Articles tagged with Cancer Patients
Researchers used CRISPR to analyze over 8,000 gene fusions in human cancer cell lines, finding that 90% do not play an essential role in cancer. A new fusion, YAP1-MAML2, was identified as critical for progression of multiple cancers, offering a potential new drug target.
Researchers evaluated 67 fitness apps on iOS and Android to assess their suitability for improving physical activity in cancer survivors. A fifth of the apps contained content suitable for people affected by cancer, focusing on aerobic-based activities with goal setting, monitoring, and feedback features.
A new clinical pathway at Christiana Care Health System's Helen F. Graham Cancer Center & Research Institute has shown better health outcomes and lower healthcare costs for cancer patients. The SCOOP pathway, launched in 2016, improved patient experiences by reducing emergency department visits, hospital admissions, and readmissions.
Researchers at The Royal Marsden NHS Foundation Trust developed a liquid biopsy test that detects DNA fragments shed by tumors into the bloodstream. The test identified 74% of patients with early-stage rectal cancer who were at risk of metastatic disease, and those with persistent DNA were more likely to develop metastatic disease.
Researchers at Burrell College of Osteopathic Medicine found that New Mexicans with 10 common cancers have a significantly worse five-year survival rate. Hispanic populations along the U.S.-Mexico border fare even worse.
Researchers analyzed over 3,500 tumor samples to identify genomic changes that inform targeted treatment strategies for men with advanced prostate cancers. The study found that more than half of patients have characteristics that suggest they are suitable for targeted therapies.
A trial remedy for racial disparities in early-stage lung and breast cancer treatment has shown nearly eliminating existing gaps. The intervention consisted of a real-time warning system, race-specific feedback, health equity training, and nurse navigators to reengage patients.
A new study found that children with inflammatory bowel disease, including ulcerative colitis and Crohn's disease, have a higher risk of developing cancer and dying early compared to the general population. The study suggests that cancer surveillance and mental health assessment are crucial for young patients with these conditions.
A large Chinese study found that type 2 diabetes is associated with an elevated risk of 11 types of cancer in men and 13 types of cancer in women. The study, which examined data from over 410,000 adults, revealed significant increases in cancer risk for both men and women with diabetes.
A computational tool assigns a bladder cancer subtype to an individual patient using genomic data, enabling personalized treatment selection. The study found that patients with the aggressive 'neuronal' subtype responded well to atezolizumab treatment, achieving high survival probabilities.
A global study predicts a 53% rise in chemotherapy demand by 2040, with an estimated 15 million patients needing treatment annually. The study recommends expanding the chemotherapy workforce to 100,000 physicians by 2040 to deliver optimal treatment.
Researchers have identified eight protein biomarkers that enable accurate differentiation between endometrioid and high-grade serous ovarian carcinomas. This breakthrough could lead to more precise diagnosis and tailored treatment for patients, reducing the risk of undertreatment or overtreatment.
Research reveals that cancer risk assessment tools are being widely underused by UK GPs, with only half of those with access using them. The study's findings highlight the need for improved training and integration of these tools into consultations to improve cancer diagnosis and survival rates.
A large study found that HER2 expression can predict DCIS recurrence and progression, enabling targeted treatments for high-risk patients. By screening DCIS patients for HER2, doctors can minimize the chance of recurrence or spread in lower-risk patients.
A new study highlights the growing need for cardio-oncology services to monitor and prevent heart disease in cancer patients. The research found that many cancer survivors are not fully aware of the risks of cardiotoxicity and lack understanding of a balanced diet, making them more susceptible to heart failure.
Researchers from Dartmouth's Norris Cotton Cancer Center have introduced an inexpensive DNA-based testing protocol for HPV in Honduras. The study found that of 1,732 women screened, 28% were positive for a high-risk HPV type, and the most common HPV genotypes detected were different than those commonly found in the US.
Researchers at the University of Michigan have developed a new method for detecting RNA fragments in blood plasma that were invisible to traditional methods. This breakthrough has potential applications in cancer detection, autoimmune side-effects monitoring, and understanding human gene activity.
Two new urine tests have shown promise in accurately detecting bladder cancer, determining its severity, and detecting recurrence. The tests use a gene variant called V1, which is elevated in bladder cancer, and have been found to be 90% effective at detecting the disease.
Researchers have developed a system to accurately deliver precise doses of radiation to cancer tissues while minimizing exposure to healthy ones. The new system uses specialized polymer gel to visualize the spatial location and dose of treatment in real-time.
A phase I clinical trial using stem cell immunotherapy will be tested on patients with advanced sarcomas and the NY-ESO-1 tumor marker. The treatment aims to generate a lasting immune response against cancer by modifying blood-forming stem cells and T cells to target specific proteins.
The number of cardiologists trained in cardio-oncology is not meeting the growing needs of cancer survivors, who are aging and developing co-morbid cardiovascular disease. Limited training programs and resources are emerging to address this need, highlighting the importance of collaboration between cardiologists and oncologists.
The ESMO Breast Cancer Congress stresses the need for a multidisciplinary approach to patient care, including cardiovascular assessment and nutritional support. A study presented at the congress found that dietary guidelines can lead to weight loss and improved quality of life in breast cancer patients.
The WINTHER trial successfully matched personalized therapy to 35% of patients with advanced cancer, showing improved overall survival for those with a high degree of matching. The trial's strategy employed RNA expression testing to tailor treatment based on gene expression differences between tumors and normal tissues.
Researchers have uncovered a new set of rules that predict how the tissue of origin influences tumor genetic makeup, with potential implications for targeted cancer therapies. The study found that cancer cells are addicted to specific NAD synthesis pathways, making them vulnerable to targeted interventions.
A study found that poor air quality significantly increases the risk of hospitalizations for respiratory issues in young cancer survivors, particularly those who received chemotherapy. The researchers tracked nearly 4,000 survivors and found that even low levels of PM2.5 can contribute to respiratory problems.
Researchers found that patients with cancer requiring emergency department care had lower admission rates and higher mortality rates at non-cancer center hospitals. This may be due to a lack of cancer expertise and missed markers of worsening disease.
A recent study found that 40.3% of people with cancer used marijuana in the past year, compared to 38.0% without cancer. Meanwhile, prescription opioid use was higher among those with cancer (13.9%) than without (6.4%).
Researchers found that treating patients with personalized, combination therapies improved response rates and overall survival in patients with therapy-resistant cancers. Highly matched patients showed a 50% response rate compared to unmatched or less well-matched patients.
A breakthrough CRISPR gene-editing tool allows for the simultaneous execution of multiple edits in DNA extracted from human cells. This technology, developed by the Gene Editing Institute and licensed to NovellusDx, can rapidly reproduce an individual patient's cancer tumor genetic features and identify driver mutations.
Acute myelogenous leukemia patients have only a one in four chance of survival after five years. Researchers created a protein atlas to identify and classify protein signatures at AML diagnosis. The online atlas helps recommend better treatment and personalized medicine for patients.
A new approach, PRO-cision Medicine, uses patient-reported outcomes to personalize cancer care. This method provides valuable information on patients' symptoms and functioning, guiding clinicians in making informed decisions.
A new algorithm can detect the molecular signature of a cancer-driving defect, identifying patients who could benefit from treatment with PARP inhibitors. The algorithm has the potential to expand greatly the pool of patients eligible for this therapy.
A consortium of researchers identified a rare but important gene target, NRG1, responsible for development of various cancer types. The study suggests that targeting this gene fusion could effectively shut down cancers, offering a new therapy possibility.
A new American Cancer Society study highlights the need to better identify patients with metastatic cancer who may not benefit from aggressive treatment. The study found wide variations in treatment patterns among patients who died within a month of diagnosis.
One-third of cancer patients use complementary and alternative medicines such as meditation, yoga, acupuncture, and herbal supplements. Many patients do not disclose their use to doctors due to lack of knowledge or perceived need for disclosure.
A nationwide survey found that 33.3% of cancer patients used complementary and alternative medicines, with herbal supplements being the most common. Many participants did not disclose their CAM use due to lack of physician inquiry or perceived unnecessary information.
A small clinical trial suggests that high-dose vitamin D may delay disease progression in patients with metastatic colorectal cancer. Patients who received high-dose vitamin D had a median delay of 13 months before their disease worsened, compared to 11 months for those in the low-dose group.
A new surgical guideline has been shown to decrease re-operation rates for breast cancer patients undergoing lumpectomy. According to a study by UBC medical student Alex Monaghan, women with early-stage breast cancer are now 72% less likely to require additional surgery.
Scientists visualized CAR T cells fighting blood cancer for the first time, revealing key interactions and behaviors. The study showed that CAR T cells can directly kill tumor cells within minutes, but their effectiveness is hindered by aggregation and infiltration issues.
A new study found that continued smoking by patients with cancer adds significant costs to subsequent cancer treatment. The analysis conservatively suggests a total of nearly $11,000 in increased treatment costs for each smoking patient after their initial cancer treatment fails.
A study published in JAMA Network Open found that continued smoking after a cancer diagnosis increases the risk of cancer treatment failure and adds $11,000 to treatment costs per patient. The research estimates $3.4 billion in national additional cancer treatment costs if patients continue to smoke.
Researchers found that Chop expression is higher in T cells from ovarian cancer patients, and high nuclear levels of Chop are associated with poor clinical responses. Blocking Chop or ER stress may help improve T cell-based immunotherapy treatments.
Metastatic cancer survivors face unprecedented challenges, including psychosocial burdens, financial strain, and emotional struggles. Experts like Terry Langbaum and Thomas Smith advocate for studying this population and improving care management to ease their journey.
Cancer research highlights canine sniffing detection, spicy compound slowing lung cancer progression. Neurodegenerative diseases examined via gum bacteria link to Alzheimer's and Parkinson's. New therapies target diabetes complications and liver failure.
Researchers at Medical College of Georgia found that higher levels of CCR4 gene are associated with better survival rates and longer lifespan in patients with colorectal cancer. The gene helps the immune system differentiate between good cells and bad cells.
Researchers found that rucaparib reduced tumor size and controlled growth in 17 out of 19 patients with BRCA1, BRCA2, or PALB2 mutations. The study provides promising early evidence for this approach as a less toxic option.
A phase I clinical trial and FDA expanded access program show LOXO-195, a next-generation TRK inhibitor, is safe and effective in patients with NTRK gene fusions resistant to first-generation TRK inhibitors. The study found that LOXO-195 induced responses in patients whose tumors had acquired specific mutations.
A prototype wearable device can continuously collect live cancer cells directly from a patient's blood, offering a biopsy alternative. This innovation could help doctors diagnose and treat cancer more effectively by providing better information for planning treatments.
A combination of ipilimumab and nivolumab has been shown to shrink tumors in patients with high-grade neuroendocrine carcinoma by 42 percent, while all low-grade patients did not see a response.
A new combination of immunotherapy and chemotherapy has caused tumors to shrink in 83% of patients with metastatic pancreatic cancer. The treatment, involving a CD40 antibody, checkpoint inhibitor, and standard-of-care chemotherapy, showed manageable side effects, suggesting a durable response.
A study suggests that increasing T cells' exposure to potassium, mimicking high potassium levels, could make cancer immunotherapies more effective. Growing T cells under conditions of high potassium preserves their stem-cell-like quality, allowing them to replicate and grow.
Dr. Daniel Von Hoff, TGen's Physician-In-Chief, has been recognized for his exceptional clinical research contributions through the Methods in Clinical Cancer Research Workshop, educating 100 students each summer. The workshop has trained nearly 2,300 graduates, who now populate leading cancer centers nationwide.
A new study found that cancer patients use more potent forms of medical marijuana with higher amounts of tetrahydrocannabinol (THC), relieving symptoms and side effects of cancer treatment. Non-cancer patients, on the other hand, prefer CBD-rich formulations for their therapeutic benefits.
A new study finds that preventive medications, such as those for blood pressure and bone health, are frequently continued until death in older adults with cancer. The use of these medications can increase the risk of serious side effects and reduce quality of life.
A recent publication touted genetic risk scores as a tool for identifying patients at high risk of heart disease, cancer, and diabetes. However, a new study questions the value of these scores, finding they have lower accuracy when considering individual patient factors.
Researchers from University of Surrey investigated public attitudes towards new Faster Diagnosis Standard (FDS) for Cancer, finding participants valued reassurance and support from GPs as highly as speedy referrals. GPs will need clear guidance to support patients under the new standard.
Researchers from University of Texas Medical Branch at Galveston developed a laser treatment that selectively destroys cancerous prostate tissue while preserving erectile and urinary functions. This technique is shown to be as effective as complete removal or radiation therapy with improved quality of life.
Researchers developed a non-invasive MRI methodology to determine if tumours have invaded lymph nodes prior to surgery. This innovation helps clinicians choose optimal treatment strategies and reduces overtreatment risks. By improving accuracy, SPI may also aid in selecting patients for pre-operative radiation and chemotherapy.
LumosVar is a computer program that can accurately identify cancer-causing genetic variants from patient tumor samples. The tool helps physicians determine individualized treatment for patients by differentiating normal DNA from mutated and cancerous DNA changes.
A recent study by Cancer Research UK reveals that African-American cancer patients with inherited red blood cell conditions are 20% more likely to experience serious adverse events. This disparity may be attributed to the rigors of therapy and the disproportionately higher incidence of these disorders in the African-American population.