Articles tagged with Cancer Patients
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A new study confirms that women aged 75 and older should continue receiving mammography screenings due to the significant risk of breast cancer in this age group. The research found a considerable incidence of breast cancer among women over 75, with most cases being invasive and treatable.
A new study found that cessation fatigue, emotional exhaustion and reduced coping resources, increases in the first six weeks of a quit attempt, leading to worse performance on smoking cessation milestones. High cessation fatigue scores predicted lower chances of going a full week without smoking at two months.
A new study published in The Lancet found that standard chemotherapy with cisplatin is more effective than cetuximab in treating HPV-positive throat cancer. Patients who received cisplatin had a significantly higher two-year overall survival rate and lower cancer recurrence rates compared to those on cetuximab.
Researchers have developed a CRISPR-based system called SLICE to rapidly assess gene function in primary immune cells, guiding decision-making for next-generation cell therapies. The new method identified genes that promote T cell replication and suppress it, revealing key regulators of proliferation.
Patients with biliary tract cancer and small intestine adenocarcinoma have responded well to a combination of dabrafenib and trametinib, surviving longer without disease progression. The median overall survival time was 11.3 months, with some patients surviving up to two years.
A phase I trial of a new drug combination using nivolumab and pixatimod has reported clinical benefit in four out of five patients with microsatellite stable colorectal cancer. The combination is thought to overcome intrinsic resistance to PD-1 inhibitors in MSS CRC, suggesting potential benefits for this patient population.
ZW25, an antibody targeting the HER2 receptor, has shown encouraging anti-tumour activity in patients with advanced cancers driven by HER2. The median time patients survived without disease progression was 6.21 months, and 13 experienced tumour shrinkage.
Researchers found fecal microbiota transplantation (FMT) to be an effective treatment for severe colitis caused by immune checkpoint inhibitors. The study showed both patients experienced significant improvements in inflammation and ulcerations after FMT, with reduced resemblance to their own pre-treatment gut microbiome.
Researchers presented a phase 2 trial showing capivasertib's potential in treating various types of cancer with the AKT mutation. The treatment resulted in tumor shrinkage in 23% of patients and prolonged time without tumor growth for 52%.
Researchers have developed a new method that can detect hard-to-trace tumor DNA in the blood by focusing on specific fragment sizes. The technique improves cancer detection and may also be applicable to other types of DNA in body fluids.
A new report by ESTRO highlights the need for improved access to radiotherapy in Europe, citing a quarter of patients who need treatment not receiving it. Experts recommend increased investment, better understanding, and integration into cancer care plans.
Head and neck squamous cell carcinoma patients who receive timely care have better survival rates compared to those with delayed care. MUSC researchers found that African American patients are disproportionately affected by delays in treatment, highlighting the need for coordinated action to address this issue.
A survey of 506 UK health professionals found that 29% would not recommend e-cigarettes to cancer patients who smoke, highlighting the need for clearer guidance and training. The study suggests that e-cigarettes are a substantially less harmful alternative to smoking tobacco for cancer patients.
A prognostic model using machine learning accurately stratifies African-American breast cancer patients into high- and low-risk populations based on protein expression levels. The model identifies a combination of four proteins associated with increased risk of death, suggesting specific therapeutic regimens for this underserved demogr...
An interactive online LGBT cultural competency training program improved oncologists' knowledge and clinical practices on LGBT patients. The program increased correct answers on LGBT-related knowledge items by 52% and favorable perspectives toward LGBT people by 70%.
Researchers discovered a new compound that enhances the efficacy of proteasome inhibitors, commonly used to treat multiple myeloma. The compound targets protein disulfide isomerases, making it effective against drug-resistant cells. This breakthrough offers hope for patients with this cancer.
Researchers found that targeting tumor sites with radiation or surgery after initial treatment can significantly improve overall survival time for patients. Progression-free survival and toxicity data also showed benefits, with median overall survival times of up to 41.2 months.
A team of researchers, led by Dr. El Bachir Affar and Dr. Marc Therrien, has made a groundbreaking discovery about the molecular mechanisms that prevent cancer from developing. They found that protein BAP1 works in tandem with partner ASXL2 to protect cells and keep organs cancer-free.
Researchers identified a link between chromatin, transcription factors, and gene activation patterns in cancer. They found that specific mutations in chromatin can lead to changes in gene activity, driving cancer growth and development. The study provides new insights into cancer biology and potential treatments.
Head and neck cancer survivors are at a higher risk of death by suicide, with the rate being two times that of other cancer survivors and four times that of the general population. The study found that approximately one-half of head and neck cancer survivors become functionally disabled after completing treatment.
Researchers have identified three proteins that regulate each other with surprising complexity, potentially leading to treatments for some forms of infertility and fighting aggressive cancers. The discovery could also inform precision medicine treatments for certain types of aggressive cancers.
The Utah Cancer Registry will continue to collect high-quality data on cancer patients in Utah for the next 10 years. The funding will support research aimed at preventing cancer and prolonging lives of those diagnosed with the disease.
A highly sensitive liquid biopsy test detects minute traces of cancer-specific DNA, accurately determining whether HPV+ oral cancer patients are free from cancer following radiation therapy. The test reduces the need for costly radiological studies and provides a more precise count of tumor DNA in the blood.
A new blood test developed by UNC Lineberger researchers demonstrates the ability to track HPV-linked head and neck cancer patients after treatment, reducing the need for costly imaging scans. Preliminary findings show that patients with positive blood tests had a higher risk of developing recurrence.
A new radiation treatment approach, hippocampal-avoidance whole-brain radiotherapy with memantine, demonstrated better preservation of cognitive function compared to traditional whole-brain radiotherapy. The study found similar cancer control and overall survival outcomes for both groups.
A new study suggests that HPV-positive throat cancer patients benefit from chemoradiotherapy, leading to higher overall survival rates compared to cetuximab treatment. Cisplatin chemotherapy and radiotherapy proved more effective in reducing cancer recurrence and improving patient outcomes.
Researchers found a unique microbial signature for esophageal cancer that could help identify at-risk individuals and develop alternative therapeutic strategies. The study suggests that analyzing the oesophageal microbiota may provide innovative diagnostic tools to improve the management of this condition.
A new study reveals that HIV-infected Hispanics in the US are at a higher risk of developing HPV-related cancers than their non-Hispanic counterparts. The study found significant disparities in cancer incidence rates among Hispanic and non-Hispanic populations, highlighting the need for targeted HPV-vaccination and screening programs.
Researchers have found a way to grow human stem cells destined to become mature sperm, providing fertility options for males diagnosed with childhood cancer. The breakthrough could help patients who are infertile due to chemotherapy and radiation treatments.
A phase II/III study found that a high concentration of multi-strain probiotic helped reduce mild to moderate episodes of chemotherapy-induced diarrhoea (CID) in cancer patients. The probiotic also reduced levels of inflammatory markers, although it did not meet its primary endpoint.
A new approach to treating advanced anal cancer is safer and more effective than current treatment, according to a randomised clinical trial. The study found that a chemotherapy combination of Carboplatin and Paclitaxel performed better in terms of survival rates and safety compared to Cisplatin and 5-fluorouracil.
Studies show that exercise can significantly reduce fatigue and improve well-being in patients with advanced lung cancer, improving symptom scores by approximately 10% during chemotherapy. Gentle aerobic exercise and strength training are recommended as part of treating the disease.
French researchers conclude that including exercise in cancer care can significantly improve symptom management, quality of life, and fitness. Studies show that regular exercise reduces pain, fatigue, and body fat while improving overall fitness, with benefits seen even among patients at highest risk of poor quality of life.
The ESMO 2018 Congress emphasizes the importance of integrating scientific advances into sustainable treatments, ensuring optimal cancer care reaches those who need it. Research highlights variations in European countries' approval times for new cancer drugs, emphasizing the need for timely reimbursement decisions.
A study suggests that immunotherapy is safe and feasible for HIV-positive cancer patients. The treatment appears to be well-tolerated as long as antiretroviral therapy is continued in parallel, the key finding of the study.
A study of oesophagogastric cancer patients found women experienced higher rates of nausea, vomiting, diarrhoea, mouth ulceration, and hair loss compared to men. The researchers analyzed data from four randomised trials involving over 1,600 patients.
A new test developed by scientists at the University of York can accurately identify life-threatening prostate cancers, which could lead to fewer unnecessary surgeries and radiotherapies. The test has shown a high accuracy rate of up to 92%, potentially reducing healthcare costs and side effects for patients.
Whole genome sequencing and exome sequencing identified clinically relevant variants in 79% of patients, guiding diagnosis, risk assessment, or drug targets. The study's comprehensive approach enables rapid analysis within 40 days, making it a promising tool for pediatric cancer treatment.
Researchers from St. Jude Children's Research Hospital present comprehensive genomic profiling data from the Genomes for Kids study, showcasing 79% of patients having somatic findings that guide clinical care. The study also highlights the role of germline variants in tumor formation and hereditary cancer predisposition syndromes.
Researchers found that stereotactic radiation therapy doubles progression-free survival and increases overall survival by a median of 13 months in patients with limited metastatic cancer. The treatment also improved survival rates, but with increased side effects.
A new blood test that detects circulating tumour DNA is being tested to determine if cancer patients need chemotherapy after surgery. The trial aims to identify high-risk patients who may benefit from aggressive treatment and low-risk patients who can avoid chemotherapy.
A nationwide Finnish study found that brain cancer survival has improved overall, with younger patients experiencing significant gains in median survival time. However, elderly patients saw minimal improvement, highlighting the need for more effective treatment strategies for this growing patient population.
A study in Germany shows that cancer patients face substantial financial impacts, including income loss and material hardship, with adverse psychological effects. The survey of 247 patients revealed that 80.6% faced higher out-of-pocket costs and 37.2% experienced significant income loss.
A clinical trial at UC San Diego Health is testing personalized vaccines that use a patient's unique cancer mutations to stimulate an immune response. The vaccine, combined with an FDA-approved checkpoint inhibitor, aims to unleash the full potential of T cells activated by the vaccine.
Researchers have identified NOTCH 1 as a key player in the metastasis of medulloblastoma, a type of pediatric brain cancer. The study also suggests that targeting this protein could lead to a more effective treatment option with fewer side effects.
A recent study analyzed over 6,000 tweets about breast cancer and found that 90% of medical information was appropriate, with prevention being the most common subtheme. The study suggests that social media can be a valuable tool for providing information on cancer prevention and health education.
A study of over 6,000 patients with advanced cancer treated in community settings shows that nearly a quarter received targeted treatment based on DNA mutations. This achievement marks a significant shift towards precision medicine, allowing more patients to benefit from innovative therapies.
A new study found that exercise effects on fatigue, fitness, and quality of life in cancer patients vary depending on their initial health characteristics. Patients with better baseline aerobic fitness experienced greater gains during treatment, while those with worse baseline values benefited more after treatment. The findings suggest...
OncoLink, Penn Medicine's patient education program, received the 2018 CPEN Excellence in Patient Education Award for its creative approaches to cancer education. The team has produced a survivorship care-plan builder and expanded OncoLink's library of resources, benefiting millions of patients.
Patients with AFib and a history of cancer are more likely to experience suboptimal antithrombotic care, leading to increased risk of stroke. Cardiology providers play a crucial role in improving outcomes for these patients, according to a study published in the Journal of the American College of Cardiology.
Researchers found that more frequent surveillance imaging was not associated with improved overall survival for NSCLC patients. Annual surveillance is recommended as a standard practice, offering no additional benefits over six-monthly visits.
Livia Schiavinato Eberlin has developed the MasSpec Pen, a tool that enables surgeons to rapidly differentiate cancerous tissue from healthy tissue in patients. Her research aims to improve cancer diagnoses and treatment options using mass spectrometry imaging.
A new initiative aims to empower Southwest Virginia residents to direct cancer research projects in their region. With $244,589 funding from PCORI, the UVA Cancer Center Without Walls team is seeking community members to join advisory boards and guide cancer research efforts.
Two TGen scientists, Dr. Daniel D. Von Hoff and Dr. Michael E. Berens, receive awards from the Arizona Bioindustry Association for their lifetime achievements in pioneering new treatments, leading coalition-building efforts, and advancing precision medicine.
A new study warns that HLH diagnoses can hide underlying malignancies, leading to delayed curative therapy for cancers. Researchers recommend using alternative diagnostic techniques to identify cancer prior to administering HLH therapy.
A phase I clinical trial found bacterial Clostridium novyi-NT spores to be tolerable and clinically effective in patients with treatment-refractory solid tumor malignancies. The therapy showed early clinical efficacy, with 86% of evaluable patients experiencing stable disease.
The conference features cutting-edge research studies to answer urgent questions in cancer immunotherapy, aiming to advance progress more rapidly for patients. New approaches to identifying responders and non-responders to immune checkpoint inhibitors are being developed.
A new cancer vaccine targeting HER2 has demonstrated clinical benefits in a phase I clinical trial, with six out of eleven evaluable patients experiencing improvements in their condition. The vaccine provided complete or partial responses and stable disease in some cases.
A patient-partnered genomics study identified immune checkpoint inhibition as a potential treatment option for patients with angiosarcomas of the head, face, neck, or scalp. The study found that patients with these tumors have high mutational burdens and may respond to immunotherapy.
Researchers identified subtle epigenetic differences that explain why some ovarian cancer patients respond to PARPi drugs, while others do not. The study adds to a vital checklist for matching patients with the right therapy for their cancer.