Articles tagged with Cancer Patients
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A new clinical trial has found that durvalumab improved progression-free survival by 17.2 months compared to placebo in patients with stage 3 non-small cell lung cancer. Overall survival rates also increased, with 66.3% of patients surviving at two years, compared to 55.6% on placebo.
Loyola will produce a more purified CAR-T cell product potentially reducing toxicities and costs. The Leukemia Research Foundation is supporting the research with a $250,000 grant.
A phase II clinical trial found that a tumor-specific vaccine combined with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to the human papilloma virus (HPV) and had a median survival of 17.5 months.
Adolescent and young adult (AYA) leukemia patients are significantly more likely to relapse than pediatric ALL patients. Factors such as lower clinical trial enrollment, shorter treatment duration, race, and insurance status contribute to this disparity.
A new study by Cancer Research UK has found that immune cells in urine samples can accurately reflect the tumor environment, offering a non-invasive window into bladder cancer. This discovery could help monitor response to immunotherapy and identify patients most likely to benefit from treatment.
Researchers found that daily lactoferrin supplementation can change salivary protein profiles in cancer patients, protecting their taste buds and odor perception. This could help patients recover from chemotherapy with improved nutrition and quality of life.
Researchers found that autologous fecal microbiota transplantation (auto-FMT) restored beneficial gut bacteria to near baseline levels within days, mitigating the effects of intense antibiotic treatment. This approach may prove a simple way to quickly restore a healthy microbiome following intensive antimicrobial therapy.
A study by Medical University of South Carolina found that breast cancer patients who received a second opinion at an NCI-designated center experienced a significant change in diagnosis, with 43% of cases altered. The review by a multidisciplinary tumor board led to the identification of additional cancers in 16 patients and changes in...
A 16-year Danish cohort study found comparable risks of recurrence between patients with unprovoked and cancer-related venous thromboembolism. The cumulative incidence of recurrence after incident VTE was over 15% in all groups, highlighting the need for revised risk stratification approaches.
Current guidelines on anticoagulation therapy for atrial fibrillation may be insufficient due to varying stroke rates among studies, suggesting a need for individualized risk assessments. A case report also highlights the successful treatment of multiple cancers with pembrolizumab in a patient with Lynch syndrome
Researchers discover cancer cells hide a key gene marker from immune system, allowing tumors to recur. By reactivating this marker, the team hopes to develop more effective immunotherapies to combat relapse.
A Special Focus Issue on Integrative Oncology investigates complementary and integrative medicine in multiple age groups, nations, and special populations. Research articles and commentaries discuss the options and effectiveness of nutritional strategies, aromatherapy, massage, and self-care toolkits for cancer patients.
Research teams identified CT45 as an independent prognostic factor for patients with high-grade serous ovarian cancer. High levels of CT45 were associated with extended disease-free survival, with patients living up to 7.5 years longer than those without sufficient CT45.
Case Western Reserve University researchers have discovered a way to predict which lung cancer patients will benefit from chemotherapy based on the arrangement of immune cells. This information may aid in decision-making for routine tissue-slide images, potentially sparing patients from invasive treatments.
Researchers found that a program designed to reduce stress in cancer patients can be taught to therapists across the country and effectively improves mood. The study involved 15 sites and 158 patients with various types of cancer, showing significant improvement on measures of mood and physical activity.
Cancer Research UK has partnered with Italian and Spanish charities to invest in six international collaborations worth approximately £30 million. The projects aim to accelerate progress in translational research by investigating immunotherapies, CAR-T cell production, and developing blood tests for advanced prostate cancer.
Elderly patients with gastric cancer undergoing elective laparoscopic gastrectomy are at high risk of postoperative pulmonary complications (PPCs). This study found that preoperative serum albumin levels were strongly associated with PPCs, suggesting that monitoring albumin can help identify patients at risk. The study's findings suppo...
A new study found that nearly half of a patient's first-degree relatives chose to undergo low-cost genetic testing after being contacted by a genetic testing laboratory. This 'cascade' testing helped identify healthy people at risk of cancer, with about 12% of those tested then inviting additional relatives to be tested.
A study estimates that prostate cancer screening and treatment for older men costs Medicare over $1.2 billion annually. The majority of this cost goes towards treating low-grade disease with Gleason scores of 6, which may not significantly impact life expectancy.
Researchers and regulators have conducted an expedited analysis of recalled blood pressure drugs, finding no association between use of potentially contaminated products and increased short-term cancer risk. However, a slightly increased risk of colorectal and uterine cancers was found in patients exposed to the impurity NDMA.
Crowdfunding sites have seen a surge in UK cancer-related appeals, with £8m raised since 2012. Critics argue that these platforms are not adequately vetting appeals, potentially leading to patients being exploited by unproven treatments.
A DNA-based analysis can predict likelihood of disease recurrence in MDS patients after a stem cell transplant, helping doctors guide treatment decisions. The test identifies mutations before and after transplantation to detect residual cancer cells.
A new study of 96 patients with chronic lymphocytic leukemia (CLL) found that those experiencing stress have higher levels of cancerous cells and cytokines in their blood. The researchers also discovered a link between stress and disease severity, even after controlling for other factors.
A new study published in CANCER journal reveals that social support is the most decisive factor associated with life satisfaction among young patients with cancer. The research found that young adults with cancer who have strong social connections experience higher life satisfaction, regardless of other factors.
A new framework combines three existing methods to find large DNA mutations in cancer cells, providing a comprehensive view of the genome. The approach may help researchers understand how cancers begin and identify potential treatment targets.
A new study analyzing 76 untreated metastases from 20 patients found that different metastatic lesions share the same driver gene mutations. The findings suggest that a biopsy of a single metastatic lesion could provide sufficient information for treatment decisions.
A study found that common mutations drive the spread of cancer in individual patients, suggesting a key understanding of how cancers metastasize. The research also identified passenger mutations that are less likely to play a critical role in cancer development.
Researchers created a new diagnostic tool using advanced analyses to identify tumors with unknown origins. The tool helped diagnose a metastasis of melanoma residing in the lung, leading to effective treatment with BRAF inhibitors.
Researchers at Cedars-Sinai Medical Center discovered how hormone therapy can cause prostate cancer to spread by transforming some cancer cells into aggressive neuroendocrine cancer-type cells. A potential simple blood test may help predict when this type of therapy resistance will occur, according to the study.
A clinical trial found that using an anti-inflammatory agent during surgery can reduce inflammation and tumor cell growth, potentially improving cancer outcomes. The study tested a solution containing Taurolidine in patients undergoing surgery for colon cancer.
A Moffitt Cancer Center research team compared chemotherapy regimens and found that a combination called ddMVAC was associated with higher complete response rates and improved survival rates compared to standard care. The study analyzed data from over 800 surgical patients with advanced bladder cancer.
A clinical study using the CURATE.AI platform successfully treated a patient with metastatic castration-resistant prostate cancer, completely halting disease progression. The AI platform continuously optimised novel drug combination dosages to achieve a durable response, allowing the patient to resume an active lifestyle.
University of Toronto researchers have identified protein NUAK2, associated with poor disease prognosis in bladder cancer. Blocking NUAK2 slows down cancer cell growth and raises hopes for treating patients.
Researchers at Mount Sinai discovered that stromal cells in bladder cancer tumors prevent immune cells from attacking them, leading to low response rates with PD-1/PD-L1 inhibitors. The study identified genes linked to more aggressive cancers and found that tumors with these genes were less responsive to treatment.
Research found cancer increases risk of death and rehospitalization in patients with broken heart syndrome. Patients with cancer also experienced higher risks of adverse events after discharge, highlighting the need for strict monitoring.
The COMPASS trial found a significant link between major bleeding events and new cancer diagnoses in patients treated with anticoagulants. Patients who experienced bleeding were more than 20% likely to receive a new cancer diagnosis.
Patients with cardiovascular disease who experience major internal bleeding are more likely to be diagnosed with cancer, particularly gastrointestinal and genitourinary tract cancers. The study, which involved over 27,000 patients in 33 countries, suggests that bleeding may serve as an early warning sign for occult cancers.
A new study from the University of Toronto found that two-thirds of current and three-quarters of former cancer patients aged 50+ are mentally flourishing. The researchers discovered that factors such as marital status, income, and childhood experiences can influence mental health outcomes.
Effective medical treatment and surgery prevent esophageal cancer in people with severe heartburn. The study used health data from 1964 to 2014 and found a significant decrease in cancer risk after treatment.
The PCORI Board approved funding for 16 new studies comparing different approaches to improve care and outcomes for conditions like opioid use, cancer, depression, and stroke. The studies aim to provide evidence for better-informed healthcare decisions.
A simple blood test identifying patients unlikely to benefit from immunotherapy for bladder cancer could save months of unnecessary treatment. The test measures pro-inflammatory molecule Interleukin-2 release from immune cells before therapy and correctly predicted therapy outcome in almost 80% of cases.
A new study reveals that carers for people with cancer are between 5 and 7 times more likely to experience clinically significant psychological morbidity compared to the general population. The study also found lower general health scores among carers, particularly at younger ages.
A new study examines the link between socioeconomic status and racial & ethnic disparities in childhood cancer survival. The research found that socioeconomic status significantly mediate the association between race/ethnicity and survival for certain types of childhood cancers, such as acute lymphoblastic leukemia, acute myeloid leuke...
A gene expression predictor was developed to indicate whether melanoma patients are likely to respond to immune checkpoint inhibitors, a novel type of immunotherapy. The predictor was accurate across multiple melanoma patient datasets and identified nearly all responders and more than half of non-responders.
The new ESCAT grading system helps distinguish between tumour DNA alterations relevant for targeted medicine decisions and those that aren't. The system enables clinicians to prioritize mutations and make data-driven treatment choices.
A SWOG study shows that enrolled patients in cancer clinical trials exhibit similar survival rates, regardless of their rural or urban status. This suggests that uniform treatment strategies and access to quality care can help resolve cancer disparities between rural and urban populations.
A study at Dartmouth has uncovered two significant pathogenic pathways contributing to the development of lung cancer. The research, led by Xuemie Ji, identified interaction pathways in the nervous system and cellular processes involved in nutrient transport and immune response.
A study by University of Colorado Anschutz Medical Campus found that doctors with personal cancer experience are 17% more likely to recommend ovarian cancer screening to low-risk women, despite guidelines against it. This bias may be due to overestimating a patient's risk and prioritizing their experience over evidence-based guidelines.
A phase 3 trial found that radiation therapy and cetuximab was associated with worse overall and progression-free survival compared to the current standard treatment with radiation and cisplatin. The study recommended releasing the data after an interim analysis showed that cetuximab with radiation was inferior to cisplatin and radiation.
The REMBRANDT dataset, hosted by Georgetown University Medical Center, contains genomic information on 671 adult patients with brain tumors. Researchers can analyze and visualize the datasets using a simple web interface, facilitating discovery and treatment development for brain cancer.
Researchers found altered nitrogen metabolism in many cancers, producing detectable changes in body fluids and contributing to new mutations. This dysregulation may facilitate early detection of cancer and predict immunotherapy success.
The Women's Preventive Services Initiative recommends annual screening for urinary incontinence in all women, assessing symptom presence and impact on activities. Early intervention may reduce symptom progression and limit costly treatment needs.
Researchers found that normal fallopian tubes can contain pre-cancerous cells that escape and later progress to cancer in the pelvic or abdominal cavity. This 'precursor escape' concept may help explain why some women present with advanced ovarian cancer beyond the fallopian tubes.
Researchers have discovered a genetic marker, MUC16 mutation, associated with higher tumor mutation load and improved responsiveness to immunotherapy in gastric cancer. This finding could help identify eligible patients for immunotherapy treatment, which currently responds positively in only 20-30% of cases.
A study by ETH Zurich researchers has discovered new cancer-specific molecular changes in RNA molecules, which could inform the development of cancer treatments. The analysis found that alternative splicing occurs more frequently in tumor tissues than healthy tissues, particularly in pulmonary adenocarcinomas.
Researchers explored using saliva for early assessment of lung cancer and detection of stress hormones, enzyme levels, and developmental disease biomarkers. Saliva liquid biopsy shows promise in detecting circulating tumor DNA of lung cancer with high performance.
Researchers at McGill University have made a groundbreaking discovery linking stomach tumours in patients with Peutz-Jeghers Syndrome to immune system inflammation. The study suggests targeting inflammatory pathways may lead to potential new treatments for this rare genetic disorder.
Patients with advanced cancer who discussed personal care goals with a trained nonclinical worker were more likely to talk with doctors, report higher satisfaction, and incur lower health costs in their final month of life. The study suggests that these conversations can improve the quality of end-of-life cancer care while lowering costs.
The NY Genome Center will create tools for personalized treatment and tackle questions about tumor biology across genetically diverse populations. Researchers aim to improve outcomes for patients by increasing participation of underrepresented ethnic groups in genomic databases.
Thyroid cancer incidence has tripled in the US over 25 years, with over 50,000 people diagnosed annually. Experts propose measures to reduce overtreatment, such as active surveillance for small papillary thyroid cancers and more conservative surgical approaches like lobectomy.