Articles tagged with Cancer Patients
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A genetic biomarker, rs28714259, identifies women with breast cancer at increased risk for anthracycline-induced congestive heart failure. The marker is associated with low ventricular ejection fraction and may help oncologists provide more precise predictions of treatment risks.
A study found that cancer patients spend a significant portion of their household income on treatment, transport, and childcare. The economic burden is often referred to as the 'financial toxicity' of cancer.
A Malaysian study found that four in five cancer survivors suffer from anxiety and depression a year after diagnosis. The study also highlighted the importance of addressing quality of life for cancer patients beyond clinical outcomes.
A routine blood test can predict how long cancer patients in palliative care will survive, researchers report. The Six Adaptable Prognostic models use three laboratory measurements to estimate death within 1-6 months, allowing physicians to re-evaluate prognosis at any time point.
Researchers present first data on rare sarcomas in Asian patients, showing poor overall survival rates. Chemotherapy improves survival in advanced cases, but treatment rates remain low, with physician-related factors possibly at play.
Researchers have created a unique model of prostate cancer biology using patient tissue, allowing them to study the differences between normal and cancerous cells. The breakthrough uses conditional reprogramming, a laboratory technique that enables continuous growth of healthy and cancer cells indefinitely.
A statewide colorectal cancer screening study found that 16% of patients diagnosed under age 50 have an inherited genetic mutation increasing their cancer risk. The study identified a broad spectrum of mutations in early-onset colon cancer patients, including those linked to breast cancer risk.
A study found that patients with oropharyngeal cancer who recur have higher levels of antibodies for proteins E6 and E7, which can detect recurrence before it's diagnosed. This biomarker could provide an early window for treatment.
A new study comparing two genetic sequencing tests found that results can differ significantly in the same patients, with only 22% of detected alterations matching between platforms. The findings have significant clinical implications, highlighting the need for more detailed comparisons of test results across larger patient populations.
A University of Alberta study found that proton pump inhibitors (PPIs) decrease capecitabine's effectiveness in gastric cancer treatment, reducing progression-free survival by over a month and overall survival by two months. PPIs can also affect colorectal cancer treatment efficacy.
A study of 450 patients found 72 with 75 unique gene mutations, affecting 16 percent of younger-onset CRC cases, suggesting genetic counseling and multigene panel testing for early-onset patients
A new study found that socially isolated breast cancer survivors had a 40% higher risk of recurrence, a 60% higher risk of dying from breast cancer, and a 70% higher risk of dying from any cause. Women with larger social networks experienced better outcomes.
A new study published in The American Journal of Pathology found that over 90% of bladder cancers lack the enzyme argininosuccinate synthetase 1, making them susceptible to arginine-degrading therapy. This approach has shown promising results in treating bladder cancer with low ASS1 expression.
A study presented at EuroEcho-Imaging 2016 found that chemotherapy caused heart damage in cancer patients with diabetes, leading to a higher risk of heart failure. The researchers also discovered that patients with diabetes experienced a significant decrease in global longitudinal strain, an early predictor of heart failure.
Research reveals that 20-40% of multiple myeloma patients have a defective ribosome, leading to a poorer prognosis but better response to Bortezomib treatment. The discovery has the potential to improve therapy selection for these patients.
A new Penn study sheds light on racial disparities in cancer-causing genetic mutations, finding differences in mutation patterns between African American and Caucasian women. The research suggests biological differences and potentially different genetic factors may be at play, guiding targeted care for at-risk patients.
A large Canadian clinical trial found that a new treatment strategy for locally advanced squamous cell head and neck cancer did not show better results compared to the current standard of care. The study provided valuable data on quality of life and biospecimens from 320 patients, informing future research.
A lack of psychiatric healthcare providers in rural areas is leaving patients without access to necessary treatment options, exacerbating the impact of untreated mental illness. The OHSU Knight Cancer Institute is working to address this issue through innovative approaches to cancer care and mental health support.
A new study published in BMC Public Health found that people who are more body vigilant are more likely to seek medical help. Researchers from the University of Surrey discovered that nearly half of those diagnosed with cancer were at an advanced stage, highlighting the importance of early diagnosis.
French researchers report harmonization study on PD-L1 immunohistochemistry testing in NSCLC. Durvalumab shows clinical activity and well-tolerability in heavily-pretreated patients with NSCLC. Patients receiving pembrolizumab report better quality of life than those on chemotherapy.
Patients with longer delays were more likely to receive palliative treatment, while early diagnosis and treatment improve cancer outcomes. The study found that patients and primary care physicians contributed significant delays, highlighting the need for increased patient awareness about symptoms and screening.
Supportive care, including pain relief and medication to prevent side effects, remains insufficient for many cancer patients, especially those on government-funded schemes in India. This can lead to delayed treatment cycles and poor quality of life. Researchers emphasize the need for better policies and access to effective treatments.
Researchers discovered two genetic mutations in the CCND1 and CCND2 genes in a subset of acute myeloid leukemia patients. These mutations were found in 15% of patients with t(8;21) AML, making them a potential target for new therapies.
A personalized cancer vaccine significantly improved outcomes for patients with acute myeloid leukemia (AML) in a clinical trial, showing protection from relapse in most patients and minimal side effects. The vaccine stimulated powerful immune responses against AML cells, using the body's own defense systems to fight cancer.
A new blood test can detect Merkel cell carcinoma (MCC) earlier and more effectively than traditional imaging studies. The test uses an immune system marker to identify patients at high risk of recurrence, allowing for earlier treatment with immune therapy.
A study led by Dr. Steven A. Rosenberg identified a method to target the cancer-causing protein produced by a mutant form of the KRAS gene, leading to cancer regression in a patient with colorectal cancer. The treatment involved infusing tumor-infiltrating lymphocytes into the patient, which recognized and attacked the mutated cells.
Researchers from IASLC present significant findings on osimertinib reducing disease progression by 70% in patients with non-small cell lung cancer. Additionally, studies demonstrate improved progression-free survival and reduced side effects for icotinib-treated patients with brain metastases.
The phase 2 portion of the ZUMA-1 study using KTE-C19 CAR-T therapy achieved complete remission in all 6 patients with refractory primary mediastinal B-cell lymphoma or transformed follicular lymphoma, with manageable toxicities. The treatment was well-tolerated, with grade 3 adverse events occurring in 17% of patients.
A new study found that psychosocial risk factors, such as depression and anxiety, are associated with higher readmission rates and longer hospital stays among blood cancer patients. The study suggests that upfront assessment of patients' ability to cope and social support can improve recovery post treatment.
Researchers found that children with Down syndrome did not experience higher rates of relapse or treatment-related mortality compared to other children treated on the same protocols. However, they suffered more treatment-related mucositis and infections. The study suggests that supportive care can help mitigate these complications.
A study of over 290,000 adults found that even low-intensity smokers had a significantly higher risk of earlier death than never smokers. The risk was particularly strong for lung cancer mortality, with low-intensity smokers experiencing nearly 9 times the risk of dying from lung cancer.
A study from Dana-Farber Cancer Institute found that 30% of lymphoma patients with autologous transplants carry genetic mutations increasing their risk of developing second blood cancers and dying from other causes. The most commonly mutated gene was PPM1D, associated with an abnormal condition called CHIP.
A study by The University of Texas MD Anderson Cancer Center found pre-leukemic mutations can predict the development of therapy-related myeloid neoplasms (t-MNs), a leukemia with poor prognosis. Patients with these mutations are at higher risk, and detecting them earlier could help prevent or treat t-MNs.
The phase 3 ECOG-ACRIN E2905 Intergroup Study found that lenalidomide plus epoetin alpha resulted in improved major erythroid response rates and a similar toxicity profile compared to lenalidomide alone. This combination therapy showed significant benefits for patients with lower-risk, erythropoietin-refractory MDS.
Patients with a history of cancer who experience severe heart attacks have a three times higher risk of noncardiac death but not higher cardiac death rates. They also face increased risks of cardiogenic shock and need more intensive treatment.
A 69-year-old Vietnam war veteran was diagnosed with pleomorphic liposarcoma, a rare type of cancer, after exposure to Agent Orange during his service. The patient's cancer has a high rate of local recurrence and ability to spread to other parts of the body, making early detection crucial.
A team of researchers has established a molecular link between Fanconi anemia and the PTEN gene, strongly associated with uterine, prostate, and brain cancer. The discovery improves understanding of Fanconi anemia and could lead to improved treatment outcomes for some cancer patients.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that alcohol intake is associated with a higher risk of invasive melanoma, especially among individuals who consume more than 20 grams of alcohol per day. White wine was the most clearly associated with increased risk.
A phase I trial of LY3039478 showed the drug's ability to inhibit Notch signalling pathway in patients with various advanced cancers. The treatment resulted in tumour shrinkage and disease stabilisation, particularly in rare cancers like adenoid cystic carcinoma.
A four-week prehabilitation program has shown promising results in preparing cancer patients for surgery by improving their physical fitness and reducing recovery time. The study involved 116 colorectal cancer patients who underwent the program before undergoing surgery.
A clinical trial led by NYU Langone Health found that psilocybin significantly reduces mental anguish in distressed cancer patients for months. The study showed that one-time treatment with psilocybin quickly brought relief from distress that then lasted for over six months in 80% of the participants.
Researchers at MUSC found that inhibiting prostaglandin production with indomethacin increases immune cells and reduces tumor burden in premalignant lesions. This activation of the immune system reduces the progression of lesions to HNSCC.
Ground-breaking studies demonstrate early benefit of targeted treatments in advanced cancers, with dramatic responses seen in patients who have failed standard therapies. Liquid biopsies enable real-time monitoring of patient progress and treatment efficacy.
Cancer Research UK is investing £226 million in cancer research over five years, focusing on translational research and supporting clinical trials. The investment aims to bring better treatments faster to cancer patients, with a particular focus on hard-to-treat cancers.
Researchers at Courage Kenny Rehabilitation Institute present studies on improving walking speed in stroke patients and managing cancer-related cognitive dysfunction, also known as chemobrain. Occupational therapy was found to improve everyday functioning and manage issues like mood, stress, and fatigue in cancer survivors.
In a phase I clinical trial, combination therapy of CB-839 and everolimus resulted in tumor control in 93% of patients with clear cell and papillary renal cell cancer. The median time without cancer growth was 8.5 months, suggesting potential as a treatment option for advanced kidney cancer.
A new study reveals that cancer patients find emotional support in personal stories from peers on online forums, not television entertainment. The researchers found that women make more use of these resources than men, providing a safe space for comfort and community.
Researchers at the University of Kent have developed a new method to extend the life of silicone voice prostheses for throat cancer patients by treating a common fungal infection. By addressing Candida albicans, patients can now carry on using their voice prosthesis for longer, reducing the risk of secondary chest infections.
Researchers at Dartmouth's Norris Cotton Cancer Center have identified the functional role of two distinct DNA modifications, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5-hmC), in glioblastoma tissues. The study found that 5hmC signatures had a strong association with patient survival.
A study of Medicare beneficiaries with cancer found those without supplemental insurance faced the highest out-of-pocket costs. Hospitalizations were a primary reason for these costs, with some patients facing expenses exceeding 63% of their household income.
The grant will help TGen accelerate the computer processing of transcriptomes from thousands of cells using a complex computational algorithm. This process will advance precision medicine by quickly informing doctors with the best options for attacking each individual patient's cancer.
Integrating palliative care into bone marrow transplantation can improve patient quality of life, relieve symptoms, and reduce depression and anxiety. Caregivers also experience benefits, including reduced depression and improved coping skills.
Researchers identified a gene variant that raises risk of severe rheumatoid arthritis, potentially leading to targeted treatment. The study found that the variant correlates with increased MIF production and structural changes in cells, resembling cancerous tissues.
The largest genomic tumor profiling effort showed that large-scale clinical application of the methods is technically feasible, but faces significant challenges and unanswered questions. The study found that at least one actionable mutation was discovered in about two-thirds of patient samples, which could inform treatment decisions.
The University of California, Irvine has received a $1.2 million grant to develop more effective ways for prostate cancer patients and their physicians to customize treatment. The two-year clinical study will use patient-reported disease burden and tumor biomarkers to evaluate the effectiveness of treatment.
Researchers at the University of Hawaii Cancer Center identified a protein called RSK2 as a driver of tumor cell invasion in glioblastoma. Inhibiting RSK2 stops the invasion and enhances chemotherapy effectiveness, offering new hope for patients with this aggressive brain cancer.
Researchers at the University of Notre Dame have made a groundbreaking discovery that could pave the way for pancreatic cancer treatment. The study reveals that exosomes, tiny vesicles released by supporting cells, can educate cancer cells on how to survive chemotherapy, making the disease resistant to treatment.
Dr. Daniel Von Hoff has been recognized as a 'Giant of Cancer Care' for his pioneering work in gastrointestinal cancer and development of new treatments. He is being honored for his commitment to improving the lives of patients and families affected by cancer.
Researchers at Moffitt Cancer Center have developed a novel approach using mathematical modeling to accurately predict patient responses to cancer drugs in virtual clinical trials. This approach enables the identification of optimal treatment schedules that improve outcomes and reduce toxicities for melanoma patients.
A new 'sponge on a string' pill test has been shown to accurately identify people with Barrett's oesophagus who are at low risk of developing oesophageal cancer. This non-invasive test may replace uncomfortable endoscopies for some patients, allowing them to be monitored instead.