Articles tagged with Cancer Patients
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A one-year follow-up study of CAR T-cell therapy for relapsed mantle cell lymphoma found that 93% of patients responded to the treatment, with 67% achieving a complete response. The therapy was shown to be effective and viable option for patients with relapsed or refractory mantle cell lymphoma.
A new study from Georgetown University Medical Center found that 38 patients with follicular lymphoma who were in remission for at least two years did not show any evidence of the disease in their blood. This suggests that these patients may be disease-free and could have a lifelong disease status.
A global trial found mosunetuzumab, an off-the-shelf antibody, can induce complete responses in patients with relapsed or refractory non-Hodgkin lymphoma. Higher doses of the drug correlate with patient responses, and remissions appear to be long-lasting.
A randomized trial found acupuncture significantly reduced radiation-induced dry mouth symptoms in head and neck cancer patients. The study, published in JAMA Network Open, suggests that incorporating acupuncture into radiation therapy may prevent severity of dry mouth symptoms, improving quality of life.
A simple health questionnaire could be a highly effective tool to pre-screen people for early signs of oesophageal cancer, enabling much earlier diagnosis and treatment. Eight factors were identified as markers in those individuals who had Barrett's oesophagus or went on to develop it.
A new study found wide variations in surgery rates for early-stage lung cancer across US counties, with socioeconomic and healthcare delivery factors contributing to the gap. Counties with higher poverty rates, non-Hispanic black populations, and lower surgeon-to-population ratios had lower surgery rates.
A study found that a specific protein, ARID1A, is linked to aggressive cholangiocarcinoma (ICC) and poor patient outcomes. The researchers identified ARID1A as a potential biomarker for predicting ICC prognosis, which could lead to more effective treatments.
A large study found that a single dose of radiotherapy is as effective as five doses in controlling pain and alleviating symptoms for end-of-life cancer patients with spinal canal compression. The study, published in JAMA, showed similar patient outcomes between one-dose and multi-fraction radiotherapy regimens.
A new study by Cancer Research UK found that nearly 3,400 patients experienced avoidable delays in their cancer diagnosis. The reasons for these delays are complex and can include long waiting times for tests, vague symptoms, and pre-existing conditions.
A meta-analysis of 44 clinical trials found that patient-reported outcomes are significantly associated with overall survival, confirming their importance as prognostic factors. This study aims to improve patient care by providing clinicians with valuable insights into cancer patients' needs and concerns.
The University of Illinois Chicago has received a $300,000 grant to develop a screening process for prescribing opioids and managing opioid use disorders in cancer patients. More than 70% of cancer patients who receive radiation treatment use opiates, with higher rates seen in those receiving chemotherapy or having head and neck cancer.
A new study found that biennial mammography screening resulted in smaller and less advanced breast cancer tumors compared to annual screenings. The study also discovered that women receiving biennial screenings tended to have more aggressive treatment options, such as chemotherapy and axillary lymph node dissection.
A new radiation therapy regimen combining lutetium-177 and actinium-225 has been shown to stabilize tumour growth and improve survival rates for patients with late-stage prostate cancer. The study demonstrated significant reductions in side effects, including dry mouth, compared to previous radionuclide therapies.
A new study published in the European Heart Journal found that over one in ten cancer patients die from cardiovascular disease, including heart disease and stroke. The study analyzed data from over 3.2 million US patients diagnosed with cancer between 1973 and 2012, revealing that certain types of cancer, such as breast and prostate ca...
A study published in Cancer Immunology Research uses AI to analyze changes in CT scans before and after immunotherapy treatment, predicting patient response. The researchers found that textural changes, not just tumor size, are a better indicator of therapy effectiveness.
A researcher at Stephenson Cancer Center is investigating how tumor cells evade detection in lung cancer patients on immunotherapy medication. He believes that PD-L1-coated exosomes are neutralizing the antibody, allowing tumors to continue growing.
Researchers identified kynurenine and indoxyl sulfate as key culprits in generating clot formation in cancer patients via AHR signaling. These metabolites can be measured in the blood to predict risk of deep vein thrombosis, and their inhibition may lead to future drug development.
Acalabrutinib, a second-generation Bruton tyrosine kinase inhibitor, has been approved by the FDA for first-line therapy in chronic lymphocytic leukemia (CLL) and small cell lymphoma (SML). The drug works by permanently binding to BTK, halting cancer cell growth signals.
A new study found that cancer survivors are at risk of developing opioid addictions, with rates varying by cancer type and patient history. The research highlights the importance of identifying patients at risk of opioid-related problems to provide alternative pain management strategies.
Researchers found that extra DNA surrounding cancer-causing genes is crucial for maintaining their activation and supporting tumor growth. This discovery could explain why some cancer treatments are effective while others fail, and may lead to new therapeutic strategies.
People living with or beyond cancer are more than twice as likely to die of a stroke compared to the general population. Certain types of cancer, such as breast, prostate, and colorectum cancers, were found to be most commonly associated with fatal strokes.
Women from Appalachia are less likely to receive breast reconstruction surgery following a mastectomy due to lack of adequate care and patient education. Researchers highlight the need for better comprehensive breast cancer care, including access to reconstructive plastic surgeons.
Men receiving care at multidisciplinary prostate cancer clinics are more likely to be informed about treatment options and receive evidence-based care, according to a new study. African American men also tend to opt for definitive therapy, challenging national trends.
The National Foundation for Cancer Research has named the winners of its Salisbury Award Competition, recognizing innovative cancer research projects. The winning project, led by Emily Han-Chung Hsiue and Jacqueline Douglass, targets cancer driver mutations with a novel antibody-based method.
Researchers suggest that exercising before, during, and after treatment, like NASA astronauts, could reduce muscle mass loss, bone demineralization, and heart problems. Cancer patients may benefit from a similar routine to counteract long-term side effects of treatments.
Advanced breast cancer patients frequently receive inaccurate one-number estimates of their average survival time. Instead, a new method provides doctors with three scenarios: best-case, worst-case and typical survival times. This approach has been shown to be more helpful, easier to understand and reassuring for patients.
Chemotherapy-induced cardiomyopathy affects approximately 9% of cancer patients, leading to reduced heart function and poor outcomes. Researchers found that pacemakers can significantly improve left ventricular ejection fraction, a measure of blood flow from the heart, in these patients.
Research found that colonoscopy accuracy has improved overall in England, but variation between providers remains. The study suggests that some independent providers have higher rates of missed cancers compared to NHS providers.
Researchers aim to reduce malnutrition among lung cancer patients by providing nutritional counseling and medically tailored meals. The study, funded by Bristol-Myers Squibb Foundation, will recruit up to 150 newly diagnosed patients with lung cancer across four medical centers.
Researchers developed a 'metaphor menu' to help patients describe cancer, avoiding disempowering language. The tool offers quotes and expressions for different stages of illness, targeting patients, carers, and doctors.
A recent study found that implementation of the Affordable Care Act improved insurance coverage for people with both HIV and cancer. However, disparities in insurance coverage still exist among minorities and low-income individuals, who are more likely to live in non-expansion states. The study suggests that further insurance coverage ...
Women from ethnic minority backgrounds experience higher levels of embarrassment and fear when seeking medical help, which can lead to delayed diagnosis and treatment. The study highlights the importance of addressing these barriers to ensure equal access to healthcare for all.
A study in JAMA Oncology found that geriatric assessment can personalize care and prompt better conversations between physicians, patients, and their families. The tool improved patient satisfaction and caregiver experiences among older adults with advanced cancer.
Researchers from NUS discovered the molecular mechanism underlying natural killer T cell lymphoma, identifying MELK as a stabilizer of EZH2 enzyme. Targeting MELK may provide an alternative approach to treating NKTL by increasing sensitivity to Bortezomib treatment.
A novel attention-based deep learning method automatically learns clinically important regions on whole-slide images to classify them. The new approach outperformed the current state-of-the-art approach that requires detailed annotations for its training.
A review of 11 studies on cancer patients' sense of taste and smell reveals a reduced taste function, particularly for sweet flavors, associated with lower appetite and caloric intake. Researchers aim to develop strategies to help patients eat well during treatment.
Researchers at the University of Pennsylvania have conducted the first-in-US trial of CRISPR-edited immune cells for cancer, demonstrating safety and feasibility with three participants. The edited T cells expanded and bound to their tumor target without serious side effects.
A new study found that bariatric surgery significantly reduces the risk of cancer in patients who lose at least 20% of their body weight. The risk was reduced by 50% compared to those who did not experience significant weight loss after surgery.
Women with a genetic predisposition for breast cancer were 2.5 times more likely to develop malignancy without weight-loss surgery, but the risk was significantly reduced after bariatric or weight-loss surgery. The study found that weight-loss surgery cut the overall risk of developing cancers linked to obesity by 20 percent.
The UK will pioneer the use of FLASH radiotherapy and artificial intelligence in cancer treatment. Cancer Research UK RadNet aims to improve cancer survival by optimising and personalising radiotherapy.
Researchers have developed a simple blood test that detects breast cancer up to five years before clinical signs appear, identifying tumor-associated antigens and autoantibodies. The test shows promising accuracy in detecting breast cancer with reasonable accuracy, especially when using panels of multiple antigens.
A new study found that only about 6 in 10 lung cancer patients in the US receive recommended treatments, with black patients and those over 80 receiving significantly lower treatment rates. The researchers highlight the importance of communicating benefits of treatment for advanced disease beyond survival.
A new study finds that acute kidney injury affects 17% of patients taking immunotherapy medications for cancer, while proton pump inhibitors increase the risk of sustained AKI. Nephrologists and oncologists must recognize these factors to diagnose and treat patients effectively.
A new study from Dana-Farber Cancer Institute and University of Texas Southwestern finds that non-white minority cancer survivors are less likely to receive treatment from culturally competent providers, with significant disparities in access to these physicians. The study highlights the critical need for culturally competent care in c...
Researchers have developed a high-resolution visual map of the RSC complex, a crucial regulator of chromosome structure and gene expression. This study provides new insights into how RSC-like complexes are involved in cancer development and has implications for understanding chromosomal genes in healthy and cancer cells.
A Mayo Clinic-led study found that microvascular endothelial dysfunction is associated with a greater than twofold risk of cancer. The condition, which affects the heart's small arteries, may be a useful marker for predicting cancer risk.
Researchers developed an algorithm that uses nonsense-mediated mRNA decay (NMD) to predict which cancer patients will respond to immunotherapy. NMDdetective identifies mutations in the genome susceptible to this quality control process, allowing for personalized treatment approaches.
A University of Michigan researcher found that breast cancer patients who endured Hurricane Katrina in 2005 have a 15% higher mortality rate than those not exposed to the storm. The study suggests disaster-related healthcare disruptions and highlights the need for improved access to healthcare during disasters.
Gabapentinoid prescriptions for adults with cancer grew from 3.3% to 8.3% between 2005 and 2015, with total prescriptions increasing from 1.2 million to 3.5 million. Further study is needed to understand the effectiveness and risks of gabapentinoids in treating cancer pain.
A recent study published in JAMA Network Open reveals that analyzing gene expression in tumor cells can reveal new targets for therapy in pediatric cancer patients. The study found that 68% of children with cancer showed potential for treatment through gene expression analysis, compared to 46% who responded to DNA mutation analysis.
A new algorithm developed by a Penn Medicine-led team flags patients who would benefit most from advance care planning conversations, leading to improved timely discussions. The study found that 51% of high-priority flagged patients died within six months compared to less than four percent in lower priority group.
Researchers at Medical University of South Carolina discover a protein P17/PERMIT that regulates mitochondrial function and could be a connection between age-related diseases. The protein helps recycle aging mitochondria, which can contribute to conditions like cancer and Alzheimer's.
Researchers discovered Hedgehog signaling shuts down chemokine secretion by tumor-associated macrophages, limiting CD8 T-cell infiltration. Blocking hedgehog pathway reverses process, promoting CD8 T-cell infiltration into tumor microenvironment.
A Dartmouth computer scientist has received a $1.5 million grant to develop machine learning approaches that can reveal relationships between clinical and pathologic findings, patient genetic profiles, and drug resistance in non-small cell lung cancer patients. The goal is to provide personalized treatment strategies for NSCLC patients.
Researchers found a panel of 17 small RNA molecules influenced by genetic alterations in cancer cells, which could lead to targeted treatments for Latinas with TNBC. The study suggests that racial and ethnic differences in miRNA expression may impact breast cancer incidence rates.
A study led by Drexel University showed that coloring and open-studio art therapy benefits stressed caregivers of cancer patients, reducing stress, anxiety, and burnout. The interventions improved positive affect, pleasure, and enjoyment while increasing desire to continue making art.
A new transatlantic research alliance aims to develop radical new strategies and technologies to detect cancer at its earliest stage, improving survival rates. The International Alliance for Cancer Early Detection will accelerate breakthroughs in early detection, leading to quicker benefits for patients.
Researchers found that aspirin use was associated with a lower risk of death among patients with biliary tract cancer, which includes gallbladder cancer. The observational study included nearly 3,000 patients and suggests that long-term aspirin use may be beneficial for these patients.
Researchers at Ohio State University Wexner Medical Center report a measurable increase in inflammation after four weeks of e-cig use without nicotine or flavors. The study suggests that even short-term usage can result in inflammatory changes at a cellular level, a concern as vaping usage is rapidly outpacing scientific understanding.
The study found that all tested tyrosine kinase inhibitors increased COX-2 expression in at least one of the tested cell lines in vitro. Fluorocoxib A uptake correlated with COX-2 expression detected by immunohistochemistry and Western blot analysis in xenografts in vivo.