Articles tagged with Cancer Patients
A Danish study of 32,000 haematological cancer patients found that one in five suffer from blood clots or bleeding, with varying risk levels depending on the type of cancer. The research highlights the need for individualized treatment and awareness of high-risk patients to prevent complications.
A new risk prediction model using clinical and radiological features can stratify individuals with lung nodules as having high or low risk of developing lung cancer. The model, which combines variables such as age, smoking history, and nodule characteristics, showed a sensitivity and specificity of 73% and 81%, respectively.
A Penn study shows a Moonshot-funded program can increase cancer patients' engagement in tobacco cessation treatments from 0% to 36%. The program's success is attributed to institutional buy-in and continuous dialogue with clinicians, which informed the development of additional support services.
Researchers sequenced canine cancer cell lines to identify human-like genetic changes driving canine cancers. The study found 61 genetic variants that match known drivers of human cancer, and showed sensitivity to human medicines.
A new systematic review highlights gaps in understanding cancer among LGBTI adolescents and young adults, who face barriers to health services. Researchers propose a Call to Action to reduce these disparities and improve cancer care for this at-risk population.
A national survey finds that half of the population believes cancer requires better treatments, and two-thirds expect most cancers to be curable by 2050. The UK public also supports a tax-funded NHS and wants closer partnerships between the public and private sectors to develop more effective cancer treatments.
A systematic review found that most non-cancerous adrenal tumors do not grow significantly over time, eliminating the need for repeated imaging. Patients with mild cortisol excess may still develop cardiovascular disease, but guidelines should be revised to reflect this low cancer risk and monitor metabolic health instead.
Research found statin therapy significantly reduced stroke risk and overall cardiovascular events in cancer patients who underwent radiation therapy for chest, head, or neck cancer. The study also showed a strong trend toward reduction in cardiovascular deaths.
Researchers at Huntsman Cancer Institute discovered a new experimental drug, selinexor, which may block a crucial survival pathway exploited by myelofibrosis cells. A clinical trial has been designed to examine the drug's effectiveness in patients with myelofibrosis.
Researchers identify barriers to trial accrual, including complexity in staying aware of available trials, identifying eligible patients, and enrolling them. The study suggests addressing these challenges through changes in trial-specific reimbursement and incentives for administrative costs.
A population-based cohort study from 4 Nordic countries found no link between TNFi use and increased cancer risk. However, a significant increase in malignant lymphomas was observed within the trial. Further analysis is needed to determine if this is due to psoriatic arthritis or TNFi treatment.
Researchers developed a biomarker test to predict disease-free survival and recurrence risk in patients with triple-negative breast cancer. The test uses formalin-fixed, paraffin-embedded tissues and has shown promise in predicting patient outcomes.
Researchers found that identifying a patient's Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment. CMS categorizes colorectal cancer into four distinct subgroups based on tumor mutations, and each subgroup is associated with different treatment outcomes.
Researchers have developed a comprehensive database of synonymous mutations found in cancer, revealing their influence on cellular functions and disease processes. The SynMIC database contains information on 659,194 entries across 88 types of cancer, providing a valuable resource for cancer researchers.
Researchers found HPV16 antibodies develop in body between 6-40 years prior to throat cancer diagnosis, increasing risk significantly. The presence of these antibodies indicates a strong increased risk of disease, particularly among white people, with an estimated 100-fold increase compared to black people.
The seven-year ORATOR trial found no difference in survival between robotic surgery and radiation therapy, but patients receiving radiation experienced better swallowing outcomes. Participants in the surgery group were at risk for complications such as pain, bleeding, and hearing loss.
A nationwide survey of 487 women found that nearly two-thirds of breast cancer patients are unaware of surgical options that can minimize scarring. The study also revealed that many patients experience negative impacts from their scars, including feelings of self-consciousness and restricted clothing choices.
A phase III international clinical trial found that treatment with apalutamide significantly improved overall survival by 33% compared to standard-of-care therapy. The study also showed apalutamide delayed disease progression, increasing the time until chemotherapy was needed.
A recent study found that taking vitamin D for at least three years may lower the risk of death among cancer patients. The researchers analyzed data from over 79,000 patients and discovered a statistically significant difference in mortality rates between those who took vitamin D and those who received a placebo.
A new center will bring together researchers to better understand the relationships between advances in radiation therapy, cancer signaling pathways, and the immune system's ability to control cancer. The center aims to uncover novel insights into cancer biology with potential for more effective treatments.
The study's primary endpoint showed that the total neoadjuvant therapy (TNT) approach was safe, associated with high rates of chemotherapy completion (>90%), but did not demonstrate a significant improvement in reducing cancer presence at surgery. Veliparib addition resulted in more side effects and reduced chemoradiation completion, y...
Researchers developed COXEN, a predictive tool that analyzes gene expression to predict response to chemotherapy in bladder cancer patients. The trial showed COXEN's ability to predict response using Gemcitabine-Cisplatin (GC) biomarker.
A survey of community oncologists found significant knowledge gaps in using genetic testing to decide cancer treatment. Researchers urge immediate education on molecular profiling to direct targeted therapies.
Cancer patients with HIV and viral hepatitis can also reap benefits of immunotherapy, study suggests. These patients respond as well to immune checkpoint inhibitors as those tested in clinical trials.
A survey of 48 oncologists and healthcare providers found that most believe medical marijuana has benefits for cancer patients, but are uncomfortable prescribing it. The main concerns include uncertain dosing, limited knowledge of available products, and potential interactions with other medications.
The latest Annual Report to the Nation on Cancer finds that overall cancer death rates continue to decline in the US. However, a special section reveals a different picture for adults ages 20-49, with higher incidence and mortality among women than men.
A pioneering blood test developed by Johns Hopkins researchers, CancerSEEK, will be developed by Thrive.EarlyDetection Corp. to detect multiple cancer types at earlier stages. The technology has received Breakthrough Device designation from the FDA and has shown high specificity and sensitivity in detecting various cancers.
Sophie Paczesny and her team aim to better understand the tumor microenvironment and identify new checkpoint molecules like ST2. They hope to develop targeted therapies using antibodies that can boost the immune system's ability to attack cancer cells.
A new blood test, DELFI, uses machine learning to identify abnormal DNA patterns in the bloodstream for early cancer detection. The test detected cancer DNA in 57-99% of patients with various stages of breast, colorectal, and other cancers.
A new urology care model developed by Flinders University focuses on supporting bladder cancer patients' partners and family, addressing their daily impacts and needs. Health professionals can capitalize on this by providing clear information, counseling, and support to manage the shock, fear, and treatment of bladder cancer.
A large-scale analysis of over 3,000 patients with early oesophagus and stomach cancer found that female patients are more likely to survive longer than male patients, but experience more severe gastrointestinal side effects during chemotherapy. Researchers hope the findings can help tailor treatment approaches for individual patients.
A new study found that one-third of patients with metastatic pancreatic cancer do not see a medical oncologist, and even more do not receive cancer-directed treatment. The data suggest that there are many missed opportunities for important discussions between patients and cancer specialists.
Researchers from QUT and Edith Cowan University published new exercise guidelines that recommend a personalized approach to exercise prescription. The guidelines suggest moderate to high intensity exercise, but emphasize the importance of tailoring the program to individual patient needs and priorities.
Researchers found that proton therapy significantly lowers the risk of severe side effects in cancer patients undergoing radiation and chemotherapy, with a relative risk reduction of two-thirds. Cure rates were almost identical between groups.
Incidence rates of uterine cancer's aggressive subtypes increased dramatically among all racial groups from 2000 to 2015, with black women having higher rates and poorer survival. Endometrioid subtypes showed stable trends in white women but increasing rates in other groups.
Researchers at Medical University of South Carolina identified a metabolic Achilles heel in cancer, exploiting glutamine addiction. A new combination treatment has shown promise in treating drug-resistant esophageal cancer cells.
A team of researchers at Medical University of South Carolina developed a natural language processing software that identified socially isolated prostate cancer patients with 90 percent accuracy. This technology can help physicians provide care informed by an awareness of their patients' social determinants of health, including social ...
The Case Comprehensive Cancer Center has been selected as a Lead Academic Participating Site by the National Cancer Institute for a six-year grant worth $8.9 million. This renewal grant enables the center to provide patients with additional access to clinical trials through the National Clinical Trials Network.
Researchers used CRISPR to analyze over 8,000 gene fusions in human cancer cell lines, finding that 90% do not play an essential role in cancer. A new fusion, YAP1-MAML2, was identified as critical for progression of multiple cancers, offering a potential new drug target.
Researchers evaluated 67 fitness apps on iOS and Android to assess their suitability for improving physical activity in cancer survivors. A fifth of the apps contained content suitable for people affected by cancer, focusing on aerobic-based activities with goal setting, monitoring, and feedback features.
A new clinical pathway at Christiana Care Health System's Helen F. Graham Cancer Center & Research Institute has shown better health outcomes and lower healthcare costs for cancer patients. The SCOOP pathway, launched in 2016, improved patient experiences by reducing emergency department visits, hospital admissions, and readmissions.
Researchers at The Royal Marsden NHS Foundation Trust developed a liquid biopsy test that detects DNA fragments shed by tumors into the bloodstream. The test identified 74% of patients with early-stage rectal cancer who were at risk of metastatic disease, and those with persistent DNA were more likely to develop metastatic disease.
Researchers at Burrell College of Osteopathic Medicine found that New Mexicans with 10 common cancers have a significantly worse five-year survival rate. Hispanic populations along the U.S.-Mexico border fare even worse.
Researchers analyzed over 3,500 tumor samples to identify genomic changes that inform targeted treatment strategies for men with advanced prostate cancers. The study found that more than half of patients have characteristics that suggest they are suitable for targeted therapies.
A trial remedy for racial disparities in early-stage lung and breast cancer treatment has shown nearly eliminating existing gaps. The intervention consisted of a real-time warning system, race-specific feedback, health equity training, and nurse navigators to reengage patients.
A new study found that children with inflammatory bowel disease, including ulcerative colitis and Crohn's disease, have a higher risk of developing cancer and dying early compared to the general population. The study suggests that cancer surveillance and mental health assessment are crucial for young patients with these conditions.
A large Chinese study found that type 2 diabetes is associated with an elevated risk of 11 types of cancer in men and 13 types of cancer in women. The study, which examined data from over 410,000 adults, revealed significant increases in cancer risk for both men and women with diabetes.
A computational tool assigns a bladder cancer subtype to an individual patient using genomic data, enabling personalized treatment selection. The study found that patients with the aggressive 'neuronal' subtype responded well to atezolizumab treatment, achieving high survival probabilities.
A global study predicts a 53% rise in chemotherapy demand by 2040, with an estimated 15 million patients needing treatment annually. The study recommends expanding the chemotherapy workforce to 100,000 physicians by 2040 to deliver optimal treatment.
Researchers have identified eight protein biomarkers that enable accurate differentiation between endometrioid and high-grade serous ovarian carcinomas. This breakthrough could lead to more precise diagnosis and tailored treatment for patients, reducing the risk of undertreatment or overtreatment.
Research reveals that cancer risk assessment tools are being widely underused by UK GPs, with only half of those with access using them. The study's findings highlight the need for improved training and integration of these tools into consultations to improve cancer diagnosis and survival rates.
A large study found that HER2 expression can predict DCIS recurrence and progression, enabling targeted treatments for high-risk patients. By screening DCIS patients for HER2, doctors can minimize the chance of recurrence or spread in lower-risk patients.
A new study highlights the growing need for cardio-oncology services to monitor and prevent heart disease in cancer patients. The research found that many cancer survivors are not fully aware of the risks of cardiotoxicity and lack understanding of a balanced diet, making them more susceptible to heart failure.
Researchers from Dartmouth's Norris Cotton Cancer Center have introduced an inexpensive DNA-based testing protocol for HPV in Honduras. The study found that of 1,732 women screened, 28% were positive for a high-risk HPV type, and the most common HPV genotypes detected were different than those commonly found in the US.
Researchers at the University of Michigan have developed a new method for detecting RNA fragments in blood plasma that were invisible to traditional methods. This breakthrough has potential applications in cancer detection, autoimmune side-effects monitoring, and understanding human gene activity.
Two new urine tests have shown promise in accurately detecting bladder cancer, determining its severity, and detecting recurrence. The tests use a gene variant called V1, which is elevated in bladder cancer, and have been found to be 90% effective at detecting the disease.
Researchers have developed a system to accurately deliver precise doses of radiation to cancer tissues while minimizing exposure to healthy ones. The new system uses specialized polymer gel to visualize the spatial location and dose of treatment in real-time.
A phase I clinical trial using stem cell immunotherapy will be tested on patients with advanced sarcomas and the NY-ESO-1 tumor marker. The treatment aims to generate a lasting immune response against cancer by modifying blood-forming stem cells and T cells to target specific proteins.
The number of cardiologists trained in cardio-oncology is not meeting the growing needs of cancer survivors, who are aging and developing co-morbid cardiovascular disease. Limited training programs and resources are emerging to address this need, highlighting the importance of collaboration between cardiologists and oncologists.
The ESMO Breast Cancer Congress stresses the need for a multidisciplinary approach to patient care, including cardiovascular assessment and nutritional support. A study presented at the congress found that dietary guidelines can lead to weight loss and improved quality of life in breast cancer patients.