Articles tagged with Human Physiology
Researchers discovered that chemotherapy drugs can affect protein synthesis in muscle cells, even at low doses. This finding has significant implications for cancer treatment and exercise rehabilitation programs, suggesting that even non-oxidative stress effects of chemotherapy should be considered.
The Zinc Status Index is a new evaluation method developed by Cornell food scientists that uses biomarkers to calculate the physiological status of a subject. It aims to provide a comprehensive assessment tool for zinc deficiency, which affects over 1 billion people worldwide.
Researchers found that when mothers and children are coordinated at the behavioral level, their physiological activity follows the mother's. The study highlights the importance of tuning in to a child's cues and being responsive to their behaviors during playtime.
Researchers studied the effects of isolation on human psychology, physiology, and team dynamics in a simulated off-world colony. The study found that crews' communication with mission control diminished over time, causing initial friction but eventually leading to increased cohesion despite cultural and personal differences.
Lactate sensors in wearables aim to monitor athletes' exertion levels, but the connection between sweat and blood lactate remains unclear. Researchers propose improvements to electrochemical sensors and develop an epidermal patch containing a lactate biosensor.
A study by José María Martín-Olalla suggests that cancelling daylight saving time could result in increased early morning activity in winter, negatively impacting human health. This is due to the UK's alignment with sunrise during winter mornings, which has helped regulate daily activity.
Researchers found that females rely more heavily on aldosterone to regulate blood pressure, whereas males primarily use angiotensin II. This discovery could lead to targeted treatments for female hypertensive patients, improving treatment outcomes and reducing the risk of heart disease and stroke.
A new study identifies 13 genes as key factors in shaping physical fitness through various forms of exercise. Genetic differences account for up to 72% of the variation in muscle strength improvements.
A new study found that urban heat exposure has tripled worldwide since the 1980s, affecting nearly a quarter of the global population. The study revealed that city dwellers are exposed to extreme heat and humidity for more person-days, with 1.7 billion people affected on multiple days.
A study by Brazilian researchers warns of extreme heat risks in northern Brazil due to savannization and climate change, posing a threat to human health and productivity. Approximately 12 million people may be exposed to extreme risk of heat stress by 2100, with severe economic implications.
A recent study published at Masonic Medical Research Institute found that electrocution-induced physiological stress can lead to overlapping cardiac conditions in individuals. The research used human induced pluripotent stem cells to investigate the mechanisms behind these conditions, shedding light on potential new treatments.
Researchers found that UVB phototherapy increases levels of romantic passion and aggression in both men and women. Exposure to sunlight affects the endocrine system's regulation of sexual hormones.
University of South Australia researchers create a computer vision system to detect premature babies' faces and vital signs from digital cameras, outperforming electrocardiogram machines. The technology has the potential to replace contact-based sensors, reducing skin tearing and infections.
Researchers found that consuming dileucine enhances the metabolic processes driving muscle growth, resulting in a 42% increase in protein synthesis. In contrast, leucine alone showed no significant impact on protein breakdown, highlighting the molecule's potential as a signaling agent for muscle-building pathways.
A new biomarker, HBcrAg, has been found to accurately predict viral load in patients with chronic hepatitis B and reflect response to anti-viral treatments. This discovery may lead to improved monitoring methods for CHB, enabling clinical decisions and potentially improving patient outcomes.
Researchers at Saint Petersburg Electrotechnical University LETI developed a high-precision instrumental method to measure rapid temperature fluctuations of human skin. This allows for non-invasive monitoring of blood flow and assessment of microcirculation disorders.
Researchers from Gero and Roswell Park Comprehensive Cancer Center discovered that biological age is changing over time, leading to reduced resilience. As people age, it takes longer to recover from stresses, and chronic diseases are linked to loss of resilience.
Researchers developed cardioids, human self-organizing cardiac organoids that recapitulate heart chamber formation and function. The model reveals how signaling and transcription factors control cardioid chamber formation and triggers an in vivo-like accumulation of extracellular matrix proteins after injury.
The study provides global and country-level estimates of humans living at high altitude, with 81.6 million people found to live above 2,500m. This data is crucial for understanding the impact of life at high altitude on human physiology, adaptation, health, and disease.
Researchers at Hebrew University have developed human-on-a-chip technology that allows for real-time monitoring of drug treatments in humans. The technology has the potential to significantly reduce testing and production time for drugs, saving time, money, and unnecessary suffering.
Researchers at Simon Fraser University are developing robots that can measure essential healthcare information, such as physiological signals and oxygen levels. The robots aim to support remote healthcare tasks and may potentially interact with patients, process data, and prescribe medication in the future.
A new study from Oregon State University uses fecal samples from Eastern North Pacific gray whales to assess endocrine levels and establish hormone baselines for stress and reproduction. The findings provide valuable context for understanding how human activities impact whales.
Researchers at the University of Malaga have developed a method to generate human oligodendrocytes from pluripotent stem cells, crucial for supporting neural activity. This breakthrough enables the creation of OLs in just three weeks, opening up new possibilities for treating neurodegenerative diseases such as multiple sclerosis and ALS.
Recent research shows that chimpanzees, like humans, increasingly prioritize mutual and equitable friendships with others as they get older. Younger adults tend to form lopsided relationships, while older chimpanzees focus on maintaining smaller, fulfilling networks of close friends.
Researchers construct a composite measure of physiological dysregulation among human populations and compare it to other primates. Despite differing lifestyles, Tsimane adults show marginally higher rates of increase in physiological dysregulation, but still lower rates compared to urban populations.
The paper discusses how cell-autonomous immunity, inherited from prokaryotic and single-celled ancestors, affects the human evolutionary story. It highlights the importance of understanding how pathogens manipulate these defenses, which are found in every cell in every body system.
Scientists discovered that transposable elements influence human brain development by partnering with two specialized proteins known as Krép-el-associated box-containing zinc finger proteins. These partnerships regulate gene expression in neurons and influence the development and function of adult organs.
Researchers have found that male seahorses transport nutrients to their developing babies during pregnancy, a complex process similar to human pregnancy. This breakthrough provides new insights into the biology of seahorse pregnancy and its potential parallels with human reproduction.
TARA's in vitro human cardiac models replicate drug responses similar to those observed in humans, supporting their use as a robust platform for new medicines evaluation. The models' ability to reproduce diverse mechanisms of action showcases their applicability for cardiac drug discovery and development.
Researchers at Rensselaer Polytechnic Institute have engineered peptides that bind selectively to polysialic acid on cells, potentially providing a barrier against viruses. The findings suggest these peptides could be used to treat diseases such as Alzheimer's, Parkinson's, and cancer.
A new University of Otago study found that mating with sterile males early in life increases female growth but reduces lifespan. Mating with fertile males later in life has the opposite effect, increasing reproductive output. The findings suggest long-term consequences of social interactions between males and females.
Breeding methodologies can increase fructan levels in winter wheat cultivars without reducing genetic diversity. Researchers successfully developed wheat cultivars with increased fructan levels using recurrent genomic selection, providing a proof-of-concept for improving nutritionally enhanced crops.
Assistant Professor Fabrizio Sergi at the University of Delaware received a NSF CAREER Award for his work on motor control and brain-body interaction using MRI-compatible robots. His research aims to improve neurorehabilitation practices for individuals with motor impairment, such as stroke survivors.
New research uses physiological cues, specifically heart rate analysis, to discern between natural humans and computer-generated faces. By extracting pulse-rate signals from video sequences, the authors can classify input faces as either CG or NAT.
A recent study in Science journal found that all cultures studied have similar music characteristics, such as fast rhythms for dance and soft tempos for lullabies. This suggests that there are fundamental universal properties of music that reflect commonalities in human cognition.
TARA Biosystems' human heart-on-a-chip technology shows promise in predicting preclinical systolic and diastolic in vivo observations for novel cardiac drug MYK-491. The platform uses human induced pluripotent stem cells to create physiologically relevant cardiac tissues.
Cell culture media has remained relatively unchanged for over 70 years, but Jason Cantor is developing 'physiologic media' that closely mimics real biological conditions. This allows researchers to study cell behavior in a more accurate and relevant way, potentially revealing fundamental insights into human diseases such as blood cancer.
Scientists at ETH Zurich have created a new family of bioresorbable magnesium alloys containing zinc and calcium, which can be resorbed by the human body. Analytical transmission electron microscopy revealed a previously unknown dealloying mechanism governing the dissolution of precipitates in the magnesium matrix.
A new study from Northwestern University suggests that human ecology has played a more significant role in shaping the human gut microbiome than genetic relationships. The research found that the human gut microbiome is more similar to that of Old World monkeys like baboons than apes like chimpanzees.
Researchers analyzed fossil data to discover nearly all early African herbivore communities were unique before 700,000 years ago. This suggests the earliest humans lived in non-analog ecosystems that differ from modern Africa's ecosystems.
A study found that the endocannabinoid system is present in human testis tissue and may be involved in regulating sperm cell development. The system includes key components such as enzymes and receptors that degrade and interact with endocannabinoids, suggesting a potential role in reproductive function.
Researchers analyzed human hair fibers from polluted areas in China and found increased degradation with higher PAH levels. Exposure to UV radiation further damaged contaminated fibers, suggesting a toxic combination.
Researchers replicated human-like drug responses in TARA's engineered heart-on-a-chip system, predicting cardiac safety and efficacy. The study validated the platform's ability to model different heart diseases and measure contractile force of Cardiotype tissues.
Researchers at Utah State University found that cyclists align in patterns within a plus-or-minus 30-degree arc corresponding to the human near-peripheral visual field. This helps them safely react to changes or disturbances from neighboring riders, leading to lower individual rider energy expenditures.
The switch from 2D to 3D cell cultures in drug discovery improves the accuracy of human physiological conditions and increases the success rates of drugs. High-content analysis with 3D cell cultures is expected to increase the quality of compounds progressing to preclinical stages.
A new study published in Addiction Biology found that drinking one pint of beer or a large glass of wine can significantly compromise a person's sense of agency. This sense of agency is crucial for human social behavior, implying knowledge of the consequences of actions. The researchers used an indirect measure called intentional bindi...
Researchers found that human endurance activities share the same metabolic limits, with energy expenditure unable to exceed 2.5 times resting metabolism. This universal limit applies across various events and muscle groups, suggesting a common adaptive mechanism.
Researchers discover that progesterone triggers the mineralocortoid receptor in elephant sharks, while aldosterone and cortisol do not. This finding provides new insights into the evolution of human physiology.
A new review suggests that social communication played a significant role in shaping the modern human face. The study, led by University of York researchers, concludes that our faces evolved not only due to factors like diet and climate but also to facilitate nonverbal communication and establish large social networks.
The NASA Twin Study has provided a comprehensive multi-omics view of the human body's response to long-term space flight. The study found increased collagen proteins in urine, correlating with vascular remodeling during space flight.
Researchers discovered a genetic variant in troponin I that disrupts calcium-binding affinity in thin muscle filaments, leading to arrhythmias in human cardiac cells. This finding may contribute to SUDI by triggering sudden cardiac arrest.
A KAIST research team found that blue-enriched white light exposure improves melatonin levels and subjective perception of alertness, mood, and visual comfort compared to warm white light. This study proposes a new approach to indoor lighting strategies, benefiting residential areas, learning environments, and working spaces.
Researchers are developing a new paradigm called 'network physiology' that examines how organs communicate and adjust to each other. This approach has the potential to improve health monitoring techniques by capturing data streams from different organ systems.
A review of over 140 studies explores climate change's impact on animal life, including humans, through increased frequency and severity of heat waves. Behavioral changes, such as altered migration patterns and increased water demands, may lead to dehydration and cellular stress.
A joint ESA-University of Bath project aims to estimate forces experienced by lower limbs in different gravity environments, mapping variation in external loads, muscle strength, and reduced gravity effect.
Researchers discuss potential benefits of inducing torpor in humans for spaceflight and medical treatment. Synthetic torpor could protect astronauts from radiation hazards and reduce demands on spacecraft mass.
Researchers pinpointed microRNA-31 as a predictive indicator of clinical outcome and functional relevance in driving the disease. The study uses an artificial gut to culture human biopsy samples and track molecular abundance, offering a personalized testing platform for therapeutic agents.
Research highlights the physiological and pathophysiological functions of olfactory receptors in human tissues, including their potential applications in cancer diagnosis and therapy. The receptors also regulate skin regeneration, intestinal digestion, and hair growth.
Current understanding of human physiology and surgery in space is crucial for future astronauts. The review highlights novel pathologies that could arise from prolonged weightlessness and exposure to cosmic radiation, emphasizing the need for specialized training and medical preparedness.
A new rabbit model with clinical similarity to human patients has been developed for Duchenne muscular dystrophy (DMD) research. The model exhibits signs of muscular dystrophy, including impaired physical activity and muscle loss, making it a promising tool for advancing DMD research and developing novel therapies.