Articles tagged with Host Pathogen Interactions
Scientists at the University of Michigan have developed a potential vaccine to prevent urinary tract infections, which affect 53% of women and 14% of men. The vaccine targets iron receptors on bacteria that cause infection, inducing an immune response in mucosal tissue.
A new study reveals that impaired axonal transport in neurons is a key factor in the development of prion diseases. The research shows that clinical symptoms correlate with reduced axonal transport in specific brain centers, providing new insights into the disease.
A subset of immune cells has been found to contribute to the development of severe malaria by suppressing the immune system and allowing parasites to grow uncontrollably. This discovery could lead to new drug targets and immunotherapies against malaria, as well as insights into other inflammatory diseases.
A recent study published in PLOS Pathogens has revealed that a majority of the global population has been infected with three recently discovered human polyomaviruses, including KIV, WU, and MCV. The study, which tested over 2,200 anonymous donor blood samples, found that infection with these viruses occurs early in childhood.
Researchers found that prior STD infections can lead to a genetic bottleneck in HIV transmission, allowing multiple viral variants to spread. The study suggests that the genital mucosa provides a natural barrier against infection, which can be compromised by inflammatory genital infections.
Researchers identified a prion protein characteristic unique to certain natural sheep scrapie cases, which may help study prion diversity and changes during cross-species transmission. The findings distinguish these isolates from bovine BSE cases.
Researchers analyzed fecal samples from 25 chimpanzee communities and found a range of SFV infection rates from 44% to 100%. The study highlights the importance of understanding cross-species infections in primates and their potential impact on human health.
New research reveals that coronavirus replication relies on the host's secretory pathway and disrupts the Golgi complex, a crucial cellular process. The study found that inhibiting this pathway can slow down or prevent viral infection.
Researchers identified Mfd as a key factor promoting fluoroquinolone resistance in Campylobacter. Eliminating Mfd from the bacteria resulted in a 100-fold reduction in antibiotic-resistant mutants.
A newly discovered arenavirus, Chapare virus, has been identified in a fatal hemorrhagic fever case in rural Bolivia. The virus produces clinical hemorrhagic symptoms similar to those associated with other New World arenaviruses, but genetically it is distinct from Junin, Machupo, Guanarito, and Sabia viruses.
Researchers identified a genetic variant associated with severe tuberculosis (TB) in Vietnam, highlighting the importance of studying host-pathogen interactions. The study suggests that understanding genetic susceptibility to infectious diseases may lead to more targeted treatments and vaccines.
A new study has identified four distinct biochemical subgroups in Creutzfeldt-Jakob disease, potentially representing different prion strains. These subgroups were found in both sporadic and iatrogenic cases of the disease, with no correlation to the prion protein gene.
The researchers have developed the first animal model of the chikungunya virus infection, which allows them to study the pathophysiology of the disease. The mouse model reveals that young age and inefficient type-I interferon signaling are risk factors for severe disease.
Researchers have reidentified the main cause of necrotic enteritis in chickens as Clostridium perfringens, producing extracellular toxins that attack the bird's intestines. The discovery of a new toxin, NetB, has led to hope for the development of effective vaccines within two years.
Researchers have developed new tools to understand HIV immune evasion. Vaccination timing significantly affects the rate of immune escape in macaques, suggesting ways to improve HIV vaccines.
Researchers found a key protein switch in Chikungunya Virus that allows it to infect and transmit through the Asian tiger mosquito, increasing its ability to spread to new locations. This mutation enables the virus to adapt to areas without typical vectors, posing a global health threat.
Virginia Bioinformatics Institute researcher receives USDA functional genomics grant to develop control of major soybean pathogen, with a focus on early stages of infection and whole genome approach. The project aims to understand the complex web of interactions between pathogens and plant genes.
The complete DNA sequence of Coxiella burnetii, the Q Fever microbe, has been deciphered, revealing information on its biology and ability to cause disease. Researchers found that the genome appears to be in the early stages of reduction, with numerous genes involved in virulence and interactions with its host.