Articles tagged with Cancer Patients
A DNA-based analysis can predict likelihood of disease recurrence in MDS patients after a stem cell transplant, helping doctors guide treatment decisions. The test identifies mutations before and after transplantation to detect residual cancer cells.
A new study of 96 patients with chronic lymphocytic leukemia (CLL) found that those experiencing stress have higher levels of cancerous cells and cytokines in their blood. The researchers also discovered a link between stress and disease severity, even after controlling for other factors.
A new study published in CANCER journal reveals that social support is the most decisive factor associated with life satisfaction among young patients with cancer. The research found that young adults with cancer who have strong social connections experience higher life satisfaction, regardless of other factors.
A new framework combines three existing methods to find large DNA mutations in cancer cells, providing a comprehensive view of the genome. The approach may help researchers understand how cancers begin and identify potential treatment targets.
A new study analyzing 76 untreated metastases from 20 patients found that different metastatic lesions share the same driver gene mutations. The findings suggest that a biopsy of a single metastatic lesion could provide sufficient information for treatment decisions.
A study found that common mutations drive the spread of cancer in individual patients, suggesting a key understanding of how cancers metastasize. The research also identified passenger mutations that are less likely to play a critical role in cancer development.
Researchers created a new diagnostic tool using advanced analyses to identify tumors with unknown origins. The tool helped diagnose a metastasis of melanoma residing in the lung, leading to effective treatment with BRAF inhibitors.
Researchers at Cedars-Sinai Medical Center discovered how hormone therapy can cause prostate cancer to spread by transforming some cancer cells into aggressive neuroendocrine cancer-type cells. A potential simple blood test may help predict when this type of therapy resistance will occur, according to the study.
A clinical trial found that using an anti-inflammatory agent during surgery can reduce inflammation and tumor cell growth, potentially improving cancer outcomes. The study tested a solution containing Taurolidine in patients undergoing surgery for colon cancer.
A Moffitt Cancer Center research team compared chemotherapy regimens and found that a combination called ddMVAC was associated with higher complete response rates and improved survival rates compared to standard care. The study analyzed data from over 800 surgical patients with advanced bladder cancer.
A clinical study using the CURATE.AI platform successfully treated a patient with metastatic castration-resistant prostate cancer, completely halting disease progression. The AI platform continuously optimised novel drug combination dosages to achieve a durable response, allowing the patient to resume an active lifestyle.
University of Toronto researchers have identified protein NUAK2, associated with poor disease prognosis in bladder cancer. Blocking NUAK2 slows down cancer cell growth and raises hopes for treating patients.
Researchers at Mount Sinai discovered that stromal cells in bladder cancer tumors prevent immune cells from attacking them, leading to low response rates with PD-1/PD-L1 inhibitors. The study identified genes linked to more aggressive cancers and found that tumors with these genes were less responsive to treatment.
Research found cancer increases risk of death and rehospitalization in patients with broken heart syndrome. Patients with cancer also experienced higher risks of adverse events after discharge, highlighting the need for strict monitoring.
The COMPASS trial found a significant link between major bleeding events and new cancer diagnoses in patients treated with anticoagulants. Patients who experienced bleeding were more than 20% likely to receive a new cancer diagnosis.
Patients with cardiovascular disease who experience major internal bleeding are more likely to be diagnosed with cancer, particularly gastrointestinal and genitourinary tract cancers. The study, which involved over 27,000 patients in 33 countries, suggests that bleeding may serve as an early warning sign for occult cancers.
A new study from the University of Toronto found that two-thirds of current and three-quarters of former cancer patients aged 50+ are mentally flourishing. The researchers discovered that factors such as marital status, income, and childhood experiences can influence mental health outcomes.
Effective medical treatment and surgery prevent esophageal cancer in people with severe heartburn. The study used health data from 1964 to 2014 and found a significant decrease in cancer risk after treatment.
The PCORI Board approved funding for 16 new studies comparing different approaches to improve care and outcomes for conditions like opioid use, cancer, depression, and stroke. The studies aim to provide evidence for better-informed healthcare decisions.
A simple blood test identifying patients unlikely to benefit from immunotherapy for bladder cancer could save months of unnecessary treatment. The test measures pro-inflammatory molecule Interleukin-2 release from immune cells before therapy and correctly predicted therapy outcome in almost 80% of cases.
A new study reveals that carers for people with cancer are between 5 and 7 times more likely to experience clinically significant psychological morbidity compared to the general population. The study also found lower general health scores among carers, particularly at younger ages.
A new study examines the link between socioeconomic status and racial & ethnic disparities in childhood cancer survival. The research found that socioeconomic status significantly mediate the association between race/ethnicity and survival for certain types of childhood cancers, such as acute lymphoblastic leukemia, acute myeloid leuke...
A gene expression predictor was developed to indicate whether melanoma patients are likely to respond to immune checkpoint inhibitors, a novel type of immunotherapy. The predictor was accurate across multiple melanoma patient datasets and identified nearly all responders and more than half of non-responders.
The new ESCAT grading system helps distinguish between tumour DNA alterations relevant for targeted medicine decisions and those that aren't. The system enables clinicians to prioritize mutations and make data-driven treatment choices.
A SWOG study shows that enrolled patients in cancer clinical trials exhibit similar survival rates, regardless of their rural or urban status. This suggests that uniform treatment strategies and access to quality care can help resolve cancer disparities between rural and urban populations.
A study at Dartmouth has uncovered two significant pathogenic pathways contributing to the development of lung cancer. The research, led by Xuemie Ji, identified interaction pathways in the nervous system and cellular processes involved in nutrient transport and immune response.
A study by University of Colorado Anschutz Medical Campus found that doctors with personal cancer experience are 17% more likely to recommend ovarian cancer screening to low-risk women, despite guidelines against it. This bias may be due to overestimating a patient's risk and prioritizing their experience over evidence-based guidelines.
A phase 3 trial found that radiation therapy and cetuximab was associated with worse overall and progression-free survival compared to the current standard treatment with radiation and cisplatin. The study recommended releasing the data after an interim analysis showed that cetuximab with radiation was inferior to cisplatin and radiation.
The REMBRANDT dataset, hosted by Georgetown University Medical Center, contains genomic information on 671 adult patients with brain tumors. Researchers can analyze and visualize the datasets using a simple web interface, facilitating discovery and treatment development for brain cancer.
Researchers found altered nitrogen metabolism in many cancers, producing detectable changes in body fluids and contributing to new mutations. This dysregulation may facilitate early detection of cancer and predict immunotherapy success.
The Women's Preventive Services Initiative recommends annual screening for urinary incontinence in all women, assessing symptom presence and impact on activities. Early intervention may reduce symptom progression and limit costly treatment needs.
Researchers found that normal fallopian tubes can contain pre-cancerous cells that escape and later progress to cancer in the pelvic or abdominal cavity. This 'precursor escape' concept may help explain why some women present with advanced ovarian cancer beyond the fallopian tubes.
Researchers have discovered a genetic marker, MUC16 mutation, associated with higher tumor mutation load and improved responsiveness to immunotherapy in gastric cancer. This finding could help identify eligible patients for immunotherapy treatment, which currently responds positively in only 20-30% of cases.
A study by ETH Zurich researchers has discovered new cancer-specific molecular changes in RNA molecules, which could inform the development of cancer treatments. The analysis found that alternative splicing occurs more frequently in tumor tissues than healthy tissues, particularly in pulmonary adenocarcinomas.
Researchers explored using saliva for early assessment of lung cancer and detection of stress hormones, enzyme levels, and developmental disease biomarkers. Saliva liquid biopsy shows promise in detecting circulating tumor DNA of lung cancer with high performance.
Researchers at McGill University have made a groundbreaking discovery linking stomach tumours in patients with Peutz-Jeghers Syndrome to immune system inflammation. The study suggests targeting inflammatory pathways may lead to potential new treatments for this rare genetic disorder.
Patients with advanced cancer who discussed personal care goals with a trained nonclinical worker were more likely to talk with doctors, report higher satisfaction, and incur lower health costs in their final month of life. The study suggests that these conversations can improve the quality of end-of-life cancer care while lowering costs.
The NY Genome Center will create tools for personalized treatment and tackle questions about tumor biology across genetically diverse populations. Researchers aim to improve outcomes for patients by increasing participation of underrepresented ethnic groups in genomic databases.
Thyroid cancer incidence has tripled in the US over 25 years, with over 50,000 people diagnosed annually. Experts propose measures to reduce overtreatment, such as active surveillance for small papillary thyroid cancers and more conservative surgical approaches like lobectomy.
A study found that fitness trackers can supplement current assessments of health status and physical function, showing increased daily activity correlates with positive patient ratings and lower adverse events. Wearable devices may help predict treatment complications and enable timely interventions.
A large-scale retrospective study has shown that nearly doubling the number of lymph nodes removed during operations for right-sided colon cancers improves the survival rate for these patients. The study found improved outcomes when at least 22 lymph nodes were harvested, with a 20% increase in five-year survival rates.
Scientists have identified a mysterious molecule called Yin Yang1 that may fuel tumour growth in breast cancer, revealing how tumours change their 'appearance' to evade treatment using epigenetics. The findings suggest doctors should take new tumour samples when a patient's cancer spreads
A new study by the University of Michigan Rogel Cancer Center found that many breast cancer patients are struggling financially due to their treatment. The study reveals that 38% of women were worried about finances, and some experienced extensive hardships, including debt and losing their home.
A new study published in the American Cancer Society journal reveals that many patients with cancer face significant financial difficulties due to treatment costs. Despite medical oncologists, surgeons, and radiation oncologists reporting some engagement with patients about financial concerns, unmet patient needs persist.
A Yale University study found that drinking artificially-sweetened beverages is associated with a significantly lower risk of colon cancer recurrence and death. Participants who drank one or more 12-ounce servings of artificially sweetened beverages per day experienced a 46% improvement in risk, compared to those who didn't.
Using complementary medicine alongside conventional cancer therapy is associated with a higher risk of death from cancer. The study analyzed data from over 1.9 million patients and found that those who used complementary medicine were more likely to refuse conventional treatments.
A new analysis suggests using comprehensive cancer centers and case managers for improved care coordination. The study also proposes developing a distress checklist based on the National Comprehensive Cancer Network Guidelines.
A national population-based cohort study found that weight loss surgery reduced the risk of hormone-related cancers (breast, endometrial, or prostate cancer) by 77%. However, gastric bypass was associated with a greater than twofold increased risk of colorectal cancer.
Researchers at Texas A&M University found that testosterone treatment can help combat cachexia, a syndrome characterized by rapid or severe loss of fat and skeletal muscle, in cancer patients. Patients treated with testosterone maintained total body mass and increased lean body mass, allowing them to perform daily activities more easily.
A landmark study published in The Lancet found that robotic surgery is as effective as traditional open surgery in treating bladder cancer. Robotic surgery patients experienced less blood loss and shorter hospital stays but longer surgeries compared to those who underwent open surgery.
A study at Queen Mary University of London has identified genetic mutations that occur early in the development of bowel cancer in patients with inflammatory bowel disease (IBD). These mutations could form the basis of a simple diagnostic test for predicting who is at high risk of developing IBD-associated colorectal cancer.
A pilot study found that a mindfulness-based program, MODEL Care, improved patients' and family caregivers' ability to cope with the emotional challenges of advanced cancer. The program enhanced their ability to have open discussions about end-of-life plans, ultimately decreasing barriers to advance care planning.
Researchers at the Center for Genomic Regulation have developed a new statistical method to identify cancer predisposition genes from tumour sequencing data, identifying 13 candidate genes with 10 being new. The method allows researchers to find risk variants without comparing cancer patients to healthy groups.
A new study found that younger patients (under 50) diagnosed with rectal cancer do not experience a survival benefit from chemotherapy, radiation, and surgery. The findings suggest early onset disease may differ in terms of biology and response to therapy.
Researchers found striking differences in terminal care across regions, fueled by physicians' beliefs and practice style. Patients' beliefs did not contribute to spending differences. The study highlights the need for better physician education and training to address end-of-life issues.
Researchers identified clusters of circulating tumour cells in blood samples from patients with locally advanced head and neck cancer, which had not spread to other organs. The presence or absence of these clusters was associated with the spread of cancer to other organs.
The foundation awarded six new Damon Runyon Clinical Investigators, who will receive $450,000 each to develop their cancer research programs. Three others received Continuation Grants totaling $300,000, supporting their ongoing research.
The University of Hawai'i Cancer Center has been awarded a $6 million Cancer Center Support Grant to fund research at the Center. The renewal of its National Cancer Institute (NCI) designation recognizes the Center's unique contributions to cancer research and care in Hawaii, particularly for diverse ethnic populations.
A new study has identified key symptoms associated with testicular cancer in UK general practice, including testicular enlargement. The research found that painful testicular enlargement may indicate cancer, contradicting traditional teaching.
Researchers at Mount Sinai have discovered two microRNA activity-based biomarkers that can predict patient outcomes and inform treatment decisions for p53-like bladder cancer. The findings hold promise for personalized treatment options, but further research is needed to translate the results into improved patient care.