Articles tagged with Cancer Patients
A clinical trial at UC San Diego Health is testing personalized vaccines that use a patient's unique cancer mutations to stimulate an immune response. The vaccine, combined with an FDA-approved checkpoint inhibitor, aims to unleash the full potential of T cells activated by the vaccine.
Researchers have identified NOTCH 1 as a key player in the metastasis of medulloblastoma, a type of pediatric brain cancer. The study also suggests that targeting this protein could lead to a more effective treatment option with fewer side effects.
A recent study analyzed over 6,000 tweets about breast cancer and found that 90% of medical information was appropriate, with prevention being the most common subtheme. The study suggests that social media can be a valuable tool for providing information on cancer prevention and health education.
A study of over 6,000 patients with advanced cancer treated in community settings shows that nearly a quarter received targeted treatment based on DNA mutations. This achievement marks a significant shift towards precision medicine, allowing more patients to benefit from innovative therapies.
A new study found that exercise effects on fatigue, fitness, and quality of life in cancer patients vary depending on their initial health characteristics. Patients with better baseline aerobic fitness experienced greater gains during treatment, while those with worse baseline values benefited more after treatment. The findings suggest...
OncoLink, Penn Medicine's patient education program, received the 2018 CPEN Excellence in Patient Education Award for its creative approaches to cancer education. The team has produced a survivorship care-plan builder and expanded OncoLink's library of resources, benefiting millions of patients.
Patients with AFib and a history of cancer are more likely to experience suboptimal antithrombotic care, leading to increased risk of stroke. Cardiology providers play a crucial role in improving outcomes for these patients, according to a study published in the Journal of the American College of Cardiology.
Researchers found that more frequent surveillance imaging was not associated with improved overall survival for NSCLC patients. Annual surveillance is recommended as a standard practice, offering no additional benefits over six-monthly visits.
Livia Schiavinato Eberlin has developed the MasSpec Pen, a tool that enables surgeons to rapidly differentiate cancerous tissue from healthy tissue in patients. Her research aims to improve cancer diagnoses and treatment options using mass spectrometry imaging.
A new initiative aims to empower Southwest Virginia residents to direct cancer research projects in their region. With $244,589 funding from PCORI, the UVA Cancer Center Without Walls team is seeking community members to join advisory boards and guide cancer research efforts.
Two TGen scientists, Dr. Daniel D. Von Hoff and Dr. Michael E. Berens, receive awards from the Arizona Bioindustry Association for their lifetime achievements in pioneering new treatments, leading coalition-building efforts, and advancing precision medicine.
A new study warns that HLH diagnoses can hide underlying malignancies, leading to delayed curative therapy for cancers. Researchers recommend using alternative diagnostic techniques to identify cancer prior to administering HLH therapy.
A phase I clinical trial found bacterial Clostridium novyi-NT spores to be tolerable and clinically effective in patients with treatment-refractory solid tumor malignancies. The therapy showed early clinical efficacy, with 86% of evaluable patients experiencing stable disease.
The conference features cutting-edge research studies to answer urgent questions in cancer immunotherapy, aiming to advance progress more rapidly for patients. New approaches to identifying responders and non-responders to immune checkpoint inhibitors are being developed.
A new cancer vaccine targeting HER2 has demonstrated clinical benefits in a phase I clinical trial, with six out of eleven evaluable patients experiencing improvements in their condition. The vaccine provided complete or partial responses and stable disease in some cases.
A patient-partnered genomics study identified immune checkpoint inhibition as a potential treatment option for patients with angiosarcomas of the head, face, neck, or scalp. The study found that patients with these tumors have high mutational burdens and may respond to immunotherapy.
Researchers identified subtle epigenetic differences that explain why some ovarian cancer patients respond to PARPi drugs, while others do not. The study adds to a vital checklist for matching patients with the right therapy for their cancer.
A new clinical trial has found that durvalumab improved progression-free survival by 17.2 months compared to placebo in patients with stage 3 non-small cell lung cancer. Overall survival rates also increased, with 66.3% of patients surviving at two years, compared to 55.6% on placebo.
Loyola will produce a more purified CAR-T cell product potentially reducing toxicities and costs. The Leukemia Research Foundation is supporting the research with a $250,000 grant.
A phase II clinical trial found that a tumor-specific vaccine combined with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to the human papilloma virus (HPV) and had a median survival of 17.5 months.
Adolescent and young adult (AYA) leukemia patients are significantly more likely to relapse than pediatric ALL patients. Factors such as lower clinical trial enrollment, shorter treatment duration, race, and insurance status contribute to this disparity.
A new study by Cancer Research UK has found that immune cells in urine samples can accurately reflect the tumor environment, offering a non-invasive window into bladder cancer. This discovery could help monitor response to immunotherapy and identify patients most likely to benefit from treatment.
Researchers found that daily lactoferrin supplementation can change salivary protein profiles in cancer patients, protecting their taste buds and odor perception. This could help patients recover from chemotherapy with improved nutrition and quality of life.
Researchers found that autologous fecal microbiota transplantation (auto-FMT) restored beneficial gut bacteria to near baseline levels within days, mitigating the effects of intense antibiotic treatment. This approach may prove a simple way to quickly restore a healthy microbiome following intensive antimicrobial therapy.
A study by Medical University of South Carolina found that breast cancer patients who received a second opinion at an NCI-designated center experienced a significant change in diagnosis, with 43% of cases altered. The review by a multidisciplinary tumor board led to the identification of additional cancers in 16 patients and changes in...
A 16-year Danish cohort study found comparable risks of recurrence between patients with unprovoked and cancer-related venous thromboembolism. The cumulative incidence of recurrence after incident VTE was over 15% in all groups, highlighting the need for revised risk stratification approaches.
Current guidelines on anticoagulation therapy for atrial fibrillation may be insufficient due to varying stroke rates among studies, suggesting a need for individualized risk assessments. A case report also highlights the successful treatment of multiple cancers with pembrolizumab in a patient with Lynch syndrome
Researchers discover cancer cells hide a key gene marker from immune system, allowing tumors to recur. By reactivating this marker, the team hopes to develop more effective immunotherapies to combat relapse.
A Special Focus Issue on Integrative Oncology investigates complementary and integrative medicine in multiple age groups, nations, and special populations. Research articles and commentaries discuss the options and effectiveness of nutritional strategies, aromatherapy, massage, and self-care toolkits for cancer patients.
Research teams identified CT45 as an independent prognostic factor for patients with high-grade serous ovarian cancer. High levels of CT45 were associated with extended disease-free survival, with patients living up to 7.5 years longer than those without sufficient CT45.
Case Western Reserve University researchers have discovered a way to predict which lung cancer patients will benefit from chemotherapy based on the arrangement of immune cells. This information may aid in decision-making for routine tissue-slide images, potentially sparing patients from invasive treatments.
Researchers found that a program designed to reduce stress in cancer patients can be taught to therapists across the country and effectively improves mood. The study involved 15 sites and 158 patients with various types of cancer, showing significant improvement on measures of mood and physical activity.
Cancer Research UK has partnered with Italian and Spanish charities to invest in six international collaborations worth approximately £30 million. The projects aim to accelerate progress in translational research by investigating immunotherapies, CAR-T cell production, and developing blood tests for advanced prostate cancer.
Elderly patients with gastric cancer undergoing elective laparoscopic gastrectomy are at high risk of postoperative pulmonary complications (PPCs). This study found that preoperative serum albumin levels were strongly associated with PPCs, suggesting that monitoring albumin can help identify patients at risk. The study's findings suppo...
A new study found that nearly half of a patient's first-degree relatives chose to undergo low-cost genetic testing after being contacted by a genetic testing laboratory. This 'cascade' testing helped identify healthy people at risk of cancer, with about 12% of those tested then inviting additional relatives to be tested.
A study estimates that prostate cancer screening and treatment for older men costs Medicare over $1.2 billion annually. The majority of this cost goes towards treating low-grade disease with Gleason scores of 6, which may not significantly impact life expectancy.
Researchers and regulators have conducted an expedited analysis of recalled blood pressure drugs, finding no association between use of potentially contaminated products and increased short-term cancer risk. However, a slightly increased risk of colorectal and uterine cancers was found in patients exposed to the impurity NDMA.
Crowdfunding sites have seen a surge in UK cancer-related appeals, with £8m raised since 2012. Critics argue that these platforms are not adequately vetting appeals, potentially leading to patients being exploited by unproven treatments.
A DNA-based analysis can predict likelihood of disease recurrence in MDS patients after a stem cell transplant, helping doctors guide treatment decisions. The test identifies mutations before and after transplantation to detect residual cancer cells.
A new study of 96 patients with chronic lymphocytic leukemia (CLL) found that those experiencing stress have higher levels of cancerous cells and cytokines in their blood. The researchers also discovered a link between stress and disease severity, even after controlling for other factors.
A new study published in CANCER journal reveals that social support is the most decisive factor associated with life satisfaction among young patients with cancer. The research found that young adults with cancer who have strong social connections experience higher life satisfaction, regardless of other factors.
A new framework combines three existing methods to find large DNA mutations in cancer cells, providing a comprehensive view of the genome. The approach may help researchers understand how cancers begin and identify potential treatment targets.
A new study analyzing 76 untreated metastases from 20 patients found that different metastatic lesions share the same driver gene mutations. The findings suggest that a biopsy of a single metastatic lesion could provide sufficient information for treatment decisions.
A study found that common mutations drive the spread of cancer in individual patients, suggesting a key understanding of how cancers metastasize. The research also identified passenger mutations that are less likely to play a critical role in cancer development.
Researchers created a new diagnostic tool using advanced analyses to identify tumors with unknown origins. The tool helped diagnose a metastasis of melanoma residing in the lung, leading to effective treatment with BRAF inhibitors.
Researchers at Cedars-Sinai Medical Center discovered how hormone therapy can cause prostate cancer to spread by transforming some cancer cells into aggressive neuroendocrine cancer-type cells. A potential simple blood test may help predict when this type of therapy resistance will occur, according to the study.
A clinical trial found that using an anti-inflammatory agent during surgery can reduce inflammation and tumor cell growth, potentially improving cancer outcomes. The study tested a solution containing Taurolidine in patients undergoing surgery for colon cancer.
A Moffitt Cancer Center research team compared chemotherapy regimens and found that a combination called ddMVAC was associated with higher complete response rates and improved survival rates compared to standard care. The study analyzed data from over 800 surgical patients with advanced bladder cancer.
A clinical study using the CURATE.AI platform successfully treated a patient with metastatic castration-resistant prostate cancer, completely halting disease progression. The AI platform continuously optimised novel drug combination dosages to achieve a durable response, allowing the patient to resume an active lifestyle.
University of Toronto researchers have identified protein NUAK2, associated with poor disease prognosis in bladder cancer. Blocking NUAK2 slows down cancer cell growth and raises hopes for treating patients.
Researchers at Mount Sinai discovered that stromal cells in bladder cancer tumors prevent immune cells from attacking them, leading to low response rates with PD-1/PD-L1 inhibitors. The study identified genes linked to more aggressive cancers and found that tumors with these genes were less responsive to treatment.
Research found cancer increases risk of death and rehospitalization in patients with broken heart syndrome. Patients with cancer also experienced higher risks of adverse events after discharge, highlighting the need for strict monitoring.
The COMPASS trial found a significant link between major bleeding events and new cancer diagnoses in patients treated with anticoagulants. Patients who experienced bleeding were more than 20% likely to receive a new cancer diagnosis.
Patients with cardiovascular disease who experience major internal bleeding are more likely to be diagnosed with cancer, particularly gastrointestinal and genitourinary tract cancers. The study, which involved over 27,000 patients in 33 countries, suggests that bleeding may serve as an early warning sign for occult cancers.
A new study from the University of Toronto found that two-thirds of current and three-quarters of former cancer patients aged 50+ are mentally flourishing. The researchers discovered that factors such as marital status, income, and childhood experiences can influence mental health outcomes.
Effective medical treatment and surgery prevent esophageal cancer in people with severe heartburn. The study used health data from 1964 to 2014 and found a significant decrease in cancer risk after treatment.
The PCORI Board approved funding for 16 new studies comparing different approaches to improve care and outcomes for conditions like opioid use, cancer, depression, and stroke. The studies aim to provide evidence for better-informed healthcare decisions.
A simple blood test identifying patients unlikely to benefit from immunotherapy for bladder cancer could save months of unnecessary treatment. The test measures pro-inflammatory molecule Interleukin-2 release from immune cells before therapy and correctly predicted therapy outcome in almost 80% of cases.
A new study reveals that carers for people with cancer are between 5 and 7 times more likely to experience clinically significant psychological morbidity compared to the general population. The study also found lower general health scores among carers, particularly at younger ages.
A new study examines the link between socioeconomic status and racial & ethnic disparities in childhood cancer survival. The research found that socioeconomic status significantly mediate the association between race/ethnicity and survival for certain types of childhood cancers, such as acute lymphoblastic leukemia, acute myeloid leuke...