Articles tagged with Cancer Patients
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Four research teams will receive a grant of $250,000 over two years to support new research projects stemming from previous advances in cancer research. The award program aims to accelerate current research and development models to bring therapeutic benefits for cancer patients.
Children and adolescents have a higher risk of dying from second cancers compared to older adults. The study found that survival rates are significantly lower for second cancers in young patients, particularly those under age 40.
The American Society of Clinical Oncology will host its 53rd Annual Meeting, featuring more than 2,150 abstracts on various cancer topics. The meeting highlights recent breakthroughs in immunotherapy and precision medicine, with a focus on improving patient care and outcomes.
Researchers have developed a malaria protein-based drug that demonstrates promising results against chemotherapy-resistant bladder cancer. The new treatment showed a dramatic response to the malaria drug combo, resulting in an 80% survival rate among treated animals.
A new study by Yusheng Feng describes an algorithm that can predict the growth of cancerous tumors, helping medical professionals make informed decisions on treatment options. The algorithm takes into account various factors such as biological events and cell patterns to provide personalized predictions.
Analyzing four initial diagnostic protocols for asymptomatic microscopic hematuria, researchers found that combining renal ultrasound and cystoscopy was the most cost-effective approach. This method reduced incremental cancer detection costs by $53,810 per case.
Researchers are exploring immune cells that normally help the body but can hinder chemotherapy's effectiveness. By understanding how these cells interact, scientists hope to create targeted therapies to preserve chemotherapy's benefits while minimizing unwanted side effects.
The University of Kentucky has been awarded a $11.2 million grant to establish a new center for cancer and metabolism research. The Center for Cancer and Metabolism will focus on understanding the link between dysfunctional metabolism and cancer, with the goal of developing novel therapies.
A vaccine combining with high-dose chemotherapy improved glioblastoma patients' progression-free and overall survival. The vaccine targeted CMV antigen pp65, which is expressed in 90% of GBM tumors.
Researchers at MUSC found that Th17 cells can be expanded outside the body without losing effectiveness, providing a promising alternative to classic T cells used in adoptive immunotherapy. This breakthrough enables longer window periods for obtaining effective T cells via expansion outside the body.
A new study found that surgeons' recommendations against contralateral prophylactic mastectomy (CPM) did not increase the likelihood of patients seeking a second opinion or receiving surgery from a different surgeon. In fact, many patients were satisfied with their treatment despite no discussion about CPM. The study surveyed 1,140 pat...
Researchers found significant evidence that inhibiting protein TERT may aid in diagnosis and treatment of acral lentiginous melanoma (ALM). In laboratory experiments, over 75% of ALM cancer cells were affected by a drug that inhibits TERT.
A demo version of a new Pathology Atlas will be presented on April 2-5 at AACR17, offering information on human gene expression levels and their relationship with cancer patients' clinical outcomes. The atlas provides analysis on nearly 8,000 cancer patients across various major cancers.
A combination of a PARP inhibitor and a kinase inhibitor showed significant tumor shrinkage in 36% of patients with platinum-resistant ovarian cancer, a surprising improvement over solo PARP inhibitor treatment. The treatment was well-tolerated, with four patients discontinuing due to toxicity.
A study by the University of Pittsburgh Cancer Institute found that higher levels of tumor-associated immune cells and certain T cell types are associated with better response to immunotherapy. This could lead to more effective treatments for patients with recurrent head and neck cancer.
A new research project aims to integrate socio-economic data with cancer trial data, providing a broader perspective on treatment effectiveness. By combining this information, researchers can predict how socio-economic factors affect various treatments and shed light on the circumstances of cancer patients in clinical trials.
Researchers develop new technologies to precisely measure protein levels serving as tumor markers for personalized cancer treatment. This approach aims to predict tumor response to cancer therapeutics and match patients with the right drug.
A study found nearly half of young breast cancer patients in five states undergo preventive mastectomy to remove the unaffected breast. The proportion of women receiving this procedure increased significantly between 2004 and 2012, particularly among those under 45, with regional variations across states.
The ASCO and Cancer Care Ontario have updated their clinical practice guideline on brachytherapy for patients with prostate cancer. The new guidelines recommend different treatment options for patients with varying risk levels, including low-risk, intermediate-risk, and high-risk prostate cancer. For eligible patients, brachytherapy is...
Researchers at the University of Texas M. D. Anderson Cancer Center have identified arginine methyltransferase 1 (PRMT1) as a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC), a deadly form of pancreatic cancer with limited treatment options. PRMT1 plays a crucial role in tumor development and maintenance, and i...
The Georgia Cancer Center is part of a national effort to study cancer disparities across racial and ethnic groups. Researchers will collect data from 2,400 patients with early-onset cancers to better understand the underlying causes.
Scientists at Sylvester Comprehensive Cancer Center have found that p300 protein acts as a tumor suppressor, preventing myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML). Eliminating p300 in mice results in rapid leukemia development.
The article reviews current screening practice for melanoma in the US, highlighting risk groups and proposing full screening recommendations. The authors critically assess the USPSTF's 2016 Draft Recommendation Statement and propose evidence-based guidelines for screenings.
A study by UNC Lineberger Comprehensive Cancer Center found that women diagnosed with cancer during their childbearing years are at a higher risk of delivering preterm and having babies with low birth weight. The study identified potential risks for mothers who are cancer survivors, including a greater risk of cesarean section deliveries.
Researchers developed a computer program to diagnose cancer and locate tumors in blood samples, with an accuracy rate of 80% for early-stage cancers. The program uses molecular patterns in cancer DNA to identify the type and location of cancer.
A genome sequencing study for rare parathyroid carcinoma has identified mutations in known cancer-related genes and pathways, providing a clear view of genetic mechanisms involved. This in-depth characterization could lead to the first therapy options for patients with this deadly cancer.
Researchers at Washington State University developed a non-invasive filter-like device to isolate prostate cancer indicators from blood and urine, enabling doctors to track disease progression and treatment response. The technology uses biomarkers to capture tumor cells' genetic information, potentially predicting effective treatments.
Researchers at Ohio State University Wexner Medical Center correlated gene mutations with acute myeloid leukemia (AML) subgroups, identifying key mutational features and potentially important genetic differences among the subgroups. The study's findings may help guide mutation testing and treatment decisions in AML patients.
A new study found that adolescent and young adult cancer survivors often experience prolonged social difficulties, persisting even after treatment. Despite initial improvements in social functioning during the first year post-diagnosis, these patients tend to remain socially impaired relative to their cancer-free peers.
Researchers identified a series of proteins in blood plasma that signify cancer presence, offering a promising early detection method. The breakthrough discovery could enable regular blood tests to monitor treatment effectiveness and detect cancer recurrence.
Researchers have identified pre-metastatic niches that prepare the ground for tumor cells to survive before invading other organs. Understanding this phenomenon could lead to new diagnostic and therapeutic tools to prevent cancer-related death.
A new study led by researchers at Mount Sinai Hospital found that early referrals to palliative care reduced healthcare utilization and increased use of support services after discharge. The study also showed significant improvements in 30-day readmission rates, hospice referral, and chemotherapy receipt.
The American Society of Clinical Oncology has released a clinical practice guideline on human papillomavirus (HPV) vaccination for the prevention of cervical cancer. The guideline offers evidence-based recommendations for four levels of resource settings, providing guidance to health care providers worldwide.
The ABC Global Alliance, led by ESO, has launched a call-to-action to improve and extend the lives of patients with advanced breast cancer by 2025. The initiative outlines key gaps and actionable imperatives across patient care, societal support, and scientific investment for mBC.
African Americans and American Indians received less likely to receive potentially curative treatments for stage I non-small cell lung cancer (NSCLC), while Asian/Pacific Islanders had better survival rates. Patients who received definitive treatment had improved survival rates, regardless of race, age, or gender.
A clinical trial shows that combining chemotherapy drug temozolomide with radiation therapy extends survival by two months in older patients with glioblastoma. The treatment also improves survival for 45% of participants, linked to a molecular marker indicating active DNA repair mechanisms.
A new computational method allows researchers to quickly compute immune cell infiltration and calculate personal immune response profiles for thousands of patients. The study reveals complex interactions between different immune cell types in the tumor microenvironment play meaningful roles in patient survival.
Patients cured of Hodgkin lymphoma are at a significantly increased risk of developing a second type of cancer, particularly if they have a family history of the disease. The risk remains high even 30 years after treatment, and is higher in those with specific genetic markers or a history of certain cancers.
Researchers are exploring parallels between military counter-insurgency tactics and cancer treatment, focusing on targeted therapies that harness the patient's own resources. By adopting an intelligence-led approach, clinicians can adapt treatment strategies to tackle evolving tumour genetic codes.
A free lung cancer screening in the Augusta area found more than double the cancer rate of previous screenings, with 3% of participants diagnosed with lung cancer. The majority of cases were caught early, with a 90% overall survival rate for those detected before symptoms appeared.
Researchers have developed a novel DNA barcode technology to improve the sensitivity of genomic sequencing. SiMSen-Seq, a technique that reduces error rates to 1 in 10,000, enables earlier detection of cancer recurrence and potential relapses.
A nearly 11-year follow-up study published in the New England Journal of Medicine shows an estimated overall survival rate of 83.3% among 1,106 patients with chronic myeloid leukemia treated with Gleevec. The treatment has been proven effective against multiple forms of cancer, including pediatric CML and gastrointestinal stromal tumor.
A team of researchers has developed a new technique to identify cancer-causing substances in the urine or blood using an integrated centrifugal microfluidic platform. The device, called Exodisc, can isolate extracellular vesicles from urine within 30 minutes and detect biomarkers for bladder cancer.
Researchers from the University of Surrey found that cancer patients prioritize palliative and end-of-life care, while nurses focus on eHealth and technology to manage symptoms at home. Both parties agree on factors affecting early cancer symptom presentation and psychosocial support services.
A study published in the Journal of Clinical Oncology finds that childhood cancer deaths within a month of diagnosis are significantly higher than previously reported, affecting young children and minority groups disproportionately. The study used a large national database to find that early deaths from some pediatric cancer subtypes w...
Researchers found several gene variants near ABCB4 and ABCB1 genes that may predispose individuals to gallbladder cancer. These variants could lead to better understanding of the disease causes and potentially develop new treatments.
A pilot study published in the journal Cancer found that neurofeedback training reduced symptoms of chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors. The study used electroencephalogram (EEG) neurofeedback to retrain brain activity and resulted in measurable changes in targeted brain regions.
A study found that fewer than three out of five women with locally advanced cervical cancer received guideline-based care, with black and Hispanic women receiving lower rates. Despite an increase in guideline-based care over time, disparities persist, highlighting the need for further investigation into barriers to treatment.
A recent study published in JAMA Oncology found that exercise alone and psychological interventions significantly reduced cancer-related fatigue. The research analyzed 113 studies involving over 11,000 patients and concluded that exercise is the most effective approach to alleviate this debilitating side effect of cancer treatment.
A meta-analysis of 113 randomized clinical trials found that exercise, psychological interventions, and their combination were effective in reducing cancer fatigue. Pharmaceutical interventions did not show the same magnitude of improvement.
A study found that while melanoma survivors limit sun exposure, some still seek out tans and get sunburns. Survivors reported suboptimal behaviors, with 20% getting sunburned in the previous year.
Researchers at Medical University of South Carolina have identified a brain circuit that inhibits automated behavior and is involved in smoking cessation. Smokers who successfully quit had lower BOLD responses in this circuit before attempting to quit.
Researchers developed a new treatment combining chemotherapy and immunotherapy to slow liver tumor growth in mice, with tumors growing 11 times smaller than in control groups. The study suggests that this approach could be translated to benefit patients with hepatocellular cancer, potentially extending and improving their quality of life.
Researchers at UNC Lineberger Comprehensive Cancer Center have launched clinical trials testing genetically engineered immune cells to fight cancer. The early-stage trials aim to improve treatment options for patients with relapsed or refractory Hodgkin or non-Hodgkin lymphoma.
A study by St. Jude Children's Research Hospital found that a decline in radiation therapy for childhood cancer treatment led to a reduction in the development of second cancers among young survivors. The study, which included over 23,000 five-year survivors, suggests that efforts to reduce late effects of treatment are paying off.
The Detroit Research on Cancer Survivors (Detroit ROCS) study aims to better understand the major factors affecting cancer progression, recurrence, mortality and quality of life in African American cancer survivors. The five-year, $9 million study will include 5,560 cancer survivors to identify key risk factors and develop intervention...
The editorial warns of significant consequences for cancer care and research in a post-Brexit world. The authors highlight uncertainties regarding research funding, patient data handling, and regulatory frameworks, which could disadvantage UK cancer patients and research if not addressed.
Scientists have made an important breakthrough in identifying specific T cells that can fight cancer, using a new method to track the diverse members of a patient's immune system. The study found that these 'rare' cells are more effective in patients who undergo complete remission after T cell infusion.
Research shows that people who are less numerate experience worse health outcomes, including for cancer patients. To cope, patients can ask for numbers, understand what the numbers mean, consider absolute risk, and narrow down treatment options.
A new study found that cancer survivors are changing their prescription drug use due to financial constraints, with a significant proportion of non-elderly adults skipping medication or seeking cheaper options. This phenomenon has important policy implications and highlights the need for improved doctor-patient communication about the ...