Articles tagged with Cancer Patients
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A study found that fitness trackers can supplement current assessments of health status and physical function, showing increased daily activity correlates with positive patient ratings and lower adverse events. Wearable devices may help predict treatment complications and enable timely interventions.
A large-scale retrospective study has shown that nearly doubling the number of lymph nodes removed during operations for right-sided colon cancers improves the survival rate for these patients. The study found improved outcomes when at least 22 lymph nodes were harvested, with a 20% increase in five-year survival rates.
Scientists have identified a mysterious molecule called Yin Yang1 that may fuel tumour growth in breast cancer, revealing how tumours change their 'appearance' to evade treatment using epigenetics. The findings suggest doctors should take new tumour samples when a patient's cancer spreads
A new study by the University of Michigan Rogel Cancer Center found that many breast cancer patients are struggling financially due to their treatment. The study reveals that 38% of women were worried about finances, and some experienced extensive hardships, including debt and losing their home.
A new study published in the American Cancer Society journal reveals that many patients with cancer face significant financial difficulties due to treatment costs. Despite medical oncologists, surgeons, and radiation oncologists reporting some engagement with patients about financial concerns, unmet patient needs persist.
A Yale University study found that drinking artificially-sweetened beverages is associated with a significantly lower risk of colon cancer recurrence and death. Participants who drank one or more 12-ounce servings of artificially sweetened beverages per day experienced a 46% improvement in risk, compared to those who didn't.
Using complementary medicine alongside conventional cancer therapy is associated with a higher risk of death from cancer. The study analyzed data from over 1.9 million patients and found that those who used complementary medicine were more likely to refuse conventional treatments.
A new analysis suggests using comprehensive cancer centers and case managers for improved care coordination. The study also proposes developing a distress checklist based on the National Comprehensive Cancer Network Guidelines.
A national population-based cohort study found that weight loss surgery reduced the risk of hormone-related cancers (breast, endometrial, or prostate cancer) by 77%. However, gastric bypass was associated with a greater than twofold increased risk of colorectal cancer.
Researchers at Texas A&M University found that testosterone treatment can help combat cachexia, a syndrome characterized by rapid or severe loss of fat and skeletal muscle, in cancer patients. Patients treated with testosterone maintained total body mass and increased lean body mass, allowing them to perform daily activities more easily.
A landmark study published in The Lancet found that robotic surgery is as effective as traditional open surgery in treating bladder cancer. Robotic surgery patients experienced less blood loss and shorter hospital stays but longer surgeries compared to those who underwent open surgery.
A study at Queen Mary University of London has identified genetic mutations that occur early in the development of bowel cancer in patients with inflammatory bowel disease (IBD). These mutations could form the basis of a simple diagnostic test for predicting who is at high risk of developing IBD-associated colorectal cancer.
A pilot study found that a mindfulness-based program, MODEL Care, improved patients' and family caregivers' ability to cope with the emotional challenges of advanced cancer. The program enhanced their ability to have open discussions about end-of-life plans, ultimately decreasing barriers to advance care planning.
Researchers at the Center for Genomic Regulation have developed a new statistical method to identify cancer predisposition genes from tumour sequencing data, identifying 13 candidate genes with 10 being new. The method allows researchers to find risk variants without comparing cancer patients to healthy groups.
A new study found that younger patients (under 50) diagnosed with rectal cancer do not experience a survival benefit from chemotherapy, radiation, and surgery. The findings suggest early onset disease may differ in terms of biology and response to therapy.
Researchers found striking differences in terminal care across regions, fueled by physicians' beliefs and practice style. Patients' beliefs did not contribute to spending differences. The study highlights the need for better physician education and training to address end-of-life issues.
Researchers identified clusters of circulating tumour cells in blood samples from patients with locally advanced head and neck cancer, which had not spread to other organs. The presence or absence of these clusters was associated with the spread of cancer to other organs.
The foundation awarded six new Damon Runyon Clinical Investigators, who will receive $450,000 each to develop their cancer research programs. Three others received Continuation Grants totaling $300,000, supporting their ongoing research.
The University of Hawai'i Cancer Center has been awarded a $6 million Cancer Center Support Grant to fund research at the Center. The renewal of its National Cancer Institute (NCI) designation recognizes the Center's unique contributions to cancer research and care in Hawaii, particularly for diverse ethnic populations.
A new study has identified key symptoms associated with testicular cancer in UK general practice, including testicular enlargement. The research found that painful testicular enlargement may indicate cancer, contradicting traditional teaching.
Researchers at Mount Sinai have discovered two microRNA activity-based biomarkers that can predict patient outcomes and inform treatment decisions for p53-like bladder cancer. The findings hold promise for personalized treatment options, but further research is needed to translate the results into improved patient care.
The Endocrine Society's Clinical Practice Guideline recommends long-term screening for growth disorders and pituitary hormone deficiencies in childhood cancer survivors who underwent radiation therapy. The guideline aims to detect endocrine disorders early and provide optimal patient care for this vulnerable population.
Researchers have found a new test that significantly improves the identification of bladder tumors likely to recur and progress. The test involves examining STAG2 gene expression in removed tumors, offering additional predictive discrimination.
Researchers identify epigenetic enzyme TET2 as a key player in controlling dormant tumor cells that can lead to cancer recurrence. A novel biomarker, 5-Hydroxymethylcytosine (5hmC), is also discovered to detect these treatment-resistant cells and predict patient outcomes.
A new regulatory axis involving the transcription factor Prox1 has been revealed to negatively regulate MMP14 protein levels, which plays a significant role in cancer progression and metastasis. This discovery provides new insights into the mechanisms governing MMP14's function in physiological processes such as wound healing.
Sanford Burnham Prebys Medical Discovery Institute has received four Padres Pedal the Cause collaborative grants to fund research projects in cancer and immunology. The projects aim to develop new insights into developing drugs and treatments designed to attack and kill cancer cells.
Researchers found no association between efavirenz and depression or suicidal ideation in Ugandan HIV patients. Efavirenz, a commonly used HIV cocktail worldwide, was previously linked to adverse psychiatric side effects in US and European populations.
A new smart probe developed by Tel Aviv University researchers can detect and visualize individual cancer cells in real-time, allowing surgeons to target specific tumor locations. The probe uses near-infrared technology to identify overproduced enzymes in cancer cells, guiding precise removal of malignant tissue.
Two Phase I/II clinical studies, PROter and PROfind, evaluate the safety and efficacy of radiolabeled PSMA-R2 for prostate cancer treatment. The trials assess tumor activity and patient response to treatment.
Scientists at the German Cancer Research Center have discovered a protein called TXNIP that controls the aging process. TXNIP inhibits thioredoxin-1, an enzyme that protects DNA from oxidative stress and slows down aging processes.
A Monash University study found that older people's reduced immune responses to cancer and vaccines are due to the accumulation of dysfunctional immune cells. The researchers discovered two types of T cells that lose their ability to fight diseases with age, leading to lower success rates for cancer immunotherapy in the elderly.
Researchers found that PIM-2 kinase negatively regulates T cell responses, while PIM-1 and PIM-3 positively regulate them. Inhibiting PIM-2 accelerated graft-versus-host disease (GVHD) in allogeneic bone marrow transplant, but also produced robust tumor immunity.
Researchers identified a new subtype of prostate cancer characterized by loss of the CDK12 gene, which was found to be more common in metastatic cases. Tumors with this alteration were responsive to immune checkpoint inhibitors, a type of immunotherapy treatment.
A new study from University Hospitals Connor Integrative Health Network reveals that improvisational music therapy can effectively manage acute pain and improve mood in adult patients with sickle cell disease. Music therapy, when actively engaged with a therapist, has a stronger impact on pain management than passive listening to music.
A collaborative effort has discovered molecular features of testicular germ cell cancers, identifying potential mutations and other molecular changes. The study found signs of duplicated DNA and defects in DNA methylation, which could inform future efforts to improve treatment decisions and help monitor patients for cancer recurrence.
Lutathera therapy has been shown to provide significantly longer time to deterioration of quality of life compared to hormone therapy alone, with median times of 28.8 months vs 6.1 months for global health status and 25.2 months vs 11.5 months for physical functioning.
Researchers found that long-term viral suppression significantly reduces cancer risk in aging HIV-positive individuals, with lower rates seen in patients with sustained suppression compared to those with early or no suppression. The study highlights the importance of viral suppression in preventing cancer and may inform strategies for ...
Researchers have discovered how p53 stops the development of lymphoma and potentially other cancers by targeting specific DNA repair genes. This new information could help doctors identify patients at risk and develop safer treatments.
The Immunoscore test accurately predicts tumor recurrence risk in patients with colon cancer, enabling intensified treatment after surgery. The test identifies two types of immune cells in the tumor and its invasive margin, providing a reliable estimation of disease progression.
A new study from Columbia University Irving Medical Center suggests that excess zinc in muscles contributes to cachexia, a debilitating muscle-wasting syndrome affecting 80% of advanced cancer patients. The discovery could pave the way for developing drugs to treat or prevent muscle wasting in cancer patients.
The Arizona Cancer and Evolution Center at ASU will use interdisciplinary approaches to understand cancer, leveraging evolutionary and ecological models to develop new treatments and management strategies. The center aims to advance fundamental understanding of cancer through innovative research efforts.
A rigorous study found that ethanol-lock therapy, widely used to reduce bloodstream infections, was ineffective in preventing new or recurring infections in young cancer patients with central venous catheters. The treatment was associated with increased complications, including catheter blockages and hospitalization.
The NCI-MATCH trial has released new findings on three arms of the trial, showing promise in patients with rare genetic changes. The study's results suggest that future studies could see more responses in populations with earlier-stage disease.
A new study published in JAMA found that increased follow-up testing of colorectal cancer patients does not improve survival rates. The study showed that patients who underwent surgery for colorectal cancer experienced the same five-year survival rate regardless of whether they received two or five follow-up tests.
Researchers at NCI developed a high-throughput method to identify mutations recognized by the immune system, leading to a complete response in a breast cancer patient. The treatment used tumor-infiltrating lymphocytes that specifically target tumor cell mutations, showing promise for treating common epithelial cancers.
A Phase II trial suggests that erdafitinib, an FGFR inhibitor, benefits patients with metastatic urothelial cancer harboring FGFR3 mutations. The therapy achieved a 40% overall response rate, including complete and partial responses, as well as stable disease in nearly half of patients.
A new study found that men with prostate cancer who experience urinary, bowel, or sexual dysfunction after treatment are more likely to experience emotional distress, which can lead to worsening function. The researchers emphasize the need for greater investment in psychosocial care to mitigate treatment side effects and improve qualit...
A recent study from the University of Pennsylvania School of Medicine found that rates of inherited mutations in genes other than BRCA1/2 are twice as high in breast cancer patients with a second primary cancer. The study also investigated polygenic risk scores, which were not strongly linked to an increased risk of cancer.
The article highlights conflicting guidance on opioid prescribing, potentially jeopardizing pain management for patients with cancer. Key areas of concern include CDC guideline recommendations that don't align with NCCN guidelines, and the lack of evidence for non-pharmacologic treatments to manage moderate to severe pain.
A new clinical trial is testing whether omega-3 capsules can stop bowel cancer from returning after liver surgery. The trial, funded by Yorkshire Cancer Research, involves 450 patients and investigates the effectiveness of a highly purified form of EPA.
Researchers at TGen and HCI are working together to combat bone metastatic breast cancer, a leading cause of pain and death for patients. By blocking the activity of RON kinase, they aim to prevent further damage to skeletal structures and enhance anti-tumor immunity.
A 2013 CLL patient achieved complete remission with a single CAR T cell infusion, sparking insights into the human genome and immune response that may enhance response rates. The successful treatment was linked to the specific location of the CAR gene within the patient's T cell DNA.
Supriya G. Mohile, an oncologist at the Wilmot Cancer Institute, has been named the winner of the B.J. Kennedy Award by ASCO for her work in geriatric oncology. The award recognizes her research and efforts to improve communication between doctors and older patients with cancer.
Researchers discovered a naturally occurring protein called apolipoprotein A-I binding protein (AIBP) that inhibits inflammatory response underlying chronic pain processing. A single spinal injection of AIBP alleviated chemotherapy pain in mice for two months with no side effects.
Researchers found that gut bacteria can control antitumor immune responses in the liver by regulating bile acid metabolism and NKT cell accumulation. This discovery has implications for understanding liver cancer mechanisms and potential therapeutic approaches.
A new study found that gentle stretching can reduce tumor size and improve immune response in a mouse model of breast cancer. The research suggests a link between stretching, inflammation resolution, and improved immune function.
Researchers at MD Anderson Cancer Center found that intense post-treatment surveillance does not improve detection of recurrence or overall survival in stage I, II, or III colorectal cancer. The study suggests that current guideline recommendations need to be reconsidered.
Two studies found that more frequent follow-up testing did not significantly impact mortality rates from any cause or colorectal cancer over five years. However, a related editorial suggests that current guidelines should be reevaluated in the context of these findings and potential harms associated with more frequent testing.
The Annual Report to the Nation on Cancer finds a decline in US cancer death rates among men and women of all racial and ethnic groups. Prostate cancer incidence has increased, while mortality has stabilized, with trends linked to changes in PSA screening.
Researchers developed a mouse model of luminal bladder cancer to study its therapeutic efficacy, focusing on checkpoint inhibitors and neo-antigens. The model revealed lower levels of immune cells in luminal tumors and differences in neo-antigen expression between subtypes.