Articles tagged with Cancer Patients
Women from Appalachia are less likely to receive breast reconstruction surgery following a mastectomy due to lack of adequate care and patient education. Researchers highlight the need for better comprehensive breast cancer care, including access to reconstructive plastic surgeons.
Men receiving care at multidisciplinary prostate cancer clinics are more likely to be informed about treatment options and receive evidence-based care, according to a new study. African American men also tend to opt for definitive therapy, challenging national trends.
The National Foundation for Cancer Research has named the winners of its Salisbury Award Competition, recognizing innovative cancer research projects. The winning project, led by Emily Han-Chung Hsiue and Jacqueline Douglass, targets cancer driver mutations with a novel antibody-based method.
Researchers suggest that exercising before, during, and after treatment, like NASA astronauts, could reduce muscle mass loss, bone demineralization, and heart problems. Cancer patients may benefit from a similar routine to counteract long-term side effects of treatments.
Advanced breast cancer patients frequently receive inaccurate one-number estimates of their average survival time. Instead, a new method provides doctors with three scenarios: best-case, worst-case and typical survival times. This approach has been shown to be more helpful, easier to understand and reassuring for patients.
Chemotherapy-induced cardiomyopathy affects approximately 9% of cancer patients, leading to reduced heart function and poor outcomes. Researchers found that pacemakers can significantly improve left ventricular ejection fraction, a measure of blood flow from the heart, in these patients.
Research found that colonoscopy accuracy has improved overall in England, but variation between providers remains. The study suggests that some independent providers have higher rates of missed cancers compared to NHS providers.
Researchers aim to reduce malnutrition among lung cancer patients by providing nutritional counseling and medically tailored meals. The study, funded by Bristol-Myers Squibb Foundation, will recruit up to 150 newly diagnosed patients with lung cancer across four medical centers.
Researchers developed a 'metaphor menu' to help patients describe cancer, avoiding disempowering language. The tool offers quotes and expressions for different stages of illness, targeting patients, carers, and doctors.
A recent study found that implementation of the Affordable Care Act improved insurance coverage for people with both HIV and cancer. However, disparities in insurance coverage still exist among minorities and low-income individuals, who are more likely to live in non-expansion states. The study suggests that further insurance coverage ...
Women from ethnic minority backgrounds experience higher levels of embarrassment and fear when seeking medical help, which can lead to delayed diagnosis and treatment. The study highlights the importance of addressing these barriers to ensure equal access to healthcare for all.
A study in JAMA Oncology found that geriatric assessment can personalize care and prompt better conversations between physicians, patients, and their families. The tool improved patient satisfaction and caregiver experiences among older adults with advanced cancer.
Researchers from NUS discovered the molecular mechanism underlying natural killer T cell lymphoma, identifying MELK as a stabilizer of EZH2 enzyme. Targeting MELK may provide an alternative approach to treating NKTL by increasing sensitivity to Bortezomib treatment.
A novel attention-based deep learning method automatically learns clinically important regions on whole-slide images to classify them. The new approach outperformed the current state-of-the-art approach that requires detailed annotations for its training.
A review of 11 studies on cancer patients' sense of taste and smell reveals a reduced taste function, particularly for sweet flavors, associated with lower appetite and caloric intake. Researchers aim to develop strategies to help patients eat well during treatment.
Researchers at the University of Pennsylvania have conducted the first-in-US trial of CRISPR-edited immune cells for cancer, demonstrating safety and feasibility with three participants. The edited T cells expanded and bound to their tumor target without serious side effects.
A new study found that bariatric surgery significantly reduces the risk of cancer in patients who lose at least 20% of their body weight. The risk was reduced by 50% compared to those who did not experience significant weight loss after surgery.
Women with a genetic predisposition for breast cancer were 2.5 times more likely to develop malignancy without weight-loss surgery, but the risk was significantly reduced after bariatric or weight-loss surgery. The study found that weight-loss surgery cut the overall risk of developing cancers linked to obesity by 20 percent.
The UK will pioneer the use of FLASH radiotherapy and artificial intelligence in cancer treatment. Cancer Research UK RadNet aims to improve cancer survival by optimising and personalising radiotherapy.
Researchers have developed a simple blood test that detects breast cancer up to five years before clinical signs appear, identifying tumor-associated antigens and autoantibodies. The test shows promising accuracy in detecting breast cancer with reasonable accuracy, especially when using panels of multiple antigens.
A new study found that only about 6 in 10 lung cancer patients in the US receive recommended treatments, with black patients and those over 80 receiving significantly lower treatment rates. The researchers highlight the importance of communicating benefits of treatment for advanced disease beyond survival.
A new study finds that acute kidney injury affects 17% of patients taking immunotherapy medications for cancer, while proton pump inhibitors increase the risk of sustained AKI. Nephrologists and oncologists must recognize these factors to diagnose and treat patients effectively.
A new study from Dana-Farber Cancer Institute and University of Texas Southwestern finds that non-white minority cancer survivors are less likely to receive treatment from culturally competent providers, with significant disparities in access to these physicians. The study highlights the critical need for culturally competent care in c...
Researchers have developed a high-resolution visual map of the RSC complex, a crucial regulator of chromosome structure and gene expression. This study provides new insights into how RSC-like complexes are involved in cancer development and has implications for understanding chromosomal genes in healthy and cancer cells.
A Mayo Clinic-led study found that microvascular endothelial dysfunction is associated with a greater than twofold risk of cancer. The condition, which affects the heart's small arteries, may be a useful marker for predicting cancer risk.
Researchers developed an algorithm that uses nonsense-mediated mRNA decay (NMD) to predict which cancer patients will respond to immunotherapy. NMDdetective identifies mutations in the genome susceptible to this quality control process, allowing for personalized treatment approaches.
A University of Michigan researcher found that breast cancer patients who endured Hurricane Katrina in 2005 have a 15% higher mortality rate than those not exposed to the storm. The study suggests disaster-related healthcare disruptions and highlights the need for improved access to healthcare during disasters.
Gabapentinoid prescriptions for adults with cancer grew from 3.3% to 8.3% between 2005 and 2015, with total prescriptions increasing from 1.2 million to 3.5 million. Further study is needed to understand the effectiveness and risks of gabapentinoids in treating cancer pain.
A recent study published in JAMA Network Open reveals that analyzing gene expression in tumor cells can reveal new targets for therapy in pediatric cancer patients. The study found that 68% of children with cancer showed potential for treatment through gene expression analysis, compared to 46% who responded to DNA mutation analysis.
A new algorithm developed by a Penn Medicine-led team flags patients who would benefit most from advance care planning conversations, leading to improved timely discussions. The study found that 51% of high-priority flagged patients died within six months compared to less than four percent in lower priority group.
Researchers at Medical University of South Carolina discover a protein P17/PERMIT that regulates mitochondrial function and could be a connection between age-related diseases. The protein helps recycle aging mitochondria, which can contribute to conditions like cancer and Alzheimer's.
Researchers discovered Hedgehog signaling shuts down chemokine secretion by tumor-associated macrophages, limiting CD8 T-cell infiltration. Blocking hedgehog pathway reverses process, promoting CD8 T-cell infiltration into tumor microenvironment.
A Dartmouth computer scientist has received a $1.5 million grant to develop machine learning approaches that can reveal relationships between clinical and pathologic findings, patient genetic profiles, and drug resistance in non-small cell lung cancer patients. The goal is to provide personalized treatment strategies for NSCLC patients.
Researchers found a panel of 17 small RNA molecules influenced by genetic alterations in cancer cells, which could lead to targeted treatments for Latinas with TNBC. The study suggests that racial and ethnic differences in miRNA expression may impact breast cancer incidence rates.
A study led by Drexel University showed that coloring and open-studio art therapy benefits stressed caregivers of cancer patients, reducing stress, anxiety, and burnout. The interventions improved positive affect, pleasure, and enjoyment while increasing desire to continue making art.
A new transatlantic research alliance aims to develop radical new strategies and technologies to detect cancer at its earliest stage, improving survival rates. The International Alliance for Cancer Early Detection will accelerate breakthroughs in early detection, leading to quicker benefits for patients.
Researchers found that aspirin use was associated with a lower risk of death among patients with biliary tract cancer, which includes gallbladder cancer. The observational study included nearly 3,000 patients and suggests that long-term aspirin use may be beneficial for these patients.
Researchers at Ohio State University Wexner Medical Center report a measurable increase in inflammation after four weeks of e-cig use without nicotine or flavors. The study suggests that even short-term usage can result in inflammatory changes at a cellular level, a concern as vaping usage is rapidly outpacing scientific understanding.
The study found that all tested tyrosine kinase inhibitors increased COX-2 expression in at least one of the tested cell lines in vitro. Fluorocoxib A uptake correlated with COX-2 expression detected by immunohistochemistry and Western blot analysis in xenografts in vivo.
Researchers at UNC Lineberger Comprehensive Cancer Center will study the impact of financial navigation services on rural cancer patients in North Carolina. The study aims to connect patients with potential financial support resources and reduce financial toxicity associated with cancer care.
A new system developed by Yale scientists uses viral gene therapy and CRISPR gene-editing technology to make cancer cells stand out from the crowd, helping the immune system spot and eliminate tumors that other forms of immunotherapies might miss.
A U-M study found that maximizer patients consume more health care resources without clear evidence of improved outcomes. Strong maximizers had four or more doctor visits, two or more ultrasounds, and one or more radioactive iodine scans in the prior year.
Researchers found that mutation and loss of TSC1 leads to decreased sensitivity to Hsp90 inhibitors, causing hypoacetylation of Hsp90. Co-targeting HDACs may restore Hsp90 acetylation and sensitivity in bladder cancer patients with TSC1 mutations.
Researchers at Georgetown University Medical Center developed a virtual review method that reduces the time needed to assess a cancer patient's tumor profile and suitability for clinical trials from 14 to 4 days. The method also increased the number of cases that could be assessed, with over 2,000 clinical trials evaluated.
A Colorado study found that lymphoma stage at diagnosis impacts types of second cancers that may form after treatment. Early-stage patients had a higher risk of solid tumors, while late-stage patients were more likely to develop hematologic malignancies.
Exercise can counteract the negative effects of cancer treatments on the cardiovascular system and relieve symptoms such as nausea and fatigue. A tailored exercise prescription is recommended for each patient based on individual characteristics, personal history, and cancer treatment.
The University of Colorado Anschutz Medical Campus has received a grant to advance implementation science and cancer control efforts. The Center will develop resources and education to enhance cancer prevention and control in Colorado and nationally.
A 40-year epidemiological study found that cancer incidence and mortality rates often move in concert for certain cancers, such as lung cancer, indicating a desirable trend. However, other cancers like thyroid, kidney, and melanoma show rising incidence rates with stagnant mortality rates, suggesting overdiagnosis may be at play
A new blood test can detect liver cancer and life-threatening vascular complications in diabetic patients with high accuracy. The test analyzes DNA in just a few drops of blood and has already shown promise in detecting other major cancers.
UT Dallas researchers have shown that hyperspectral imaging and AI can predict the presence of cancer cells with 80-90% accuracy in 293 tissue specimens. This technology, called a smart surgical microscope, aims to reduce operating time, lower medical costs, and save lives.
The BEACON CRC Phase III clinical trial found that the three-drug combination of encorafenib, binimetinib, and cetuximab significantly improved overall survival in patients with BRAF-mutated metastatic colorectal cancer. Median OS for the triplet-targeted therapy was 9 months compared to 5.4 months for standard therapy.
A study published in Nature Medicine suggests that whole genome sequencing of tumour cells can predict prognosis and identify effective treatments for patients with triple negative breast cancers. The technique reveals genetic signatures and mutations, providing clues to develop new drugs and improve treatment outcomes.
A new study presents promising results from the CheckMate 358 trial, a phase I/II investigational immune-therapy trial combining nivolumab and ipilimumab for recurrent and metastatic cervical cancer. The combination showed higher clinical benefit rates compared to single-agent treatments.
A new blood test has been developed to detect multiple types of cancer, including hormone receptor-negative breast, colorectal, and pancreatic cancer, with a high degree of accuracy. The test uses next-generation sequencing technology to probe DNA for methylation patterns associated with cancer.
A combination of ipilimumab and nivolumab has stopped or reversed melanoma progression for five years in nearly half of patients, offering new hope for advanced melanoma patients. The Checkmate 067 trial found a 52% five-year overall survival rate, with 74% treatment-free after five years.
A comprehensive tobacco treatment program at the University of Texas M.D. Anderson Cancer Center resulted in an average of 45% smoking abstinence rates among participating cancer patients. This rate surpasses that of previous minimal interventions like quitlines, which averaged less than 20% abstinence rates.
A comprehensive tobacco treatment program in an oncologic setting significantly improves smoking cessation rates, affecting patient outcomes with cancer who smoke. Average seven-day abstinence rates reached 44% at the nine-month follow-up.
The RADICALS-RT trial found no difference in disease recurrence between men who received radiotherapy shortly after surgery and those who waited for cancer to come back. The study confirms that observation should be the standard approach after surgery, with radiotherapy used only if the cancer recurs.
Researchers found that adding durvalumab to radiation and chemotherapy significantly decreased the recurrence of lung cancer in both chest and distant sites, with new lesions occurring primarily in the brain. This suggests that aggressive local therapies may further extend survival for patients with non-small cell lung cancer.
Researchers at Cleveland Clinic identified a metabolite associated with specific PTEN mutations, distinguishing those at high risk for neurodevelopmental disorders from cancer. The findings may help tailor treatments to individual patients with germline PTEN mutations.