Articles tagged with Cancer Patients
A study investigated the work ability of young adult cancer survivors, finding that low education, female sex, lymphoedema, fatigue, depression, and reduced physical quality of life are associated with reduced work ability. Treatment intensity was not significantly related to work ability.
The 'Triggers' tool evaluates cancer patients' palliative care needs at an earlier stage, enabling early referrals and potentially improving prognosis. A pilot study showed that 75% of patients who triggered positive on the tool items had a moderate need for specialist palliative care.
New research found that Medicaid expansion is associated with a significant decrease in uninsured rates among low-income adults with newly diagnosed cancer. In addition, there is a small but statistically significant trend toward earlier stage cancer diagnoses in Medicaid expansion states.
The KEYNOTE-059 trial found an overall objective response rate of 12% with pembrolizumab alone in pretreated patients, and more promising activity in patients with newly diagnosed metastatic cancer. The study also showed that patients with PD-L1 expression were more likely to respond to the treatment.
A novel peptide mimics the pathway that HPV-positive cancer cells use to respond to treatment, leading to increased cell death in HPV-negative cancer cells. The peptide improves therapeutic intervention in HPV-negative head and neck cancers.
A multi-drug and multi-tumour clinical trial shows that precision oncology using DNA sequencing can identify patient subgroups benefiting from existing drugs. Over 70 patients have started treatment, with a 37% clinical benefit rate observed.
A team of scientists at UT Austin has developed a handheld instrument that rapidly and accurately diagnoses cancerous tissue during surgery. The MasSpec Pen is over 96% accurate and can detect cancer in marginal regions, potentially improving treatment and reducing recurrence rates.
An observational study found that stroke survivors had a higher incidence of cancer compared to the general population, with most cases diagnosed within six months after a stroke. The study identified several factors associated with increased risk of developing cancer in stroke patients.
A new study by Dartmouth researchers has precisely determined the mechanism of cancer drug gemcitabine in human patients, enabling more effective combination therapies and rational clinical trial design. The research bridged the gap between experimental models and human trials, providing valuable insights into the drug's effects on cel...
A recent study by researchers at the Medical University of South Carolina identifies CNPY2 as a key molecule triggering the unfolded protein response, which contributes to certain metabolic disorders. The study found that CNPY2 plays a crucial role in sustaining cellular stress when the UPR becomes active.
A study found that only 2% of patients with suspected cancer were diagnosed using tumor markers, while most requests led to no diagnosis. The unnecessary tests cost over £95,000 over a year.
This review indicates that adipose tissue can affect cancer development through various mechanisms, including inflammation, cell metabolism, and immune clearance. The study found that different types of fat have distinct effects on cancer cells, with some types promoting tumor growth and others inhibiting it.
Research supports e-cigarette use as a smoking cessation aid with consistent daily use increasing the odds of quit success by 10%, but those using e-cigarettes less frequently face lower quit rates.
Researchers have created laboratory models of 12 types of pediatric cancer, enabling the study of tumor development and sensitivity to drugs. The HHMI is making these models and related data freely available to the scientific community, aiming to accelerate the discovery of new therapies for childhood cancers.
Researchers found that concurrent administration of anti-OX40 and anti-PD1 antibodies attenuated the effect of anti-OX40, resulting in poor treatment outcomes in mice. Sequential treatment with anti-OX40 followed by anti-PD1 improved therapeutic efficacy in some cases.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that the average cost of treating oropharyngeal cancer in Texas for two years is $139,749. The study suggests that HPV vaccination could prevent many cases of the disease and result in significant cost savings.
A new study identified over 11,000 miR-122 binding sites in a mouse model and found that three conserved target genes are associated with poor human HCC patient survival. The findings could help doctors predict liver cancer patient survival and develop an anticancer drug.
A non-coding RNA, PNUTS lncRNA, encourages cancer growth and metastasis by soaking up microRNA-205 that prevents epithelial-to-mesenchymal transition. In breast and lung cancer cell lines, PNUTS lncRNA promotes tumor development.
A new research study reveals that a nanolaser called spaser can detect and kill circulating tumor cells in the bloodstream, preventing cancer metastases. The spaser is biocompatible and selectively targets cancer cells with high folate receptor expression.
A re-analysis of USPSTF evidence suggests flexible sigmoidoscopy may reduce all-cause mortality, contrary to previous guidelines. Researchers found that looking at cohorts as separate trials, rather than aggregating them, strengthened the evidence supporting screening with flexible sigmoidoscopy.
Many young cancer patients are not receiving adequate fertility information and support, according to a new Psycho-Oncology review of published literature. The analysis found that clinicians' lack of knowledge and unclear roles hinder the provision of fertility preservation services.
A study published in Kidney Cancer journal found a decline in California kidney cancer incidence rates from 2009 to 2013, with stabilization of the trend. The research also showed an increase in partial nephrectomies, a surgical treatment that preserves long-term kidney function.
The Human Pathology Atlas analyzes human genes in all major cancers, revealing patterns that influence patient survival. The atlas provides a powerful tool for personalized medicine, with potential applications in lung and colorectal cancer.
A recent study has made a groundbreaking discovery in the treatment of anal cancer, suggesting that current methods of checking for lymph node spread may be overestimating survival rates. This finding has significant implications for patient care, potentially leading to more targeted and effective treatments.
Researchers at the Netherlands Cancer Institute discovered that PD-L1 is stabilized by protein CMTM6, making it a potential new therapeutic target for cancer treatment. This finding may also improve the prediction of treatment success in patients with current PD-L1 blockers.
Researchers developed a DNA sequencing-based method to detect early stage cancers by analyzing circulating tumor DNA in blood plasma. The approach, called TEC-Seq, identified cancer driver genes in over 90% of patients with colorectal, ovarian, lung, and breast cancers.
Researchers developed a genome sequencing method that can detect clinically relevant mutations using just 5 circulating tumor cells. The technique, known as long fragment read (LFR), is more comprehensive than gene panels and can analyze the entire genomic content of small numbers of cells.
A study using liquid biopsies found distinct genomic profiles in 99.7% of patients with CUP, harboring potentially targetable alterations. These findings suggest that liquid biopsies can guide treatment response in this patient population.
A new assay called OSU-SpARKFuse detects genetic changes in cancer cells and identifies novel gene fusions. The assay was validated using control specimens and then used to assess 95 tissue samples from patients with advanced cancer.
A new blood test can detect miniscule amounts of cancer DNA released into the blood, allowing for rapid detection of genetic mutations. This test has the potential to be personalized to recognize mutations unique to individual cancers.
A study found that older cancer patients and their caregivers often differ in assessing the patient's physical abilities, with caregivers rating them as having poorer function. This disparity is associated with greater caregiver burden. The researchers suggest considering caregiver burden when assessing patients' needs.
A Yale-led team has identified specific gene combinations that cause deadly brain cancer glioblastoma and found two mutations that make tumors resistant to chemotherapy. The new technology can also pinpoint triggers of other types of cancers.
Patients with newly diagnosed cancer face a substantially increased short-term risk of arterial thromboembolism. Lung, gastric, and pancreatic cancers are associated with the highest risk, while advanced disease increases overall tumor burden.
Researchers at Allina Health have found robotic-assisted surgery to be effective and safe for a select group of patients undergoing transhiatal esophagectomy. The study, which analyzed data from 100 patients, highlights the benefits of robotic technology in improving surgical outcomes.
A study by Fumiko Chino and colleagues found that nearly all insured cancer patients experience financial burden, with those underinsured paying up to 31% of their income on healthcare costs. The research highlights the need for interventions to improve patient health care cost literacy and mitigate future treatment-related expenses.
Researchers from Yale University studied 840 patients with curable cancers and found that those who used only alternative therapy had a higher risk of death. The study suggests that conventional cancer treatment is more effective in improving survival rates.
A study by Duke University researchers found that one-third of insured cancer patients pay more out-of-pocket than expected, despite health coverage. This 'financial toxicity' can lead to decreased treatment adherence and worsen mental and physical state.
A new analysis shows that breast cancer prognoses have significantly improved for young women treated with breast conserving surgery between 1997 and 2010. The study found a dramatic reduction in breast cancer recurrences and deaths after the implementation of new diagnostic and treatment strategies in 2005.
The NIH is awarding $18.9 million to accelerate the use of genome sequencing in clinical care, focusing on diverse and underserved populations. The Clinical Sequencing Evidence-Generating Research (CSER2) Consortium will develop innovative approaches and best practices to integrate genomic medicine into healthcare settings.
A new NCI study identifies more than 100 genes necessary for cancer cells to respond to T cell-mediated killing, shedding light on resistance to immunotherapies. The findings offer a blueprint for studying tumor resistance and developing new therapeutics.
Researchers found that age and tumor type are key factors in initial denial, with cancers outside brain/spine denied 4.5 times more frequently. Despite this, 97% of cases were overturned on appeal, highlighting the need to streamline the appeals process.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have published a study on K-80003, an anti-cancer agent that prevents activation of the PI3K pathway, resulting in inhibition of cancer cell growth.
Researchers found a higher prevalence of cancer at baseline screening in individuals with Li-Fraumeni syndrome, highlighting the feasibility of a comprehensive cancer screening protocol. The study demonstrated that whole body MRI screening can detect new primary cancers in up to 7 percent of patients.
A new study sequenced DNA and RNA of 500 patients with metastatic cancer, revealing a host of molecular factors driving tumor growth and spread. The analysis identified potential treatment targets and shed light on the underlying mechanisms behind metastatic cancer.
Leading European organisations call on EU to increase funding and legislation for independent academic research in oncology. This approach aims to optimise knowledge development, accelerate commercial drug development, and improve access for patients.
A study published in The Oncologist found that cancer patients with delirium who visit emergency departments are more likely to be admitted to hospital and die earlier. Delirium can be caused by various factors, including advanced cancer itself, medications, or infections.
A nationwide study found that cancer patients with cardiac arrest in the hospital have a survival rate of less than 10 percent, compared to 20-25 percent for non-cancer patients. The study aims to provide guidance on end-of-life care decisions.
A new imaging technique has revealed a more diverse and flexible DNA structure than previously thought, featuring small folds of DNA in close proximity. This discovery provides exciting insights into how chromatin directs gene expression and regulation.
Researchers used a contrast agent to make tumor cells glow during surgery, combining it with PET scans to identify malignant nodules. This approach improved diagnostics and led to the removal of more cancerous nodules from lung cancer patients.
A new study found that the combination of nivolumab and ipilimumab therapy demonstrates manageable safety, notable antitumor activity, and durable responses with promising long-term overall survival in patients with metastatic renal cell cancer. The treatment shows enhanced antitumor activity compared to monotherapy in tumor types such...
Research found that four molecular subtypes of gastric cancer have different prognoses and responses to chemotherapy, with the EBV subtype associated with the best outcome and the GS subtype with no benefit. The study suggests that classifying gastric cancer cases by subtype could provide personalized treatment options.
Researchers found an increased mutation rate in genes, including TP53, among African-American patients with smoking-related cancers. The study suggests that these genetic differences may contribute to resistance to chemotherapy and poorer outcomes.
Cachexia, a deadly weight loss condition in cancer patients, is caused by systemic inflammatory reactions triggered by cancer cells. Researchers discovered that autophagic stimuling compounds and pro-inflammatory cytokine IL-6 are associated with muscle mass loss, providing potential treatment options.
A new study found that higher levels of daily physical activity were associated with better performance on cognitive tasks, particularly attention, memory, and multitasking. Exercise was linked to reduced fatigue, which in turn improved cognitive function.
In preclinical studies, tumors with constitutive IDO1 expression responded to COX-2 inhibitor celecoxib and improved T-cell infiltration, making them more likely to respond to anti-PD1 therapies. COX-2 inhibitors may reverse IDO1-mediated immunosuppression in some cancers.
The UNC Lay Patient Navigation Program aims to address financial, emotional, and social support needs of cancer patients in North Carolina. The program will be implemented in 10 hospitals across the state, providing lay navigators with training and tools to offer critical support.
A new longitudinal study found that 32% of young adult cancer survivors experience consistently low social functioning over time. The researchers highlight the need for support programs and screening at diagnosis to address these challenges.
Approval rates climbed steadily from 85% to 95% among privately insured patients, with fewer delays in clearance. The ACA provision required private insurers to cover clinical trial participation, benefiting those with insurance.
The GW Cancer Center received a $100,000 grant from the Avon Foundation to fund a patient navigator and Spanish-speaking support group for breast cancer patients in the D.C. area. The program will provide resources to help 300 breast cancer patients overcome barriers in the healthcare system.
Researchers have identified a wide genetic variety in medulloblastoma, the most common type of childhood brain cancer. This discovery could lead to more precise subgroups and individualized treatments, improving curative chances and reducing side effects.