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Long-term effect of home blood pressure self-monitoring plus medication self-titration for patients with hypertension

A secondary analysis of a randomized clinical trial found that home blood pressure self-monitoring plus medication self-titration reduces BP in the longer term without increasing healthcare use or adverse events. This simple, inexpensive intervention has potential to improve long-term hypertension control in routine clinical practice.

SourceJAMA Network·JournalJAMA Network Open·DateMay 10, 2024

Hourly heat exposure and acute ischemic stroke

A study of 82,000 patients found a strong association between hourly heat exposure and the onset of acute ischemic stroke. The findings suggest that high ambient temperatures may contribute to an increased risk of cerebrovascular events under global warming.

SourceJAMA Network·JournalJAMA Network Open·DateFeb 28, 2024

Time to treatment with intravenous thrombolysis before thrombectomy and functional outcomes in acute ischemic stroke

Intravenous thrombolysis (IVT) plus thrombectomy demonstrates significant benefits over thrombectomy alone when administered within a short timeframe after symptom onset. This study, based on individual participant data from six randomized clinical trials, found IVT before thrombectomy to be time-dependent and statistically significant.

SourceJAMA Network·JournalJAMA·DateFeb 7, 2024

Contrasting characteristics and outcomes of sports-related and non–sports-related traumatic brain injury

This study found that sports-related traumatic brain injuries (TBI) result in higher rates of functional limitations six months after injury. In contrast, patients with non-sports related TBI exhibit better mental health and post-concussion symptom recovery. The findings highlight the need for a more nuanced understanding of TBI outcomes.

SourceJAMA Network·JournalJAMA Network Open·DateJan 24, 2024

Perinatal depression and risk of suicidal behavior

Women with perinatal depression are at a heightened risk of suicidal behavior, particularly in the first year after diagnosis, with persistent elevations throughout 18 years of follow-up. The study emphasizes the need for vigilant clinical monitoring to support this vulnerable group.

SourceJAMA Network·JournalJAMA Network Open·DateJan 9, 2024

Revealing the landscape of software as a medical device industry

The study reveals a diverse landscape of software as a medical device (SaMD) with notable progress in artificial intelligence/machine learning-based devices, accounting for 22% of all FDA-approved SaMDs. Established companies focus on incremental innovations, while new entrants and start-ups drive disruptive innovation.

SourceTokyo Institute of Technology·JournalJournal of Medical Internet Research·TypeData/statistical analysis·DateDec 7, 2023

Study reveals gaps in fracture risk communication and patients’ preferences for visual representation

A new study has found that most patients with osteoporosis want to receive information on their fracture risk, but only half of them actually get it. Patients prefer visual representations, such as graphs with a colored traffic-light system, to communicate fracture risk and are more likely to take medication if presented in this way.

SourceInternational Osteoporosis Foundation·JournalOsteoporosis International·TypeExperimental study·DateNov 20, 2023

Decline in estimated glomerular filtration rate after dapagliflozin in heart failure with mildly reduced or preserved ejection fraction

Patients with heart failure treated with dapagliflozin experienced frequent initial estimated glomerular filtration rate declines, but without increased cardiovascular or kidney event risks. The study suggests that sodium-glucose cotransporter-2 inhibitors can be safely continued in patients experiencing eGFR decline.

SourceJAMA Network·JournalJAMA Cardiology·DateNov 12, 2023