Articles tagged with Cancer Patients
Researchers have discovered a key mechanism behind pancreatic cancer's aggressive growth, which may help explain why promising drugs work and when they won't. The finding identifies a weakness in the cancer cells' metabolism that could be exploited to improve treatment outcomes.
A Phase 1B study led by the University of Texas MD Anderson Cancer Center demonstrated positive safety results for pegilodecakin when combined with pembrolizumab and nivolumab. The treatment showed promising anti-tumor activity in patients with non-small cell lung cancer and kidney cancer.
Cancer cells adapt to treatment with checkpoint blocker drugs by altering a metabolic process, leading to shorter survival for patients. The study suggests that identifying biomarkers of metabolic changes related to treatment with checkpoint blockers could help identify patients who might benefit from combination therapy.
A researcher at the Oklahoma Tobacco Research Center has been awarded a five-year grant to study the long-term effects of vaping on human health. The study aims to examine the effects of vaping on respiratory function and determine if users become susceptible to other tobacco products.
Researchers will focus on extending clinical research in cardiovascular and neurocognitive complications of cancer treatments to improve patient well-being. The team aims to protect the heart from damage caused by chemotherapy drugs and define who may be at risk.
Researchers propose targeting cancer patients' mindsets to improve their health, functioning, and well-being. They identify specific mindsets that can impact cancer patients' health, such as viewing cancer as manageable or seeing the body as capable and resilient.
A study of nearly 1.9 million breast cancer patients found that men have lower three-year and five-year survival rates compared to women. The analysis attributed the difference to undertreatment and clinical characteristics.
SU2C Catalyst teams investigate new treatments for triple-negative breast cancer and metastatic hormone-sensitive prostate cancer, combining medicines like atezolizumab and ipatasertib with radiation and hormone therapy.
A study of 585 cancer patients in Australia and Vietnam found that 'bad luck' or fate was the third most common perceived cause of their cancer. This misconception can lead to a lack of willingness to change behavior related to diet, lifestyle, treatment, and care.
The Georgia Cancer Center at Augusta University has received a six-year $6 million grant from the NCI to improve access to clinical trials for minority and rural populations. The grant will be used to recruit patients to conduct multi-site cancer clinical trials and care delivery studies in their communities.
A major new study has found that cancer patients who miss an urgent referral appointment for their symptoms are 12% more likely to die within 12 months of diagnosis. The study also revealed that non-attending patients with cancer had a higher risk of advanced stage disease at diagnosis, which can lead to poorer outcomes.
Javier Jo's research aims to detect oral cancer at an early stage using a hand-held endoscope that can recognize patterns and signatures of precancerous and cancerous lesions. The technology has the potential to increase the number of patients diagnosed with oral cancer at an earlier stage, improving survival rates and quality of life.
A new liquid biopsy test can detect microsatellite instability (MSI) and tumor mutational burden (TMB), indicating which patients are likely to benefit from immune checkpoint inhibitors. The test produced a specificity of greater than 99% and sensitivity of 78% for MSI, and 67% for TMB.
A recent study published in the New England Journal of Medicine reveals that unmarried patients with cancer are significantly less likely to receive potentially life-saving surgeries or radiotherapies compared to their married counterparts. The disparity persists despite extensive research findings suggesting otherwise.
A Brazilian multicenter study found that older hospitalized patients with cancer have a high prevalence of malnutrition, affecting nearly half of the patient population. The study highlights the need for nutritional assessments soon after hospitalization to prevent malnutrition and weight loss.
Cancer patients who continue smoking after diagnosis have a higher mortality rate and increased risk for second cancer development. The IASLC Declaration recommends screening all cancer patients for tobacco use and advising on tobacco cessation.
LSU Health New Orleans has been awarded a $13.6 million grant to expand its clinical trials network, providing cancer care and access to over 50% of newly diagnosed patients in the region. The new network will also increase minority patient participation in clinical trials.
Research studies by SWOG Cancer Research Network reveal that low-income cancer patients and those without insurance may not receive the same treatment benefits as their counterparts. Socioeconomic deprivation is found to be a significant factor in cancer outcomes, even after adjusting for race and insurance status.
Researchers at MD Anderson Cancer Center confirm ubiquitin specific protease 21 (UPS21) as a frequently amplified gene in pancreatic ductal adenocarcinoma (PDAC), a form of pancreatic cancer. Depletion of UPS21 impairs tumor growth, promoting malignant transformation and cancer cell stemness.
Researchers from Osaka University found that microRNA methylation levels can discriminate cancer patients from healthy individuals with high sensitivity and specificity. The study suggests that methylation of specific mature microRNAs could be a more powerful indicator of early-stage pancreatic cancer than existing biomarkers.
A lack of government action on NHS staffing undermines efforts to diagnose cancer early, with nearly half of all cancers diagnosed in England at stage 3 or 4. The health service needs an extra 1,700 radiologists and nearly 2,000 therapeutic radiographers to improve staff efficiency.
Research finds that patients experiencing internal bleeding after a heart attack may be at higher risk of developing cancer. The study suggests that early detection of bleeding can lead to improved cancer prognosis.
Researchers at H. Lee Moffitt Cancer Center describe a promising new treatment combination for patients with non-small cell lung cancer, showing preliminary efficacy and improved tolerance compared to standard treatments.
A new drug, TAK-228, has demonstrated effectiveness in treating metastatic bladder cancer, slowing tumor growth and progression. The study found that four of seven patients showed a positive response to the treatment.
A recent study found that primary care physicians recommend health promotion to at least some cancer survivors, but oncologists and specialists rarely do. Cancer survivors face increased risks of cardiovascular disease if they don't adopt healthy lifestyles.
A recent study published in Journal of Adolescent and Young Adult Oncology found that 30% of young adult cancer patients (ages 18-39) tested positive for a breakdown product of cannabis. Cannabis users were more likely to be male and report having more severe symptoms, including pain and nausea.
Researchers are conducting a phase 1 clinical trial using CAR-T cells, which have been shown to attack and kill cancers. The goal is to learn more about how these super-powered immune cells interact with solid tumors to develop effective treatments for various types of cancer.
A team of researchers at Georgetown University Medical Center has identified a chain of molecules critical for pancreatic ductal adenocarcinoma (PDAC) growth and survival. Inhibiting this 'Yap' biological network may effectively regress early-stage PDAC, and pairing it with other drugs could halt more advanced stage tumors.
A clinical trial discovered that selinexor, a novel therapy, effectively knocked down bone marrow cancer in over a quarter of patients, including two who achieved complete remission. The treatment showed promise for patients resistant to multiple therapies and offered new hope for those with limited treatment options.
Researchers analyzed genomic data from 317 MCC patients and found two distinct populations with different genetic profiles and treatment responses. Immunotherapies showed high effectiveness in both groups, with better response rates when given early treatment.
Research published in Gut journal suggests a link between antibiotic use and increased risk of bowel cancer, particularly for cancers of the proximal colon. Conversely, rectal cancer risk was found to be lower among those prescribed antibiotics, possibly due to differences in gut microbiome activity.
The study aims to improve caregiver physical and emotional well-being, increase confidence for caregiving, and enhance patient outcomes. Researchers will use simulation-based learning to train 180 family caregivers, comparing results to a control group.
Researchers at Moffitt Cancer Center have discovered a new treatment approach that may help nearly a third of lung cancer patients with KRAS mutations. The combination therapy targets the MEK kinase and enhances anti-tumor immunity through cytokines TNFα and IFNγ.
A new study found that even low-intensity exercise was associated with a nearly 20% reduction in cancer progression or death in patients with advanced colorectal cancer. Patients who engaged in moderate exercise while undergoing chemotherapy tended to have delayed disease progression and fewer severe side effects from treatment.
The study examined 3,368 medical aid in dying prescriptions from Oregon (1998-2017) and Washington (2009-2017), finding that most patients were insured, non-Hispanic white individuals with cancer. The primary reasons for pursuing medical aid in dying were loss of autonomy, impaired quality of life, and loss of dignity.
Moffitt researchers identified three subtypes of squamous cell lung cancer (SCC) with distinct genetic, chromosomal, and protein alterations. The inflamed subtype is characterized by immune cell infiltration and higher PD-1 levels, while the redox subtype has altered oxidation-reduction signaling pathways. These subtypes did not correl...
Adults aged 85 years and older account for the fastest-growing age group in the US, with higher cancer incidence rates but lower screening and treatment rates. The most common cancers among this population are lung, breast, prostate, and colorectum, but late-stage diagnosis and poorer survival outcomes are also reported.
A study analyzing published research found Nordic walking reduces swelling and improves physical fitness in breast cancer patients. However, more well-designed studies are needed to explore its full potential.
Five postdoctoral scholars will collaborate with experts in physical and biomedical science to better understand the interplay between the immune system and cancers. The fellowships aim to develop new treatments using a patient's immune system to prevent, control, and treat cancer.
A study of UK patients diagnosed with colorectal cancer between 2006 and 2013 found that those under 50 experienced more non-specific symptoms before referral to specialists. Younger patients also had longer intervals between diagnosis and referral, highlighting a need for primary care awareness.
Scientists have developed a personalized platform called TARDIS that accurately detects circulating tumor DNA and signs of residual disease in breast cancer patients. The assay demonstrated a significant improvement in sensitivity, enabling earlier detection of tumors and monitoring patient response to chemotherapy.
A new 'liquid biopsy' blood test called TARDIS detects circulating tumor DNA in patient blood, enabling precise monitoring of disease progression and response to treatment. The test's high sensitivity could help plan surgical resection and radiation therapy after pre-operative therapy.
A liquid biopsy assay demonstrated high accuracy in detecting microsatellite instability (MSI) status in cancer patients, with an overall accuracy of 98.4%. The study showed that the assay could identify MSI-high tumors and predict clinical outcomes, offering potential benefits for personalized treatment planning.
A study published in Nature Immunology reveals that immune cells' activation state prior to anti-PD-1 therapy is crucial for cancer response. The researchers found a way to overcome resistance by activating T cells through vaccines, suggesting a new approach to enhance PD-1 inhibitors.
The GW Cancer Center is conducting a randomized, placebo-controlled phase III trial to investigate cemiplimab's safety and effectiveness in preventing recurrence and metastasis in high-risk cutaneous squamous cell carcinoma. The study aims to enroll over 400 participants worldwide.
A new study has found that elderly cancer patients who are HIV-positive have poorer outcomes compared to those without the virus. The research found higher mortality rates from breast and prostate cancers among HIV-infected patients.
Researchers compared outcomes in patients with and without HIV who received stage-appropriate cancer treatment after a cancer diagnosis at age 65. The study found no significant difference in overall survival between the two groups, suggesting that age alone may not be a determining factor in cancer treatment outcomes.
A new study has found that psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer. Patients who experienced stress-related disorders or stressful life events were 33% more likely to die from the disease compared to those who did not report stress.
The National Cancer Institute has recognized Sylvester Comprehensive Cancer Center as a top-tier US cancer center due to its outstanding research and clinical care. The designation is a testament to the dedication of every member of the cancer center.
A breakthrough new drug CBL0137 has proven effective in mice treated with chemotherapy and is being tested as a potential treatment for all types of cancer, including solid tumours. The drug works by reactivating the body's P53 pathway to kill off damaged cells.
Researchers discovered that natural killer (NK) cells can express PD-L1 and provide anti-tumor activity when treated with checkpoint inhibitors. PD-L1+ NK cells can control tumor growth by killing tumors and secreting cytokines, providing a new immunotherapeutic avenue.
Antonio Giordano, a Hollings Cancer Center clinical scholar, is researching novel treatments for triple-negative breast cancer. He aims to develop a PLK1-inhibitor drug and explore the role of tumor-infiltrating lymphocytes in prognosis.
Research from St. Jude Children's Research Hospital found a link between inherited BRCA2 mutations and an increased risk of childhood non-Hodgkin lymphoma. The study analyzed data from 1,380 lymphoma survivors and found that members with BRCA2 mutations were more likely to develop the disease.
A study published in JAMA Oncology reports higher than expected five-year survival rates for patients with melanoma, renal cell carcinoma, and non-small-cell lung cancer treated with nivolumab. The treatment showed durable responses and improved outcomes for patients without cancer-related symptoms.
A new AI tool developed by Dana-Farber Cancer Institute can extract high-value cancer outcomes from unstructured radiology reports with comparable accuracy to human reviewers. The tool, trained on over 14,000 imaging reports, was able to replicate human assessments of disease-free survival and progression-free survival.
A new, non-invasive bladder cancer treatment method uses a 'liquid biopsy' from urine to identify molecular underpinnings of each patient's unique bladder cancer. The technique, called conditional reprogramming or CR, has shown promising results in detecting and treating the disease.
The FDA has approved erdafitinib as a targeted therapy for patients with advanced bladder cancer who have specific gene mutations in the FGFR3 gene. The drug achieved a 40% overall response rate and was well-tolerated, offering an alternative to existing treatments.
Researchers at the University of Maryland and National Cancer Institute identified 12 distinct gene-pair relationships in tumor cells that could be targeted for cancer therapy. These relationships were associated with varying levels of expression in the two genes and correlated with cancer patient survival.
A global report found that one in three cancer patients struggle to access psychological support, with 34% saying it was not available despite needing it. The survey also identified key areas for improvement, including swift diagnosis, information-sharing, and integrated multidisciplinary care.
Tiny devices based on microfluidics can analyze bodily fluids to detect early signs of cancer, enabling widespread screening. They also help develop personalized treatments by predicting patient responses to drug candidates.