Articles tagged with Vascular Diseases
Researchers developed a new imaging approach called VascuViz to visualize blood vessels at different spatial scales. The method enables detailed mathematical models and complementary images to clarify the role of blood flow in health and disease, advancing our understanding of tissues throughout the body.
A study led by Ohio State University Wexner Medical Center finds that Black patients with dilated cardiomyopathy have a higher risk of family members being affected. The research analyzed data from 1,220 patients and their relatives, revealing that 39% of Black patients had at least one first-degree family member with the condition.
Researchers at West Virginia University are investigating the link between chronic stress and Alzheimer's disease using animal models. They aim to understand how xanthine oxidase may sabotage brain blood vessels in Alzheimer's patients, and explore whether a medication can block this pathway to keep the brain healthy.
A study suggests that nearly 60 percent of the risk associated with coronary artery disease may be explained by changes in hundreds of genes working together in networks across several organs. Fat processing hormones may play a central role in coordinating this activity.
Researchers found that a unique protein variant in modern humans offers better protection against oxidative stress, but also increases the risk of vascular disease and inflammatory bowel disease. The Neanderthal variant is carried by around 1-2% of the population on the Indian subcontinent.
Scientists have found that the gene PBK is overexpressed in pulmonary hypertension, causing excessive cell proliferation and thickening of pulmonary artery walls. They are now exploring PBK inhibitors to reduce cell proliferation and improve heart and lung function.
Researchers found that up to one in five patients experience increased troponin levels after major surgery, indicating potential heart damage. These patients were also more likely to be anaemic before the operation.
A study of HIV-positive black and Latino men found that methamphetamine use combined with intimate partner violence boosts inflammatory and antiviral genes, leading to immune system exhaustion. This combination may increase the risk of developing cardiovascular disease and other disorders.
A new study published in the Journal of Experimental Medicine showed that a fast-tracked stroke drug, 3K3A-APC, protected mice from injury to the brain's white matter, a leading cause of dementia. The drug may also be effective in slowing down progression of cognitive impairment.
Researchers found that candesartan reduces accumulation of extracellular matrix proteins and normalizes blood flow in mice with hereditary cerebral small vessel disease. The study suggests a potential new treatment avenue for age-related cerebral arteriopathy.
A USF Health study reveals that fibrinogen can directly interact with neurons, leading to inflammation and neurodegeneration in Alzheimer's disease and traumatic brain injury. The researchers found that blocking the binding of fibrinogen to its receptors may alleviate short-term memory problems associated with these diseases.
A study found that consuming high amounts of herbs and spices daily can lead to significant reductions in systolic and diastolic blood pressure. The researchers discovered that adding just 1.3 teaspoons of herbs and spices a day to an average American diet resulted in lower blood pressure after four weeks.
Researchers at GIST create an optical technique called optical speckle image velocimetry that can image dynamic changes in cerebral blood flow, allowing for the diagnosis of brain health. The technique provides high-time resolution and measures both speed and direction of blood flow.
Microglia play a vital support role in maintaining blood vessels in the brain, regulating blood flow and capillary diameter. This discovery may lead to new therapies for diseases affecting small brain vessels, such as Alzheimer's and stroke.
Researchers found that a cancer chemotherapy drug can restore memory and cognitive function in mice with Alzheimer’s disease by inhibiting blood vessel growth. The study suggests repurposing approved anti-cancer drugs as treatments for Alzheimer’s disease, potentially shortening clinical development time.
A pre-clinical study by University of Illinois Chicago researchers shows that a drug targeting specific immune pathways can prevent lung damage and death in mice infected with the SARS-CoV-2 virus. The study suggests targeted treatments may be more suitable for COVID-19 patients than broad immune suppressants.
Researchers at Karolinska Institutet studied long-term outcomes of patients with pacemakers after transcatheter aortic valve replacement and found no significant difference in mortality. The study included over 3,400 patients, with 481 receiving permanent pacemakers within 30 days of surgery.
Atrial fibrillation screening in 75- and 76-year-olds may significantly reduce the risk of stroke, severe bleeding, and death. The study, published in The Lancet, found that at least 2,300 cases of stroke or death could be avoided per year with national screening.
A new study examining the association between type 2 diabetes mellitus and skin diseases reveals a strong link between the two conditions. The research, published in Chinese Medical Journal, found that 93.5% of individuals with T2DM had skin problems, including over 47 types of comorbid skin diseases.
Alzheimer's disease disorganises blood vessels around amyloid plaques, causing loss of vessels and worsening pathology. This mechanism aggravates the disease by reducing the brain's ability to clean toxic substances, leading to increased strain on oxygen and nutrient supply.
Researchers have identified a connection between perivascular fibroblast cells and ALS disease onset, suggesting a correlation between elevated protein marker SPP1 levels and aggressive disease process. This discovery has potential implications for earlier diagnoses and future treatments.
A new study has found that people with cerebral small vessel disease who have blood-brain barrier leakage have more brain tissue damage over two years than those with less leakage. The study also found a higher leakage rate at the start of the study resulted in more loss of tissue microstructure around brain lesions.
A new surgical technique, Encephaloduroarteriosynangiosis (EDAS), demonstrates reduced recurrent stroke rates from 37% to 10.7%. The EDAS procedure reroutes arteries to segments at risk of stroke, mimicking the process of 'gardening' for blood flow.
A large study of over 2,300 patients found that paclitaxel-coated balloons and stents do not increase mortality rates compared to conventional devices. The results resolve a long-standing debate on the safety of these treatments for peripheral arterial disease.
A new study from La Jolla Institute for Immunology reveals that a metabolic enzyme called ADA2 inhibits inflammation in blood vessels and restrains the immune system. The researchers found that ADA2's loss stimulates a robust innate immune response, which can lead to harmful inflammation.
A new study published in the Journal of Vascular Surgery found that the Ellipsys System created durable vascular access for ESRD patients who require hemodialysis, with a patency rate of 96% after one year. This minimally invasive procedure reduces reliance on riskier vascular access options and improves patient safety.
Researchers have identified a link between yield decline and soilborne disease symptoms in winter squash, including stunting and root rot. The study's findings suggest that rotating out of winter squash production for at least 3-4 years can help prevent disease symptoms.
Researchers discovered a mechanism by which blood vessels' inner liner grows in response to transient increases in blood pressure. This process may lead to therapeutics that cut off tumors or help rebuild damaged vessels. The study's findings have implications for combating tumor growth and disease.
A Swedish study has found that abdominal arterial aneurysm is associated with elevated subtypes of white blood cells in older men. Quitting smoking also appears to positively impact the disease's course.
Most patients with COVID-19 pneumonia have ground-glass opacities (86.1%) or mixed GGO and consolidation (64.4%), according to a multi-center study published in the American Journal of Roentgenology. The lesions are often peripheral, bilateral, lower lung predominant, and multifocal.
A study of nearly 65,000 patients has found that paclitaxel-coated devices are safe and not linked to an increase in deaths. The analysis, which is the largest of its kind, suggests that drug-eluting stents and balloons have no increased risk of death over long-term follow-up.
Researchers found that people with mild cognitive impairment may have different brain changes depending on the type of dementia they have. The study suggests that these changes could potentially be used to track early changes in Alzheimer's disease and cerebrovascular disease.
Researchers at Boston University School of Medicine examined coatings on drug-coated balloon catheters using microscopy and cell cultures to improve delivery efficiency. They found that coating shape affects drug transfer, leading to better device performance and potential outcomes.
Researchers at the University of Cincinnati are studying the use of neuroimaging to pinpoint the risk factors of stroke recurrence, which affects nearly 800,000 people annually in the US. The study aims to identify patients at higher risk for recurrent strokes by assessing imaging for signs of small vessel disease in the brain.
A new minimally-invasive surgical technique has been developed to create dialysis access for patients with severe kidney disease. The WavelinQ endoAVF System allows vascular surgeons to create a connection between an artery and vein using magnets, reducing the risk of complications and surgeries.
A new study published in Vascular Medicine found that e-cigarette users experience significant cardiovascular elevation, comparable to cigarette smokers. The research revealed elevated blood pressure and heart rate after using e-cigarettes, with some effects lasting up to 45 minutes.
Researchers have discovered a possible treatment approach for cerebral small vessel disease (SVD), the most common cause of dementia and stroke in older adults. Studies with rats showed that treating SVD can reverse changes in blood vessels in the brain associated with the condition, as well as prevent damage to brain cells.
A randomized clinical trial of 200 patients with PAD found that a home-based exercise program with a wearable activity monitor and telephone coaching did not improve walking endurance. The results suggest that traditional in-person exercise programs may be more effective in improving walking ability for this patient population.
A new study by Northwestern University found that a home-based exercise program with wearable devices and telephone coaching did not improve walking ability in patients with peripheral artery disease. The researchers suggest that this approach may worsen pain for participants, limiting their activity levels.
The April 2018 issue of Vascular Medicine explores the latest imaging and diagnostic techniques for vascular disease. Key findings include updates on ABI testing, duplex ultrasound, MRA, and CTA, as well as recent advances in MRI for patients with PAD.
Researchers at UCSB used star ascidian to study the interaction between cells and their physical environment, finding a mechanism that allows blood vessels to shrink without impeding blood flow. This discovery has implications for understanding cellular development and metastasis in cancer.
A recent study found that high blood sugar following leg surgery is common and associated with poorer outcomes, including increased infection rates, hospital stays, and mortality. Patients without diabetes were also at a higher risk of complications, highlighting the importance of glucose management in surgical interventions.
A new progeria-on-a-chip model has provided insights into the mechanisms of premature aging and vascular disease. The study found that cells from HGPS donors exhibited an exacerbated response to biomechanical strain, leading to increased inflammation.
Researchers at the University of Bristol have developed a set of guidelines for assessing vascular cognitive impairment, which can help determine the likelihood that cognitive decline was caused by vascular disease. The guidelines are based on pathological criteria and can be used to streamline research into dementia.
A new study found a correlation between microscopic brain damage and impaired cognitive performance in patients with symptomatic carotid artery disease. The researchers used diffusion tensor imaging to assess white matter tract skeleton mean diffusivity, which showed the closest correlation with cognitive impairment.
A new study reveals an unconventional antibody that targets the patient's vascular response to sepsis, converting a harmful protein into a protective one. This approach stabilizes blood vessels, strengthens barrier function, and quells systemic inflammation, prolonging survival in mice with sepsis.
The Society for Vascular Medicine coalition advocates for PAD treatment guidelines that improve health outcomes in Medicare beneficiaries. The recommendations include reclassifying the ankle brachial index, comprehensive medical intervention, and supervised exercise training programs.
Elsevier has launched a new open access journal, Journal of Vascular Surgery Cases, to publish high-quality case reports on all aspects of vascular diseases. The journal aims to provide novel and timely information to practicing clinicians and researchers in the field.
Researchers found that African Americans have impaired blood flow regulation in the brain, contributing to a greater risk of stroke and other cerebrovascular diseases. The study suggests underlying mechanisms of blood vessel dysfunction occur in relatively young and healthy African Americans.
Newly created endothelial colony-forming cells can proliferate into human blood vessels, restoring blood flow in mice with damaged tissues. The discovery opens the door for potential treatments for diseases like amputation and blindness.
The Physical Activity and Nutrition in Children Study found that low levels of physical activity combined with heavy use of electronic media increases the risk for type 2 diabetes and vascular diseases in 6-8 year-old children. Heavy electronic media use is also linked to higher risk factors even in physically active children.
A study found that longer diabetes duration is associated with brain volume loss and grey matter shrinkage, contrary to previous assumptions about its impact on small vessel ischemic disease. The researchers suggest potential implications for cognitive decline in patients with diabetes.
A new classification system for emergency operations has been implemented in Finland, allowing for fair and efficient management of a large volume of such surgeries. The system has objectively measurable benefits, including decreased nighttime emergency operations without compromising elective surgeries.
A phase 2 study found that GM-CSF therapy did not improve treadmill walking time in patients with intermittent claudication, a common symptom of peripheral artery disease. The treatment may still warrant further investigation due to observed secondary outcomes.
The study identified the DNA transcription factor SRF and its cofactors MRTF-A and MRTF-B as critical regulators of vascularization in the postnatal mouse eye. Loss of Srf led to microaneurysms and excess blood vessel formation similar to human retinal diseases.
Researchers identify ATRX as a crucial gene in maintaining genomic stability, preventing chromosomal mutations and rearrangements that can cause disease and aging. Atrx deficiency in mice leads to increased DNA damage, endocrine dysfunction, shortened lifespans, and degenerative phenotypes similar to human premature aging disorders.
Patients with peripheral artery disease who received ramipril for 24 weeks experienced significant improvements in pain-free walking time and maximum walking time, as well as enhanced physical health and quality of life. Ramipril also showed promise in improving patient-perceived ability to perform daily activities.
Depression in Medicare recipients over 65 is associated with prevalent mild cognitive impairment (MCI) and increased dementia risk. The study found that depression was related to higher MCI and dementia risks, as well as progression from MCI to dementia.
Research suggests that lifelong depression increases the risk of developing vascular dementia, while late-life depression may be an early symptom of Alzheimer's disease. A study of over 13,000 participants found a significant association between depressive symptoms in midlife and late life with increased risk of dementia.
The Journal of Vascular and Interventional Radiology's impact factor increased by nearly 15% in 2010, reflecting its commitment to quality and tradition of excellence. The journal has expanded its reach through new media channels, including a podcast channel and redesigned website.