Articles tagged with Cancer Genomics
A study led by Clemson University geneticist Allison Hickman has identified 11 high-priority genes associated with uterine cancer. These genes are potential targets for drug therapies, offering new hope for effective treatment options.
A new analysis links genetic variants associated with high blood levels of lipoprotein A to a higher risk of prostate cancer, including advanced or early-age-onset cases. The study found no significant associations for other blood lipids.
A new study has revealed the dynamics of DNA replication 'licensing,' a process that regulates genome replication during cell division. The researchers found that heterochromatin regions are more susceptible to under-replication and DNA damage when the G1 phase is shortened, potentially leading to genomic instability in cancer cells.
A new bilateral tumor model was demonstrated to be useful for investigating the relationship between T-cell repertoire and cancer immunotherapy's therapeutic effects. The study found that T-cell profiles of both tumors were almost identical, indicating a similar anti-tumor response in a single mouse.
Researchers at Osaka University have made a breakthrough in understanding the molecular mechanisms behind Intrahepatic cholangiocarcinoma (ICC), a deadly form of liver cancer. By identifying TRAF3 and NIK as key players, they have uncovered potential therapeutic targets for novel ICC treatment.
Researchers found that alterations in the RNF43 and ZNRF3 genes lead to an accumulation of lipids and inflammation in the liver, increasing the risk of developing non-alcoholic steatohepatitis (NASH) and fatty liver disease. These genetic changes also affect liver cell proliferation, contributing to the progression of liver diseases.
Scientists at La Jolla Institute for Immunology have discovered a link between TET enzyme deficiency and the formation of unusual DNA structures, such as G-quadruplexes and R-loops, which contribute to genomic instability. The study suggests that regulating these structures may be key to controlling cancer development.
Researchers have described a dynamic genomic landscape of tumour heterogeneity in hepatocellular carcinoma, highlighting the need for novel strategies targeting heterogeneous tumors. The study, published in National Science Review, used multi-omic data to reveal variations in genetic and transcriptomic profiles across patients.
A study found that men with Li-Fraumeni syndrome have a 25-fold increased risk of developing aggressive prostate cancer, and those with inherited TP53 variants are diagnosed at a young age. Routine screening for prostate cancer is recommended for these individuals.
A comprehensive genomic analysis reveals the genetic basis of neuroendocrine carcinoma of the gastrointestinal system, a rare cancer that is highly resistant to treatment. The study identifies key biological processes underlying the development of the disease, including structural variants, methylation events, and gene fusions.
Researchers at UNC Lineberger Comprehensive Cancer Center have developed a novel way to classify breast cancers into 12 distinct biological groups using both genetic and pathologic data. This classification method has the potential to aid future research efforts and enable faster translation of molecular findings into clinical use.
Researchers have developed new preclinical models to understand gastric cancer development and spread. Using these models, they identified Lgr5-expressing tumour cells as responsible for driving gastric cancer growth and spread, establishing them as a potential therapeutic target.
A study by University of Seville researchers reveals that messenger RNA modifying factors play a crucial role in the repair of DNA breaks. The discovery could lead to better understanding of rare diseases and cancer. Messenger RNA editing facilitates the removal of trapped RNA molecules, allowing for proper DNA repair.
A functional precision medicine study demonstrates that treatment selection based on results from drug sensitivity testing can be clinically useful in patients with aggressive hematological cancer. The approach combines deep molecular profiling with comprehensive drug sensitivity testing to advance the therapy decision-making system.
Researchers developed a novel model to identify specific genes and genetic alterations in multiple myeloma, stratifying the cancer's severity via DNA and RNA sequencing. This model revealed diverse subtypes and high-risk patients beyond current classifications.
A Mount Sinai study reveals that young adult cancer patients exhibit distinct genetic hallmarks and immune system responses compared to their older counterparts. These findings suggest personalized treatment approaches for young adults with various types of cancers.
Researchers conducted genomic evaluations of advanced malignancies to develop matched, individualized combination therapies. The study found that precision cancer therapy improved median overall survival rate by 3.9 months compared to standard care.
A nationwide survey of Australian medical oncologists found that most were confident consenting patients for genomic profiling, but less confident discussing secondary germline findings. The study suggests that understanding oncologists' perspectives is crucial to integrating genomic profiling into routine care.
Researchers at Weill Cornell Medicine have profiled individual cells from patients' brain tumors in unprecedented detail, revealing distinct states and programming marks that could be targeted with future drugs. The study offers insights into glioma dynamics and may lead to better detection, staging, monitoring, and treatment methods.
Cancer is driven by changes to DNA and epigenome, which evolve during the cancer life cycle. Advanced technologies are mapping genomic and epigenomic changes in three-dimensional tumour context, revealing new insights into cancer formation and progression.
A study by Weill Cornell Medicine identified Oct2 as the key determinant of B-cell humoral immune response, suggesting that the destiny of antibody-producing cells is predetermined. This discovery may lead to new insights into tissue development and cancer development.
Researchers found that high levels of MYO10 induce chronic inflammation, reducing T cell function, but also increasing immune response. This led to improved outcomes with immune checkpoint blockade therapy for certain tumors.
Researchers identified DNA mutations from platinum-based chemotherapies in AML patients, suggesting treatment-associated cancer development. The study's findings imply that clonal hematopoiesis precedes chemotherapy exposure.
A novel population of long-lived T cells, called 'lymph node resident memory T cells,' provides protection against melanoma by persisting in lymph nodes. These cells were found to counteract melanoma spreading in mice and predicted better outcomes for human melanoma patients with lymph node metastases.
Researchers identify molecular targets for improved prostate cancer therapy by comparing genomic changes in cancer cells eradicated and resistant to treatment. The study also finds L1 retrotransposition as a dynamic source of cancer heterogeneity.
Researchers found that the gene TCF-1 regulates specific Treg cells, leading to more severe and inflammatory colon cancers. Without TCF-1, these cells become activated and gain a gut-homing feature, resulting in harsher cancer outcomes.
The Vilcek Foundation has awarded four prizes worth $250,000 to foreign-born scientists in the United States. The prizes recognize outstanding career contributions to biomedical science and innovative research. This year's recipients include Vishva M. Dixit, Markita del Carpio Landry, Hani Goodarzi, and Harris Wang.
A research team has developed a cell printing technology to produce 3D cancer spheroids with varying diameters and blood vessels. This enables the reproduction of cancer metastasis properties, paving the way for personalized cancer treatments.
Researchers used a comprehensive knowledgebase to identify 22 actionable genes and 43 candidate drugs for biliary tract cancer, which may lead to the development of targeted therapies. The study's findings contribute to personalized treatment options for this rare tumor worldwide.
Gastrointestinal stroma tumors (GIST) are rare cancers that can be problematic to detect and treat. Researchers have identified the mutational drivers for GIST in the stomach and found a potential drug therapy, temozolomide, which showed promising results in treating patients with specific mutations.
Researchers identified DSS1 as a critical protein in breast cancer progression and found that depleting it makes cancer cells more responsive to lower doses of anti-cancer drugs. This technique may reduce drug-induced side effects in breast cancer patients, providing a safer treatment option.
Researchers at Massachusetts General Hospital have identified two separate genetic alterations that enable triple-negative breast cancer cells to develop resistance to a highly effective drug. The findings could help improve therapy and prolong survival for patients with this aggressive form of breast cancer.
A study by UCI researchers reveals two ways APOBEC3A is controlled in response to stress, offering potential therapeutic strategies against cancers and viral infections. The findings could lead to new treatments that prevent DNA mutations caused by the enzyme, reducing disease progression and resistance.
A comprehensive molecular map of lung squamous cell carcinoma has identified potential new drug targets, including the gene NSD3, and highlighted immune regulation pathways that could help cancer evade immunotherapies. The study's findings have also revealed metabolic dysregulation and crosstalk between different cellular processes.
Researchers at the University of Helsinki have made a significant advance in fibroids research by identifying a new mechanism of tumorigenesis. Multiple tumors carried mutations in genes involved in histone trafficking, which affected gene expression levels and led to hereditary predisposition to the disease.
Researchers have developed a new integrative genetic test, LYNX, that analyzes standard and novel molecular markers in common lymphoid neoplasms. The test provides accurate detection of mutations, identification of large genome-wide chromosomal aberrations, and assessment of immunoglobulin and T-cell receptor gene rearrangements.
Researchers developed a machine learning tool, BoostDM, that evaluates the potential contribution of mutations in genes to cancer development. The tool helps understand how tumors are caused at the molecular level and can facilitate medical decisions regarding therapy.
A genetic variant in the TCERG1L gene has been identified as a risk factor for cisplatin-induced hearing loss in children with cancer, increasing the risk by three times. The finding could lead to predictive tests to inform treatment decisions and advance pediatric cancer care.
Scientists from UCLA Jonsson Comprehensive Cancer Center identified TAF12 as critical to the formation of preinitiation complexes, which are necessary for gene transcription. Eliminating TAF12 destroys preinitiation complexes and drastically reduces genome-wide transcription.
Researchers developed AstroPath, a platform combining astronomy and pathology to analyze tumor microenvironments. It predicts response to anti-PD-1 therapy in melanoma patients, providing new insights into cancer treatment options.
Scientists discovered that the genome is organized like a library system, with liquid parts accessible and solid-like islands storing unused information. This organization relies on physics of different states of matter, providing new insights into disease mechanisms and potential treatments.
A study published in Oncotarget found a distinct global DNA hypermethylation pattern and gene expression signature in liver cancer among patients with Indigenous American ancestry. This molecular subtype of HCC preferentially affects people with Indigenous ancestry, highlighting the importance of considering anthropological background ...
Researchers found that Tasmanian devils' genome has undergone widespread evolution in response to transmissible cancer, but distinct sets of genes are involved at different timescales. The study suggests that conservation efforts should focus on maintaining genetic diversity across a wide set of functionally important genes.
University of Virginia researchers have developed a new computational method to map the folding patterns of chromosomes in three dimensions. This will help scientists understand the genetic cause of cancer and advance other areas of medical research.
The scientific community is urged to adopt more inclusive practices in preclinical and basic science research to promote personalized medicine. Researchers highlight the lack of diversity in commonly used human cell lines, which are predominantly of European descent, and emphasize the need for representative cell lines to better unders...
A new machine learning technique, MethSig, analyzes DNA methylation changes in tumor cells to infer which ones are driving tumor growth. The algorithm identifies a small number of cancer-driving events, consistent across patients and tumor types.
Researchers at Cold Spring Harbor Laboratory found that a protein called Asterix/Gtf1 suppresses small specific regions of mobile genetic elements by binding to tRNA molecules. This discovery could lead to understanding how cells protect themselves against these elements and potentially tame an overly restless genome.
Researchers found that tumour samples from over 2,600 patients with different types of cancer contain a high prevalence of genetic diversity within individual tumours. This variation is a challenge for doctors as treatment may not be effective against another subclone, and certain subclones can initiate tumour spread or drug resistance.
Researchers at IRB Barcelona have discovered the HMCES enzyme to be a Achilles heel of some lung tumours with high mutations caused by the APOBEC system. Blocking HMCES is damaging to cancer cells but less so for healthy cells, making it a promising target for future treatments.
An international study reveals that the MutS protein, known as the guardian of our genome, coordinates the essential DNA repair process from beginning to end. The researchers used cryo-electron microscopy to visualize the protein and describe its mechanism of action.
A new study by NYU Rory Meyers College of Nursing found that breast cancer survivors with high genomic test scores report higher overall fear and greater perceived consequences compared to those with low scores. Anxiety and emotional response to cancer are the best predictors of fear, explaining 58% of variance in fear of recurrence.
Researchers have developed an AI system to analyze DNA-sequenced mesotheliomas, revealing similar evolutionary paths that predict aggressiveness and possible therapy. This breakthrough could lead to improved patient outcomes for those with this aggressive form of cancer.
A new study led by University of Maryland researchers found that DNA from tissue samples can be used to accurately predict the age of bats in the wild. The study showed age-related changes to DNA are different between long-lived and short-lived bat species, especially near genes associated with cancer and immunity.
The study demonstrates MEK inhibitors as a promising targeted therapy for basal subtype bladder cancer, highlighting the importance of 3D cell culture drug screening. Established genomic and transcriptomic data are correlated with drug response to identify novel groups of tumors vulnerable to specific drugs.
A new review highlights biological differences in prostate cancer development across ethnicities, identifying potential improvements for African American men. The study aims to reduce incidence and mortality rates by leveraging these differences.
Researchers have found that short strands of cell-free DNA in urine can indicate a difference between healthy individuals and those with cancer. The DNA fragments are protected from degradation and can provide meaningful information about disease complexity like cancer.
A new genomic test helps oncologists determine which patients with recurrent prostate cancer may benefit from hormone therapy, guiding precision medicine efforts. The Decipher test, measuring tumor gene activity, predicts risk of metastasis and death, even after adjusting for other factors.
Lung cancer is a leading cause of death in Singapore and the world, with Asian populations exhibiting distinct genetic alterations. The World Conference on Lung Cancer Singapore presented new data on EGFR mutation and TKI-drug resistance, highlighting the need for targeted treatment approaches.
A new study reveals that errors in chromosome packing may cause B-cell blood cancers. Researchers identified a critical protein called DIS3 that maintains genomic architecture and prevents cancer. The findings could lead to new biomarkers and therapies targeting genome instability.
A recent study published in JAMA Oncology found significant racial disparities in breast cancer prognosis testing among Black women, who have higher recurrence and mortality rates than non-Hispanic white women. The study suggests that genomic tumor tests may require re-calibration to reflect racial differences.