Articles tagged with High Fat Diets
A recent study in fruit flies discovered a molecular connection between obesity and heart disease, with the protein TOR playing a key role. Researchers found that manipulating TOR protected the hearts of obese flies from damage caused by high-fat diets.
Researchers found a significant link between paternal weight, diet, and an increased risk of diabetes in offspring through epigenetic changes. The study, published in Nature, showed that high-fat diets in fathers can 'program' metabolic disease in their children.
A high-fat diet causes brain cells to become insulated, rendering them unable to detect signals of fullness. The insulation also creates a further complication in that the body is unable to detect signals to increase energy use and burn off calories.
Research at Michigan State University's Breast Cancer and the Environment Research Center found that a high-fat diet during puberty can lead to inflammation in the mammary glands, promoting breast cancer growth. The study suggests that this link may be independent of obesity.
A high-fat diet is found to activate nuclear factor kappa B (NF-κB) in the prostate, leading to inflammation, oxidative stress, and proliferation. The study provides direct evidence of a link between a high-fat diet and an increased risk of benign prostatic hyperplasia, prostatitis, and prostate cancer.
Animal research suggests that a high-fat diet consumed by nursing mothers increases the risk of obesity and pre-diabetes in their offspring. In contrast, consuming a high-fat diet during pregnancy only reduces the risk of obesity when combined with postnatal breastfeeding on a low-fat diet.
A high-fat diet is associated with reduced dopamine release and reuptake in the striatum of rats. This change in brain neurochemistry affects motivation and willingness to work for food reward, mirroring effects seen in humans with obesity.
Research suggests that a pregnant mother's diet can interact with her child's genetic predispositions to affect the type or severity of birth defects, including congenital heart disease. A high-fat diet has been shown to increase the risk of this condition in mice offspring, highlighting the importance of a balanced diet during pregnancy.
Researchers found that mice lacking the FIH protein process fat differently, resulting in improved health outcomes on a high-fat diet. The lean mice exhibit enhanced insulin sensitivity and lower cholesterol levels compared to their normal littermates.
A new study by Dr. Steven Hunter found that low-carbohydrate high-fat diets do not lead to greater weight loss and increase cardiovascular disease risks. The research highlights the potential dangers of these diets for people at risk of Type 2 diabetes and obesity.
Researchers at UT Southwestern Medical Center have found that the brain plays a vital role in mediating resveratrol's anti-diabetic actions. When injected into the brain, resveratrol alleviated inflammation and activated sirtuin proteins, which may help prevent diet-induced diabetes.
A high-fat diet impairs muscle health in adolescents with pre-diabetes, leading to initial adaptations but ultimately decreased ability to use fat or glucose as fuel. The study suggests early therapeutic interventions are needed to prevent long-term functional impairment.
A controversy surrounds Sweden's promotion of low-carb high-fat (LCHF) diets, sparking concern over national public health and individual well-being. Despite scientific evidence, a group of experts was removed from the Swedish National Board of Health and Welfare due to perceived conflicts of interest.
Rats fed high-fat diets for four days showed decreased muscle oxygen use, increased heart size, and impaired maze completion. After nine days, they made more mistakes and took longer to complete tasks compared to those on a low-fat diet.
Rats fed a high-fat diet showed reduced physical endurance and cognitive decline after nine days. They were able to run only 50% as far on a treadmill as those on a low-fat diet.
Researchers found that curcumin, a compound in turmeric, suppresses angiogenic activity in mice fed high-fat diets, leading to reduced fat tissue growth and lower blood cholesterol levels. The study suggests potential benefits for preventing fat tissue growth in humans.
A specific gene called protein kinase C beta (PKC beta) plays a crucial role in the weight-gain response to a high-fat diet. Mice genetically engineered to lack PKC beta showed minimal health effects and resisted fat-induced obesity, insulin resistance, and liver damage. The study suggests that blocking this gene could be a therapeutic...
A study by University of Cincinnati researchers found that high-fat diets can cause inflammation in fat tissue surrounding blood vessels, potentially leading to cardiovascular disease. The study suggests a direct link between poor dietary habits and inflammation of blood vessels, independent of weight gain or cholesterol levels.
A gene variant that protects against weight gain and insulin resistance becomes a bad actor on high-fat diets, new research suggests. Mice with the Ala12 variant show improved insulin sensitivity and better plasma lipid profiles on balanced diets but worsen these outcomes when fed a diet high in fat.
A high-fat diet can affect circadian rhythms, leading to hormone imbalance, obesity, psychological disorders, and cancer. Fasting and a low-fat diet regulate adiponectin signaling pathways, while a high-fat diet disrupts these pathways, contributing to metabolic disorders.
Research published in The FASEB Journal found that a mother's high-fat diet during pregnancy can lead to oversized offspring and an increased risk of obesity in children. This is because fat causes the placenta to produce excessive nutrients for the fetus.
A new study found that exposing fetal mice to high saturated fats can cause them and their offspring to develop type 2 diabetes. This unusual form of inheritance, known as metabolic programming, has implications for human health, particularly for children born to malnourished mothers.
A study published by The Endocrine Society found that a mother's prenatal diet high in fat can lead to an early onset of puberty in her child, increasing the risk of adulthood obesity. The research also showed alterations in sex hormones and higher body fat levels in adult offspring.
A Northwestern University study found that a high-fat diet disrupts the body's internal clock, causing animals to eat during their natural rest periods. The study suggests that this disruption can lead to negative effects on metabolism and increase the risk of obesity and diabetes.
Researchers found that high-fat diets can shift mice's activity patterns, causing them to eat more during the day and altering molecular components of the circadian clock. The study suggests that metabolic processes, like nutrient status, may influence the internal body clock.
Researchers found that a high-fat diet decreases regulatory T cells in the liver, leading to inflammation and increased susceptibility to liver injury. Switching to a normal diet reverses this effect.
Researchers found that mice without CD38 were protected from high-fat diet-induced obesity and glucose intolerance. The study suggests that a CD38 deficiency has a protective effect against obesity, highlighting the importance of genes in regulating body weight.
A study by University of Virginia researchers found that mice lacking the Nocturnin gene were resistant to weight gain on a high-fat diet and had normal liver fat levels. This discovery may lead to new treatments for inhibiting obesity and its effects on health.
Research from Oregon Health & Science University reveals that children born to overeating mothers are at risk for liver and pancreas damage, contributing to early-onset obesity and diabetes. Brain changes in the hypothalamus also occur, predisposing them to weight problems.
Researchers genetically engineered mice to overexpress a protein that regulates fat storage, finding they remained lean despite consuming an equally high-fat diet. The study suggests potential therapeutic strategies for obesity and insulin resistance.
Researchers found that exposure to fine particle air pollution and a high-fat diet together contribute to the development of atherosclerosis in laboratory mice. The study suggests that even low concentrations of air pollution may accelerate the progression of atherosclerosis, particularly among those with risk factors.
Researchers found that air pollution can cause atherosclerosis, the hardening of arteries, when combined with a high-fat diet. Mice exposed to polluted air developed more plaque and high blood pressure, indicating a clear cause-and-effect relationship between PM2.5 exposure and cardiovascular disease.
A study by Dr. Mihai Covasa and colleagues found that a high-fat diet can reduce the body's sensitivity to cholecystokinin, a hormone that helps regulate appetite, in rats. This reduced sensitivity leads to increased overconsumption of highly palatable foods high in dietary fat.
Recent animal studies suggest that high-fat diets can impair memory and cognitive function, increasing the risk of age-related cognitive impairment. Diets rich in saturated fats and sugar may worsen cognitive losses due to stress and sleep apnea.
Researchers found that removing a key molecule called beta3 increased lung inflammation and clogged arteries in fat-fed mice. The study suggests that long-term suppression of this molecule may actually exacerbate heart disease.
A study on infant rats suggests that high-fat diets and increased production of uncoupling protein 2 (UCP2) may protect the newborn brain from seizure-induced cell injury. The ketogenic high-fat diet is shown to work in human children to prevent or reduce seizures, sparking new research into its potential benefits.
Researchers found that high-fat diets lead to an accumulation of lithocholic acid, a toxic compound produced when the body processes cholesterol. The vitamin D receptor plays a crucial role in eliminating this acid, which may help prevent colon cancer. However, excessive vitamin D intake can cause other health issues.
Researchers found that certain genes in blood vessels produce a protective protein called HO-1, which inhibits atherosclerosis. This discovery provides new leads for treating and preventing heart disease by targeting these genetic pathways.
A study found that genetic variations can cause individuals to be more resistant to a cholesterol-lowering diet or at greater cardiovascular risk from a high-fat diet. Apolipoprotein B gene polymorphisms were associated with increased plasma total cholesterol concentrations in certain genotypes.
A new study published in UB's School of Health Related Professions found that female collegiate soccer players performed longer at a higher intensity on a diet composed of 35% fat than on lower-fat diets. The women showed no increase in weight, body fat, or blood pressure despite consuming a higher amount of fat.