Articles tagged with Cancer Patients
Many young cancer patients are not receiving adequate fertility information and support, according to a new Psycho-Oncology review of published literature. The analysis found that clinicians' lack of knowledge and unclear roles hinder the provision of fertility preservation services.
A study published in Kidney Cancer journal found a decline in California kidney cancer incidence rates from 2009 to 2013, with stabilization of the trend. The research also showed an increase in partial nephrectomies, a surgical treatment that preserves long-term kidney function.
The Human Pathology Atlas analyzes human genes in all major cancers, revealing patterns that influence patient survival. The atlas provides a powerful tool for personalized medicine, with potential applications in lung and colorectal cancer.
A recent study has made a groundbreaking discovery in the treatment of anal cancer, suggesting that current methods of checking for lymph node spread may be overestimating survival rates. This finding has significant implications for patient care, potentially leading to more targeted and effective treatments.
Researchers at the Netherlands Cancer Institute discovered that PD-L1 is stabilized by protein CMTM6, making it a potential new therapeutic target for cancer treatment. This finding may also improve the prediction of treatment success in patients with current PD-L1 blockers.
Researchers developed a DNA sequencing-based method to detect early stage cancers by analyzing circulating tumor DNA in blood plasma. The approach, called TEC-Seq, identified cancer driver genes in over 90% of patients with colorectal, ovarian, lung, and breast cancers.
Researchers developed a genome sequencing method that can detect clinically relevant mutations using just 5 circulating tumor cells. The technique, known as long fragment read (LFR), is more comprehensive than gene panels and can analyze the entire genomic content of small numbers of cells.
A study using liquid biopsies found distinct genomic profiles in 99.7% of patients with CUP, harboring potentially targetable alterations. These findings suggest that liquid biopsies can guide treatment response in this patient population.
A new assay called OSU-SpARKFuse detects genetic changes in cancer cells and identifies novel gene fusions. The assay was validated using control specimens and then used to assess 95 tissue samples from patients with advanced cancer.
A new blood test can detect miniscule amounts of cancer DNA released into the blood, allowing for rapid detection of genetic mutations. This test has the potential to be personalized to recognize mutations unique to individual cancers.
A study found that older cancer patients and their caregivers often differ in assessing the patient's physical abilities, with caregivers rating them as having poorer function. This disparity is associated with greater caregiver burden. The researchers suggest considering caregiver burden when assessing patients' needs.
A Yale-led team has identified specific gene combinations that cause deadly brain cancer glioblastoma and found two mutations that make tumors resistant to chemotherapy. The new technology can also pinpoint triggers of other types of cancers.
Patients with newly diagnosed cancer face a substantially increased short-term risk of arterial thromboembolism. Lung, gastric, and pancreatic cancers are associated with the highest risk, while advanced disease increases overall tumor burden.
Researchers at Allina Health have found robotic-assisted surgery to be effective and safe for a select group of patients undergoing transhiatal esophagectomy. The study, which analyzed data from 100 patients, highlights the benefits of robotic technology in improving surgical outcomes.
A study by Fumiko Chino and colleagues found that nearly all insured cancer patients experience financial burden, with those underinsured paying up to 31% of their income on healthcare costs. The research highlights the need for interventions to improve patient health care cost literacy and mitigate future treatment-related expenses.
Researchers from Yale University studied 840 patients with curable cancers and found that those who used only alternative therapy had a higher risk of death. The study suggests that conventional cancer treatment is more effective in improving survival rates.
A study by Duke University researchers found that one-third of insured cancer patients pay more out-of-pocket than expected, despite health coverage. This 'financial toxicity' can lead to decreased treatment adherence and worsen mental and physical state.
A new analysis shows that breast cancer prognoses have significantly improved for young women treated with breast conserving surgery between 1997 and 2010. The study found a dramatic reduction in breast cancer recurrences and deaths after the implementation of new diagnostic and treatment strategies in 2005.
The NIH is awarding $18.9 million to accelerate the use of genome sequencing in clinical care, focusing on diverse and underserved populations. The Clinical Sequencing Evidence-Generating Research (CSER2) Consortium will develop innovative approaches and best practices to integrate genomic medicine into healthcare settings.
A new NCI study identifies more than 100 genes necessary for cancer cells to respond to T cell-mediated killing, shedding light on resistance to immunotherapies. The findings offer a blueprint for studying tumor resistance and developing new therapeutics.
Researchers found that age and tumor type are key factors in initial denial, with cancers outside brain/spine denied 4.5 times more frequently. Despite this, 97% of cases were overturned on appeal, highlighting the need to streamline the appeals process.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have published a study on K-80003, an anti-cancer agent that prevents activation of the PI3K pathway, resulting in inhibition of cancer cell growth.
Researchers found a higher prevalence of cancer at baseline screening in individuals with Li-Fraumeni syndrome, highlighting the feasibility of a comprehensive cancer screening protocol. The study demonstrated that whole body MRI screening can detect new primary cancers in up to 7 percent of patients.
A new study sequenced DNA and RNA of 500 patients with metastatic cancer, revealing a host of molecular factors driving tumor growth and spread. The analysis identified potential treatment targets and shed light on the underlying mechanisms behind metastatic cancer.
Leading European organisations call on EU to increase funding and legislation for independent academic research in oncology. This approach aims to optimise knowledge development, accelerate commercial drug development, and improve access for patients.
A study published in The Oncologist found that cancer patients with delirium who visit emergency departments are more likely to be admitted to hospital and die earlier. Delirium can be caused by various factors, including advanced cancer itself, medications, or infections.
A nationwide study found that cancer patients with cardiac arrest in the hospital have a survival rate of less than 10 percent, compared to 20-25 percent for non-cancer patients. The study aims to provide guidance on end-of-life care decisions.
A new imaging technique has revealed a more diverse and flexible DNA structure than previously thought, featuring small folds of DNA in close proximity. This discovery provides exciting insights into how chromatin directs gene expression and regulation.
Researchers used a contrast agent to make tumor cells glow during surgery, combining it with PET scans to identify malignant nodules. This approach improved diagnostics and led to the removal of more cancerous nodules from lung cancer patients.
A new study found that the combination of nivolumab and ipilimumab therapy demonstrates manageable safety, notable antitumor activity, and durable responses with promising long-term overall survival in patients with metastatic renal cell cancer. The treatment shows enhanced antitumor activity compared to monotherapy in tumor types such...
Research found that four molecular subtypes of gastric cancer have different prognoses and responses to chemotherapy, with the EBV subtype associated with the best outcome and the GS subtype with no benefit. The study suggests that classifying gastric cancer cases by subtype could provide personalized treatment options.
Researchers found an increased mutation rate in genes, including TP53, among African-American patients with smoking-related cancers. The study suggests that these genetic differences may contribute to resistance to chemotherapy and poorer outcomes.
Cachexia, a deadly weight loss condition in cancer patients, is caused by systemic inflammatory reactions triggered by cancer cells. Researchers discovered that autophagic stimuling compounds and pro-inflammatory cytokine IL-6 are associated with muscle mass loss, providing potential treatment options.
A new study found that higher levels of daily physical activity were associated with better performance on cognitive tasks, particularly attention, memory, and multitasking. Exercise was linked to reduced fatigue, which in turn improved cognitive function.
In preclinical studies, tumors with constitutive IDO1 expression responded to COX-2 inhibitor celecoxib and improved T-cell infiltration, making them more likely to respond to anti-PD1 therapies. COX-2 inhibitors may reverse IDO1-mediated immunosuppression in some cancers.
The UNC Lay Patient Navigation Program aims to address financial, emotional, and social support needs of cancer patients in North Carolina. The program will be implemented in 10 hospitals across the state, providing lay navigators with training and tools to offer critical support.
A new longitudinal study found that 32% of young adult cancer survivors experience consistently low social functioning over time. The researchers highlight the need for support programs and screening at diagnosis to address these challenges.
Approval rates climbed steadily from 85% to 95% among privately insured patients, with fewer delays in clearance. The ACA provision required private insurers to cover clinical trial participation, benefiting those with insurance.
The GW Cancer Center received a $100,000 grant from the Avon Foundation to fund a patient navigator and Spanish-speaking support group for breast cancer patients in the D.C. area. The program will provide resources to help 300 breast cancer patients overcome barriers in the healthcare system.
Researchers have identified a wide genetic variety in medulloblastoma, the most common type of childhood brain cancer. This discovery could lead to more precise subgroups and individualized treatments, improving curative chances and reducing side effects.
The Damon Runyon Cancer Research Foundation has awarded nearly $4.16M in fellowships to 18 early-career scientists conducting basic and translational cancer research. These four-year awards provide independent funding to investigate novel ideas with potential impact on cancer prevention, diagnosis, and treatment.
A study found that women with breast cancer who undergo nipple-sparing mastectomy have a low rate of recurrence within five years, comparable to standard mastectomies. The procedure leaves the natural nipple intact and has several advantages over standard mastectomy.
A 20-year study found that surgery for early-stage prostate cancer did not prolong life and often caused serious complications. Most men with early prostate cancer are more likely to survive with limited or no treatment.
A newly identified biomarker panel correctly detects early pancreatic cancer in human cells, improving the ability to diagnose patients at different stages of their disease. The panel combines plasma thrombospondin-2 with CA19-9 levels for reliable detection of pancreatic cancer, potentially altering treatment outcomes.
Entinostat inhibits myeloid derived suppressor cells, leading to enhanced antitumor activity when combined with PD-1 blockade. This preclinical study suggests entinostat may provide an effective combination treatment approach for patients with solid tumors.
A simple test for bladder cancer has been developed that can predict its return in over 80% of patients, identifying the faulty protein TERT. This new method detects bladder cancers earlier than existing tests and distinguishes them from urinary tract infections, potentially helping doctors start treatment sooner.
Researchers at the University of Cambridge have developed a new statistical model to estimate kidney function in cancer patients, improving chemotherapy dosing accuracy. The model reduces errors from over 20% to 11.7% compared to existing methods.
A recent study found that nearly 10% of terminal cancer patients are unwilling to face their prognosis, hindering them from making informed end-of-life plans. Healthcare professionals should assess patients' readiness for prognostic information and provide sensitive coaching to cultivate accurate awareness.
Common insurance plans leave access to top cancer hospitals at risk due to narrow network exclusions. Researchers call for greater transparency and more patient access.
A new study found that patients with pre-existing serious health conditions, such as heart disease or Inflammatory Bowel Disease (IBD), may experience a delay of up to 26 days in receiving a bowel cancer diagnosis. This can lead to more severe outcomes and poorer treatment options.
A study by St. Jude Children's Research Hospital found that abdominal radiation increases the risk of premature ovarian insufficiency in female cancer survivors, which can lead to infertility and poor overall health. Researchers recommend estrogen replacement therapy to mitigate these risks.
The Damon Runyon Cancer Research Foundation has awarded four physician-scientists with over $1.8 million in funding to pursue cancer research. The awards provide critical support to enhance translation and clinical research, addressing the financial disincentives that often deter physicians from pursuing a research career.
TGen is developing 'liquid biopsies' that can help clinicians accurately treat patients with high-risk breast cancer. These non-invasive blood tests could enable continuous monitoring of a patient's progress, reducing the need for surgery, chemotherapy, and radiation.
A new study shows that liquid biopsies can provide more information than traditional tissue biopsies, helping doctors tailor care based on individual disease biology. The tests detected genetic mutations that made cancer resistant to treatment, allowing for better patient care.
Researchers identified significant gene mutations and differences in the upper digestive tract that could help develop tailored treatment options for cancer patients. The study found a set of frequently mutated genes in small bowel adenocarcinomas, which may affect therapy choice and targeting.
The National Cancer Institute's Proteogenomic Translational Research Centers aim to bring proteogenomics to cancer patients. By analyzing blood samples, researchers hope to identify proteins that indicate response to specific treatments.
A systematic review and meta-analysis of published studies found strong evidence that e-cigarette use increases the risk of subsequent cigarette smoking among adolescents and young adults. E-cigarettes may mimic smoking behavior through similar hand-to-mouth movements and contain nicotine, potentially enhancing addiction.
Researchers at Duke University Medical Center have discovered a new antibody that can restore the effectiveness of chemotherapy rituximab in leukemia patients with natural resistance. The study found that adding the antibody to rituximab increased cancer cell death by 45% in five out of 11 patients.
A recent study found that the percentage of breast cancers diagnosed at early Stage 1 increased by 3.6 percentage points after the Affordable Care Act took effect. This increase was particularly notable among African American and Latina patients, who saw significant gains in Stage 1 diagnoses.
Scientists have successfully employed a novel type of imaging that uses glucose metabolism activity to identify solid tumors or aggressively growing areas. This method, called magnetization transfer effect, allows for the visualization of changes in glucose levels in brain tissue without the need for radioactivity.