Articles tagged with Cancer Patients
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Researchers at UNC Lineberger Comprehensive Cancer Center will study the impact of financial navigation services on rural cancer patients in North Carolina. The study aims to connect patients with potential financial support resources and reduce financial toxicity associated with cancer care.
A new system developed by Yale scientists uses viral gene therapy and CRISPR gene-editing technology to make cancer cells stand out from the crowd, helping the immune system spot and eliminate tumors that other forms of immunotherapies might miss.
A U-M study found that maximizer patients consume more health care resources without clear evidence of improved outcomes. Strong maximizers had four or more doctor visits, two or more ultrasounds, and one or more radioactive iodine scans in the prior year.
Researchers found that mutation and loss of TSC1 leads to decreased sensitivity to Hsp90 inhibitors, causing hypoacetylation of Hsp90. Co-targeting HDACs may restore Hsp90 acetylation and sensitivity in bladder cancer patients with TSC1 mutations.
Researchers at Georgetown University Medical Center developed a virtual review method that reduces the time needed to assess a cancer patient's tumor profile and suitability for clinical trials from 14 to 4 days. The method also increased the number of cases that could be assessed, with over 2,000 clinical trials evaluated.
A Colorado study found that lymphoma stage at diagnosis impacts types of second cancers that may form after treatment. Early-stage patients had a higher risk of solid tumors, while late-stage patients were more likely to develop hematologic malignancies.
Exercise can counteract the negative effects of cancer treatments on the cardiovascular system and relieve symptoms such as nausea and fatigue. A tailored exercise prescription is recommended for each patient based on individual characteristics, personal history, and cancer treatment.
The University of Colorado Anschutz Medical Campus has received a grant to advance implementation science and cancer control efforts. The Center will develop resources and education to enhance cancer prevention and control in Colorado and nationally.
A 40-year epidemiological study found that cancer incidence and mortality rates often move in concert for certain cancers, such as lung cancer, indicating a desirable trend. However, other cancers like thyroid, kidney, and melanoma show rising incidence rates with stagnant mortality rates, suggesting overdiagnosis may be at play
A new blood test can detect liver cancer and life-threatening vascular complications in diabetic patients with high accuracy. The test analyzes DNA in just a few drops of blood and has already shown promise in detecting other major cancers.
UT Dallas researchers have shown that hyperspectral imaging and AI can predict the presence of cancer cells with 80-90% accuracy in 293 tissue specimens. This technology, called a smart surgical microscope, aims to reduce operating time, lower medical costs, and save lives.
The BEACON CRC Phase III clinical trial found that the three-drug combination of encorafenib, binimetinib, and cetuximab significantly improved overall survival in patients with BRAF-mutated metastatic colorectal cancer. Median OS for the triplet-targeted therapy was 9 months compared to 5.4 months for standard therapy.
A study published in Nature Medicine suggests that whole genome sequencing of tumour cells can predict prognosis and identify effective treatments for patients with triple negative breast cancers. The technique reveals genetic signatures and mutations, providing clues to develop new drugs and improve treatment outcomes.
A new study presents promising results from the CheckMate 358 trial, a phase I/II investigational immune-therapy trial combining nivolumab and ipilimumab for recurrent and metastatic cervical cancer. The combination showed higher clinical benefit rates compared to single-agent treatments.
A new blood test has been developed to detect multiple types of cancer, including hormone receptor-negative breast, colorectal, and pancreatic cancer, with a high degree of accuracy. The test uses next-generation sequencing technology to probe DNA for methylation patterns associated with cancer.
A combination of ipilimumab and nivolumab has stopped or reversed melanoma progression for five years in nearly half of patients, offering new hope for advanced melanoma patients. The Checkmate 067 trial found a 52% five-year overall survival rate, with 74% treatment-free after five years.
A comprehensive tobacco treatment program at the University of Texas M.D. Anderson Cancer Center resulted in an average of 45% smoking abstinence rates among participating cancer patients. This rate surpasses that of previous minimal interventions like quitlines, which averaged less than 20% abstinence rates.
A comprehensive tobacco treatment program in an oncologic setting significantly improves smoking cessation rates, affecting patient outcomes with cancer who smoke. Average seven-day abstinence rates reached 44% at the nine-month follow-up.
The RADICALS-RT trial found no difference in disease recurrence between men who received radiotherapy shortly after surgery and those who waited for cancer to come back. The study confirms that observation should be the standard approach after surgery, with radiotherapy used only if the cancer recurs.
Researchers found that adding durvalumab to radiation and chemotherapy significantly decreased the recurrence of lung cancer in both chest and distant sites, with new lesions occurring primarily in the brain. This suggests that aggressive local therapies may further extend survival for patients with non-small cell lung cancer.
Researchers at Cleveland Clinic identified a metabolite associated with specific PTEN mutations, distinguishing those at high risk for neurodevelopmental disorders from cancer. The findings may help tailor treatments to individual patients with germline PTEN mutations.
Researchers have discovered a key mechanism behind pancreatic cancer's aggressive growth, which may help explain why promising drugs work and when they won't. The finding identifies a weakness in the cancer cells' metabolism that could be exploited to improve treatment outcomes.
A Phase 1B study led by the University of Texas MD Anderson Cancer Center demonstrated positive safety results for pegilodecakin when combined with pembrolizumab and nivolumab. The treatment showed promising anti-tumor activity in patients with non-small cell lung cancer and kidney cancer.
Cancer cells adapt to treatment with checkpoint blocker drugs by altering a metabolic process, leading to shorter survival for patients. The study suggests that identifying biomarkers of metabolic changes related to treatment with checkpoint blockers could help identify patients who might benefit from combination therapy.
A researcher at the Oklahoma Tobacco Research Center has been awarded a five-year grant to study the long-term effects of vaping on human health. The study aims to examine the effects of vaping on respiratory function and determine if users become susceptible to other tobacco products.
Researchers will focus on extending clinical research in cardiovascular and neurocognitive complications of cancer treatments to improve patient well-being. The team aims to protect the heart from damage caused by chemotherapy drugs and define who may be at risk.
Researchers propose targeting cancer patients' mindsets to improve their health, functioning, and well-being. They identify specific mindsets that can impact cancer patients' health, such as viewing cancer as manageable or seeing the body as capable and resilient.
A study of nearly 1.9 million breast cancer patients found that men have lower three-year and five-year survival rates compared to women. The analysis attributed the difference to undertreatment and clinical characteristics.
SU2C Catalyst teams investigate new treatments for triple-negative breast cancer and metastatic hormone-sensitive prostate cancer, combining medicines like atezolizumab and ipatasertib with radiation and hormone therapy.
A study of 585 cancer patients in Australia and Vietnam found that 'bad luck' or fate was the third most common perceived cause of their cancer. This misconception can lead to a lack of willingness to change behavior related to diet, lifestyle, treatment, and care.
The Georgia Cancer Center at Augusta University has received a six-year $6 million grant from the NCI to improve access to clinical trials for minority and rural populations. The grant will be used to recruit patients to conduct multi-site cancer clinical trials and care delivery studies in their communities.
A major new study has found that cancer patients who miss an urgent referral appointment for their symptoms are 12% more likely to die within 12 months of diagnosis. The study also revealed that non-attending patients with cancer had a higher risk of advanced stage disease at diagnosis, which can lead to poorer outcomes.
Javier Jo's research aims to detect oral cancer at an early stage using a hand-held endoscope that can recognize patterns and signatures of precancerous and cancerous lesions. The technology has the potential to increase the number of patients diagnosed with oral cancer at an earlier stage, improving survival rates and quality of life.
A new liquid biopsy test can detect microsatellite instability (MSI) and tumor mutational burden (TMB), indicating which patients are likely to benefit from immune checkpoint inhibitors. The test produced a specificity of greater than 99% and sensitivity of 78% for MSI, and 67% for TMB.
A recent study published in the New England Journal of Medicine reveals that unmarried patients with cancer are significantly less likely to receive potentially life-saving surgeries or radiotherapies compared to their married counterparts. The disparity persists despite extensive research findings suggesting otherwise.
A Brazilian multicenter study found that older hospitalized patients with cancer have a high prevalence of malnutrition, affecting nearly half of the patient population. The study highlights the need for nutritional assessments soon after hospitalization to prevent malnutrition and weight loss.
Cancer patients who continue smoking after diagnosis have a higher mortality rate and increased risk for second cancer development. The IASLC Declaration recommends screening all cancer patients for tobacco use and advising on tobacco cessation.
LSU Health New Orleans has been awarded a $13.6 million grant to expand its clinical trials network, providing cancer care and access to over 50% of newly diagnosed patients in the region. The new network will also increase minority patient participation in clinical trials.
Research studies by SWOG Cancer Research Network reveal that low-income cancer patients and those without insurance may not receive the same treatment benefits as their counterparts. Socioeconomic deprivation is found to be a significant factor in cancer outcomes, even after adjusting for race and insurance status.
Researchers at MD Anderson Cancer Center confirm ubiquitin specific protease 21 (UPS21) as a frequently amplified gene in pancreatic ductal adenocarcinoma (PDAC), a form of pancreatic cancer. Depletion of UPS21 impairs tumor growth, promoting malignant transformation and cancer cell stemness.
Researchers from Osaka University found that microRNA methylation levels can discriminate cancer patients from healthy individuals with high sensitivity and specificity. The study suggests that methylation of specific mature microRNAs could be a more powerful indicator of early-stage pancreatic cancer than existing biomarkers.
A lack of government action on NHS staffing undermines efforts to diagnose cancer early, with nearly half of all cancers diagnosed in England at stage 3 or 4. The health service needs an extra 1,700 radiologists and nearly 2,000 therapeutic radiographers to improve staff efficiency.
Research finds that patients experiencing internal bleeding after a heart attack may be at higher risk of developing cancer. The study suggests that early detection of bleeding can lead to improved cancer prognosis.
Researchers at H. Lee Moffitt Cancer Center describe a promising new treatment combination for patients with non-small cell lung cancer, showing preliminary efficacy and improved tolerance compared to standard treatments.
A new drug, TAK-228, has demonstrated effectiveness in treating metastatic bladder cancer, slowing tumor growth and progression. The study found that four of seven patients showed a positive response to the treatment.
A recent study found that primary care physicians recommend health promotion to at least some cancer survivors, but oncologists and specialists rarely do. Cancer survivors face increased risks of cardiovascular disease if they don't adopt healthy lifestyles.
A recent study published in Journal of Adolescent and Young Adult Oncology found that 30% of young adult cancer patients (ages 18-39) tested positive for a breakdown product of cannabis. Cannabis users were more likely to be male and report having more severe symptoms, including pain and nausea.
Researchers are conducting a phase 1 clinical trial using CAR-T cells, which have been shown to attack and kill cancers. The goal is to learn more about how these super-powered immune cells interact with solid tumors to develop effective treatments for various types of cancer.
A team of researchers at Georgetown University Medical Center has identified a chain of molecules critical for pancreatic ductal adenocarcinoma (PDAC) growth and survival. Inhibiting this 'Yap' biological network may effectively regress early-stage PDAC, and pairing it with other drugs could halt more advanced stage tumors.
A clinical trial discovered that selinexor, a novel therapy, effectively knocked down bone marrow cancer in over a quarter of patients, including two who achieved complete remission. The treatment showed promise for patients resistant to multiple therapies and offered new hope for those with limited treatment options.
Researchers analyzed genomic data from 317 MCC patients and found two distinct populations with different genetic profiles and treatment responses. Immunotherapies showed high effectiveness in both groups, with better response rates when given early treatment.
Research published in Gut journal suggests a link between antibiotic use and increased risk of bowel cancer, particularly for cancers of the proximal colon. Conversely, rectal cancer risk was found to be lower among those prescribed antibiotics, possibly due to differences in gut microbiome activity.
The study aims to improve caregiver physical and emotional well-being, increase confidence for caregiving, and enhance patient outcomes. Researchers will use simulation-based learning to train 180 family caregivers, comparing results to a control group.
Researchers at Moffitt Cancer Center have discovered a new treatment approach that may help nearly a third of lung cancer patients with KRAS mutations. The combination therapy targets the MEK kinase and enhances anti-tumor immunity through cytokines TNFα and IFNγ.
A new study found that even low-intensity exercise was associated with a nearly 20% reduction in cancer progression or death in patients with advanced colorectal cancer. Patients who engaged in moderate exercise while undergoing chemotherapy tended to have delayed disease progression and fewer severe side effects from treatment.
The study examined 3,368 medical aid in dying prescriptions from Oregon (1998-2017) and Washington (2009-2017), finding that most patients were insured, non-Hispanic white individuals with cancer. The primary reasons for pursuing medical aid in dying were loss of autonomy, impaired quality of life, and loss of dignity.
Moffitt researchers identified three subtypes of squamous cell lung cancer (SCC) with distinct genetic, chromosomal, and protein alterations. The inflamed subtype is characterized by immune cell infiltration and higher PD-1 levels, while the redox subtype has altered oxidation-reduction signaling pathways. These subtypes did not correl...
Adults aged 85 years and older account for the fastest-growing age group in the US, with higher cancer incidence rates but lower screening and treatment rates. The most common cancers among this population are lung, breast, prostate, and colorectum, but late-stage diagnosis and poorer survival outcomes are also reported.
A study analyzing published research found Nordic walking reduces swelling and improves physical fitness in breast cancer patients. However, more well-designed studies are needed to explore its full potential.
Five postdoctoral scholars will collaborate with experts in physical and biomedical science to better understand the interplay between the immune system and cancers. The fellowships aim to develop new treatments using a patient's immune system to prevent, control, and treat cancer.