Articles tagged with Cancer Patients
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new NCI study identifies more than 100 genes necessary for cancer cells to respond to T cell-mediated killing, shedding light on resistance to immunotherapies. The findings offer a blueprint for studying tumor resistance and developing new therapeutics.
Researchers found that age and tumor type are key factors in initial denial, with cancers outside brain/spine denied 4.5 times more frequently. Despite this, 97% of cases were overturned on appeal, highlighting the need to streamline the appeals process.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have published a study on K-80003, an anti-cancer agent that prevents activation of the PI3K pathway, resulting in inhibition of cancer cell growth.
Researchers found a higher prevalence of cancer at baseline screening in individuals with Li-Fraumeni syndrome, highlighting the feasibility of a comprehensive cancer screening protocol. The study demonstrated that whole body MRI screening can detect new primary cancers in up to 7 percent of patients.
A new study sequenced DNA and RNA of 500 patients with metastatic cancer, revealing a host of molecular factors driving tumor growth and spread. The analysis identified potential treatment targets and shed light on the underlying mechanisms behind metastatic cancer.
Leading European organisations call on EU to increase funding and legislation for independent academic research in oncology. This approach aims to optimise knowledge development, accelerate commercial drug development, and improve access for patients.
A study published in The Oncologist found that cancer patients with delirium who visit emergency departments are more likely to be admitted to hospital and die earlier. Delirium can be caused by various factors, including advanced cancer itself, medications, or infections.
A nationwide study found that cancer patients with cardiac arrest in the hospital have a survival rate of less than 10 percent, compared to 20-25 percent for non-cancer patients. The study aims to provide guidance on end-of-life care decisions.
A new imaging technique has revealed a more diverse and flexible DNA structure than previously thought, featuring small folds of DNA in close proximity. This discovery provides exciting insights into how chromatin directs gene expression and regulation.
Researchers used a contrast agent to make tumor cells glow during surgery, combining it with PET scans to identify malignant nodules. This approach improved diagnostics and led to the removal of more cancerous nodules from lung cancer patients.
A new study found that the combination of nivolumab and ipilimumab therapy demonstrates manageable safety, notable antitumor activity, and durable responses with promising long-term overall survival in patients with metastatic renal cell cancer. The treatment shows enhanced antitumor activity compared to monotherapy in tumor types such...
Research found that four molecular subtypes of gastric cancer have different prognoses and responses to chemotherapy, with the EBV subtype associated with the best outcome and the GS subtype with no benefit. The study suggests that classifying gastric cancer cases by subtype could provide personalized treatment options.
Researchers found an increased mutation rate in genes, including TP53, among African-American patients with smoking-related cancers. The study suggests that these genetic differences may contribute to resistance to chemotherapy and poorer outcomes.
Cachexia, a deadly weight loss condition in cancer patients, is caused by systemic inflammatory reactions triggered by cancer cells. Researchers discovered that autophagic stimuling compounds and pro-inflammatory cytokine IL-6 are associated with muscle mass loss, providing potential treatment options.
A new study found that higher levels of daily physical activity were associated with better performance on cognitive tasks, particularly attention, memory, and multitasking. Exercise was linked to reduced fatigue, which in turn improved cognitive function.
In preclinical studies, tumors with constitutive IDO1 expression responded to COX-2 inhibitor celecoxib and improved T-cell infiltration, making them more likely to respond to anti-PD1 therapies. COX-2 inhibitors may reverse IDO1-mediated immunosuppression in some cancers.
The UNC Lay Patient Navigation Program aims to address financial, emotional, and social support needs of cancer patients in North Carolina. The program will be implemented in 10 hospitals across the state, providing lay navigators with training and tools to offer critical support.
A new longitudinal study found that 32% of young adult cancer survivors experience consistently low social functioning over time. The researchers highlight the need for support programs and screening at diagnosis to address these challenges.
Approval rates climbed steadily from 85% to 95% among privately insured patients, with fewer delays in clearance. The ACA provision required private insurers to cover clinical trial participation, benefiting those with insurance.
The GW Cancer Center received a $100,000 grant from the Avon Foundation to fund a patient navigator and Spanish-speaking support group for breast cancer patients in the D.C. area. The program will provide resources to help 300 breast cancer patients overcome barriers in the healthcare system.
Researchers have identified a wide genetic variety in medulloblastoma, the most common type of childhood brain cancer. This discovery could lead to more precise subgroups and individualized treatments, improving curative chances and reducing side effects.
The Damon Runyon Cancer Research Foundation has awarded nearly $4.16M in fellowships to 18 early-career scientists conducting basic and translational cancer research. These four-year awards provide independent funding to investigate novel ideas with potential impact on cancer prevention, diagnosis, and treatment.
A study found that women with breast cancer who undergo nipple-sparing mastectomy have a low rate of recurrence within five years, comparable to standard mastectomies. The procedure leaves the natural nipple intact and has several advantages over standard mastectomy.
A 20-year study found that surgery for early-stage prostate cancer did not prolong life and often caused serious complications. Most men with early prostate cancer are more likely to survive with limited or no treatment.
A newly identified biomarker panel correctly detects early pancreatic cancer in human cells, improving the ability to diagnose patients at different stages of their disease. The panel combines plasma thrombospondin-2 with CA19-9 levels for reliable detection of pancreatic cancer, potentially altering treatment outcomes.
Entinostat inhibits myeloid derived suppressor cells, leading to enhanced antitumor activity when combined with PD-1 blockade. This preclinical study suggests entinostat may provide an effective combination treatment approach for patients with solid tumors.
A simple test for bladder cancer has been developed that can predict its return in over 80% of patients, identifying the faulty protein TERT. This new method detects bladder cancers earlier than existing tests and distinguishes them from urinary tract infections, potentially helping doctors start treatment sooner.
Researchers at the University of Cambridge have developed a new statistical model to estimate kidney function in cancer patients, improving chemotherapy dosing accuracy. The model reduces errors from over 20% to 11.7% compared to existing methods.
A recent study found that nearly 10% of terminal cancer patients are unwilling to face their prognosis, hindering them from making informed end-of-life plans. Healthcare professionals should assess patients' readiness for prognostic information and provide sensitive coaching to cultivate accurate awareness.
Common insurance plans leave access to top cancer hospitals at risk due to narrow network exclusions. Researchers call for greater transparency and more patient access.
A new study found that patients with pre-existing serious health conditions, such as heart disease or Inflammatory Bowel Disease (IBD), may experience a delay of up to 26 days in receiving a bowel cancer diagnosis. This can lead to more severe outcomes and poorer treatment options.
A study by St. Jude Children's Research Hospital found that abdominal radiation increases the risk of premature ovarian insufficiency in female cancer survivors, which can lead to infertility and poor overall health. Researchers recommend estrogen replacement therapy to mitigate these risks.
The Damon Runyon Cancer Research Foundation has awarded four physician-scientists with over $1.8 million in funding to pursue cancer research. The awards provide critical support to enhance translation and clinical research, addressing the financial disincentives that often deter physicians from pursuing a research career.
TGen is developing 'liquid biopsies' that can help clinicians accurately treat patients with high-risk breast cancer. These non-invasive blood tests could enable continuous monitoring of a patient's progress, reducing the need for surgery, chemotherapy, and radiation.
A new study shows that liquid biopsies can provide more information than traditional tissue biopsies, helping doctors tailor care based on individual disease biology. The tests detected genetic mutations that made cancer resistant to treatment, allowing for better patient care.
Researchers identified significant gene mutations and differences in the upper digestive tract that could help develop tailored treatment options for cancer patients. The study found a set of frequently mutated genes in small bowel adenocarcinomas, which may affect therapy choice and targeting.
The National Cancer Institute's Proteogenomic Translational Research Centers aim to bring proteogenomics to cancer patients. By analyzing blood samples, researchers hope to identify proteins that indicate response to specific treatments.
A systematic review and meta-analysis of published studies found strong evidence that e-cigarette use increases the risk of subsequent cigarette smoking among adolescents and young adults. E-cigarettes may mimic smoking behavior through similar hand-to-mouth movements and contain nicotine, potentially enhancing addiction.
Researchers at Duke University Medical Center have discovered a new antibody that can restore the effectiveness of chemotherapy rituximab in leukemia patients with natural resistance. The study found that adding the antibody to rituximab increased cancer cell death by 45% in five out of 11 patients.
A recent study found that the percentage of breast cancers diagnosed at early Stage 1 increased by 3.6 percentage points after the Affordable Care Act took effect. This increase was particularly notable among African American and Latina patients, who saw significant gains in Stage 1 diagnoses.
Scientists have successfully employed a novel type of imaging that uses glucose metabolism activity to identify solid tumors or aggressively growing areas. This method, called magnetization transfer effect, allows for the visualization of changes in glucose levels in brain tissue without the need for radioactivity.
A combined molecular biology test can accurately identify benign pancreatic lesions, potentially sparing patients from unnecessary cancer screenings and operations. The test uses two proteins to rule out precancer and cancer, with a sensitivity of 95.5% and specificity of 100% for distinguishing between serous cystic neoplasms (SCN) an...
A phase III clinical trial shows that nivolumab improves response rates in stage IV lung cancer patients with specific molecular characteristics. The study found a 75% response rate among patients with high tumor mutation burden and PDL-1 positive status.
A survey of 102 young cancer patients aged 13-24 found that digital resources could enhance their experience and engagement. The study's lead author believes digital support resources can address unmet needs and improve patient outcomes.
Researchers from Nationwide Children's Hospital used a combination of immunotherapies in a mouse model of rhabdomyosarcoma, finding that combining oncolytic virotherapy and PD-1 blockades was more effective than either approach alone. This new strategy marshals more T-cells to attack tumors without increasing regulatory T-cells.
Children as young as 8 years old can reliably assess experimental therapy effects on symptoms and quality of life. Self-reported patient outcomes could be a new endpoint in clinical trials, enabling clinicians to better manage side effects.
A new study suggests that the experimental drug GGTI-2418 can block a specific protein from degrading another protein that helps kill cancer cells. This discovery has important implications for treating cancers with defective PTEN, as it may allow for a combination of inhibitors to target multiple pathways involved in tumor growth.
Researchers at Queen Mary University of London have developed a highly accurate blood test that can identify patients with aggressive prostate cancer. The test detects rare cells in the blood, including megakaryocytes, which are strongly linked to patient survival, and 'EMTed' CTCs, associated with poor patient outcomes.
Researchers at Wayne State University and Barbara Ann Karmanos Cancer Institute aim to improve cancer immunotherapy by using PET imaging to detect dendritic cells in tumors. This non-invasive method may help predict treatment outcome and guide patient care.
A Phase III trial shows that peptide-receptor radionuclide therapy significantly improves patient wellbeing, particularly in advanced midgut neuroendocrine tumors. Lutathera treatment provided more relief for patients than high-dose octreotide, with improved quality-of-life metrics and fewer side effects.
Researchers at Huntsman Cancer Institute discovered a new science that could provide better therapeutic options for Philadelphia chromosome-positive ALL patients. The new drug inhibits DNA repair proteins, reducing leukemia load by 50-70% in mouse models.
In a clinical trial of 86 patients with colorectal and other cancers, scientists found that half respond to pembrolizumab due to mutations in their tumors. This could lead to a new standard-of-care including mismatch repair deficiency testing to identify patients who may benefit from immunotherapy.
A new clinical study found that genetic defects in mismatch repair (MMR) pathway tumors can indicate successful response to PD-1 blockade immunotherapy. The trial showed pembrolizumab controlled disease in 66 patients and caused complete tumor disappearance in 18, with no recurrence for an average of 8.3 months.
A new study found that chemotherapy can significantly impair walking gait and balance in breast cancer patients, leading to a higher risk of falls. Researchers advocate for integrating objective measures of physical function into oncology follow-up care to reduce fall risk and improve treatment compliance.
Research found that slow-growing breast cancers with favorable biologic factors have an excellent prognosis, often outliving patients. The study suggests that large, aggressive tumors are more likely to cause harm and should be prioritized for screening.
The NCI-MATCH precision medicine cancer treatment trial has reached its goal of sequencing the tumors of 6,000 patients two years ahead of schedule. This is due to wide-scale adoption throughout the NCTN and NCORP networks, resulting in an unprecedented rate of patient enrollment.
Cancer genomics researchers found a significant association between PONDS-forming sequences and cancer. They discovered that short inverted repeats are enriched at translocation breakpoints in human cancer genomes.
Researchers developed nanoparticles that combine two immunotherapy tactics to target and destroy tumor cells, slowing growth in mice with different cancers. The treatment showed promise in treating various tumor types without severe side effects.
Researchers found that capecitabine results in fewer side effects and improved quality of life, while being as effective as CMF in preventing breast cancer recurrence. Over 85% of patients did not experience their cancer returning for at least five years.
A study published in Journal of Clinical Oncology found that patients undergoing androgen deprivation therapy experience significant changes in physical function and skills of daily living. After treatment, most patients show improvement in overall geriatric health, with some even experiencing increases in daily function.