Articles tagged with Cancer Patients
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A breath analysis test showed good diagnostic accuracy for esophagogastric cancer in a study of 335 patients, including those already diagnosed with the disease. The test identified abnormally regulated volatile organic compounds in the breath associated with esophagogastric cancer.
A federally funded trial found that using mobile and sensor technology reduced symptom severity in patients with head and neck cancer. The technology, called CYCORE, enabled remote monitoring of patient symptoms, allowing doctors to detect concerning symptoms early and respond more rapidly.
A study of 1,800 lung cancer screening sites found that only 1.9% of eligible heavy smokers were screened in 2016. Despite USPSTF and ASCO guidelines, low screening rates persist, with the South having the lowest rate at 1.6%. The study highlights the need for effective public service campaigns to encourage lung cancer screening.
Researchers have developed new treatment regimens that significantly boost survival rates for children and young adults with rare forms of leukemia and lymphoma, such as T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LL). The trial showed that 90% of patients lived at least four years after starting tre...
A meta-analysis of 20 randomised trials found that patients' sex may impact the efficacy of immunotherapy in cancer treatment. Women showed a lower survival benefit compared to men, regardless of cancer type and drug administered.
Next-generation sequencing (NGS) testing for all known lung cancer-related gene changes at diagnosis is more cost-effective and faster than testing one or a limited number of genes. This approach can save up to $2.1 million for Medicare and $250,000 for commercial insurance providers.
A randomized clinical trial found that acupuncture and cognitive behavioral therapy (CBT-I) decreased insomnia severity among cancer survivors, with CBT-I being more effective for those with mild symptoms. The study suggests that patients have more choices to manage their insomnia beyond traditional medicines.
Researchers found that patients with mutations in DNA repair genes like ATM and RB1 tend not to live as long as those without. These mutations can make tumor cells more susceptible to certain treatments, bringing potential hope for targeted therapies.
A new study published in Urologic Oncology suggests that MRI fusion biopsy is a more effective method for detecting clinically significant prostate cancer in patients with prior negative biopsies. The study analyzed data from over 700 patients and found that fusion biopsy detected 30.7% of clinically significant cancers, compared to 4....
Researchers have discovered universal antibodies that can recognize and neutralize a wide range of microorganisms, including bacteria, yeasts, and viruses. These breakthrough findings hold promise for developing new treatments for life-threatening infections, particularly in patients with weakened immune systems.
A new study examines clinical, functional, and neurophysiological outcomes in 121 long-term childhood cancer survivors. Chemotherapy-induced peripheral neuropathy can be a potentially long-lasting adverse effect of chemotherapy agents.
A new computational strategy simplifies complex cancer biomolecular data by emphasizing patient-to-patient variation in molecular signatures of cancer cells. This approach aims to provide a personalized treatment plan by analyzing the genetic makeup and impaired biological pathways of individual patients.
Researchers have developed criteria for routine genetic screening of patients with medulloblastoma, a rare and malignant tumor predominantly affecting children. This analysis of 1022 patients identified six genes frequently affected by genetic alterations, increasing cancer risk in up to 20% of the patient population.
A new study found that patients with low risk of local recurrence can safely undergo surgery alone without receiving chemoradiotherapy. This strategy could reduce the number of patients who receive chemoradiotherapy by half, with minimal risk of undertreatment.
A daily tablet has been shown to significantly reduce the risk of blood clots in cancer patients, with a lower rate of recurrence compared to traditional anticoagulant treatment. The study also found increased bleeding risks with the oral drug rivaroxaban.
Researchers developed a method to identify men with locally advanced prostate cancer who are less likely to respond well to radiotherapy. A 28-gene signature accurately identifies hypoxic tumour tissue in patients with prostate cancer that invades nearby structures. This signature could lead to improved treatment outcomes for patients.
A survey of over 200 oncologists reveals that most have discussed medical marijuana use with patients, but many lack knowledge on its effectiveness. The study highlights the need for clinical trials and education to inform cancer care.
A new AI method developed by MD Anderson researchers uses deep neural networks to automate the contouring of high-risk clinical target volumes in head and neck cancers. The model achieves comparable results to trained oncologists, offering a potential solution to reduce inter-physician variability and improve treatment efficiency.
A new phase 1 trial has shown that CAR T therapy CYAD-01 can induce a complete remission in a patient with acute myeloid leukemia, lasting nine months. This breakthrough is significant as it is the first time CAR T therapy has been effective without preconditioning chemotherapy.
Researchers have identified six genes associated with an increased risk of developing medulloblastoma, a common childhood brain tumor. Genetic screening guidelines have been developed to help patients understand their lifetime cancer risk and manage their care.
A new quality-control test developed by TGen can detect cancer in blood with high accuracy, filtering out contaminants and evaluating cfDNA samples. This test has shown promising results in several cancer types, including melanoma and breast cancer.
A randomized clinical trial found that flushing the bladder with a chemotherapy drug immediately after surgery significantly reduces the chances of bladder cancer returning. The study, published in JAMA, showed a 34% reduction in the risk of recurrence for patients receiving the treatment.
The center aims to study ways to reduce cancer risk among underserved individuals and improve outcomes among those with a diagnosis, utilizing tools like mobile health technology.
Cancer remains a significant concern as the HIV-infected population ages. By 2030, prostate and lung cancers are projected to be the most common cancers among individuals with HIV, due to their weakened immune systems.
A new study suggests that shifting cancer diagnosis from emergency hospital admissions to GP referrals could save thousands of lives and £2,130 per life saved. The shift would come at a small additional cost to the NHS.
Pancreatic cancer researchers and clinicians will work together to build a state-wide biobank, collecting data from diverse patient groups to minimize disparities and personalize care. The goal is to develop more effective therapeutic strategies tailored to individual needs, improving survival rates and quality of life.
The GlobalSurg3 study will pool data from hundreds of hospitals worldwide to compare surgery quality and highlight ways to improve patient care. The initiative aims to provide high-quality surgical care to millions of patients diagnosed with breast, gastric, or colon cancer annually.
Early intervention after completed clinical staging leads to increased survival rates in non-small cell lung cancer patients. Surgery within eight weeks from diagnosis significantly improves overall survival.
A study by Dana-Farber Cancer Institute and Broad Institute identified five genetic subtypes of diffuse large B cell lymphoma, which can help predict individual patient outcomes and guide personalized treatment. The analysis revealed clear links between specific genetic signatures and how patients respond to standard treatment.
A multi-center study discovered how adenosine to inosine (A-to-I) RNA editing contributes to protein diversity in breast cancer, increasing cancer cell proliferation and invasion. The findings suggest that individualizing therapies for each patient is reliant upon a better understanding of the protein genome.
A new review by Boston University School of Public Health researchers found that less than one-fifth of participants in cancer-related clinical trials are obese. Obesity was associated with an increased risk of progression, recurrence, and death for specific cancer types.
Researchers at University of Pennsylvania School of Medicine have identified five strategies to reduce unplanned acute care for cancer patients, including leveraging advanced big data analytics, team-based care, and early palliative care. These best practices aim to improve patient experience and reduce hospital utilization.
Research suggests that tiny differences in patient position during radiotherapy can lead to reduced survival chances, particularly when tumours are close to vital organs like the heart. Tightening treatment guidelines could improve survival rates by ensuring more accurate patient positioning.
A combination of XL888, a HSP90 inhibitor, and vemurafenib, a BRAF inhibitor, was found to be safe and effective in treating advanced melanoma patients, with 75% experiencing a response. The treatment resulted in manageable toxicities and durable responses.
A new University of Kansas research effort has resulted in a low-cost, reliable blood test that uses a small plastic chip to deliver diagnostic information similar to bone biopsies. The test has the potential to eliminate the need for invasive bone biopsies and guide treatment for multiple myeloma and other cancers.
A brief bedside visual art intervention (BVAI) improved mood and reduced pain and anxiety in patients with haematological cancers. The study found significant improvements in positive mood and pain scores, as well as decreases in negative mood and anxiety.
A new study suggests that adolescents and young adults with acute leukemia have a survival advantage when receiving treatment at pediatric cancer centers versus adult centers, particularly those affiliated with the National Cancer Institute. This is due to the more experienced care teams in these settings.
A new neuropathy measurement tool has been developed and found effective in quantifying symptoms and treatment efficacy. Minor revisions can improve its validity and universality for adoption in clinics and research settings.
A peer-reviewed study published in Oncotarget found that OncoDNA's comprehensive testing and analysis services, combining multiple biomarkers, increased oncologists' ability to make informed treatment decisions. The study showed a significant improvement in overall survival for late-stage patients, from six months to over 12 months.
The Global ROS1 Initiative is a patient-researcher collaboration that aims to accelerate research on ROS1 cancer. Members have contributed tumor samples and participated in epidemiological surveys, providing valuable insights into the disease.
A new blood test biomarker has been developed to distinguish between benign and malignant lung tumors with 98% accuracy. This breakthrough technology allows healthcare providers to confidently diagnose and treat patients with low-to-moderate risk nodules, reducing the need for invasive procedures.
A study published in Circulation found that patients with acute thrombosis in the leg are at a three-fold higher risk of developing cancer during the first six months after the blood clot. The risk is highest for smoking-related forms of cancer, such as lung and pancreatic cancer.
Scientists developed a high-speed microscopy platform that can measure tumor sensitivity to drugs in hours, rather than days, and has shown promising results in treating melanoma
Researchers from SU2C and Cancer Research Institute found that administering immunotherapy before surgery activates T-cells to hunt and destroy distant cancerous cells, preventing relapse. The approach showed encouraging outcomes in 45% of patients, with few evidence of cancer remaining upon follow-up.
A preclinical study by MD Anderson Cancer Center researchers found that precancerous colon polyps in patients with Lynch syndrome display immune system activation, challenging traditional models of cancer immune activation. The study suggests immunotherapy may be useful for colorectal cancer prevention in certain high-risk groups.
The SU2C Multiple Myeloma Dream Team aims to revolutionize the treatment of the incurable blood cancer by detecting precursor conditions such as MGUS or SMM. The team plans to analyze blood samples from approximately 50,000 people to identify biomarkers that can predict high-risk progression.
Researchers found that giving patients a single dose of anti-PD-1 therapy before surgery can predict tumor response and patient outcomes. The study also revealed that immune cells active against cancer were present in patients with longer recurrence-free survival.
A phase I clinical trial of BLU-667, a novel precision-targeted drug, reports significant durable disease control in patients with RET-driven cancers. The study reveals an overall response rate of 37% for RET-driven cancers, with responses of 45% for non-small cell lung cancer.
A study found that patients with a treating pivot nurse had higher patient satisfaction scores and better quality-of-life outcomes compared to those without such support. The coordinated care improved patients' understanding of their disease, treatment side-effects, and overall strength in fighting cancer.
A new study reports that consuming high amounts of carbohydrates and sugar prior to treatment for head and neck cancer may increase patients' risks of cancer recurrence and mortality. However, moderate fat and starchy food consumption after treatment appears to have protective benefits, reducing disease recurrence and death rates.
A lifestyle consistent with American Cancer Society (ACS) guidelines was associated with a lower risk of death in patients with stage III colon cancer. Patients who followed these guidelines had improved survival rates compared to those who did not.
Researchers found that simultaneous chemotherapy and immunotherapy is safe and patients with certain genetic mutations may respond particularly well. The combination approach was shown to boost immune cells in the blood, allaying previous concerns about chemotherapy's impact on immunotherapy.
A new NCI study revises molecular classification for diffuse large B-cell lymphoma, identifying four prominent genetic subtypes that can help explain treatment response. The study's findings will aid in predicting prognosis and tailoring therapy for patients with DLBCL.
Research analysis found unintended weight loss to be the second-highest risk factor for some forms of cancer. The study of 11.5 million patients revealed significant associations with colorectal, lung, pancreatic, and renal cancers, emphasizing the need for streamlined services to investigate non-specific symptoms like weight loss.
A study found that only 16% of respondents were aware of drug shortages, and those with a personal history of cancer were more likely to be aware. Most respondents wanted to be informed about substitution due to shortages and would transfer care to avoid major differences in efficacy.
A large study of breast cancer patients found that radiotherapy and chemotherapy do not significantly increase the risk of heart disease. Good risk management in hospitals and short interval screenings may offset elevated risks. The study's findings are considered positive for treatment of breast cancer.
A groundbreaking cancer genomics study reveals new molecular classifications, enabling the re-classification of 33 tumor types into 28 distinct clusters. These findings hold promise for immune-based and other novel cancer therapeutics, as well as repurposing drugs used to treat other diseases.
The PDX Finder is a free global portal for cancer models, offering over 1900 clinically relevant models from multiple repositories. Researchers can search and submit their own models to accelerate collaborative research and time-saving.
Researchers analyzed genomic and molecular data from 33 cancer types and identified 28 molecular clusters. The study provides new insights into cancer classification and potential treatment options.
Researchers have developed a new classification system for cancer based on molecular characteristics, identifying 28 subtypes and improving treatment options. The new approach has the potential to revolutionize cancer diagnosis and patient care.