Articles tagged with Cancer Patients
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A phase III international clinical trial found that treatment with apalutamide significantly improved overall survival by 33% compared to standard-of-care therapy. The study also showed apalutamide delayed disease progression, increasing the time until chemotherapy was needed.
A recent study found that taking vitamin D for at least three years may lower the risk of death among cancer patients. The researchers analyzed data from over 79,000 patients and discovered a statistically significant difference in mortality rates between those who took vitamin D and those who received a placebo.
A new center will bring together researchers to better understand the relationships between advances in radiation therapy, cancer signaling pathways, and the immune system's ability to control cancer. The center aims to uncover novel insights into cancer biology with potential for more effective treatments.
The study's primary endpoint showed that the total neoadjuvant therapy (TNT) approach was safe, associated with high rates of chemotherapy completion (>90%), but did not demonstrate a significant improvement in reducing cancer presence at surgery. Veliparib addition resulted in more side effects and reduced chemoradiation completion, y...
Researchers developed COXEN, a predictive tool that analyzes gene expression to predict response to chemotherapy in bladder cancer patients. The trial showed COXEN's ability to predict response using Gemcitabine-Cisplatin (GC) biomarker.
A survey of community oncologists found significant knowledge gaps in using genetic testing to decide cancer treatment. Researchers urge immediate education on molecular profiling to direct targeted therapies.
Cancer patients with HIV and viral hepatitis can also reap benefits of immunotherapy, study suggests. These patients respond as well to immune checkpoint inhibitors as those tested in clinical trials.
A survey of 48 oncologists and healthcare providers found that most believe medical marijuana has benefits for cancer patients, but are uncomfortable prescribing it. The main concerns include uncertain dosing, limited knowledge of available products, and potential interactions with other medications.
The latest Annual Report to the Nation on Cancer finds that overall cancer death rates continue to decline in the US. However, a special section reveals a different picture for adults ages 20-49, with higher incidence and mortality among women than men.
A pioneering blood test developed by Johns Hopkins researchers, CancerSEEK, will be developed by Thrive.EarlyDetection Corp. to detect multiple cancer types at earlier stages. The technology has received Breakthrough Device designation from the FDA and has shown high specificity and sensitivity in detecting various cancers.
Sophie Paczesny and her team aim to better understand the tumor microenvironment and identify new checkpoint molecules like ST2. They hope to develop targeted therapies using antibodies that can boost the immune system's ability to attack cancer cells.
A new blood test, DELFI, uses machine learning to identify abnormal DNA patterns in the bloodstream for early cancer detection. The test detected cancer DNA in 57-99% of patients with various stages of breast, colorectal, and other cancers.
A new urology care model developed by Flinders University focuses on supporting bladder cancer patients' partners and family, addressing their daily impacts and needs. Health professionals can capitalize on this by providing clear information, counseling, and support to manage the shock, fear, and treatment of bladder cancer.
A large-scale analysis of over 3,000 patients with early oesophagus and stomach cancer found that female patients are more likely to survive longer than male patients, but experience more severe gastrointestinal side effects during chemotherapy. Researchers hope the findings can help tailor treatment approaches for individual patients.
A new study found that one-third of patients with metastatic pancreatic cancer do not see a medical oncologist, and even more do not receive cancer-directed treatment. The data suggest that there are many missed opportunities for important discussions between patients and cancer specialists.
Researchers from QUT and Edith Cowan University published new exercise guidelines that recommend a personalized approach to exercise prescription. The guidelines suggest moderate to high intensity exercise, but emphasize the importance of tailoring the program to individual patient needs and priorities.
Researchers found that proton therapy significantly lowers the risk of severe side effects in cancer patients undergoing radiation and chemotherapy, with a relative risk reduction of two-thirds. Cure rates were almost identical between groups.
Incidence rates of uterine cancer's aggressive subtypes increased dramatically among all racial groups from 2000 to 2015, with black women having higher rates and poorer survival. Endometrioid subtypes showed stable trends in white women but increasing rates in other groups.
Researchers at Medical University of South Carolina identified a metabolic Achilles heel in cancer, exploiting glutamine addiction. A new combination treatment has shown promise in treating drug-resistant esophageal cancer cells.
A team of researchers at Medical University of South Carolina developed a natural language processing software that identified socially isolated prostate cancer patients with 90 percent accuracy. This technology can help physicians provide care informed by an awareness of their patients' social determinants of health, including social ...
The Case Comprehensive Cancer Center has been selected as a Lead Academic Participating Site by the National Cancer Institute for a six-year grant worth $8.9 million. This renewal grant enables the center to provide patients with additional access to clinical trials through the National Clinical Trials Network.
Researchers used CRISPR to analyze over 8,000 gene fusions in human cancer cell lines, finding that 90% do not play an essential role in cancer. A new fusion, YAP1-MAML2, was identified as critical for progression of multiple cancers, offering a potential new drug target.
Researchers evaluated 67 fitness apps on iOS and Android to assess their suitability for improving physical activity in cancer survivors. A fifth of the apps contained content suitable for people affected by cancer, focusing on aerobic-based activities with goal setting, monitoring, and feedback features.
A new clinical pathway at Christiana Care Health System's Helen F. Graham Cancer Center & Research Institute has shown better health outcomes and lower healthcare costs for cancer patients. The SCOOP pathway, launched in 2016, improved patient experiences by reducing emergency department visits, hospital admissions, and readmissions.
Researchers at The Royal Marsden NHS Foundation Trust developed a liquid biopsy test that detects DNA fragments shed by tumors into the bloodstream. The test identified 74% of patients with early-stage rectal cancer who were at risk of metastatic disease, and those with persistent DNA were more likely to develop metastatic disease.
Researchers at Burrell College of Osteopathic Medicine found that New Mexicans with 10 common cancers have a significantly worse five-year survival rate. Hispanic populations along the U.S.-Mexico border fare even worse.
Researchers analyzed over 3,500 tumor samples to identify genomic changes that inform targeted treatment strategies for men with advanced prostate cancers. The study found that more than half of patients have characteristics that suggest they are suitable for targeted therapies.
A trial remedy for racial disparities in early-stage lung and breast cancer treatment has shown nearly eliminating existing gaps. The intervention consisted of a real-time warning system, race-specific feedback, health equity training, and nurse navigators to reengage patients.
A new study found that children with inflammatory bowel disease, including ulcerative colitis and Crohn's disease, have a higher risk of developing cancer and dying early compared to the general population. The study suggests that cancer surveillance and mental health assessment are crucial for young patients with these conditions.
A large Chinese study found that type 2 diabetes is associated with an elevated risk of 11 types of cancer in men and 13 types of cancer in women. The study, which examined data from over 410,000 adults, revealed significant increases in cancer risk for both men and women with diabetes.
A computational tool assigns a bladder cancer subtype to an individual patient using genomic data, enabling personalized treatment selection. The study found that patients with the aggressive 'neuronal' subtype responded well to atezolizumab treatment, achieving high survival probabilities.
A global study predicts a 53% rise in chemotherapy demand by 2040, with an estimated 15 million patients needing treatment annually. The study recommends expanding the chemotherapy workforce to 100,000 physicians by 2040 to deliver optimal treatment.
Researchers have identified eight protein biomarkers that enable accurate differentiation between endometrioid and high-grade serous ovarian carcinomas. This breakthrough could lead to more precise diagnosis and tailored treatment for patients, reducing the risk of undertreatment or overtreatment.
Research reveals that cancer risk assessment tools are being widely underused by UK GPs, with only half of those with access using them. The study's findings highlight the need for improved training and integration of these tools into consultations to improve cancer diagnosis and survival rates.
A large study found that HER2 expression can predict DCIS recurrence and progression, enabling targeted treatments for high-risk patients. By screening DCIS patients for HER2, doctors can minimize the chance of recurrence or spread in lower-risk patients.
A new study highlights the growing need for cardio-oncology services to monitor and prevent heart disease in cancer patients. The research found that many cancer survivors are not fully aware of the risks of cardiotoxicity and lack understanding of a balanced diet, making them more susceptible to heart failure.
Researchers from Dartmouth's Norris Cotton Cancer Center have introduced an inexpensive DNA-based testing protocol for HPV in Honduras. The study found that of 1,732 women screened, 28% were positive for a high-risk HPV type, and the most common HPV genotypes detected were different than those commonly found in the US.
Researchers at the University of Michigan have developed a new method for detecting RNA fragments in blood plasma that were invisible to traditional methods. This breakthrough has potential applications in cancer detection, autoimmune side-effects monitoring, and understanding human gene activity.
Two new urine tests have shown promise in accurately detecting bladder cancer, determining its severity, and detecting recurrence. The tests use a gene variant called V1, which is elevated in bladder cancer, and have been found to be 90% effective at detecting the disease.
Researchers have developed a system to accurately deliver precise doses of radiation to cancer tissues while minimizing exposure to healthy ones. The new system uses specialized polymer gel to visualize the spatial location and dose of treatment in real-time.
A phase I clinical trial using stem cell immunotherapy will be tested on patients with advanced sarcomas and the NY-ESO-1 tumor marker. The treatment aims to generate a lasting immune response against cancer by modifying blood-forming stem cells and T cells to target specific proteins.
The number of cardiologists trained in cardio-oncology is not meeting the growing needs of cancer survivors, who are aging and developing co-morbid cardiovascular disease. Limited training programs and resources are emerging to address this need, highlighting the importance of collaboration between cardiologists and oncologists.
The ESMO Breast Cancer Congress stresses the need for a multidisciplinary approach to patient care, including cardiovascular assessment and nutritional support. A study presented at the congress found that dietary guidelines can lead to weight loss and improved quality of life in breast cancer patients.
The WINTHER trial successfully matched personalized therapy to 35% of patients with advanced cancer, showing improved overall survival for those with a high degree of matching. The trial's strategy employed RNA expression testing to tailor treatment based on gene expression differences between tumors and normal tissues.
Researchers have uncovered a new set of rules that predict how the tissue of origin influences tumor genetic makeup, with potential implications for targeted cancer therapies. The study found that cancer cells are addicted to specific NAD synthesis pathways, making them vulnerable to targeted interventions.
A study found that poor air quality significantly increases the risk of hospitalizations for respiratory issues in young cancer survivors, particularly those who received chemotherapy. The researchers tracked nearly 4,000 survivors and found that even low levels of PM2.5 can contribute to respiratory problems.
Researchers found that patients with cancer requiring emergency department care had lower admission rates and higher mortality rates at non-cancer center hospitals. This may be due to a lack of cancer expertise and missed markers of worsening disease.
A recent study found that 40.3% of people with cancer used marijuana in the past year, compared to 38.0% without cancer. Meanwhile, prescription opioid use was higher among those with cancer (13.9%) than without (6.4%).
Researchers found that treating patients with personalized, combination therapies improved response rates and overall survival in patients with therapy-resistant cancers. Highly matched patients showed a 50% response rate compared to unmatched or less well-matched patients.
A breakthrough CRISPR gene-editing tool allows for the simultaneous execution of multiple edits in DNA extracted from human cells. This technology, developed by the Gene Editing Institute and licensed to NovellusDx, can rapidly reproduce an individual patient's cancer tumor genetic features and identify driver mutations.
Acute myelogenous leukemia patients have only a one in four chance of survival after five years. Researchers created a protein atlas to identify and classify protein signatures at AML diagnosis. The online atlas helps recommend better treatment and personalized medicine for patients.
A new approach, PRO-cision Medicine, uses patient-reported outcomes to personalize cancer care. This method provides valuable information on patients' symptoms and functioning, guiding clinicians in making informed decisions.
A new algorithm can detect the molecular signature of a cancer-driving defect, identifying patients who could benefit from treatment with PARP inhibitors. The algorithm has the potential to expand greatly the pool of patients eligible for this therapy.
A consortium of researchers identified a rare but important gene target, NRG1, responsible for development of various cancer types. The study suggests that targeting this gene fusion could effectively shut down cancers, offering a new therapy possibility.
A new American Cancer Society study highlights the need to better identify patients with metastatic cancer who may not benefit from aggressive treatment. The study found wide variations in treatment patterns among patients who died within a month of diagnosis.
One-third of cancer patients use complementary and alternative medicines such as meditation, yoga, acupuncture, and herbal supplements. Many patients do not disclose their use to doctors due to lack of knowledge or perceived need for disclosure.
A nationwide survey found that 33.3% of cancer patients used complementary and alternative medicines, with herbal supplements being the most common. Many participants did not disclose their CAM use due to lack of physician inquiry or perceived unnecessary information.
A small clinical trial suggests that high-dose vitamin D may delay disease progression in patients with metastatic colorectal cancer. Patients who received high-dose vitamin D had a median delay of 13 months before their disease worsened, compared to 11 months for those in the low-dose group.
A new surgical guideline has been shown to decrease re-operation rates for breast cancer patients undergoing lumpectomy. According to a study by UBC medical student Alex Monaghan, women with early-stage breast cancer are now 72% less likely to require additional surgery.
Scientists visualized CAR T cells fighting blood cancer for the first time, revealing key interactions and behaviors. The study showed that CAR T cells can directly kill tumor cells within minutes, but their effectiveness is hindered by aggregation and infiltration issues.