Pezcoller Foundation-AACR International Award for her seminal work on mammalian skin, skin stem cells, and related diseases. Her research has had a profound impact on cancer research and other disciplines, including genetics and dermatology.
A University of Colorado study shows that teens who watched a video about the cosmetic effects of UV exposure were more likely to use sunscreen than those who watched a health-based video. This finding suggests that addressing appearance-related concerns can be an effective way to modify sun-protective behaviors in teenagers.
Researchers found that overproduction of SRSF6 promotes abnormal growth and prevents normal tissue repair, leading to early changes seen in skin cancer. The study suggests a new link between wound healing and cancer.
Researchers at CNIO discovered a connection between microtubules and cell-cell junctions that holds skin stem cells together to support skin architecture. This finding sheds light on the importance of cellular components in maintaining skin function and may lead to new regenerative or anti-cancer therapies.
Researchers at UCLA discovered a mechanism by which certain adult stem cells suppress their ability to initiate skin cancer during dormancy. The study found that PTEN gene plays a crucial role in tumor suppression via quiescence in hair follicle stem cells.
A study led by NIH scientists found that a variant form of the p53 gene increases the risk of testicular cancer up to threefold in white men. The research suggests that this variant helps protect light-skinned individuals from UV skin damage, but allows testicular stem cells to grow in the presence of DNA damage.
A genetic variation that enhances p53's activity has been identified as a common mutation increasing the risk of testicular cancer in light-skinned individuals. This SNP, named KITLG p53 RE SNP, was positively selected in Caucasian gene pools due to its potential protective effect against UV radiation-induced skin damage.
A genetic variant associated with a high risk of testicular cancer in Caucasians may also offer protection against harmful ultraviolet rays, suggesting it may have evolved to benefit light-skinned individuals. The study identifies a DNA sequence variation in the p53 gene that regulates cell functions and tumor formation.
Researchers discover that increasing c-Fos expression in the skin promotes the development of squamous cell carcinomas, a highly aggressive type of skin cancer. Anti-inflammatory drugs can decrease tumor progression by blocking the immune response induced by c-Fos.
Researchers at the University of Nottingham have developed a highly accurate prototype technique to detect cancerous tissue during surgery. This technique can produce detailed maps of tissue rich in information at the molecular level, enabling fast and objective diagnosis of cancer cells.
The skin uses a unique method to renew itself, with differentiated levels of stem cells and their micro-environment determining cell types. This challenges current stem cell models and provides new knowledge on skin cancer and wound healing.
A new study published in PNAS reveals that the TRPV4 molecule plays a key role in sunburn pain, which is caused by UVB radiation. The researchers found that blocking this molecule could provide protection against painful effects of sunburn and possibly other causes of pain.
Researchers at Queen Mary University of London discovered that omega-3 fatty acids selectively inhibit the growth of malignant and pre-malignant cells without affecting normal cells, suggesting potential use in cancer treatment and prevention. Further research is needed to define therapeutic doses.
Researchers have developed new techniques using lasers, LEDs, and optics to visualize and analyze the skin's structure and function. These methods hold promise for various medical applications, including burn treatment, cancer detection, and wound healing.
Researchers at IMIM have discovered a new function of the IB protein involved in squamous-cell carcinoma development. The study found that nuclear IB is lost during tumour progression, making it a potential biomarker for diagnosis and prognosis.
Research published in the Journal of Leukocyte Biology found that excessive mast cells lead to delayed wound healing due to overproduction of IL-10. The study provides a potential therapeutic target for future drug development.
Researchers have identified a unique odor signature associated with melanoma cells, which can be used to detect the deadliest form of skin cancer. A nanotechnology-based sensor also demonstrated reliable differentiation between melanoma cells and normal skin cells.
A new UCSF study urges doctors to consider patient risks and benefits when treating benign skin cancers in elderly patients, who may endure complications but not live long enough to benefit from treatment. The study found that most non-melanoma skin cancers were treated surgically, despite limited life expectancy or tumor recurrence ri...
Researchers from various disciplines are collaborating on a four-year project to encourage vacationers to use advanced sun protection behaviors. The program, launched at 40 resorts nationwide, aims to reduce skin cancer cases through education and awareness.
Kenneth Tsai, M.D., Ph.D., has been awarded the Sixth Annual Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research. The project aims to map the molecular path from normal skin to squamous cell carcinoma, with the goal of identifying biomarkers and targets for chemoprevention and therapy.
A new technique for reconstructing the nose after skin cancer has been developed at Michigan Medicine, offering a more efficient and effective solution. The procedure eliminates the need for a skin flap, reducing the risk of complications and allowing patients to achieve good cosmetic results without undergoing a second surgery.
Silibinin kills UVA-damaged cells, protecting against DNA damage. It also protects human skin cells from UVB radiation by increasing expression of interleukin-12, promoting cell repair.
A Kaiser Permanente study found basal cell and squamous cell carcinomas occur more than twice as often among HIV-positive individuals compared to those who are HIV-negative. The risk for these cancers is consistent with the growing evidence about this population's increased risk for a broad range of cancers.
Researchers at INSERM have identified CD98hc as a crucial molecule involved in maintaining skin homeostasis, which is essential for tissue function and regeneration. Removing the gene CD98hc disrupts skin balance and healing processes, leading to faults in cell proliferation, migration, and hair follicle cycles.
Researchers at Fox Chase Cancer Center found that low lymphocyte counts are associated with poor survival rates in Merkel cell carcinoma patients. Patients with higher lymphocyte counts tend to live longer after treatment and have better disease-free survival.
Researchers at Moffitt Cancer Center studied the relationship between sunlight exposure patterns and timing to understand its contribution to basal cell carcinoma and squamous cell carcinoma. Blistering sunburns and working outdoors were found to be associated with both types of skin cancer.
A study published in Archives of Dermatology found that nearly 40% of participants in Germany had ever used a sunbed, with women being more likely to use them. The main motivations for tanning were relaxation and attractiveness, while the risk of skin cancer was significantly increased by sunbed use.
Researchers found that mice exposed to a drug that increases TSLP levels are protected from developing skin tumors. Elevated TSLP also triggers an immune response that targets and destroys cancer cells. The study suggests that hyper-vigilance of the immune system may have benefits in fighting off skin cancer.
Researchers developed an advanced optics system to noninvasively map out the network of tiny blood vessels beneath the outer layer of patients' skin, potentially revealing telltale signs of disease. The imaging system shows promise for clinical application in diagnosing and treating skin cancer.
A Kaiser Permanente study found that long-term use of blood pressure medications increasing sun sensitivity is associated with a higher risk of squamous cell lip cancer in non-Hispanic whites. The risk appeared to increase with longer duration of medication use, and was not explained by cigarette smoking.
A team of Harvard researchers has found a connection between climate change, ozone depletion, and an increase in skin cancer incidence. The study suggests that climate change may lead to more damaging ultraviolet (UV) radiation reaching the Earth's surface, resulting in higher rates of skin cancer. The research also raises concerns abo...
Researchers have identified a protein called α9β1, which inhibits airway smooth muscle contraction and may be used to develop treatment options for asthma. Additionally, studies have shown that LRH-1 plays a crucial role in glucose-sensing and coordinating glucose and lipid metabolism in the liver.
A new study reveals how sunburn occurs when UV radiation damages RNA in skin cells, triggering an inflammatory response that can lead to healing and potentially even cancer. The discovery may lead to the development of treatments that block this process without exposing patients to harmful UV light.
Researchers found associations between certain types of cutaneous human papillomavirus (HPV) and squamous cell carcinoma (SCC). The study investigated five HPV genera and found significant associations between HPV 10 in genus alpha and SCC, as well as beta HPV types 5, 8, 17, and 24.
Researchers at Northwestern University have developed a novel gene regulation technology that can selectively target disease-causing genes in skin cells. The treatment uses spherical arrangements of nucleic acids to penetrate the skin and deliver therapeutics, offering new hope for life-saving therapies for skin cancers and other skin ...
Researchers at H. Lee Moffitt Cancer Center found a synergy between sun exposure and cutaneous HPV infection in developing non-melanoma skin cancers like basal cell carcinoma and squamous cell carcinoma. People with low melanin production, such as those with light skin, are more susceptible to these risks.
A new ACS video series provides an overview of the chemistry behind sunscreens, explaining how they protect against UV rays. The video also offers pointers on shopping for effective sunscreen products, highlighting the importance of SPF numbers in choosing the right product.
A population-based study has found that high levels of ultraviolet radiation at birth, sun-sensitive skin type, and a history of skin cancer decreased the risk of pancreatic cancer. Participants born in areas with high UV radiation had a 24% lower risk compared to those born in low UV areas.
A meta-analysis and review of medical literature found a clear association between smoking and an increased risk of cutaneous squamous cell carcinoma. The study, which included data from 11 countries, showed a 52% significant increase in odds for current or ever smokers.
A customized patch treatment for basal cell carcinoma has shown an 80% cure rate without surgery or major radiation therapy. The phosphorus-32 skin patch delivers a fragmented dose of radiation to cancerous lesions, killing facial tumors in patients with facial basal cell carcinoma.
A phase II clinical study shows that vismodegib can dramatically shrink basal cell skin cancers and prevent new ones in patients with basal cell nevus syndrome, a rare genetic condition. The treatment offers an alternative to surgical removal, but side effects remain a consideration.