Articles tagged with Vascular Diseases
Cells from menstrual blood, known as endometrial regenerative cells (ERCs), have been shown to restore blood flow in a mouse model with advanced peripheral artery disease. This breakthrough discovery holds promise for the treatment of critical limb ischemia, which causes approximately 150,000 amputations per year.
Researchers at the Salk Institute identified a probable molecular basis for the interaction between diabetes and Alzheimer's disease. The study found that damaged blood vessels in the brain of young diabetic mice suffered from significant memory loss and inflammation before any overt signs of Alzheimer's disease appeared.
A long-term study published in Neurology found that men who develop diabetes in mid-life are nearly one-and-a-half times more likely to develop Alzheimer's disease than those without insulin problems. The association was strongest in people without the APOE4 gene, which is known to increase Alzheimer's risk.
Research finds that leaky blood vessels in mice with ALS mutations expose neurons to toxic substances, contributing to disease progression. The study opens a new front in understanding ALS, a debilitating disease that affects motor neurons.
A four-year study found that walking and moderate exercise significantly lowered the risk of developing vascular dementia in people over 65. Participants who exerted more energy through physical activities like walking, gardening, or house work had a 27% lower risk compared to those with less energy expenditure.
A study published in PLOS ONE found that mice with amyotrophic lateral sclerosis (ALS) have a compromised blood-spinal cord barrier, leading to vascular leakage and potential mechanisms for motor neuron damage. Researchers hope this finding will lead to the development of new treatments targeting the barrier's repair.
A study published in Journal of Vascular Surgery found increased aortic arch calcium content and complex arch morphology are associated with higher risk of embolization during carotid artery stenting in patients over 75. This may lead to the use of alternative techniques to reduce risk.
Researchers found that female diabetic rats had reduced nitric oxide levels, while male diabetic rats produced more, leading to increased vascular dysfunction. The study suggests sex-specific therapeutic interventions may be necessary for effective treatment of vascular disease in diabetes.
Scientists have linked a genetic disorder to mutations in the TREX1 gene, which may also be relevant to common health problems like diabetes and vascular dementia. The discovery could accelerate efforts to understand and treat retinal vasculopathy with cerebral leukodystrophy, a rare condition that causes vision loss and mini-strokes.
Varicose veins affect 75-150 million people worldwide and traditional therapy involves costly surgery. Vascular Insights aims to reduce convalescence, complications, and pain with a single, disposable product for elimination of varicose veins.
A study found that depressed older adults are more likely to develop cognitive impairment within six years, with those experiencing moderate to high depression facing nearly twice the risk. The researchers discovered no correlation between depression and vascular disease, suggesting alternative mechanisms for the association.
End-stage renal disease (ESRD) has increased in Canada and worldwide since 1980, with 25,000 Canadians receiving life-sustaining treatment. Despite its benefits, there is a marked regional disparity in transplant rates, highlighting the need for tailored guidelines on eligibility across various criteria.
A study by Rice University/Baylor College of Medicine found that areas with more vascular surgeons have lower amputation rates and more bypass surgery performed. The disease affects 8-12 million people and is a major cause of amputations, especially in diabetics.
A study of 180 Catholic nuns and priests found that nearly half with mild cognitive impairment met pathologic criteria for Alzheimer's disease. Meanwhile, about a quarter had cerebral infarcts, indicating a possible 'reserve' capacity in the brain that prevents cognitive decline despite pathology.
Researchers at NYU School of Medicine discovered that glycyrrhizic acid can kill cells infected with Kaposi sarcoma-associated herpesvirus, triggering apoptosis in transformed B lymphocytes. This finding suggests a potential new treatment approach for latent viral infections.
A study of 676 individuals with PAD found that those with lower ABI levels had greater declines in walking endurance and speed. Leg symptoms, particularly pain on exertion, also predicted rates of functional decline.
A new study reveals that rural South Africa is facing a significant stroke crisis, with rates of disability comparable to those in developed countries. The prevalence of disabled stroke survivors has important implications for healthcare systems, highlighting the need for adapted care strategies and early treatment.
Researchers found African-Americans are two to four times more likely to undergo lower limb amputations, with higher rates among above-knee amputations. The study highlights the need for further investigation into underlying causes and public health initiatives to alleviate excess risk of limb loss.
Research suggests that high homocysteine levels are related to brain atrophy, with elderly individuals experiencing greater loss of brain cells and volume. Additionally, elevated homocysteine levels have been found to be associated with a higher risk of vascular disease in both healthy and Alzheimer's patients.
Researchers use MRI and magnetic resonance spectroscopy to detect Alzheimer's disease by measuring chemical markers in the brain. The study found that this technique can distinguish patients with Alzheimer's from those without the disease and identify patterns of damage consistent with the disease.
Researchers found that angiogenesis, the formation of new blood vessels, contributes to arthritic disease progression. Treatment with an integrin antagonist reduced joint swelling, pannus formation, and cartilage erosion in animal models.
Scientists have identified a correlation between activated CD44 and disease flare-ups in pediatric patients with lupus and rheumatoid arthritis. The study suggests that monitoring blood levels of activated CD44 may enable early prediction of exacerbations, potentially leading to improved treatment outcomes.
The American Urological Association's 93rd Annual Meeting featured groundbreaking research on prostate cancer, erectile dysfunction, and kidney diseases. Researchers presented studies showcasing the importance of PSA testing in African American men and the effectiveness of sildenafil in treating erectile dysfunction.
Fetal cells may be linked to an immune system reaction in women with systemic sclerosis, a form of scleroderma. The study found that 46% of women with the condition had male DNA in their blood and skin biopsies.
Researchers discovered a molecule, ERAB, that causes early neuron damage in Alzheimer's disease. The finding may lead to therapies that inhibit the interaction of ERAB and amyloid-B peptide, protecting neurons from damage.
A new study finds that first and second generation Japanese-American men living in Hawaii have a higher risk of Alzheimer's disease compared to European-ancestry Americans. The study also notes that rates of vascular dementia remain unchanged in this population.