Articles tagged with High Fat Diets
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Researchers at Joslin Diabetes Center found that gut microbes contribute to signs of negative feelings and brain chemistry in obese mice. Antibiotics reversed these behaviors, demonstrating a significant link between the microbiome and mental health outcomes.
Researchers at Oregon State University discovered that compounds derived from hops can improve glucose intolerance, insulin resistance, and sensitivity to leptin in people with metabolic syndrome. The findings suggest that these compounds may be a promising treatment option for the condition.
A study led by Georgia State University found that dietary fiber inulin prevented metabolic syndrome by restoring gut microbiota levels, increasing intestinal epithelial cell production, and regulating interleukin-22 expression. This study suggests that fermentable fibers like inulin may promote better health by suppressing obesity and...
A BYU study with mice reveals stress can alter gut microbiota to resemble a high-fat diet, potentially contributing to gender-specific health disparities. Researchers found distinct changes in female mice's digestive microorganisms upon exposure to stress.
A recent mouse study at UC Davis School of Veterinary Medicine reveals that a high fat, ketogenic diet increases median life span by 13% and improves quality of health in later life. The study also shows improvements in memory and motor function, as well as prevention of age-related markers of inflammation.
A new study by University of Missouri researchers found that physical activity changes diet preferences in male rats, but not female rats. The study suggests that environmental factors like exercise may influence how males and females eat.
Researchers found that early exercise can alter the way bones metabolize energy from food, reducing inflammation-linked genes. This 'bone memory' effect persists into mid-life, setting up a healthier response to high-fat diets.
Researchers found a molecular link between obesity, inflammation, and cardiovascular diseases. Targeting thrombin with dabigatran protected mice from diet-induced obesity-related disease.
Researchers find that a high-fat diet during pregnancy alters brain and endocrine system development in offspring, leading to anxiety and depression. A control group showed no such effects.
A new study found that exercise training had a different impact on body weight control in male and female rats fed a high fat diet. Male rats who exercised ate less food and gained less weight compared to sedentary males, while exercising female rats did not reduce their food intake. The research team believes chronic exercise may be i...
Scientists found that certain compounds produced by gut bacteria can predict how animals will respond to high-fat diets, including weight gain and tolerance to glucose. The study uses urine chemical signatures to identify individuals at risk of obesity and related health conditions.
A high-fat diet from childhood may increase sensitivity to dopamine later in adulthood, leading to increased reward-seeking behavior. The study found that male rats exhibited increased locomotor activity and dopamine cell activity after a high-fat diet exposure.
A new study finds that tamoxifen reduces food intake and prevents fat accumulation, insulin resistance, and fatty liver deposits in female mice fed a high-fat diet. Tamoxifen's protective effects are attributed to the activation of ER°-AF1, opening up possibilities for new therapies.
Researchers found that cinnamon supplements reduced belly fat, improved sugar and insulin levels, and increased antioxidant molecules in rats fed a high-fat diet. This suggests that cinnamon may mitigate the negative effects of a high-fat diet on cardiovascular health.
Researchers at Hiroshima University have identified a molecule, NPGL, that increases appetite during fasting and decreases it during gorging. This discovery suggests that the body has an evolved mechanism to maintain weight at a constant level, regardless of diet or energy intake.
Research suggests that vitamin A within a high-fat diet can negatively affect liver gene expression associated with glucose and fat metabolism. Rats fed with normal and deficient vitamin A levels showed significant differences in body mass, liver fat content, and insulin signaling pathways.
A new mouse study found that exposure to a high-fat diet in the womb and immediately after birth may increase offspring risk for nonalcoholic fatty liver disease later in life. The offspring of pregnant mice that consumed a high-fat diet developed liver fibrosis, a type of tissue scarring that is a sign of more serious disease.
Researchers have made significant discoveries on treating obesity and related health issues, including a potential new treatment for weight loss. A mouse study found that avoiding foods high in methionine may be as effective as long-term restriction in promoting weight loss and improving blood sugar levels. Additionally, studies sugges...
A mouse experiment revealed that hydroxytyrosol, a compound found in extra-virgin olive oil, can reverse markers of insulin resistance and non-alcoholic fatty liver disease. The study showed that hydroxytyrosol exerts a protective effect in the liver by improving enzyme activity and fatty acid composition.
Researchers discovered that vitamin D deficiency contributes to metabolic syndrome progression in mice by disrupting gut bacteria balance. Vitamin D supplementation improves metabolic syndrome outcomes by recovering gut bacteria balance and reducing blood sugar levels.
A recent study published by the American Chemical Society found that red cabbage microgreens can help lower LDL, or 'bad', cholesterol and liver triglyceride levels in mice on high-fat diets. The microgreens contained more polyphenols and glucosinolates than mature red cabbage, making them a promising source of health benefits.
A new study found that sweet potato peptide, produced from the water wasted during processing, helps reduce body weight and fat levels in mice fed high-fat diets. The peptide activates appetite suppression and controls lipid metabolism, suggesting a potential slimming effect.
A small molecule could provide a new therapeutic approach to fighting excessive weight gain in cases where diets or exercise have no effect. The research team found that blocking a specific protein promotes gene expression of the protein that burns calories and prevents fat gain.
Researchers identify Adamts1 as a key regulator of fat cell differentiation, triggered by high-fat diets and stress hormones. The hormone's production affects fat storage in different parts of the body, with implications for obesity treatment.
Scientists have discovered that the Rap1 gene plays a crucial role in energy balance and that its inhibition can restore sensitivity to leptin, a hormone that regulates appetite and body weight. The study suggests that targeting Rap1 may be a potential therapeutic approach for treating human obesity.
A study has discovered a new mechanism in the mouse brain that regulates obesity, finding that Rap1 gene inhibition can reduce body weight and improve leptin sensitivity, potentially leading to a new therapeutic target for treating human obesity.
Research suggests that mango supplementation can prevent the loss of beneficial gut bacteria often induced by a high-fat diet. This is achieved through the regulation of gut bacteria in favor of Bifidobacteria and Akkermansia, as well as enhanced short-chain fatty acid production.
A study published in the Journal of Physiology found that fish oil pills can prevent and counter the negative effects of a high-fat diet. Mice fed fish oil had lower body fat and improved insulin resistance compared to those on a high-fat diet.
A study published by the American Chemical Society found that citrus flavanones, a type of antioxidant, can reduce oxidative stress and inflammation caused by high-fat diets. This reduction leads to lower levels of cell-damage markers in the blood and liver, as well as reduced fat accumulation and damage in the liver.
A Buck Institute study found a key protein involved in nutrient sensing differs between male and female mice, impacting diabetes risk. Boosting this protein reduces obesity and insulin resistance in male mice.
A high fat diet and increased body weight do not impair but may even accelerate cartilage repair in a mouse model. The study's findings suggest that the mechanism behind this phenomenon is related to inflammatory and metabolic changes.
Researchers aim to create more small, energy-burning fat cells that enable the body to use fat as fuel rather than store it as unhealthy padding. By studying the protein HDAC9, they hope to develop new treatments for obesity-related diseases like diabetes and cardiovascular disease.
Researchers found that chronic high fat diet disturbs neural messages in rats by shifting gut bacteria populations. Manipulating the gut microbiome can reverse this effect, leading to less overeating and weight gain. Additionally, specific foods like blueberries may also target and improve the microbiota composition.
A study in mice lacking the proinflammatory signaling molecule TAK1 demonstrates protection against diet-induced obesity and insulin resistance. The removal of TAK1 from mice fed a high fat diet prevented additional weight gain and improved glucose tolerance.
Research suggests mango's anti-obesity, anti-cancer, anti-inflammatory, and intestinal health roles. Studies in mice and humans reveal potential benefits of mango consumption on body composition, glucose homeostasis, and gut inflammatory markers.
Two laboratory studies found that grape polyphenols reduced body fat, improved gut barrier function and increased beneficial bacteria in mice fed high-fat diets.
A study found that a variant of the p53 tumor suppressor gene is linked to obesity and type 2 diabetes, with mice carrying the variant showing increased weight gain and glucose intolerance. The research suggests that the variant may have evolved in colder climates to promote energy storage, but its modern-day implications are negative.
A high-fat diet drives a population boom of intestinal stem cells and generates a pool of other cells that behave like stem cells, leading to an increase in tumor formation. The researchers found that the high-fat diet changes the biology of both stem cells and non-stem-cell populations, ultimately resulting in more tumors.
Researchers found that a high-fat diet drives an increase in intestinal stem cells and stem-like cells, which can give rise to tumors. The diet also activates a nutrient-sensing pathway that promotes cell growth and mutations leading to cancer.
A high-fat diet drives a population boom of intestinal stem cells and generates a pool of 'stem-like' cells that can give rise to tumors. The study suggests a link between high-fat diets and increased colon cancer risk by altering the function of intestinal stem cells.
A Yale team discovered that a high-fat diet can disrupt pathways involved in synaptic plasticity and metabolism, leading to depression-like symptoms. Ketamine reverses these effects, suggesting a potential solution for treating depression associated with metabolic disorders.
Researchers at University of Cincinnati discovered that a high-fat diet causes dysfunction in red blood cells, which can lead to the development of cardiovascular disease. The study found that red blood cells play a key role in fueling adipose tissue inflammation and promoting atherosclerosis.
A new mouse study reveals that high-fat diets can lead to anxiety and depressive symptoms, as well as measurable brain changes. The study also found that completely reversing the diet improved metabolic impairments and reduced anxious symptoms.
Researchers found that high-fat diets impair stomach receptors that signal fullness, leading to delayed feelings of satisfaction and increased food consumption. The study suggests that capsaicin in hot chillies may prevent overeating through its action on these nerves.
Research from Tufts University reveals that hyperlipidemia, high cholesterol and high triglycerides, accelerates heart-transplant rejection in mice. The studies, published online in the American Journal of Transplantation, found that mice fed a high-fat diet rejected their transplants faster than those on a lower-fat diet.
A recent study by Virginia Tech researchers found that the body's muscle begins to process nutrients differently after just five days of a high-fat diet. This change can have dire consequences on the rest of the body and may lead to the development of diabetes and other diseases.
Research by Penn State College of Medicine found that maternal high-fat diets during pregnancy and lactation may prime offspring for weight gain and obesity. Neural activity involved in energy balance and appetite regulation was compromised, suggesting a link between maternal diet and obesity later in life.
A molecule found in some plants, 7,8-DHF, has been shown to mimic the effects of a growth factor induced by exercise in female mice. It increases energy expenditure without suppressing appetite, helping them maintain a healthy weight on a high-fat diet. In contrast, male mice still develop obesity and diabetes.
A new study suggests that reversing brain inflammation caused by a high-fat diet greatly improves symptoms related to obesity and type II diabetes. Administering butein to obese mice improved glucose tolerance and brain insulin signalling, even at lower doses compared to non-treated mice.
Research reveals that high-fat diets and maternal obesity during pregnancy compromise the blood-forming stem cell system in the developing fetus. This may contribute to the rise in immune diseases and allergic dispositions in children. The study provides a model for testing whether dietary interventions can repair the damage.
Wild blueberries (bilberries) have been shown to mitigate the negative effects of a high-fat diet on blood pressure and nutrition-derived inflammatory responses. The study found that bilberries reduced pro-inflammatory effects, prevented elevated blood pressure, and improved glucose tolerance in mice fed a high-fat diet.
Researchers at Salk Institute discover that confining caloric consumption to an 8- to 12-hour period can significantly reduce weight gain, improve body composition, and even reverse obesity and diabetes in mice. The study's findings add to mounting evidence highlighting the importance of time-restricted eating for overall health.
Researchers at the University of Copenhagen found that a high-fat diet can postpone signs of brain aging in mice with a defective DNA repair system. This could lead to new treatment possibilities for children with Cockayne syndrome and patients with Alzheimer's and Parkinson's disease.
A new study in mice found that male and female brains respond to high-fat diets in remarkably different ways, with males experiencing greater inflammation and reduced cardiac function. The findings suggest that dietary advice should be made more sex-specific, with women allowed occasional high-fat meals and men advised to avoid them.
Researchers have found that high-fat diets can lead to brain inflammation and heart disease in male laboratory mice but not in female counterparts. The study suggests sex-specific nutritional guidance is needed for effective obesity treatment.
A study found that a type of gut bacteria called Clostridium ramosum promotes obesity in mice, particularly when fed a high-fat diet. The bacteria appears to improve nutrient uptake, leading to increased energy conversion and weight gain.
Research suggests that a high-fat diet can accelerate neurological symptoms in mice genetically predisposed to Parkinson's disease. This diet also causes damage in the brain and affects glucose and insulin regulation.
New research found an epigenetic link between a mother's diet and an offspring's risk of future obesity. Excess methylation on the Pomc gene blocks its expression, leading to delayed satiety response and increased food intake.
Researchers found that PPARγ activity in pro-opiomelanocortin neurons is crucial for whole-body energy balance and glucose metabolism. Mice lacking PPARγ in these neurons gained less weight and had improved glucose levels when fed a high-fat diet.
A Vanderbilt study finds that bacteria produce a therapeutic compound that inhibits weight gain, insulin resistance, and other adverse effects of a high-fat diet in mice. The researchers genetically modified E. coli to produce NAPE, which reduces food intake and weight gain, suggesting a potential new treatment for obesity.