Articles tagged with Cancer Patients
A rapid diagnosis centre has reduced waiting times for patients with non-specific symptoms who may have cancer to under 6 days. The study also found that if the RDC runs at full capacity, Swansea Bay University Health Board could save £157,858 and gain 9.2 quality-adjusted life years.
Researchers at Ohio State University Wexner Medical Center suggest a new approach to treating advanced, progressing bile duct cancer. The study found that adding an mTOR inhibitor may re-sensitize tumor cells to FGFR inhibitors in patients who develop resistance to these agents.
A Phase III clinical trial found that eating seven or more servings of vegetables and fruits daily did not provide extra protection against prostate cancer. Despite this, a healthy diet rich in fruits and vegetables may help patients tolerate cancer treatments.
Researchers at Ohio State University Comprehensive Cancer Center discover a direct connection between thrombin and TGF-b1, a cytokine promoting tumor progression and suppressing immune responses. Blocking this mechanism prevents tumor resistance to immunotherapy and increases tumor-infiltrating immune cells.
A $300,000 grant will help UniSA researcher Dr Stephanie Reuter Lange explore how computer-based modelling can optimise cancer treatment and remove the need for expensive clinical trials. The goal is to tailor drug dosages to individual patients to maximise tumour response and minimise side effects.
Research shows that HPV-negative oropharynx cancer patients are at a significantly higher risk of dying from any cause within two years. In contrast, HPV-positive patients have a lower risk of dying from head and neck cancer and other types of cancer.
Researchers analyzed genome-scale data from male adolescents to understand changes in stem cells during puberty. They found that testosterone is crucial for maintaining mature testis development, and disruptions can lead to infertility and increased risk of testicular cancer.
A new study shows that the 21-gene recurrence score test, commonly used to predict disease recurrence and chemotherapy benefit in breast cancer patients, may also help determine whether radiation therapy is necessary. Patients with intermediate or high scores are more likely to see their cancer return and benefit from radiation.
Researchers found that surgically removing the entire tumor can boost median survival length from eight months to 16 months or more. The study analyzed data from 103 patients and suggests surgery may be a viable treatment option for brainstem high-grade gliomas, which are rare and deadly brain cancers.
The study found significant tumor shrinkage in two out of three patients with salivary gland tumors treated with T-DM1. The benefit lasted for at least two years in one patient, suggesting a promising activity for this rare cancer type.
A team of researchers at Dartmouth's Norris Cotton Cancer Center has collected real-time data to show that light is produced inside the eye during head and neck radiation therapy, elicitng a visual sensation. This evidence supports the idea that Cherenkov light emission from the eye can cause a visual effect.
A new study strengthens the link between vitamin E acetate and EVALI (e-cigarette or vaping product use-associated lung injury), finding it in BAL fluid from 48 of 51 EVALI patients but not healthy individuals. The CDC analyzed samples from 16 states and compared them to 99 healthy individuals.
A study published in JAMA Oncology found that proton therapy is just as effective as X-ray radiation therapy in treating cancer, but causes fewer side effects and lower hospitalization rates. This could lead to improved quality of life for patients and reduced healthcare costs.
Researchers found that younger patients with stomach cancer often present with more aggressive disease, a worse prognosis, and reduced effectiveness of traditional chemotherapy treatments. The study highlights the importance of increased awareness and early detection for this increasingly prevalent form of stomach cancer.
Researchers have developed a new approach to study the bone marrow in unprecedented resolution, revealing previously unknown cell types and their local environments. The study provides a novel basis for studying blood diseases such as leukemias and has made its dataset publicly accessible for further research.
A new study explores women's knowledge and perceptions of breast density and breast cancer screening across three states with varying notification laws. Women from all states had varying knowledge about their own breast density and breast density in general, and expressed a strong desire for more information.
A Hebrew University research team has discovered a potential link between the BCG vaccine and reduced Alzheimer's disease risk in cancer patients. The study found that those who received the BCG vaccine had significantly lower rates of developing Alzheimer's compared to those who did not.
Researchers are assembling the largest dataset of veterans with either condition or both to compare conditions and outcomes. They hope to find correlations between mental health and prostate cancer aggressiveness and explore biological risks like inflammation.
The Affordable Care Act provision allowing young adults to be covered under their parents' insurance led to improved care for colorectal cancer patients. Young adults diagnosed with stage IIB-IIIC colorectal cancer were 34% more likely to receive adjuvant chemotherapy post-ACA compared to pre-ACA.
The NCI-MATCH trial found a 36% response rate across various cancers with DNA mismatch repair deficiencies, including rare and uncommon tumor types. The results provide an important signal for further study and potential treatment options.
Researchers developed a new classification system for tumors based on genome sequencing, assigning patients to one of sixteen groups. The system provides important information for diagnosis and treatment, including potential responses to immunotherapy.
A systematic review and meta-analysis of 14 randomized clinical trials found evidence suggesting acupuncture and acupressure can reduce cancer pain. The studies showed varied but generally positive effects on pain reduction, with some suggesting improved outcomes in patients receiving acupuncture or acupressure.
A recent study published in Nature Communications used AI to analyze pathology images from human cancer patients and identified new features relevant to cancer prognosis. The AI's predictions were found to be more accurate than those made by human pathologists, with a higher accuracy rate when combined with human-established criteria.
A novel assay developed at the Champalimaud Centre for the Unknown uses zebrafish 'avatars' to test radio-sensitivity in human tumor cells. The assay has shown promising results, with 85% success rate in predicting how tumors will respond to specific drugs.
Researchers discovered a key factor, USF1, that inhibits p53 activity, promoting gastric cancer development. USF1 levels can indicate poor prognosis and help identify patients at higher risk of severe forms of gastric cancer.
A large US population-based analysis found that breast cancer survivors face significant non-cancer-related deaths, including heart diseases and Alzheimer's. Most deaths occurred within 10 years of diagnosis, with patients at higher risk for chronic liver disease and other conditions compared to the general population.
Researchers from Boston University School of Medicine identified a three times higher incidence of VTE among African American patients compared to Caucasian patients. The study also found that African American patients were more likely to develop VTE in certain cancer types such as lung, gastric (stomach) and colorectal.
Researchers found a microbiome signature associated with endometrial cancer risk, particularly in postmenopausal women, and verified established risk factors including obesity and high vaginal pH. The study aims to develop a screening tool for early detection of endometrial cancer.
Researchers at UCLouvain have made breakthroughs in understanding the immune system's role in cancer. They developed a new drug targeting immune system cells to stimulate anti-tumour responses, and are now testing it in human clinical trials.
Researchers found that standard pathology tests provide better information on likely outcome and best treatment options for patients with bladder cancer than molecular subtyping techniques. The study suggests that more study is needed before molecular subtypes are used to guide patient care.
Researchers found that residual cancer burden index and classification are accurate and reliable tools to assess patient prognosis. The results suggest that continuous RCB index can predict risk of breast cancer recurrence across all four breast cancer subtypes.
A novel noninvasive technique using acoustofluidics analyzes saliva for the presence of human papilloma virus-16 (HPV-16), associated with oropharyngeal cancers. The test detected OPC in 40% of patients tested and 80% of confirmed cases, offering early detection, risk assessment, and screening.
The American College of Medical Genetics and Genomics recommends evaluating all breast cancer patients for hereditary predisposition. However, they caution that there is insufficient evidence to support genetic testing for BRCA1/2 or multi-gene panels in all breast cancer patients.
Researchers found that colon cancer cells deficient in p53 use the mevalonate pathway to survive, producing ubiquinone to synthesize new DNA. Statins inhibit this pathway, inducing apoptosis in cancer cells.
Recent study suggests a modest association between radioiodine treatment for hyperthyroidism and increased risk of solid cancer, including breast cancer. The Society for Endocrinology and British Thyroid Association advise caution in interpreting the findings and highlight the need for further research.
The European Research Council has awarded €2 million to Ruben van Boxtel's research on late effects of childhood cancer treatment, focusing on developing second cancers. Van Boxtel aims to identify the components of treatment that cause DNA changes and predict patient risk for developing a second novel cancer.
Gastric intestinal metaplasia is a marker associated with increased risk of gastric cancer, prompting the need for standardized clinical practice. The new AGA guideline provides evidence-based recommendations for testing H. pylori eradication and surveillance strategies.
A Phase II study found that pairing standard chemotherapy azacitidine with the drug enasidenib significantly boosts complete remission in patients with acute myeloid leukemia (AML) and IDH2 mutations. The combination therapy was well-tolerated and showed improved overall response rates compared to chemotherapy alone.
A new combination therapy of lower-dose chemotherapy and monoclonal antibodies has shown a 98% response rate in older patients with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic leukemia. The three-year survival rate was 54%, with 30 patients in complete remission without signs of minimal residual disease.
A one-year follow-up study of CAR T-cell therapy for relapsed mantle cell lymphoma found that 93% of patients responded to the treatment, with 67% achieving a complete response. The therapy was shown to be effective and viable option for patients with relapsed or refractory mantle cell lymphoma.
A new study from Georgetown University Medical Center found that 38 patients with follicular lymphoma who were in remission for at least two years did not show any evidence of the disease in their blood. This suggests that these patients may be disease-free and could have a lifelong disease status.
A global trial found mosunetuzumab, an off-the-shelf antibody, can induce complete responses in patients with relapsed or refractory non-Hodgkin lymphoma. Higher doses of the drug correlate with patient responses, and remissions appear to be long-lasting.
A randomized trial found acupuncture significantly reduced radiation-induced dry mouth symptoms in head and neck cancer patients. The study, published in JAMA Network Open, suggests that incorporating acupuncture into radiation therapy may prevent severity of dry mouth symptoms, improving quality of life.
A simple health questionnaire could be a highly effective tool to pre-screen people for early signs of oesophageal cancer, enabling much earlier diagnosis and treatment. Eight factors were identified as markers in those individuals who had Barrett's oesophagus or went on to develop it.
A new study found wide variations in surgery rates for early-stage lung cancer across US counties, with socioeconomic and healthcare delivery factors contributing to the gap. Counties with higher poverty rates, non-Hispanic black populations, and lower surgeon-to-population ratios had lower surgery rates.
A study found that a specific protein, ARID1A, is linked to aggressive cholangiocarcinoma (ICC) and poor patient outcomes. The researchers identified ARID1A as a potential biomarker for predicting ICC prognosis, which could lead to more effective treatments.
A large study found that a single dose of radiotherapy is as effective as five doses in controlling pain and alleviating symptoms for end-of-life cancer patients with spinal canal compression. The study, published in JAMA, showed similar patient outcomes between one-dose and multi-fraction radiotherapy regimens.
A new study by Cancer Research UK found that nearly 3,400 patients experienced avoidable delays in their cancer diagnosis. The reasons for these delays are complex and can include long waiting times for tests, vague symptoms, and pre-existing conditions.
A meta-analysis of 44 clinical trials found that patient-reported outcomes are significantly associated with overall survival, confirming their importance as prognostic factors. This study aims to improve patient care by providing clinicians with valuable insights into cancer patients' needs and concerns.
The University of Illinois Chicago has received a $300,000 grant to develop a screening process for prescribing opioids and managing opioid use disorders in cancer patients. More than 70% of cancer patients who receive radiation treatment use opiates, with higher rates seen in those receiving chemotherapy or having head and neck cancer.
A new study found that biennial mammography screening resulted in smaller and less advanced breast cancer tumors compared to annual screenings. The study also discovered that women receiving biennial screenings tended to have more aggressive treatment options, such as chemotherapy and axillary lymph node dissection.
A new radiation therapy regimen combining lutetium-177 and actinium-225 has been shown to stabilize tumour growth and improve survival rates for patients with late-stage prostate cancer. The study demonstrated significant reductions in side effects, including dry mouth, compared to previous radionuclide therapies.
A new study published in the European Heart Journal found that over one in ten cancer patients die from cardiovascular disease, including heart disease and stroke. The study analyzed data from over 3.2 million US patients diagnosed with cancer between 1973 and 2012, revealing that certain types of cancer, such as breast and prostate ca...
A study published in Cancer Immunology Research uses AI to analyze changes in CT scans before and after immunotherapy treatment, predicting patient response. The researchers found that textural changes, not just tumor size, are a better indicator of therapy effectiveness.
A researcher at Stephenson Cancer Center is investigating how tumor cells evade detection in lung cancer patients on immunotherapy medication. He believes that PD-L1-coated exosomes are neutralizing the antibody, allowing tumors to continue growing.
Researchers identified kynurenine and indoxyl sulfate as key culprits in generating clot formation in cancer patients via AHR signaling. These metabolites can be measured in the blood to predict risk of deep vein thrombosis, and their inhibition may lead to future drug development.
Acalabrutinib, a second-generation Bruton tyrosine kinase inhibitor, has been approved by the FDA for first-line therapy in chronic lymphocytic leukemia (CLL) and small cell lymphoma (SML). The drug works by permanently binding to BTK, halting cancer cell growth signals.
A new study found that cancer survivors are at risk of developing opioid addictions, with rates varying by cancer type and patient history. The research highlights the importance of identifying patients at risk of opioid-related problems to provide alternative pain management strategies.
Researchers found that extra DNA surrounding cancer-causing genes is crucial for maintaining their activation and supporting tumor growth. This discovery could explain why some cancer treatments are effective while others fail, and may lead to new therapeutic strategies.
People living with or beyond cancer are more than twice as likely to die of a stroke compared to the general population. Certain types of cancer, such as breast, prostate, and colorectum cancers, were found to be most commonly associated with fatal strokes.