Articles tagged with Cancer Patients
A new study from Dana-Farber Cancer Institute and University of Texas Southwestern finds that non-white minority cancer survivors are less likely to receive treatment from culturally competent providers, with significant disparities in access to these physicians. The study highlights the critical need for culturally competent care in c...
Researchers have developed a high-resolution visual map of the RSC complex, a crucial regulator of chromosome structure and gene expression. This study provides new insights into how RSC-like complexes are involved in cancer development and has implications for understanding chromosomal genes in healthy and cancer cells.
A Mayo Clinic-led study found that microvascular endothelial dysfunction is associated with a greater than twofold risk of cancer. The condition, which affects the heart's small arteries, may be a useful marker for predicting cancer risk.
Researchers developed an algorithm that uses nonsense-mediated mRNA decay (NMD) to predict which cancer patients will respond to immunotherapy. NMDdetective identifies mutations in the genome susceptible to this quality control process, allowing for personalized treatment approaches.
A University of Michigan researcher found that breast cancer patients who endured Hurricane Katrina in 2005 have a 15% higher mortality rate than those not exposed to the storm. The study suggests disaster-related healthcare disruptions and highlights the need for improved access to healthcare during disasters.
Gabapentinoid prescriptions for adults with cancer grew from 3.3% to 8.3% between 2005 and 2015, with total prescriptions increasing from 1.2 million to 3.5 million. Further study is needed to understand the effectiveness and risks of gabapentinoids in treating cancer pain.
A recent study published in JAMA Network Open reveals that analyzing gene expression in tumor cells can reveal new targets for therapy in pediatric cancer patients. The study found that 68% of children with cancer showed potential for treatment through gene expression analysis, compared to 46% who responded to DNA mutation analysis.
A new algorithm developed by a Penn Medicine-led team flags patients who would benefit most from advance care planning conversations, leading to improved timely discussions. The study found that 51% of high-priority flagged patients died within six months compared to less than four percent in lower priority group.
Researchers at Medical University of South Carolina discover a protein P17/PERMIT that regulates mitochondrial function and could be a connection between age-related diseases. The protein helps recycle aging mitochondria, which can contribute to conditions like cancer and Alzheimer's.
Researchers discovered Hedgehog signaling shuts down chemokine secretion by tumor-associated macrophages, limiting CD8 T-cell infiltration. Blocking hedgehog pathway reverses process, promoting CD8 T-cell infiltration into tumor microenvironment.
A Dartmouth computer scientist has received a $1.5 million grant to develop machine learning approaches that can reveal relationships between clinical and pathologic findings, patient genetic profiles, and drug resistance in non-small cell lung cancer patients. The goal is to provide personalized treatment strategies for NSCLC patients.
Researchers found a panel of 17 small RNA molecules influenced by genetic alterations in cancer cells, which could lead to targeted treatments for Latinas with TNBC. The study suggests that racial and ethnic differences in miRNA expression may impact breast cancer incidence rates.
A study led by Drexel University showed that coloring and open-studio art therapy benefits stressed caregivers of cancer patients, reducing stress, anxiety, and burnout. The interventions improved positive affect, pleasure, and enjoyment while increasing desire to continue making art.
A new transatlantic research alliance aims to develop radical new strategies and technologies to detect cancer at its earliest stage, improving survival rates. The International Alliance for Cancer Early Detection will accelerate breakthroughs in early detection, leading to quicker benefits for patients.
Researchers found that aspirin use was associated with a lower risk of death among patients with biliary tract cancer, which includes gallbladder cancer. The observational study included nearly 3,000 patients and suggests that long-term aspirin use may be beneficial for these patients.
Researchers at Ohio State University Wexner Medical Center report a measurable increase in inflammation after four weeks of e-cig use without nicotine or flavors. The study suggests that even short-term usage can result in inflammatory changes at a cellular level, a concern as vaping usage is rapidly outpacing scientific understanding.
The study found that all tested tyrosine kinase inhibitors increased COX-2 expression in at least one of the tested cell lines in vitro. Fluorocoxib A uptake correlated with COX-2 expression detected by immunohistochemistry and Western blot analysis in xenografts in vivo.
Researchers at UNC Lineberger Comprehensive Cancer Center will study the impact of financial navigation services on rural cancer patients in North Carolina. The study aims to connect patients with potential financial support resources and reduce financial toxicity associated with cancer care.
A new system developed by Yale scientists uses viral gene therapy and CRISPR gene-editing technology to make cancer cells stand out from the crowd, helping the immune system spot and eliminate tumors that other forms of immunotherapies might miss.
A U-M study found that maximizer patients consume more health care resources without clear evidence of improved outcomes. Strong maximizers had four or more doctor visits, two or more ultrasounds, and one or more radioactive iodine scans in the prior year.
Researchers found that mutation and loss of TSC1 leads to decreased sensitivity to Hsp90 inhibitors, causing hypoacetylation of Hsp90. Co-targeting HDACs may restore Hsp90 acetylation and sensitivity in bladder cancer patients with TSC1 mutations.
Researchers at Georgetown University Medical Center developed a virtual review method that reduces the time needed to assess a cancer patient's tumor profile and suitability for clinical trials from 14 to 4 days. The method also increased the number of cases that could be assessed, with over 2,000 clinical trials evaluated.
A Colorado study found that lymphoma stage at diagnosis impacts types of second cancers that may form after treatment. Early-stage patients had a higher risk of solid tumors, while late-stage patients were more likely to develop hematologic malignancies.
Exercise can counteract the negative effects of cancer treatments on the cardiovascular system and relieve symptoms such as nausea and fatigue. A tailored exercise prescription is recommended for each patient based on individual characteristics, personal history, and cancer treatment.
The University of Colorado Anschutz Medical Campus has received a grant to advance implementation science and cancer control efforts. The Center will develop resources and education to enhance cancer prevention and control in Colorado and nationally.
A 40-year epidemiological study found that cancer incidence and mortality rates often move in concert for certain cancers, such as lung cancer, indicating a desirable trend. However, other cancers like thyroid, kidney, and melanoma show rising incidence rates with stagnant mortality rates, suggesting overdiagnosis may be at play
A new blood test can detect liver cancer and life-threatening vascular complications in diabetic patients with high accuracy. The test analyzes DNA in just a few drops of blood and has already shown promise in detecting other major cancers.
UT Dallas researchers have shown that hyperspectral imaging and AI can predict the presence of cancer cells with 80-90% accuracy in 293 tissue specimens. This technology, called a smart surgical microscope, aims to reduce operating time, lower medical costs, and save lives.
The BEACON CRC Phase III clinical trial found that the three-drug combination of encorafenib, binimetinib, and cetuximab significantly improved overall survival in patients with BRAF-mutated metastatic colorectal cancer. Median OS for the triplet-targeted therapy was 9 months compared to 5.4 months for standard therapy.
A study published in Nature Medicine suggests that whole genome sequencing of tumour cells can predict prognosis and identify effective treatments for patients with triple negative breast cancers. The technique reveals genetic signatures and mutations, providing clues to develop new drugs and improve treatment outcomes.
A new study presents promising results from the CheckMate 358 trial, a phase I/II investigational immune-therapy trial combining nivolumab and ipilimumab for recurrent and metastatic cervical cancer. The combination showed higher clinical benefit rates compared to single-agent treatments.
A new blood test has been developed to detect multiple types of cancer, including hormone receptor-negative breast, colorectal, and pancreatic cancer, with a high degree of accuracy. The test uses next-generation sequencing technology to probe DNA for methylation patterns associated with cancer.
A combination of ipilimumab and nivolumab has stopped or reversed melanoma progression for five years in nearly half of patients, offering new hope for advanced melanoma patients. The Checkmate 067 trial found a 52% five-year overall survival rate, with 74% treatment-free after five years.
A comprehensive tobacco treatment program at the University of Texas M.D. Anderson Cancer Center resulted in an average of 45% smoking abstinence rates among participating cancer patients. This rate surpasses that of previous minimal interventions like quitlines, which averaged less than 20% abstinence rates.
A comprehensive tobacco treatment program in an oncologic setting significantly improves smoking cessation rates, affecting patient outcomes with cancer who smoke. Average seven-day abstinence rates reached 44% at the nine-month follow-up.
The RADICALS-RT trial found no difference in disease recurrence between men who received radiotherapy shortly after surgery and those who waited for cancer to come back. The study confirms that observation should be the standard approach after surgery, with radiotherapy used only if the cancer recurs.
Researchers found that adding durvalumab to radiation and chemotherapy significantly decreased the recurrence of lung cancer in both chest and distant sites, with new lesions occurring primarily in the brain. This suggests that aggressive local therapies may further extend survival for patients with non-small cell lung cancer.
Researchers at Cleveland Clinic identified a metabolite associated with specific PTEN mutations, distinguishing those at high risk for neurodevelopmental disorders from cancer. The findings may help tailor treatments to individual patients with germline PTEN mutations.
Researchers have discovered a key mechanism behind pancreatic cancer's aggressive growth, which may help explain why promising drugs work and when they won't. The finding identifies a weakness in the cancer cells' metabolism that could be exploited to improve treatment outcomes.
A Phase 1B study led by the University of Texas MD Anderson Cancer Center demonstrated positive safety results for pegilodecakin when combined with pembrolizumab and nivolumab. The treatment showed promising anti-tumor activity in patients with non-small cell lung cancer and kidney cancer.
Cancer cells adapt to treatment with checkpoint blocker drugs by altering a metabolic process, leading to shorter survival for patients. The study suggests that identifying biomarkers of metabolic changes related to treatment with checkpoint blockers could help identify patients who might benefit from combination therapy.
A researcher at the Oklahoma Tobacco Research Center has been awarded a five-year grant to study the long-term effects of vaping on human health. The study aims to examine the effects of vaping on respiratory function and determine if users become susceptible to other tobacco products.
Researchers will focus on extending clinical research in cardiovascular and neurocognitive complications of cancer treatments to improve patient well-being. The team aims to protect the heart from damage caused by chemotherapy drugs and define who may be at risk.
Researchers propose targeting cancer patients' mindsets to improve their health, functioning, and well-being. They identify specific mindsets that can impact cancer patients' health, such as viewing cancer as manageable or seeing the body as capable and resilient.
A study of nearly 1.9 million breast cancer patients found that men have lower three-year and five-year survival rates compared to women. The analysis attributed the difference to undertreatment and clinical characteristics.
SU2C Catalyst teams investigate new treatments for triple-negative breast cancer and metastatic hormone-sensitive prostate cancer, combining medicines like atezolizumab and ipatasertib with radiation and hormone therapy.
A study of 585 cancer patients in Australia and Vietnam found that 'bad luck' or fate was the third most common perceived cause of their cancer. This misconception can lead to a lack of willingness to change behavior related to diet, lifestyle, treatment, and care.
The Georgia Cancer Center at Augusta University has received a six-year $6 million grant from the NCI to improve access to clinical trials for minority and rural populations. The grant will be used to recruit patients to conduct multi-site cancer clinical trials and care delivery studies in their communities.
A major new study has found that cancer patients who miss an urgent referral appointment for their symptoms are 12% more likely to die within 12 months of diagnosis. The study also revealed that non-attending patients with cancer had a higher risk of advanced stage disease at diagnosis, which can lead to poorer outcomes.
Javier Jo's research aims to detect oral cancer at an early stage using a hand-held endoscope that can recognize patterns and signatures of precancerous and cancerous lesions. The technology has the potential to increase the number of patients diagnosed with oral cancer at an earlier stage, improving survival rates and quality of life.
A new liquid biopsy test can detect microsatellite instability (MSI) and tumor mutational burden (TMB), indicating which patients are likely to benefit from immune checkpoint inhibitors. The test produced a specificity of greater than 99% and sensitivity of 78% for MSI, and 67% for TMB.
A recent study published in the New England Journal of Medicine reveals that unmarried patients with cancer are significantly less likely to receive potentially life-saving surgeries or radiotherapies compared to their married counterparts. The disparity persists despite extensive research findings suggesting otherwise.
A Brazilian multicenter study found that older hospitalized patients with cancer have a high prevalence of malnutrition, affecting nearly half of the patient population. The study highlights the need for nutritional assessments soon after hospitalization to prevent malnutrition and weight loss.
Cancer patients who continue smoking after diagnosis have a higher mortality rate and increased risk for second cancer development. The IASLC Declaration recommends screening all cancer patients for tobacco use and advising on tobacco cessation.
LSU Health New Orleans has been awarded a $13.6 million grant to expand its clinical trials network, providing cancer care and access to over 50% of newly diagnosed patients in the region. The new network will also increase minority patient participation in clinical trials.
Research studies by SWOG Cancer Research Network reveal that low-income cancer patients and those without insurance may not receive the same treatment benefits as their counterparts. Socioeconomic deprivation is found to be a significant factor in cancer outcomes, even after adjusting for race and insurance status.
Researchers at MD Anderson Cancer Center confirm ubiquitin specific protease 21 (UPS21) as a frequently amplified gene in pancreatic ductal adenocarcinoma (PDAC), a form of pancreatic cancer. Depletion of UPS21 impairs tumor growth, promoting malignant transformation and cancer cell stemness.
Researchers from Osaka University found that microRNA methylation levels can discriminate cancer patients from healthy individuals with high sensitivity and specificity. The study suggests that methylation of specific mature microRNAs could be a more powerful indicator of early-stage pancreatic cancer than existing biomarkers.
A lack of government action on NHS staffing undermines efforts to diagnose cancer early, with nearly half of all cancers diagnosed in England at stage 3 or 4. The health service needs an extra 1,700 radiologists and nearly 2,000 therapeutic radiographers to improve staff efficiency.
Research finds that patients experiencing internal bleeding after a heart attack may be at higher risk of developing cancer. The study suggests that early detection of bleeding can lead to improved cancer prognosis.