Articles tagged with High Fat Diets
A new study found that 12% of Americans are responsible for eating half of all beef consumed on a given day. The study analyzed data from the CDC's National Health and Nutrition Examination Survey and found that these individuals, mostly men or those between 50-65 years old, eat disproportionately large amounts of beef.
Researchers at the Salk Institute discovered that high-fat diets change gut bacteria and bile acids, leading to inflammation and affecting intestinal stem cell replenishment. The altered bile acids cause inflammation and increase cancer risk in mice.
A recent study led by Dr. Itamar Harel reveals that manipulating AMP biosynthesis can extend lifespan and promote metabolic health in vertebrates. The research used the turquoise killifish as a model organism and found remarkable effects on energy metabolism, including a fasting-like profile and enhanced resistance to high-fat diets.
Researchers investigated hepatic hydrogen sulfide production in a mouse model of Hutchinson-Gilford Progeria Syndrome (HGPS) and found reduced H2S levels in RC-fed mice, with partial rescue on high-fat diet. This study suggests that accelerated aging in HGPS may be partially explained by reduced hepatic H2S levels.
A new study reveals that neurons expressing steroidogenic factor 1 (SF1) influence inflammation in white and brown adipose tissue. SF1 neurons help suppress inflammatory responses in inguinal WAT, but not in epididymal WAT, and activate thermogenic activity in BAT.
Researchers have developed a simple blood test that can diagnose De Vivo disease, a rare and disabling neurological disorder. The test, called METAglut1, has a high sensitivity and specificity, allowing for accurate diagnosis in a short amount of time.
A study published in Scientific Reports found that rats exposed to high-fat diets during pregnancy and early life developed a preference for salty taste. This preference was linked to increased levels of AT1 protein in the taste buds, which can lead to higher sodium intake and potentially contribute to obesity and diet-linked diseases.
A study published in Nature Communications found that removing the SAPS3-inhibiting component frees AMPK to activate, allowing mice to maintain normal weight and avoid obesity. The discovery could lead to a new approach for treating metabolic disorders such as obesity, diabetes, and fatty liver disease.
A study found that time-restricted feeding improves muscle performance in obese fruit flies by upregulating genes related to glycine production and utilization. This approach may provide a natural alternative therapy for managing obesity-related pathologies.
Pregnant women who fast during Ramadan tend to give birth to babies with lower weights. However, this effect is reduced in women consuming a high-fat diet outside of fasting hours, according to new research.
A high-fat diet allows the immune system to eliminate a parasitic worm that causes long-lasting infections in the large intestine. This discovery may lead to new treatments for millions suffering from intestinal parasitic infections worldwide.
Researchers found that clearance of p16Ink4a-positive cells did not impact β-cell mass, but improved β-cell function and proliferative capacity in a subset of HFD mice. The targeted subpopulation of β-cells is non-proliferative and non-SASP producing.
Females with more subcutaneous fat are protected against brain inflammation, a risk factor for dementia and stroke. Removing subcutaneous fat increases brain inflammation in females, even on low-fat diets.
Researchers found that excess fat triggers immune cells to overeat serotonin in the brain of developing male mice, leading to depression-like behavior. Female mice are not affected in the same way, with higher levels of oxytocin linked to social withdrawal.
A new study in mice suggests that a short-term high-fat diet can induce hyperalgesic priming and allodynia, even in the absence of injury or preexisting conditions like obesity or diabetes. Researchers found that palmitic acid, a type of saturated fatty acid, binds to nerve cells, causing inflammation and mimicking injury to neurons.
Researchers discovered that a ketogenic diet high in saturated fats can reprogram the mouse immune system, making it better at fighting off infections but more susceptible to systemic inflammatory conditions. The study also found that another type of fat, oleic acid, may be able to counteract the harmful effects of palmitic acid.
Researchers at Tulane University have discovered that following a low-carbohydrate diet can lead to reduced hemoglobin A1c levels and improved fasting glucose levels among individuals with unmedicated diabetes and prediabetes. The study suggests that a low-carb diet may be a useful approach for preventing and treating Type 2 diabetes.
A new study in mice has mapped the cells, genes, and pathways that respond to exercise and diet, offering potential targets for drugs that mimic exercise's benefits. Exercise was found to push these systems in the opposite direction of high-fat diets.
Researchers found that knocking out TXNIP in alpha cells improves diabetes-associated hyperglycemia and hyperglucagonemia. This discovery suggests a new potential treatment for Type 1 diabetes.
A new study from St. Michael's Hospital found that a low-carb vegan diet has the same health effects as a vegetarian diet, but at a much lower cost to the environment. The researchers also discovered that the lower carbon emission value of the vegan diet was associated with a larger reduction in blood cholesterol.
A study found that high-fat diets fuel the creation of inflammatory immune cells in mouse bone marrow. These cells can later invade fat tissue, leading to insulin resistance and other complications associated with obesity. The bone marrow's sensitivity to environmental changes plays a crucial role in this process.
Studies investigate lifestyle interventions to achieve nutritional ketosis and its impact on chronic illness, sleep, and cardiovascular disease in the military. Researchers aim to understand how ketogenic diet, ketone-based beverages, and their effects on clinical outcomes will benefit soldiers' health.
Recent studies show that grape consumption can reduce fatty liver and extend lifespans, with Dr. John Pezzuto's team finding changes in genetic expression and antioxidant genes in mice. Adding grapes to a high-fat diet also had positive effects on behavior and cognition.
Research found that acidic activated charcoal from Shinshu Ina's specialty Akamatsu tree suppresses weight gain due to a high-fat diet by increasing bile acid, cholesterol, triglyceride, and fatty acid excretion. No damage to the gastrointestinal mucosa or lungs was observed.
A long-term high-fat diet has been shown to cause significant weight gain and metabolic disorders in mice, leading to anxiety, depression, and worsening Alzheimer's disease. The study suggests a clear link between chronic obesity and diabetes with cognitive decline.
Researchers discovered that porous cell membrane formation allows cancer-inducing proteins to escape and promote tumor growth in nonalcoholic steatohepatitis-associated liver cancer. The release of IL-33 and IL-1β from senescent hepatic stellate cells accelerates cancer development by suppressing anti-tumor immunity.
A high-fat diet can lead to increased fructose metabolism in the small intestine, resulting in the release of glycerate into circulation. This can cause damage to insulin-producing pancreatic beta cells, increasing the risk of glucose tolerance disorders and Type 2 diabetes mellitus.
A study found that high fat diets and synthetic substances in unregulated athletic performance enhancers can activate a receptor accelerating the progression of pre-cancerous lesions to pancreatic cancer in mice. Limiting exposure to these substances may help prevent pancreatic cancer development.
Virginia Tech scientists led by Sora Shin are investigating the brain pathways responsible for high-fat diet overconsumption. The study aims to identify a framework for understanding how leptin-responsive circuits respond to food exposure and increase the risk of emotional overeating after abstinence.
Researchers linked dietary cholesterol to exacerbation of viral infections in mice, showing that high levels of cholesterol made mice sicker when infected with influenza. The study found that dietary cholesterol increased the number of cytokine-producing immune cells in the lungs, contributing to excessive inflammation.
Researchers at the Beckman Institute found a direct link between high-fat diets and heightened nitric oxide levels, which can lead to increased risk of inflammation and cancer development. The study used a molecular probe to visualize changes in the tumor microenvironment.
Researchers investigate how enzymes regulate metabolism, weight gain, and liver disease, revealing diet's significant role in obesity and altered lipid profiles. The study also shows that age affects metabolic processes, leading to weight gain, increased fat storage, and unhealthy liver changes.
A novel therapy using sustained release of nitric oxide has been shown to ameliorate obesity and Type 2 diabetes in mice fed a high-fat diet. The therapy was found to decrease body weight, improve glucose tolerance, and stimulate the browning of adipose tissue.
Researchers at Shibaura Institute of Technology discovered that tocotrienols, a subtype of vitamin E, can lower body weight, reduce white adipose tissue, and protect the liver in mice fed with a high-fat diet. The study suggests a potential compound to prevent obesity and its secondary diseases.
A new study from Northwestern University found that once-weekly prednisone treatment improved exercise endurance, increased lean body mass, and reduced weight in obese mice. The treatment also promoted nutrient uptake into muscles and increased adiponectin levels, a hormone that helps protect against diabetes and insulin resistance.
Researchers from NTU Singapore and Waseda University found that fermented soybean waste improves fat metabolism and mitigates the effects of diet-induced obesity. The study, published in Metabolites, showed that mice fed fermented okara gained less body mass and had lower levels of fat and cholesterol.
A study led by Dr. Cubas found that regular nut consumption is associated with a lower prevalence of abdominal obesity and metabolic syndrome in elderly people in northern Spain. The research, published in International Journal of Environmental Research and Public Health, involved 556 participants aged 65-79 years.
A new study reveals that a high-sugar and high-fat diet can disrupt the natural adaptation of the digestive system by accelerating the division and differentiation of intestinal stem cells. This can lead to an increased risk of obesity, type 2 diabetes, and gastrointestinal cancer.
Research suggests that obesity triggers inflammation, leading to an increase in myeloid-derived suppressor cells, which break down bone tissue. This can result in gum disease and tooth loss. The study found a significant link between high-fat diets and increased osteoclasts and alveolar bone destruction.
Researchers found that regular cycles of a fasting-mimicking diet in mice helped counteract the negative effects of a high-fat, high-calorie diet. The study suggests that this diet may have potential as 'medicine' to prevent obesity and heart disease.
A team of researchers simulated the loss of physical activity during COVID19 lockdowns to study its effects on metabolism. They found that mice's energy sources shifted based on their diet composition after a sharp decline in exercise, leading to weight gain.
A high-fat diet increases the incidence of colorectal cancer by suppressing MHC-II levels in intestinal cells. This disruption allows cancer cells to grow unchecked. Researchers hope that reconfiguring the gut microbiome and boosting immune recognition molecules can help combat cancer.
The study found that store-wide confectionery sales decreased and fruit and vegetable sales increased when unhealthy products were removed from checkouts and aisles, resulting in nearly 10,000 extra portions of fruit and vegetables being sold weekly.
Researchers found that high-fat diets disrupt the body clock's satiety control, leading to overeating and obesity in rats. The study suggests that restoring the proper functioning of the body clock may help tackle obesity.
A high-fat diet causes inflammation and damages intestinal epithelial cells, leading to the growth of harmful microbes and increased production of trimethylamine-N-oxide, a metabolite associated with cardiovascular disease. Researchers found that restoring intestinal function with a drug can blunt this effect.
A team of University of California, Irvine scientists discovered a novel pharmacological approach to attenuate mitochondrial dysfunction that drives diet-induced obesity. They found that a small molecule, SH-BC-893, can correct metabolic disease even when mice continue to consume an unhealthy Western diet.
Scientists discovered beige fat cells mediate subcutaneous fat's brain protection and provide anti-inflammatory effects. Beige fat transplantation restored cognitive function in obese mice with dementia-like behavior.
A new study has identified key pathways linking high-fat diets to atherosclerosis in mice, shedding light on the role of neutrophils and citrullination in inflammation. Researchers found that blocking this process could lead to reduced neutrophil adhesion and potentially prevent blocked arteries.
Research by Oregon State University suggests that compounds xanthohumol and tetrahydroxanthohumol can mitigate diet-induced accumulation of fat in the liver. The compounds act as antagonists for PPARγ, reducing fat storage and inflammation in the liver.
A study published in Nature found that altering eating habits or disrupting the circadian clock can lead to depletion of healthy fat cells, causing defects in fat storage and excess lipid spilling into organs. This disruption may be difficult to reverse, increasing the risk of Type 2 diabetes and insulin resistance.
A new Arizona State University study has shown that high fat diets can trigger a molecular cascade of events leading to colon cancer through intestinal stem cells. The research found that PPARs, specifically PPAR delta and alpha, play a crucial role in elevating cancer risk by stimulating the metabolism of fats.
Researchers at Karolinska Institutet found that reducing apolipoprotein CIII levels can protect against high-fat diet-induced obesity, insulin resistance and liver damage. The study showed that a treatment targeting apoCIII reversed metabolic derangements in mice.
A high fat diet has been found to activate a response in the heart that leads to destructive growth and increased risk of heart attacks. The research, published in Biochemical and Biophysical Research Communications, found that mice fed a high fat diet had twice the amount of oxidative stress on their heart cells.
A high-fat diet impairs immune cell function inside tumors, reducing their antitumor activity. Blocking metabolic rewiring in cancer cells enhances anti-tumor immunity and improves immunotherapies.
Researchers found that triclosan disrupts metabolism and the gut microbiome, leading to accelerated development of fatty liver and fibrosis. The study provides new insights into risk factors for non-alcoholic fatty liver disease (NAFLD) in humans.
A mother's high-fat diet during pregnancy may alter the taste buds of her offspring, leading to a greater attraction to unhealthy food and obesity in adulthood. The study found that adult progeny fed with such a diet had more sweet-taste receptors inside their taste buds.
A high-fat diet combined with antibiotic use significantly increases the risk of developing pre-IBD. The study suggests that this combination disrupts mitochondria in cells of the large intestinal lining, leading to gut inflammation and a vicious cycle of replacing good bacteria with harmful microbes.
A new study published in Cell Metabolism found that disulfiram, normally used to treat alcohol use disorder, can help obese mice normalize their body weight and reverse metabolic damage. The drug's anti-inflammatory properties are believed to be key to its beneficial effects.
A new study from the University of Copenhagen suggests that transplanted intestinal contents could be effective against obesity and type 2 diabetes. Researchers found that obese mice with unhealthy lifestyles gained significantly less weight and avoided type 2 diabetes when they received viruses transplanted from the stool of lean mice.
Researchers found that high-fat diets caused impaired cognitive function in obese rats, affecting their mental exhaustion. The study, published in The FASEB Journal, suggests a link between excess weight and compromised cognitive abilities.