Articles tagged with Cancer Patients
Scientists at Sylvester Comprehensive Cancer Center have found that p300 protein acts as a tumor suppressor, preventing myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML). Eliminating p300 in mice results in rapid leukemia development.
The article reviews current screening practice for melanoma in the US, highlighting risk groups and proposing full screening recommendations. The authors critically assess the USPSTF's 2016 Draft Recommendation Statement and propose evidence-based guidelines for screenings.
A study by UNC Lineberger Comprehensive Cancer Center found that women diagnosed with cancer during their childbearing years are at a higher risk of delivering preterm and having babies with low birth weight. The study identified potential risks for mothers who are cancer survivors, including a greater risk of cesarean section deliveries.
Researchers developed a computer program to diagnose cancer and locate tumors in blood samples, with an accuracy rate of 80% for early-stage cancers. The program uses molecular patterns in cancer DNA to identify the type and location of cancer.
A genome sequencing study for rare parathyroid carcinoma has identified mutations in known cancer-related genes and pathways, providing a clear view of genetic mechanisms involved. This in-depth characterization could lead to the first therapy options for patients with this deadly cancer.
Researchers at Washington State University developed a non-invasive filter-like device to isolate prostate cancer indicators from blood and urine, enabling doctors to track disease progression and treatment response. The technology uses biomarkers to capture tumor cells' genetic information, potentially predicting effective treatments.
Researchers at Ohio State University Wexner Medical Center correlated gene mutations with acute myeloid leukemia (AML) subgroups, identifying key mutational features and potentially important genetic differences among the subgroups. The study's findings may help guide mutation testing and treatment decisions in AML patients.
A new study found that adolescent and young adult cancer survivors often experience prolonged social difficulties, persisting even after treatment. Despite initial improvements in social functioning during the first year post-diagnosis, these patients tend to remain socially impaired relative to their cancer-free peers.
Researchers identified a series of proteins in blood plasma that signify cancer presence, offering a promising early detection method. The breakthrough discovery could enable regular blood tests to monitor treatment effectiveness and detect cancer recurrence.
Researchers have identified pre-metastatic niches that prepare the ground for tumor cells to survive before invading other organs. Understanding this phenomenon could lead to new diagnostic and therapeutic tools to prevent cancer-related death.
A new study led by researchers at Mount Sinai Hospital found that early referrals to palliative care reduced healthcare utilization and increased use of support services after discharge. The study also showed significant improvements in 30-day readmission rates, hospice referral, and chemotherapy receipt.
The American Society of Clinical Oncology has released a clinical practice guideline on human papillomavirus (HPV) vaccination for the prevention of cervical cancer. The guideline offers evidence-based recommendations for four levels of resource settings, providing guidance to health care providers worldwide.
The ABC Global Alliance, led by ESO, has launched a call-to-action to improve and extend the lives of patients with advanced breast cancer by 2025. The initiative outlines key gaps and actionable imperatives across patient care, societal support, and scientific investment for mBC.
African Americans and American Indians received less likely to receive potentially curative treatments for stage I non-small cell lung cancer (NSCLC), while Asian/Pacific Islanders had better survival rates. Patients who received definitive treatment had improved survival rates, regardless of race, age, or gender.
A clinical trial shows that combining chemotherapy drug temozolomide with radiation therapy extends survival by two months in older patients with glioblastoma. The treatment also improves survival for 45% of participants, linked to a molecular marker indicating active DNA repair mechanisms.
A new computational method allows researchers to quickly compute immune cell infiltration and calculate personal immune response profiles for thousands of patients. The study reveals complex interactions between different immune cell types in the tumor microenvironment play meaningful roles in patient survival.
Patients cured of Hodgkin lymphoma are at a significantly increased risk of developing a second type of cancer, particularly if they have a family history of the disease. The risk remains high even 30 years after treatment, and is higher in those with specific genetic markers or a history of certain cancers.
Researchers are exploring parallels between military counter-insurgency tactics and cancer treatment, focusing on targeted therapies that harness the patient's own resources. By adopting an intelligence-led approach, clinicians can adapt treatment strategies to tackle evolving tumour genetic codes.
A free lung cancer screening in the Augusta area found more than double the cancer rate of previous screenings, with 3% of participants diagnosed with lung cancer. The majority of cases were caught early, with a 90% overall survival rate for those detected before symptoms appeared.
Researchers have developed a novel DNA barcode technology to improve the sensitivity of genomic sequencing. SiMSen-Seq, a technique that reduces error rates to 1 in 10,000, enables earlier detection of cancer recurrence and potential relapses.
A nearly 11-year follow-up study published in the New England Journal of Medicine shows an estimated overall survival rate of 83.3% among 1,106 patients with chronic myeloid leukemia treated with Gleevec. The treatment has been proven effective against multiple forms of cancer, including pediatric CML and gastrointestinal stromal tumor.
A team of researchers has developed a new technique to identify cancer-causing substances in the urine or blood using an integrated centrifugal microfluidic platform. The device, called Exodisc, can isolate extracellular vesicles from urine within 30 minutes and detect biomarkers for bladder cancer.
Researchers from the University of Surrey found that cancer patients prioritize palliative and end-of-life care, while nurses focus on eHealth and technology to manage symptoms at home. Both parties agree on factors affecting early cancer symptom presentation and psychosocial support services.
A study published in the Journal of Clinical Oncology finds that childhood cancer deaths within a month of diagnosis are significantly higher than previously reported, affecting young children and minority groups disproportionately. The study used a large national database to find that early deaths from some pediatric cancer subtypes w...
Researchers found several gene variants near ABCB4 and ABCB1 genes that may predispose individuals to gallbladder cancer. These variants could lead to better understanding of the disease causes and potentially develop new treatments.
A pilot study published in the journal Cancer found that neurofeedback training reduced symptoms of chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors. The study used electroencephalogram (EEG) neurofeedback to retrain brain activity and resulted in measurable changes in targeted brain regions.
A study found that fewer than three out of five women with locally advanced cervical cancer received guideline-based care, with black and Hispanic women receiving lower rates. Despite an increase in guideline-based care over time, disparities persist, highlighting the need for further investigation into barriers to treatment.
A recent study published in JAMA Oncology found that exercise alone and psychological interventions significantly reduced cancer-related fatigue. The research analyzed 113 studies involving over 11,000 patients and concluded that exercise is the most effective approach to alleviate this debilitating side effect of cancer treatment.
A meta-analysis of 113 randomized clinical trials found that exercise, psychological interventions, and their combination were effective in reducing cancer fatigue. Pharmaceutical interventions did not show the same magnitude of improvement.
A study found that while melanoma survivors limit sun exposure, some still seek out tans and get sunburns. Survivors reported suboptimal behaviors, with 20% getting sunburned in the previous year.
Researchers at Medical University of South Carolina have identified a brain circuit that inhibits automated behavior and is involved in smoking cessation. Smokers who successfully quit had lower BOLD responses in this circuit before attempting to quit.
Researchers developed a new treatment combining chemotherapy and immunotherapy to slow liver tumor growth in mice, with tumors growing 11 times smaller than in control groups. The study suggests that this approach could be translated to benefit patients with hepatocellular cancer, potentially extending and improving their quality of life.
Researchers at UNC Lineberger Comprehensive Cancer Center have launched clinical trials testing genetically engineered immune cells to fight cancer. The early-stage trials aim to improve treatment options for patients with relapsed or refractory Hodgkin or non-Hodgkin lymphoma.
A study by St. Jude Children's Research Hospital found that a decline in radiation therapy for childhood cancer treatment led to a reduction in the development of second cancers among young survivors. The study, which included over 23,000 five-year survivors, suggests that efforts to reduce late effects of treatment are paying off.
The Detroit Research on Cancer Survivors (Detroit ROCS) study aims to better understand the major factors affecting cancer progression, recurrence, mortality and quality of life in African American cancer survivors. The five-year, $9 million study will include 5,560 cancer survivors to identify key risk factors and develop intervention...
The editorial warns of significant consequences for cancer care and research in a post-Brexit world. The authors highlight uncertainties regarding research funding, patient data handling, and regulatory frameworks, which could disadvantage UK cancer patients and research if not addressed.
Scientists have made an important breakthrough in identifying specific T cells that can fight cancer, using a new method to track the diverse members of a patient's immune system. The study found that these 'rare' cells are more effective in patients who undergo complete remission after T cell infusion.
Research shows that people who are less numerate experience worse health outcomes, including for cancer patients. To cope, patients can ask for numbers, understand what the numbers mean, consider absolute risk, and narrow down treatment options.
A new study found that cancer survivors are changing their prescription drug use due to financial constraints, with a significant proportion of non-elderly adults skipping medication or seeking cheaper options. This phenomenon has important policy implications and highlights the need for improved doctor-patient communication about the ...
A new, multidisciplinary model of cervical cancer care developed by a University of Pennsylvania team in Botswana cut the delay between diagnosis and treatment by more than 50 percent. The model streamlined care and communication between providers, reducing delays in treatment and simplifying the overall process.
Early cancer diagnosis doesn't always result in longer life, as screenings come with built-in risks like false positives and missed diagnoses. Research suggests that frequent screening may not extend quality of life, but rather just delays the inevitable. The study's findings challenge the conventional notion that early detection is al...
A new study has found that walking can significantly improve the physical and emotional wellbeing of patients with advanced cancer. Researchers discovered that participants who walked for at least 30 minutes on alternate days reported improvements in their quality of life, including reduced weight and increased morale.
A study found that adolescents and young adults (AYAs) with acute leukemia had significantly worse survival rates if not treated at specialized cancer centers. AYAs treated at these centers had outcomes comparable to children, suggesting treatment quality can mitigate poor outcomes.
BioCanRx announces funding for 16 collaborative research projects on novel therapies to cure cancer, including CAR-T cell therapy development in Canada. The investment will enable Canadian researchers to develop expertise and capacity required to deliver this technology.
A new UTSA study has found a potential link between a medication used to prevent infections in cancer patients and the regeneration of sperm from stem cells. Researchers discovered that G-CSF, a drug commonly used to recover from chemotherapy and radiation treatments, can also help restore male fertility.
Scientists have identified a new mechanism by which the Epstein-Barr virus (EBV) causes cancer, involving a viral protein that leads to chromosomal instability. The discovery has significant implications for vaccine development and cancer prevention.
A blood test can detect bladder cancer patients' prognoses by analyzing circulating tumour cells in their blood. The presence of these cells is a predictor of cancer recurrence and death.
A breakthrough trial at the University of Minnesota found that a new UMN-developed drug, eBAT, significantly improved the six-month survival rate for dogs with hemangiosarcoma (HSA) to approximately 70%. The study's results suggest potential for translation into human clinical trials.
A new study from Karolinska Institutet shows that short-course preoperative radiotherapy combined with delayed surgery reduces the adverse side-effects of rectal cancer surgery. Patients with delayed surgery develop fewer complications while maintaining equally good oncological outcomes.
Scientists have identified a distinct cell population in tumours that inhibits the body's immune response to fight cancer. By targeting these cells, researchers hope to enhance the immune system's ability to attack cancer cells.
The APOLLO network partners with the Paulovich Laboratory to develop a panel of tests to measure key proteins in tumors, enabling targeted cancer treatments. The effort aims to improve precision-based medicine by combining genomic and proteomic approaches.
A University of Colorado Cancer Center study characterizes the uptick of myeloid-derived suppressor cells in human cancer patients' spleens, revealing their immunosuppressive function. Higher splenocyte counts were associated with increased risk of death and decreased overall survival.
Researchers found that cancer survivors value telehealth for its flexibility, convenience, and anonymity, allowing them to manage their care remotely. However, some prefer traditional methods of care, highlighting the need for personalized approaches.
A recent study found that normal-weight postmenopausal women who are metabolically unhealthy have a significantly increased risk for colorectal cancer compared to those who are metabolically healthy. This highlights the importance of assessing metabolic health status in women, which can be done using standard clinical tests.
A study from Queen Mary University of London discovered that thick skin on the palms and soles is linked to oesophageal cancer, a prevalent disease in the UK. Researchers found an inherited form of cancer called Tylosis, which causes severe skin thickening, also increases the risk of developing oesophageal cancer.
A blood test detecting hypermethylation in tumor DNA predicts shorter survival for women with high levels of cancer-linked DNA, indicating worsening disease. The test, cMethDNA, may help identify breast cancers at higher risk for recurrence and track treatment success.
A study found that inhibiting CCR4 in a mouse model of renal cell carcinoma reduced tumor proliferation and changed the composition of immune cells. The results suggest anti-CCR4 antibodies as a potential therapeutic for multiple cancers linked to abnormal CCR4 expression.
A breath test measuring five chemicals has shown promising results for detecting oesophagus and stomach cancers in a large patient trial. The test achieved an overall accuracy of 85%, outperforming the current method of endoscopy.
A large study found that breast conserving therapy (BCT) is superior to mastectomy in early-stage breast cancer patients with no metastases. BCT, combined with radiation therapy, offers a survival advantage for patients aged over 50 years and those with comorbidity.
A new immunotherapy, pembrolizumab, has shown significant activity against mucosal melanoma tumors and prolonged survival in patients with bladder cancer. The treatment demonstrated a response rate of 16% and improved overall survival rates compared to chemotherapy.