Articles tagged with Cancer Genetics
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A new algorithm uses machine learning to identify genes that spur tumor growth by linking DNA mutations to altered functionality. The method can predict and validate cancer-driving genes in any database or real population sample.
Researchers have found that MYC and TWIST1, two genes that promote cancer development, work together to recruit immune cells to tumors, creating an environment that facilitates cancer cell spread. Blocking a key step in this process may help prevent metastasis.
A new study suggests that targeted screening for men at higher genetic risk of prostate cancer could prevent nearly one in six deaths from the disease. The research modeled the harms and benefits of introducing four-yearly PSA screening for all men aged 55 to 69 versus more targeted checks for those at higher risk.
Researchers at Moffitt Cancer Center have developed a new platform for creating genetically engineered mice to study melanoma, which is significantly faster than the traditional approach. This new method uses chimera mouse models and chimera-derived melanoma cell lines to provide a faster way to study skin cancer.
Splice-altering mutations can contribute to inherited predisposition to cancer by altering RNA splicing patterns. The cBROCA method identifies altered transcripts and associated genes, revealing potential therapeutic targets.
The American College of Medical Genetics and Genomics recommends evaluating breast cancer patients for genetic testing based on existing clinical criteria. Genetic testing should include full gene sequencing and be conducted in a lab certified by the College of American Pathologists or Clinical Laboratory Improvement Amendments.
Researchers at Karolinska Institutet found a new mechanism that renders the MYC gene overactive in cancer cells. The MYC gene is normally controlled by environmental cues and cell architecture, leading to uncontrolled growth.
A new study reveals that male breast cancer patients require a lower recurrence score threshold for predicting mortality compared to females, highlighting distinct biology and prognostic factors between the sexes.
A new study shows an association between a family history of cancer and childhood asthma diagnosis in over 20% of children, highlighting the importance of extra asthma screening efforts.
Researchers at Penn State College of Medicine developed a new method to model gene interactions and predict changes over time. The idopNetwork can create personalized networks for individual patients, showing complex gene connections and predicting outcomes.
A study by Dartmouth researchers found that a specific genetic subgroup of triple-negative breast cancer and ovarian cancer is vulnerable to heat shock protein 90 (HSP90) inhibitors. This discovery may lead to improved treatment strategies for patients with these cancers.
Researchers have successfully created mice with hyper-long telomeres, which live longer and healthier lives without any genetic modification. This breakthrough shows that lengthening telomeres can increase longevity and delay metabolic ageing, paving the way for potential future treatments.
Increased inflammatory activity found in FTD patients, associated with parkinsonism symptoms and rapid disease progression. The study also revealed a low prevalence of cancer among FTD patients, suggesting an overactive immune system may contribute to the disease.
A new system developed by Yale scientists uses viral gene therapy and CRISPR gene-editing technology to make cancer cells stand out from the crowd, helping the immune system spot and eliminate tumors that other forms of immunotherapies might miss.
The 2019 Nobel Prize has been awarded to William G. Kaelin Jr, Gregg L. Semenza, and Sir Peter J. Ratcliffe for their discoveries of how cells sense and adapt to oxygen availability. This mechanism has far-reaching implications for treating conditions like cancer, heart attack, and stroke.
A novel transfection method called nano-electro-injection delivers DNA into immune cells two to three times more efficiently than conventional methods. This technique improves the process of generating high-quality genetically modified immune cells for cancer immunotherapy, reducing cell stress and improving cell health.
A new treatment approach for metastatic prostate cancer has shown promising results, delaying disease progression by more than double and potentially extending lives. The treatment targets genetic alterations that enable cancer cells to repair themselves, leading to significant extensions in time before the disease grows and spreads.
Scientists at UCL have developed a method to reactivate 'tumour suppressor' genes silenced by cancer cells. This finding could lead to new targeted biotherapies for cancer treatment.
Researchers at Cedars-Sinai have developed a rapid method to genetically alter laboratory mice, producing personalized models of complex cancers. The technique overcomes drawbacks in current techniques and can be used to modify patient-derived cells.
Researchers at The Institute of Cancer Research have discovered the three-dimensional structure and function of the 'mix n match' protein DHX8, which helps control a process linked to cancer progression and drug resistance. This study opens up a potentially exciting new way to tackle drug-resistant cancers.
New USPSTF recommendations for BRCA1/2 genetic testing are beneficial, increasing use of genetic counseling and testing for those with high risk. However, concerns remain about large-panel genetic tests, direct-to-consumer multi-panel tests, and racial and socioeconomic disparities in genetic testing uptake.
Scientists have discovered a rare, inherited gene mutation that significantly increases the risk of pancreatic and other cancers. The RABL3 mutation was found in a family with multiple relatives diagnosed with pancreatic cancer, and zebrafish carrying the mutation also showed dramatically higher rates of cancer.
Researchers discovered how the process of cell differentiation is orchestrated during embryogenesis, revealing the DNA sequence code of a key gene called hunchback. By understanding how this 'on/off switch' works, scientists gain new insights into genetic activity and its implications for birth defects and disease.
A new study found that genetic testing motivates people at risk of developing melanoma to change their behavior, including reducing sun exposure. Participants who received genetic counseling showed sustained reductions in UV radiation exposure and lighter skin pigmentation over time.
A new study has established the strongest evidence yet of a causal relationship between obesity and various serious conditions. The research analyzed data from the UK Biobank to assess associations between body mass index (BMI) and disease outcomes in 337,536 people.
Scientists have developed a new computational method that reveals genetic patterns in individual cells, enabling the diagnosis of specific genetic defects and potentially rectifying them with CRISPR. This breakthrough advances precision medicine by providing personalized treatment options for patients with unexplained infertility.
Researchers will investigate loss of DNA repair mechanisms and secondary mutations leading to cancer. The goal is to develop improved cancer treatment regimens and predict drug efficacy.
Research analyzed mortality rates among 10,451 MLB players from 1906 to 2006, finding differences in death rates by position and career length. Longer playing careers were associated with lower cardiovascular-related deaths but increased cancer deaths.
Researchers at the Wellcome Sanger Institute found that low doses of radiation increase p53 mutations, giving cancer-capable cells a competitive advantage. However, antioxidants can boost healthy cells to outcompete mutant cells.
Research at the University of Sussex identified how genetic variations in two main EBV strains impact their behavior in infecting white blood cells. These differences affect the virus's ability to drive rapid cell growth, a key factor in the development of lymphoma.
Ashkenazi Jewish women with known BRCA status have a 98% 5-year survival rate compared to 74% for those without knowledge, requiring less chemotherapy and extensive surgery. Early testing could prevent breast cancer or start high-risk screening at an earlier age.
Researchers identify DNA-PK as a master regulator of gene networks promoting aggressive prostate cancer behaviors. A clinical trial combining standard-of-care with a first-in-man DNA-PK inhibitor shows promising early results.
A new study found that gastric cancer is affecting more young Hispanic people in the US, with poorer outcomes than older patients. Women under 40 were more likely to have diffuse-type tumours and stage IV disease at diagnosis, leading to a median overall survival of just 7 months.
Researchers found that cancer cells respond differently to targeted drugs based on tumour type and genetic weaknesses. The study suggests rethinking precision medicine and designing clinical trials with both gene faults and tumour type in mind.
Researchers analyzed RNA sequence data from human stem cells as they developed into cardiomyocytes, identifying hundreds of genes associated with varying expression. These 'shooting star' differences may explain complex diseases like cancer and heart disease.
Researchers found that children with chromosomal defects were almost 12 times more likely to develop cancer than those without birth defects. Children with non-chromosomal defects had a 2.5 times increased risk of cancer compared to those without birth defects.
Researchers from CRCHUM identified the genetic signature of an ineffective immune response to cancer, including 28 genes that are also found in patients with other diseases. This signature could help predict which patients will fare worse.
Researchers at the University of Alberta have identified a specific genetic marker linked to an increased risk of breast cancer in premenopausal women. The study found that up to 40% of women carrying the genetic variation are at higher risk of developing breast cancer compared to those without it.
DNA microscopy enables spatially mapping genetic material without optical equipment, allowing researchers to track molecular positions and variations. The technique has potential applications in understanding biological processes, cancer, and immune system development.
A nationwide register study found no increased risk of congenital malformations in children conceived after their fathers received radiotherapy or chemotherapy treatment for testicular cancer. The study, published in PLOS Medicine, followed 4,207 children of 2,380 fathers and compared the risks before and after treatment.
A new genetic basis of a type of brain aneurysm has been identified, suggesting that an existing cancer drug can counter its effects. Researchers have discovered 'gain-of-function variants' in the PDGFRB protein, which causes it to remain locked in a hyper-active form.
A new blood biopsy technique allows for comprehensive genetic profiling of cancer cells, capturing variation among cells within a single patient. This improves treatment monitoring and targeting by identifying genes active in cancer cells and tracking their response to therapy.
Researchers found that tumors with a higher degree of microsatellite instability (MSI) are more likely to respond to immunotherapy. MSI-high tumors have a higher amount of indel mutations, which can generate neoantigens recognized by the immune system.
A phase I clinical trial using stem cell immunotherapy will be tested on patients with advanced sarcomas and the NY-ESO-1 tumor marker. The treatment aims to generate a lasting immune response against cancer by modifying blood-forming stem cells and T cells to target specific proteins.
Researchers at Johns Hopkins Medicine developed a gel-like platform that activates and multiplies cancer-fighting T-cells, outperforming traditional methods in mouse experiments. The artificial lymph node technology has potential for regenerative immunology-based therapy.
A new study published in the Journal of Hepatology reports that whole-exome sequencing (WES) can diagnose the genetic cause of liver disease in a significant proportion of adult patients. The analysis identified four monogenic disorders in five unrelated adults, enabling new treatment options and shedding light on underlying molecular ...
A new algorithm developed by Stanford researchers can accurately identify individuals at risk of familial hypercholesterolemia (FH), a cholesterol-raising genetic disease that increases the risk of early and fatal heart problems. The algorithm, trained on data from over 200 FH patients, correctly flagged 88% of cases in testing runs.
A new online tool allows researchers to determine the genetic ancestral origin of over 1300 cancer cell lines, revealing a lack of representation from diverse populations. The study found that European and East Asian origins were overrepresented, while African American and Hispanic/Latino origins were underrepresented.
A common genetic variant on the 5p15.33 locus is associated with a high risk of stroke in childhood cancer survivors who received cranial radiation therapy (CRT). The study found that survivors who carried this variant had nearly three times the risk of developing stroke compared to those without it.
A phase I clinical trial and FDA expanded access program show LOXO-195, a next-generation TRK inhibitor, is safe and effective in patients with NTRK gene fusions resistant to first-generation TRK inhibitors. The study found that LOXO-195 induced responses in patients whose tumors had acquired specific mutations.
Researchers found tarloxotinib effective against various cancer types, including ovarian and breast cancers with NRG1 gene fusions. The drug targets low-oxygen conditions, making it potentially more tolerable than existing therapies.
Researchers from the CNIO Hereditary Endocrine Cancer Group have identified a new gene, DLST, involved in the development of paragangliomas and phaeochromocytomas. Mutations in this gene were found to be directly linked to the disease, providing a potential breakthrough in diagnosis and treatment.
The Cancer Control and Survivorship Program at St. Jude Children's Research Hospital has been awarded the 13th annual AACR Team Science Award for its innovative research advancing childhood cancer treatment and long-term survival outcomes. The program's work has significantly contributed to our understanding of pediatric cancer epidemi...
Researchers found that mda-7/IL-24 reduces the expression of an enzyme called DICER, which processes microRNAs for specific cellular functions. This effect occurs only in cancer cells and provides potential therapeutic targets for cancer treatment.
A study found that high-fructose corn syrup consumption enhances tumor growth in genetically predisposed mice with intestinal adenomas. The researchers discovered that HFCS leads to dramatic increases in tumor size and grade through altered metabolism, independent of obesity.
The study analyzed tumor DNA from 843 patients with colorectal cancer, identifying associations between genetic mutations and treatment responses. Patients with microsatellite instability had longer survival when treated with bevacizumab, while those with high tumor mutational burden lived longer than those with less variation.
A team of scientists has discovered a unique genetic signature, or 'fingerprint', in cancer cells that can be targeted to selectively eliminate abnormal cells. This breakthrough could lead to more effective and less toxic cancer treatments.
Researchers found that younger patients with early-onset colorectal cancer have unique genetic mutations and subtypes of the disease. Patients with predisposing conditions, such as inflammatory bowel disease, also exhibit distinct clinical and genetic characteristics compared to those without such conditions.
Researchers at Bar-Ilan University discovered the intricate molecular mechanism of the guidance receptor 'Robo', which reacts to signals in its environment while avoiding premature activity. The findings provide a basis for designing effective drugs targeting Robo receptors, potentially treating various neurological and cancer conditions.
Scientists have developed techniques to track the global changes in gene activation caused by MYC, a potent cancer gene. The new toolkit reveals subtle differences in gene expression between individual cells, which may lead to cancer.