Articles tagged with Skin Cancer
A study led by NIH scientists found that a variant form of the p53 gene increases the risk of testicular cancer up to threefold in white men. The research suggests that this variant helps protect light-skinned individuals from UV skin damage, but allows testicular stem cells to grow in the presence of DNA damage.
A genetic variant associated with a high risk of testicular cancer in Caucasians may also offer protection against harmful ultraviolet rays, suggesting it may have evolved to benefit light-skinned individuals. The study identifies a DNA sequence variation in the p53 gene that regulates cell functions and tumor formation.
A genetic variation that enhances p53's activity has been identified as a common mutation increasing the risk of testicular cancer in light-skinned individuals. This SNP, named KITLG p53 RE SNP, was positively selected in Caucasian gene pools due to its potential protective effect against UV radiation-induced skin damage.
Researchers discover that increasing c-Fos expression in the skin promotes the development of squamous cell carcinomas, a highly aggressive type of skin cancer. Anti-inflammatory drugs can decrease tumor progression by blocking the immune response induced by c-Fos.
Researchers at the University of Nottingham have developed a highly accurate prototype technique to detect cancerous tissue during surgery. This technique can produce detailed maps of tissue rich in information at the molecular level, enabling fast and objective diagnosis of cancer cells.
The skin uses a unique method to renew itself, with differentiated levels of stem cells and their micro-environment determining cell types. This challenges current stem cell models and provides new knowledge on skin cancer and wound healing.
A new study published in PNAS reveals that the TRPV4 molecule plays a key role in sunburn pain, which is caused by UVB radiation. The researchers found that blocking this molecule could provide protection against painful effects of sunburn and possibly other causes of pain.
Researchers at Queen Mary University of London discovered that omega-3 fatty acids selectively inhibit the growth of malignant and pre-malignant cells without affecting normal cells, suggesting potential use in cancer treatment and prevention. Further research is needed to define therapeutic doses.
Researchers have developed new techniques using lasers, LEDs, and optics to visualize and analyze the skin's structure and function. These methods hold promise for various medical applications, including burn treatment, cancer detection, and wound healing.
Researchers at IMIM have discovered a new function of the IB protein involved in squamous-cell carcinoma development. The study found that nuclear IB is lost during tumour progression, making it a potential biomarker for diagnosis and prognosis.
Research published in the Journal of Leukocyte Biology found that excessive mast cells lead to delayed wound healing due to overproduction of IL-10. The study provides a potential therapeutic target for future drug development.
Researchers have identified a unique odor signature associated with melanoma cells, which can be used to detect the deadliest form of skin cancer. A nanotechnology-based sensor also demonstrated reliable differentiation between melanoma cells and normal skin cells.
A new UCSF study urges doctors to consider patient risks and benefits when treating benign skin cancers in elderly patients, who may endure complications but not live long enough to benefit from treatment. The study found that most non-melanoma skin cancers were treated surgically, despite limited life expectancy or tumor recurrence ri...
Researchers from various disciplines are collaborating on a four-year project to encourage vacationers to use advanced sun protection behaviors. The program, launched at 40 resorts nationwide, aims to reduce skin cancer cases through education and awareness.
Kenneth Tsai, M.D., Ph.D., has been awarded the Sixth Annual Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research. The project aims to map the molecular path from normal skin to squamous cell carcinoma, with the goal of identifying biomarkers and targets for chemoprevention and therapy.
A new technique for reconstructing the nose after skin cancer has been developed at Michigan Medicine, offering a more efficient and effective solution. The procedure eliminates the need for a skin flap, reducing the risk of complications and allowing patients to achieve good cosmetic results without undergoing a second surgery.
Silibinin kills UVA-damaged cells, protecting against DNA damage. It also protects human skin cells from UVB radiation by increasing expression of interleukin-12, promoting cell repair.
A Kaiser Permanente study found basal cell and squamous cell carcinomas occur more than twice as often among HIV-positive individuals compared to those who are HIV-negative. The risk for these cancers is consistent with the growing evidence about this population's increased risk for a broad range of cancers.
Researchers at INSERM have identified CD98hc as a crucial molecule involved in maintaining skin homeostasis, which is essential for tissue function and regeneration. Removing the gene CD98hc disrupts skin balance and healing processes, leading to faults in cell proliferation, migration, and hair follicle cycles.
Researchers at Fox Chase Cancer Center found that low lymphocyte counts are associated with poor survival rates in Merkel cell carcinoma patients. Patients with higher lymphocyte counts tend to live longer after treatment and have better disease-free survival.
Researchers at Moffitt Cancer Center studied the relationship between sunlight exposure patterns and timing to understand its contribution to basal cell carcinoma and squamous cell carcinoma. Blistering sunburns and working outdoors were found to be associated with both types of skin cancer.
Researchers found that mice exposed to a drug that increases TSLP levels are protected from developing skin tumors. Elevated TSLP also triggers an immune response that targets and destroys cancer cells. The study suggests that hyper-vigilance of the immune system may have benefits in fighting off skin cancer.
A study published in Archives of Dermatology found that nearly 40% of participants in Germany had ever used a sunbed, with women being more likely to use them. The main motivations for tanning were relaxation and attractiveness, while the risk of skin cancer was significantly increased by sunbed use.
Researchers developed an advanced optics system to noninvasively map out the network of tiny blood vessels beneath the outer layer of patients' skin, potentially revealing telltale signs of disease. The imaging system shows promise for clinical application in diagnosing and treating skin cancer.
A Kaiser Permanente study found that long-term use of blood pressure medications increasing sun sensitivity is associated with a higher risk of squamous cell lip cancer in non-Hispanic whites. The risk appeared to increase with longer duration of medication use, and was not explained by cigarette smoking.
A team of Harvard researchers has found a connection between climate change, ozone depletion, and an increase in skin cancer incidence. The study suggests that climate change may lead to more damaging ultraviolet (UV) radiation reaching the Earth's surface, resulting in higher rates of skin cancer. The research also raises concerns abo...
Researchers have identified a protein called α9β1, which inhibits airway smooth muscle contraction and may be used to develop treatment options for asthma. Additionally, studies have shown that LRH-1 plays a crucial role in glucose-sensing and coordinating glucose and lipid metabolism in the liver.
A new study reveals how sunburn occurs when UV radiation damages RNA in skin cells, triggering an inflammatory response that can lead to healing and potentially even cancer. The discovery may lead to the development of treatments that block this process without exposing patients to harmful UV light.
Researchers at Northwestern University have developed a novel gene regulation technology that can selectively target disease-causing genes in skin cells. The treatment uses spherical arrangements of nucleic acids to penetrate the skin and deliver therapeutics, offering new hope for life-saving therapies for skin cancers and other skin ...
Researchers found associations between certain types of cutaneous human papillomavirus (HPV) and squamous cell carcinoma (SCC). The study investigated five HPV genera and found significant associations between HPV 10 in genus alpha and SCC, as well as beta HPV types 5, 8, 17, and 24.
Researchers at H. Lee Moffitt Cancer Center found a synergy between sun exposure and cutaneous HPV infection in developing non-melanoma skin cancers like basal cell carcinoma and squamous cell carcinoma. People with low melanin production, such as those with light skin, are more susceptible to these risks.
A new ACS video series provides an overview of the chemistry behind sunscreens, explaining how they protect against UV rays. The video also offers pointers on shopping for effective sunscreen products, highlighting the importance of SPF numbers in choosing the right product.
A population-based study has found that high levels of ultraviolet radiation at birth, sun-sensitive skin type, and a history of skin cancer decreased the risk of pancreatic cancer. Participants born in areas with high UV radiation had a 24% lower risk compared to those born in low UV areas.
A meta-analysis and review of medical literature found a clear association between smoking and an increased risk of cutaneous squamous cell carcinoma. The study, which included data from 11 countries, showed a 52% significant increase in odds for current or ever smokers.
A customized patch treatment for basal cell carcinoma has shown an 80% cure rate without surgery or major radiation therapy. The phosphorus-32 skin patch delivers a fragmented dose of radiation to cancerous lesions, killing facial tumors in patients with facial basal cell carcinoma.
A phase II clinical study shows that vismodegib can dramatically shrink basal cell skin cancers and prevent new ones in patients with basal cell nevus syndrome, a rare genetic condition. The treatment offers an alternative to surgical removal, but side effects remain a consideration.
Lt. Col. Dore Gilbert, a California-based dermatologist, received the Members Making a Difference award for his service in the U.S. Army Reserve providing skin cancer screenings and supporting patients undergoing chemotherapy and radiation treatments.
A new study found that early childhood neglect may increase the risk of adult skin cancer recurrence, particularly in individuals who have experienced severe stress. The research suggests that early life experiences can affect immune response, making people more susceptible to certain types of cancers.
A new study suggests that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin can decrease the risk of squamous cell carcinoma and malignant melanoma. The findings indicate a potential cancer-protective effect of NSAID use, which should be considered when discussing benefits and harms.
Rutgers scientists found that surgical removal of abdominal fat from obese mice fed a high-fat diet reduces UV-induced skin cancer risk. The study suggests that removing original fat tissue may reduce the biochemical properties of new fat tissue, leading to less harmful cancer risks.
A study published in Cancer Research found that RalA and RalB proteins are associated with aggressive cancer characteristics in human tumors. The signature of genes changed by these proteins predicts poor outcomes. Removing these proteins from cancer cells may stop the genetic changes that cause aggressive cancer.
Young people are at risk of severe skin damage from autumn UV levels, which can lead to cancer-causing skin aging and wrinkles. Researchers used a unique non-invasive UV camera to measure the relationship between lifetime sun exposure and skin cancer risk.
The American College of Physicians recommends screening women for intimate partner violence in healthcare settings to discuss IPV with clinicians. Physician counseling also increases sun-protective behaviors among patients at greatest risk for skin cancer, particularly children and young adults with fair skin.
Two scientists, Elaine Fuchs and Howard Green, have been awarded the March of Dimes Prize in Developmental Biology for their groundbreaking research on skin stem cells and inherited skin disorders. Their work has saved thousands of lives and holds promise for new therapies for baldness and other diseases.
A study of Medicare data reveals that surgical treatment for nonmelanoma skin cancer has increased substantially since 2001, primarily due to the growing use of Mohs micrographic surgery (MMS). MMS was more likely performed on lesions on the lip and eyelid, and its use varied by age and region.
Researchers found EPR to be 30-46% better at identifying nonmelanoma skin cancer cases compared to claims data. The study suggests using EPR as an alternative for effectively tracking these cases, potentially improving disease burden estimates.
A UK study provides insight into the relationship between manganese superoxide dismutase (MnSOD) and cancer progression. The research found that MnSOD expression was suppressed early in skin carcinogenesis but increased at late stages, highlighting its role as a p53-regulated gene.
A new study found that transplant patients with head and neck cancer are more likely to be non-smokers and non-drinkers, and less likely to survive past one year of diagnosis. The risk for developing head and neck cancer is small, but the study highlights the need for regular screenings and aggressive treatment.
Researchers have discovered that a leukemia drug called Campath can effectively treat L-CTCL without increasing the risk of infections. The treatment targets only circulating cancerous T-cells, while sparing tissue-resident T-cells that provide frontline immune protection.
Researchers found that blocking the mutated BRAF protein in melanoma cells sets off a cellular cascade in other skin cells with pre-disposing mutations, leading to accelerated development of skin squamous cell carcinomas. The study provides molecular insight into this side effect and suggests strategies to prevent secondary tumors.
Researchers found that imiquimod converts plasmacytoid DCs into tumor-killing effector cells, clearing tumors in a mouse model of melanoma. This discovery has implications for antitumor therapies targeting both skin cancers and other types.
The collaboration aims to build on Professor Susann Schweiger's discovery of the mechanism controlling disease-causing protein production. The project seeks to prevent toxic protein buildup in the brain and potentially provide a treatment for Huntington's Disease.
Researchers found a strong association between smoking and squamous cell carcinoma in women, with increased risk seen with higher cigarette consumption. Smoking history was more strongly linked to SCC in women than men, with a four-fold increase in those who had smoked for 20 years or more.
Male mice have lower catalase activity, leading to higher oxidative stress and increased susceptibility to UVB-induced skin damage. Women may have natural antioxidant protection that reduces their risk of developing skin cancer.
Certain IBD patients may have an increased risk of nonmelanoma skin cancer, particularly those on thiopurine immunosuppressants. Researchers emphasize the need for dermatologic screening and sun protection in these patients.
Researchers at Monash University discovered a gene that helps protect against squamous cell carcinoma, the most common form of skin cancer. The absence of this gene is a profound driver of SCC tumours, leading to unchecked cell growth and cancer.
A new study suggests a possible link between radon exposure and non-melanoma skin cancer in the southwest region of England. The research found a correlation between areas with high radon concentrations and squamous cell carcinoma cases.
Researchers found a strong association between tanning bed use and an increased risk for three common skin cancers: basal cell carcinoma, squamous cell carcinoma, and melanoma. The study tracked 73,494 nurses who used tanning beds during high school and college, finding that more frequent exposure led to higher risks.
Researchers found that morning UV exposure increases skin cancer risk by 500% compared to afternoon exposure. The study's findings imply that restricting sunbathing or tanning booth visits to morning hours could help prevent skin cancer in humans.
Researchers found that an antiparasitic agent used to treat African sleeping sickness may provide long-term protection against nonmelanoma skin cancers. The study, conducted on 209 participants, showed a reduced incidence of skin cancers among those who took the drug for five years compared to those who received a placebo.