Articles tagged with Cancer Patients
A recent study published in Nature Communications used AI to analyze pathology images from human cancer patients and identified new features relevant to cancer prognosis. The AI's predictions were found to be more accurate than those made by human pathologists, with a higher accuracy rate when combined with human-established criteria.
A novel assay developed at the Champalimaud Centre for the Unknown uses zebrafish 'avatars' to test radio-sensitivity in human tumor cells. The assay has shown promising results, with 85% success rate in predicting how tumors will respond to specific drugs.
Researchers discovered a key factor, USF1, that inhibits p53 activity, promoting gastric cancer development. USF1 levels can indicate poor prognosis and help identify patients at higher risk of severe forms of gastric cancer.
A large US population-based analysis found that breast cancer survivors face significant non-cancer-related deaths, including heart diseases and Alzheimer's. Most deaths occurred within 10 years of diagnosis, with patients at higher risk for chronic liver disease and other conditions compared to the general population.
Researchers from Boston University School of Medicine identified a three times higher incidence of VTE among African American patients compared to Caucasian patients. The study also found that African American patients were more likely to develop VTE in certain cancer types such as lung, gastric (stomach) and colorectal.
Researchers found a microbiome signature associated with endometrial cancer risk, particularly in postmenopausal women, and verified established risk factors including obesity and high vaginal pH. The study aims to develop a screening tool for early detection of endometrial cancer.
Researchers at UCLouvain have made breakthroughs in understanding the immune system's role in cancer. They developed a new drug targeting immune system cells to stimulate anti-tumour responses, and are now testing it in human clinical trials.
Researchers found that standard pathology tests provide better information on likely outcome and best treatment options for patients with bladder cancer than molecular subtyping techniques. The study suggests that more study is needed before molecular subtypes are used to guide patient care.
Researchers found that residual cancer burden index and classification are accurate and reliable tools to assess patient prognosis. The results suggest that continuous RCB index can predict risk of breast cancer recurrence across all four breast cancer subtypes.
A novel noninvasive technique using acoustofluidics analyzes saliva for the presence of human papilloma virus-16 (HPV-16), associated with oropharyngeal cancers. The test detected OPC in 40% of patients tested and 80% of confirmed cases, offering early detection, risk assessment, and screening.
The American College of Medical Genetics and Genomics recommends evaluating all breast cancer patients for hereditary predisposition. However, they caution that there is insufficient evidence to support genetic testing for BRCA1/2 or multi-gene panels in all breast cancer patients.
Researchers found that colon cancer cells deficient in p53 use the mevalonate pathway to survive, producing ubiquinone to synthesize new DNA. Statins inhibit this pathway, inducing apoptosis in cancer cells.
Recent study suggests a modest association between radioiodine treatment for hyperthyroidism and increased risk of solid cancer, including breast cancer. The Society for Endocrinology and British Thyroid Association advise caution in interpreting the findings and highlight the need for further research.
The European Research Council has awarded €2 million to Ruben van Boxtel's research on late effects of childhood cancer treatment, focusing on developing second cancers. Van Boxtel aims to identify the components of treatment that cause DNA changes and predict patient risk for developing a second novel cancer.
Gastric intestinal metaplasia is a marker associated with increased risk of gastric cancer, prompting the need for standardized clinical practice. The new AGA guideline provides evidence-based recommendations for testing H. pylori eradication and surveillance strategies.
A Phase II study found that pairing standard chemotherapy azacitidine with the drug enasidenib significantly boosts complete remission in patients with acute myeloid leukemia (AML) and IDH2 mutations. The combination therapy was well-tolerated and showed improved overall response rates compared to chemotherapy alone.
A new combination therapy of lower-dose chemotherapy and monoclonal antibodies has shown a 98% response rate in older patients with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic leukemia. The three-year survival rate was 54%, with 30 patients in complete remission without signs of minimal residual disease.
A one-year follow-up study of CAR T-cell therapy for relapsed mantle cell lymphoma found that 93% of patients responded to the treatment, with 67% achieving a complete response. The therapy was shown to be effective and viable option for patients with relapsed or refractory mantle cell lymphoma.
A new study from Georgetown University Medical Center found that 38 patients with follicular lymphoma who were in remission for at least two years did not show any evidence of the disease in their blood. This suggests that these patients may be disease-free and could have a lifelong disease status.
A global trial found mosunetuzumab, an off-the-shelf antibody, can induce complete responses in patients with relapsed or refractory non-Hodgkin lymphoma. Higher doses of the drug correlate with patient responses, and remissions appear to be long-lasting.
A randomized trial found acupuncture significantly reduced radiation-induced dry mouth symptoms in head and neck cancer patients. The study, published in JAMA Network Open, suggests that incorporating acupuncture into radiation therapy may prevent severity of dry mouth symptoms, improving quality of life.
A simple health questionnaire could be a highly effective tool to pre-screen people for early signs of oesophageal cancer, enabling much earlier diagnosis and treatment. Eight factors were identified as markers in those individuals who had Barrett's oesophagus or went on to develop it.
A new study found wide variations in surgery rates for early-stage lung cancer across US counties, with socioeconomic and healthcare delivery factors contributing to the gap. Counties with higher poverty rates, non-Hispanic black populations, and lower surgeon-to-population ratios had lower surgery rates.
A study found that a specific protein, ARID1A, is linked to aggressive cholangiocarcinoma (ICC) and poor patient outcomes. The researchers identified ARID1A as a potential biomarker for predicting ICC prognosis, which could lead to more effective treatments.
A large study found that a single dose of radiotherapy is as effective as five doses in controlling pain and alleviating symptoms for end-of-life cancer patients with spinal canal compression. The study, published in JAMA, showed similar patient outcomes between one-dose and multi-fraction radiotherapy regimens.
A new study by Cancer Research UK found that nearly 3,400 patients experienced avoidable delays in their cancer diagnosis. The reasons for these delays are complex and can include long waiting times for tests, vague symptoms, and pre-existing conditions.
A meta-analysis of 44 clinical trials found that patient-reported outcomes are significantly associated with overall survival, confirming their importance as prognostic factors. This study aims to improve patient care by providing clinicians with valuable insights into cancer patients' needs and concerns.
The University of Illinois Chicago has received a $300,000 grant to develop a screening process for prescribing opioids and managing opioid use disorders in cancer patients. More than 70% of cancer patients who receive radiation treatment use opiates, with higher rates seen in those receiving chemotherapy or having head and neck cancer.
A new study found that biennial mammography screening resulted in smaller and less advanced breast cancer tumors compared to annual screenings. The study also discovered that women receiving biennial screenings tended to have more aggressive treatment options, such as chemotherapy and axillary lymph node dissection.
A new radiation therapy regimen combining lutetium-177 and actinium-225 has been shown to stabilize tumour growth and improve survival rates for patients with late-stage prostate cancer. The study demonstrated significant reductions in side effects, including dry mouth, compared to previous radionuclide therapies.
A new study published in the European Heart Journal found that over one in ten cancer patients die from cardiovascular disease, including heart disease and stroke. The study analyzed data from over 3.2 million US patients diagnosed with cancer between 1973 and 2012, revealing that certain types of cancer, such as breast and prostate ca...
A study published in Cancer Immunology Research uses AI to analyze changes in CT scans before and after immunotherapy treatment, predicting patient response. The researchers found that textural changes, not just tumor size, are a better indicator of therapy effectiveness.
A researcher at Stephenson Cancer Center is investigating how tumor cells evade detection in lung cancer patients on immunotherapy medication. He believes that PD-L1-coated exosomes are neutralizing the antibody, allowing tumors to continue growing.
Researchers identified kynurenine and indoxyl sulfate as key culprits in generating clot formation in cancer patients via AHR signaling. These metabolites can be measured in the blood to predict risk of deep vein thrombosis, and their inhibition may lead to future drug development.
Acalabrutinib, a second-generation Bruton tyrosine kinase inhibitor, has been approved by the FDA for first-line therapy in chronic lymphocytic leukemia (CLL) and small cell lymphoma (SML). The drug works by permanently binding to BTK, halting cancer cell growth signals.
A new study found that cancer survivors are at risk of developing opioid addictions, with rates varying by cancer type and patient history. The research highlights the importance of identifying patients at risk of opioid-related problems to provide alternative pain management strategies.
Researchers found that extra DNA surrounding cancer-causing genes is crucial for maintaining their activation and supporting tumor growth. This discovery could explain why some cancer treatments are effective while others fail, and may lead to new therapeutic strategies.
People living with or beyond cancer are more than twice as likely to die of a stroke compared to the general population. Certain types of cancer, such as breast, prostate, and colorectum cancers, were found to be most commonly associated with fatal strokes.
Women from Appalachia are less likely to receive breast reconstruction surgery following a mastectomy due to lack of adequate care and patient education. Researchers highlight the need for better comprehensive breast cancer care, including access to reconstructive plastic surgeons.
Men receiving care at multidisciplinary prostate cancer clinics are more likely to be informed about treatment options and receive evidence-based care, according to a new study. African American men also tend to opt for definitive therapy, challenging national trends.
The National Foundation for Cancer Research has named the winners of its Salisbury Award Competition, recognizing innovative cancer research projects. The winning project, led by Emily Han-Chung Hsiue and Jacqueline Douglass, targets cancer driver mutations with a novel antibody-based method.
Researchers suggest that exercising before, during, and after treatment, like NASA astronauts, could reduce muscle mass loss, bone demineralization, and heart problems. Cancer patients may benefit from a similar routine to counteract long-term side effects of treatments.
Advanced breast cancer patients frequently receive inaccurate one-number estimates of their average survival time. Instead, a new method provides doctors with three scenarios: best-case, worst-case and typical survival times. This approach has been shown to be more helpful, easier to understand and reassuring for patients.
Chemotherapy-induced cardiomyopathy affects approximately 9% of cancer patients, leading to reduced heart function and poor outcomes. Researchers found that pacemakers can significantly improve left ventricular ejection fraction, a measure of blood flow from the heart, in these patients.
Research found that colonoscopy accuracy has improved overall in England, but variation between providers remains. The study suggests that some independent providers have higher rates of missed cancers compared to NHS providers.
Researchers aim to reduce malnutrition among lung cancer patients by providing nutritional counseling and medically tailored meals. The study, funded by Bristol-Myers Squibb Foundation, will recruit up to 150 newly diagnosed patients with lung cancer across four medical centers.
Researchers developed a 'metaphor menu' to help patients describe cancer, avoiding disempowering language. The tool offers quotes and expressions for different stages of illness, targeting patients, carers, and doctors.
A recent study found that implementation of the Affordable Care Act improved insurance coverage for people with both HIV and cancer. However, disparities in insurance coverage still exist among minorities and low-income individuals, who are more likely to live in non-expansion states. The study suggests that further insurance coverage ...
Women from ethnic minority backgrounds experience higher levels of embarrassment and fear when seeking medical help, which can lead to delayed diagnosis and treatment. The study highlights the importance of addressing these barriers to ensure equal access to healthcare for all.
A study in JAMA Oncology found that geriatric assessment can personalize care and prompt better conversations between physicians, patients, and their families. The tool improved patient satisfaction and caregiver experiences among older adults with advanced cancer.
Researchers from NUS discovered the molecular mechanism underlying natural killer T cell lymphoma, identifying MELK as a stabilizer of EZH2 enzyme. Targeting MELK may provide an alternative approach to treating NKTL by increasing sensitivity to Bortezomib treatment.
A novel attention-based deep learning method automatically learns clinically important regions on whole-slide images to classify them. The new approach outperformed the current state-of-the-art approach that requires detailed annotations for its training.
A review of 11 studies on cancer patients' sense of taste and smell reveals a reduced taste function, particularly for sweet flavors, associated with lower appetite and caloric intake. Researchers aim to develop strategies to help patients eat well during treatment.
Researchers at the University of Pennsylvania have conducted the first-in-US trial of CRISPR-edited immune cells for cancer, demonstrating safety and feasibility with three participants. The edited T cells expanded and bound to their tumor target without serious side effects.
A new study found that bariatric surgery significantly reduces the risk of cancer in patients who lose at least 20% of their body weight. The risk was reduced by 50% compared to those who did not experience significant weight loss after surgery.
Women with a genetic predisposition for breast cancer were 2.5 times more likely to develop malignancy without weight-loss surgery, but the risk was significantly reduced after bariatric or weight-loss surgery. The study found that weight-loss surgery cut the overall risk of developing cancers linked to obesity by 20 percent.
The UK will pioneer the use of FLASH radiotherapy and artificial intelligence in cancer treatment. Cancer Research UK RadNet aims to improve cancer survival by optimising and personalising radiotherapy.
Researchers have developed a simple blood test that detects breast cancer up to five years before clinical signs appear, identifying tumor-associated antigens and autoantibodies. The test shows promising accuracy in detecting breast cancer with reasonable accuracy, especially when using panels of multiple antigens.
A new study found that only about 6 in 10 lung cancer patients in the US receive recommended treatments, with black patients and those over 80 receiving significantly lower treatment rates. The researchers highlight the importance of communicating benefits of treatment for advanced disease beyond survival.
A new study finds that acute kidney injury affects 17% of patients taking immunotherapy medications for cancer, while proton pump inhibitors increase the risk of sustained AKI. Nephrologists and oncologists must recognize these factors to diagnose and treat patients effectively.