Articles tagged with Cancer Patients
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A new study from Dartmouth College finds that patients with depression and advanced cancer live longer when exposed to palliative care interventions designed to improve quality of life. The intervention showed improved survival rates for those higher in depression compared to the usual care group.
Researchers developed a hybrid Th1/17 T cell that combines the strong effector traits of Th1 cells with the durability of Th17 cells, providing a potent and durable anti-tumor response in preclinical models. The hybrid cells maintained their effectiveness even after long-term persistence in the body.
Women with ER-positive breast cancer still face a substantial risk of cancer returning or spreading even 20 years after diagnosis, according to a new analysis. The risk is directly tied to the original cancer's size and characteristics, as well as the number of lymph nodes involved.
Researchers at German Cancer Research Center discovered a link between energy metabolism and epigenetic code in leukemias and brain cancer. The enzyme BCAT1 plays a key role in the development of malignant tumors, including acute myeloid leukemia and breast cancer.
Scientists at Mount Sinai developed a mathematical model that accurately predicts how tumors will respond to immunotherapies. The model also identifies key neoantigens that can stimulate an immune response, offering new insights for developing personalized cancer treatments.
A new category of immunotherapies called checkpoint inhibitors shows promise in treating cancers in HIV patients, who were previously excluded from clinical trials. The ongoing study suggests that these drugs can be safely used to manage cancer in people with HIV, providing a new hope for this population.
Researchers at FAU have identified two mechanisms by which H. pylori destroys the stomach's protective layer, allowing bacteria to access deeper tissue layers and inflict further damage. The team also discovered that the injected bacterial toxin reprograms host cells, making them potentially cancerous.
A new HCI study reveals that a two-drug combination significantly reduces precancerous polyps in FAP patients, leading to near-complete blockade of cancer growth pathways. The treatment also activates immune responses aimed at destroying pre-cancerous polyps.
Current RECIST guidelines face challenges in measuring cancer response with emerging targeted therapies. Researchers propose a new baseline approach to track stability and separate tumor burden from treated areas.
A study of 1,678 RA patients found no increased risk of second malignancy among those treated with biologics after a primary cancer diagnosis. Hazard ratios showed a slightly higher mortality rate among RA patients who received biologics before their cancer diagnosis.
Two studies reveal that gut bacteria play a crucial role in cancer treatment response, with certain beneficial microbes linked to improved survival and efficacy of immunotherapy. Patients with healthier gut flora tend to have more immune cells that can target tumors.
Researchers identified four genes - KRAS, CDKN2A, SMAD4, and TP53 - that influence pancreatic cancer survival. Patients with three or four altered genes had poorer disease-free and overall survival rates compared to those with single or dual alterations.
Preclinical studies demonstrate onalespib's effectiveness in inhibiting HSP90, reducing cell-survival proteins and tumor growth. The agent shows promise as a single treatment or in combination with temozolomide for glioblastoma patients.
Scientists at the University of Birmingham are pioneering a new approach to bowel cancer treatment using mini tumor models. The study, funded by Cancer Research UK, aims to identify new treatments and improve existing ones for this common yet deadly disease.
Researchers found that a diet low in glutamine can enhance chemotherapy's effectiveness and increase life span in mice with medulloblastoma. The study offers hope for improved treatments for childhood brain tumors, which are often associated with significant side effects.
Researchers found that PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) lacking BRCA mutations. The study suggests that PARP inhibitors may be effective in selected patients with other alterations in DNA damage repair genes.
The Lancet Oncology Commission recommends prioritizing key areas for US$2 billion funding to advance cancer research and treatment, focusing on prevention, targeted interventions, and patient-centered data sharing. The report aims to improve cancer care for underserved groups and reduce health disparities.
A nationwide population-based study found that death rates from lupus remain high compared to the general population, with significant disparities observed among older persons, females, blacks, and Hispanics. The study suggests that targeted research and public health programs may help address these disparities.
CancerLinQ is a big-data, real-world health information technology system that enables near real-time access to individual patient data for informed decision-making. The platform allows practitioners and researchers to tap into longitudinal, de-identified data and analytics.
The American Cancer Society has awarded Boston University School of Medicine with a three-year, $270,000 Institutional Research Grants program award to support early-stage cancer research by junior faculty. This funding will provide grants per year and is valued for its opportunity to establish proof-of-concept.
A researcher has discovered a protein that drives tumor growth in gallbladder cancer, providing an important prognostic marker for improved patient outcomes. The findings may lead to more effective treatment options and new drug therapies.
Researchers have successfully tested a new molecule capable of preventing peripheral neuropathy induced by chemotherapy in cancer patients. The molecule has shown positive results in reducing the appearance of disorders associated with nerve dysfunction.
Two studies comparing robotic-assisted to laparoscopic surgical procedures found no significant differences in postoperative complications or quality of life for patients with renal mass or rectal cancer. Robotic-assisted surgery was associated with prolonged operating times and higher hospital costs, but not increased risk of major co...
Patients with advanced cancer who experience high levels of physical and psychological symptoms have longer hospital stays and higher risk of unplanned readmissions. Researchers found that symptom management is crucial for improving patient outcomes and quality of life.
Patients with advanced cancer experience frequent and prolonged hospitalizations, often due to moderate to severe fatigue, poor well-being, and depression. These symptoms are linked to longer hospital stays and a higher risk of unplanned hospital readmissions.
A new clinical trial found that a brief in-person intervention, PRISM, can improve psychosocial health and quality of life in adolescents and young adults living with cancer. The intervention cultivated internal and existential resources to strengthen stress management and goal-setting.
A study of nine women suggests that ovarian tumors may originate in the fallopian tubes, providing insights into cancer origin and potential prevention strategies. The researchers found identical genetic errors in chromosome 17 and BRCA genes in all patients, supporting the fallopian tube theory.
A new study found that patients with advanced cancer prefer face-to-face interaction with their doctors, with better communication skills and professionalism. After watching both videos, 72% of participants favored the face-to-face interaction, highlighting the importance of human connection in healthcare.
The study found that the uninsured rate for adults with new cancer diagnoses decreased from 5.73% to 3.81% in 2014, a gain of 1.92 percentage points across multiple cancers and demographic groups. Coverage gains were particularly significant for Hispanic individuals and those with early- or late-stage disease.
A national cancer survey found 23% of childhood cancer survivors experienced job lock, staying at jobs for health insurance coverage. Female survivors and those with chronic conditions were more likely to report job lock. The study highlights the need for education and literacy about insurance options to support employed cancer survivors.
A study found that young non-Hispanic white women who tan indoors are more likely to be dependent on indoor tanning due to beliefs about physical appearance and depressive symptoms. The research, published in Cancer Epidemiology, Biomarkers & Prevention, suggests a need for targeted interventions to address this behavior change.
A study published in JAMA Oncology found that the number of newly diagnosed cancer patients who were uninsured fell by one-third in the first year of the Affordable Care Act's implementation. Significant gains were seen among various demographic groups and stages of diagnosis, with declines in uninsured rates among Hispanics and those ...
Researchers found that on average, one to ten driver mutations are required for cancer to emerge. The study also reveals the number of mutations driving cancer varies considerably across different cancer types. By using an evolutionary approach, scientists can identify key genes and mutations involved in cancer evolution.
Researchers found that arsenic trioxide can be a powerful therapy for glioblastoma multiforme, extending patient survival by three to four times. The treatment targets specific genomic signatures of brain tumor cells, allowing for precision medicine and matching the right drug to the right patient.
Researchers identified effective treatments for patients with rare cancers through genomic analysis, resulting in stabilization, shrinkage, or remission for half the patients. Precision medicine offers new hope for managing these uncommon but significant cancers.
Scientists at Mount Sinai & Sema4 validated a biomarker indicative of glioblastoma patient prognosis and likely response to therapies. BUB1B-sensitive tumors had significantly worse prognosis but were more likely to respond to many drugs already in clinical use.
A new clinical trial, led by TGen's Dr. Von Hoff, will pair an immunotherapy drug with a Vitamin D Receptor agonist to treat pancreatic cancer. The study aims to remodel the tumor microenvironment and improve the delivery of immunotherapy.
The University of Texas M.D. Anderson Cancer Center has been selected as one of four national Cancer Immune Monitoring and Analysis Centers (CIMACs) under the Partnership for Accelerating Cancer Therapies (PACT). CIMACs will provide expertise in systematic collection, processing, and analysis of blood and tumor samples to improve immun...
The inaugural SU2C Catalyst projects aim to explore new uses for powerful medicines in combination with other pharmaceutical company medicines, devices, and therapies. This program supports the selection of proposals by industry-specific sub-committees and significantly expedites the process of going from ideas to contracts to trials.
A study published in JNCI Journal of the National Cancer Institute found that cryotherapy can prevent symptoms of chemotherapy-induced peripheral neuropathy, improving quality of life for cancer patients. Cryotherapy involves wearing frozen gloves and socks during chemotherapy to reduce pain, numbness, and tingling.
Researchers from SingHealth, Duke-NUS Medical School, and NCCS have sequenced the complete genetic blueprint of durian, a tropical fruit known for its unique smell. The study reveals that durian has approximately 46,000 genes, nearly double those found in humans.
A new study from Georgetown University found that the 2001 NY State Medicaid expansion significantly increased racial disparities in access to high-quality cancer surgery. The proportion of minority Medicaid patients treated at top hospitals decreased, while white patients' access improved.
A recent study published in Annals of Surgery found that bariatric surgery lowers the risk of developing certain types of cancer, including postmenopausal breast cancer and endometrial cancer, by up to 50% among severely obese patients. The study also showed a significant reduction in risk for colon cancer and pancreatic cancer.
Scientists have characterized the complex process of human sperm stem cell development, revealing four distinct cellular phases. The study's findings may lead to better tools for diagnosing and treating male infertility, as well as uncovering genetic changes underlying cancers associated with male infertility.
A blood test for human papillomavirus (HPV) may help forecast treatment response in throat cancer patients, according to preliminary findings. Patients with low or undetectable HPV16 levels in the blood had higher risk of persistent or recurrent disease.
A study found that healthcare professionals' recommendations were the most important factor in driving decisions by women at high risk of breast cancer to take selective estrogen receptor modulators (SERMs) for chemoprevention. The recommendation played a statistically significant role and was associated with attitudes, beliefs, and ex...
A study led by St. Jude Children's Research Hospital found that fertility preservation is associated with increased optimism about the future for survivors, but remains underutilized by at-risk patients with cancer. Meeting with a fertility specialist and parental recommendations are key factors in deciding to bank sperm.
A new study found that surgical cancer centers in England are investing heavily in unproven technologies to stay competitive, despite a lack of evidence on their effectiveness. This trend has led to the closure of several centers, with patients often traveling to alternative facilities offering robotic surgery.
Researchers at NIH uncovered the first evidence of a brain lymphatic system, suggesting vessels act as a pipeline between brain and immune system. The discovery uses MRI to scan brains of healthy volunteers and confirms results in human and nonhuman primate brains.
Researchers found that patients with high numbers of alterations detected in their DNA collected from blood samples had a higher response rate to treatment, and median survival was longer. The study suggests that counting mutations in the bloodstream could help predict response to checkpoint inhibitor therapy.
University of Minnesota researchers report a novel encapsulation approach to identify and maintain dormant cancer cells in a quiescent state. This method involves immobilizing cells within a rigid silica-PEG matrix, which prevents movement and proliferation, allowing for differential response between cancer cell lines.
Researchers at Osaka University developed a non-invasive imaging technique using multiphoton microscopy (MPM) to quantify cancer severity. The method, called non-labeling multiphoton microscopy (NL-MPM), uses second harmonic generation and autofluorescence to detect malignancy with high accuracy.
A study by University of California San Diego School of Medicine researchers reveals that a simple blood test can predict which patients will respond to checkpoint inhibitor-based immunotherapies, with 45% of patients showing significant response. The findings suggest that patients with high numbers of genomic alterations in their tumo...
The partnership aims to address health disparities by conducting research on patient-derived cancers and training students in cancer health disparities-based precision medicine. This collaboration seeks to bridge the gap in understanding how to plan cancer prevention and care for underserved populations.
A pilot program using big data predicts ED visits in lung cancer patients with 33% accuracy. The model identifies high-risk patients who are 6.6 times more likely to visit the ED compared to low-risk patients.
Researchers at Ohio State University Wexner Medical Center have discovered a DNA-level biomarker that can predict overall survival for patients with anaplastic astrocytoma, a rare form of brain cancer. The study found that MGMT promoter methylation status is significantly associated with overall survival outcomes.
A recent study by Duke Cancer Institute found that ACA Medicaid expansion significantly reduced uninsured rates among white patients and those living in higher-income areas, but had little impact on black patients and residents of high-poverty areas. In contrast, states without expanded Medicaid saw a decline in uninsured rates primari...
A study by Anna Kirstine Winthereik shows that general practitioners who prioritize home visits reduce the time terminally ill cancer patients spend in hospitals and increase the likelihood of them dying at home. The study also highlights a positive correlation between frequent home visits and reduced hospital bed days.
A new study found that Medicaid expansion significantly reduced uninsured rates for cancer patients receiving radiation therapy, with the greatest benefits seen among vulnerable individuals living in high-poverty areas. The uninsured rate dropped by half in fully expanded states and only 5 percent in non-expansion states.
Researchers at Cologne University Hospital have discovered a novel inhibitor that specifically targets NMC tumours, a rare and lethal form of cancer. The study's findings provide valuable insights into the molecular mechanism responsible for the effectiveness of the inhibitor, paving the way for new and improved therapies.