Articles tagged with Cancer Patients
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A new, multidisciplinary model of cervical cancer care developed by a University of Pennsylvania team in Botswana cut the delay between diagnosis and treatment by more than 50 percent. The model streamlined care and communication between providers, reducing delays in treatment and simplifying the overall process.
Early cancer diagnosis doesn't always result in longer life, as screenings come with built-in risks like false positives and missed diagnoses. Research suggests that frequent screening may not extend quality of life, but rather just delays the inevitable. The study's findings challenge the conventional notion that early detection is al...
A new study has found that walking can significantly improve the physical and emotional wellbeing of patients with advanced cancer. Researchers discovered that participants who walked for at least 30 minutes on alternate days reported improvements in their quality of life, including reduced weight and increased morale.
A study found that adolescents and young adults (AYAs) with acute leukemia had significantly worse survival rates if not treated at specialized cancer centers. AYAs treated at these centers had outcomes comparable to children, suggesting treatment quality can mitigate poor outcomes.
BioCanRx announces funding for 16 collaborative research projects on novel therapies to cure cancer, including CAR-T cell therapy development in Canada. The investment will enable Canadian researchers to develop expertise and capacity required to deliver this technology.
A new UTSA study has found a potential link between a medication used to prevent infections in cancer patients and the regeneration of sperm from stem cells. Researchers discovered that G-CSF, a drug commonly used to recover from chemotherapy and radiation treatments, can also help restore male fertility.
Scientists have identified a new mechanism by which the Epstein-Barr virus (EBV) causes cancer, involving a viral protein that leads to chromosomal instability. The discovery has significant implications for vaccine development and cancer prevention.
A blood test can detect bladder cancer patients' prognoses by analyzing circulating tumour cells in their blood. The presence of these cells is a predictor of cancer recurrence and death.
A breakthrough trial at the University of Minnesota found that a new UMN-developed drug, eBAT, significantly improved the six-month survival rate for dogs with hemangiosarcoma (HSA) to approximately 70%. The study's results suggest potential for translation into human clinical trials.
A new study from Karolinska Institutet shows that short-course preoperative radiotherapy combined with delayed surgery reduces the adverse side-effects of rectal cancer surgery. Patients with delayed surgery develop fewer complications while maintaining equally good oncological outcomes.
Scientists have identified a distinct cell population in tumours that inhibits the body's immune response to fight cancer. By targeting these cells, researchers hope to enhance the immune system's ability to attack cancer cells.
The APOLLO network partners with the Paulovich Laboratory to develop a panel of tests to measure key proteins in tumors, enabling targeted cancer treatments. The effort aims to improve precision-based medicine by combining genomic and proteomic approaches.
A University of Colorado Cancer Center study characterizes the uptick of myeloid-derived suppressor cells in human cancer patients' spleens, revealing their immunosuppressive function. Higher splenocyte counts were associated with increased risk of death and decreased overall survival.
Researchers found that cancer survivors value telehealth for its flexibility, convenience, and anonymity, allowing them to manage their care remotely. However, some prefer traditional methods of care, highlighting the need for personalized approaches.
A recent study found that normal-weight postmenopausal women who are metabolically unhealthy have a significantly increased risk for colorectal cancer compared to those who are metabolically healthy. This highlights the importance of assessing metabolic health status in women, which can be done using standard clinical tests.
A study from Queen Mary University of London discovered that thick skin on the palms and soles is linked to oesophageal cancer, a prevalent disease in the UK. Researchers found an inherited form of cancer called Tylosis, which causes severe skin thickening, also increases the risk of developing oesophageal cancer.
A blood test detecting hypermethylation in tumor DNA predicts shorter survival for women with high levels of cancer-linked DNA, indicating worsening disease. The test, cMethDNA, may help identify breast cancers at higher risk for recurrence and track treatment success.
A study found that inhibiting CCR4 in a mouse model of renal cell carcinoma reduced tumor proliferation and changed the composition of immune cells. The results suggest anti-CCR4 antibodies as a potential therapeutic for multiple cancers linked to abnormal CCR4 expression.
A breath test measuring five chemicals has shown promising results for detecting oesophagus and stomach cancers in a large patient trial. The test achieved an overall accuracy of 85%, outperforming the current method of endoscopy.
A large study found that breast conserving therapy (BCT) is superior to mastectomy in early-stage breast cancer patients with no metastases. BCT, combined with radiation therapy, offers a survival advantage for patients aged over 50 years and those with comorbidity.
A new immunotherapy, pembrolizumab, has shown significant activity against mucosal melanoma tumors and prolonged survival in patients with bladder cancer. The treatment demonstrated a response rate of 16% and improved overall survival rates compared to chemotherapy.
New cancer drugs have shown clinical benefit, but disparities in national health technology assessment outcomes hinder patient access. In the UK, prices for some common drugs increased by over 1000% between 2011 and 2016.
A Dartmouth study found that health insurance reduces cancer disparities, but does not eliminate them. Patients from disadvantaged communities showed a larger benefit from health insurance, highlighting the need for improved access to care.
Researchers found that metformin significantly increased tumor cell apoptosis and altered the cancer microenvironment in patients with head and neck cancer. The study suggests that metformin may make cancer more susceptible to standard therapies and has potential immunotherapeutic effects.
Premature death rates declined among Hispanics, blacks, and Asian/Pacific Islanders due to fewer deaths from cancer, heart disease, and HIV. In contrast, white and American Indian/Alaska Native populations experienced increased rates driven by accidents, drug overdoses, and suicide.
Younger patients with colon cancer are nearly 2 to 8 times more likely to receive postoperative chemotherapy than older patients, yet no added survival benefit is seen for these patients. The study's findings suggest overtreatment of young and middle-aged adults with colon cancer.
The European LeukemiaNet has released updated guidelines for the diagnosis and treatment of acute myeloid leukemia (AML) in adults, including revised genetic categories and a proposed response category based on minimal residual disease status. These recommendations aim to improve patient outcomes and harmonize clinical trials.
Patient navigators are a valuable resource for American Indians and Alaskan Natives with cancer, helping them overcome barriers to diagnosis and care. Researchers found that patients working with a navigator were almost four times more likely to have a definitive diagnosis within a year of an abnormal screening result.
Researchers at Huntsman Cancer Institute identified a protein called Macrophage Stimulating Protein (MSP) that causes bone destruction in metastatic breast cancer. A new drug, Ron inhibitor, blocks the activity of MSP, showing promising results in early clinical trials.
A study published in the Journal of the American College of Surgeons found that the New York State Medicaid expansion improved access to cancer surgery for the uninsured, but failed to reduce racial disparities. The proportion of minority patients undergoing cancer surgery remained unchanged relative to whites.
UTA's integrated cancer research program is strengthening with $6 million grants, bolstering basic research, precision medicine, and screening diagnostics. The University aims to make transformative advances in key areas related to cancer while providing top-notch educational experiences for students.
Researchers found that breast cancer tumors evolve to produce their own estrogen supply, making treatments like aromatase inhibitors ineffective. The study, published in Nature Genetics, aims to increase treatment options for patients whose cancer has returned and spread.
The European Society for Medical Oncology advocates for strict adherence to approval standards and accelerated introduction of biosimilars into clinical settings. This move aims to enhance the sustainability and affordability of cancer treatment, with potential benefits including reduced costs and increased accessibility.
According to a study published in Journal of Thoracic Oncology, advanced stage Non-Small Cell Lung Cancer (NSCLC) patients receiving standard of care treatment have significantly longer overall survival rates compared to those not receiving treatment. This trend is observed across various stages of the disease.
A new classification system for glioblastoma, a lethal brain cancer, has been developed by incorporating molecular variables. The refined model significantly improves the prognosis of patients treated with radiation and temozolomide, offering better clinical decision-making options.
A combination of steroids and sirolimus with immune checkpoint inhibitors may help prevent organ rejection in kidney transplant patients undergoing cancer treatment. This discovery shows promise for people with cancer who have also had a kidney transplant, potentially allowing them to receive full benefits from immunotherapy.
A new drug combination that adds chloroquine to targeted treatment has stabilized a 26-year-old brain cancer patient's disease, increasing both quality and quantity of life. The treatment was effective in two other brain cancer patients with similar diseases.
Chronic kidney disease patients spent a median $1,439 in annual out-of-pocket costs, compared to $770 for cancer patients and $748 for stroke patients. The study found that these high costs are due to the need for multiple medications and frequent doctor visits.
In mouse models, NRP2a inhibited tumor cell proliferation while NRP2b promoted metastasis and progression. Cancer stem cells were also reduced in NRP2b knockdown models, providing new insights into lung cancer progression. The study suggests that targeting NRP2b may lead to improved therapies for non-small cell lung cancer.
Researchers at Massachusetts General Hospital have found that tumor necrosis factor receptor type II (TNFR2) may be a major target for immuno-oncology treatments. The team's findings suggest that blocking TNFR2 could restore the ability of a patient's immune system to attack tumors, while also directly killing cancer cells.
A new study suggests that increasing KLL-specific T cells infiltrating the tumor improves patient survival in Merkel cell carcinoma. The research team found that about 20% of patients have T cells specific for this target, which is associated with better outcomes.
Research in mice suggests that melanomas and other cancers driven by BRAF V600E mutation will grow faster in response to a high-fat diet. Lipid-lowering agents such as statins can slow tumor growth, even on normal diets. The findings highlight the potential of precision diets tailored to individual patients' cancer mutations.
Scientists developed a biosensor that can detect cancer proteins in serum samples, allowing for early detection of tumors. The method is faster and more accurate than traditional methods, with a 440-fold higher sensitivity.
A University of North Carolina researcher argues that integrating patient-reported symptoms into clinical practice can improve patient outcomes. Despite demonstrated benefits, cost and technology barriers prevent the widespread adoption of electronic symptom reporting.
Researchers have discovered that Dab2 controls a population of fat stem cells that slowly disappears with maturity. This finding may reinforce the importance of steering children away from high-fat diets and lead to new pharmaceutical strategies to combat childhood obesity.
A landmark study reveals that men with a family history of prostate cancer and the BRCA2 gene fault have a more aggressive form of prostate cancer. The study shows that these cancers are genetically similar to advanced cancers, explaining why BRCA2 patients have poor outcomes.
A Mayo Clinic study finds that vaginal microbes are distinct in women with endometrial cancer compared to those without the disease. Researchers hope to use vaginal swabs as an early screening tool and investigate the role of the microbiome in preventing endometrial cancer.
A recent study published in JAMA Oncology suggests that chemotherapy can still benefit patients with non-small-cell lung cancer who recover slowly from surgery. The study found that delaying chemotherapy by up to four months did not increase the risk of death and may even lower it compared to earlier treatment.
A study by Yale researchers found that older lung cancer patients can spend an average of one in three days interacting with the healthcare system within the first 60 days after surgery or radiation therapy. Patients with a higher number of medical conditions treated with surgery had the most post-treatment burdens.
Researchers have identified a gene mutation driving the formation of metaplastic breast cancer, a subtype of triple negative breast cancer. A therapeutic compound has been validated to slow tumor growth and increase chemotherapy efficacy.
A study published in Journal of Clinical Oncology found that new therapies for non-small cell lung cancer resulted in a median 1.5-month survival increase, but this gain was largely offset by higher outpatient spending due to the expensive medications.
A new HER2-targeted dendritic cell vaccine has shown promising results in a clinical trial, stimulating an immune response in 80% of patients and inducing regression of early-stage breast tumors. The vaccine was well-tolerated and effective in both invasive and non-invasive disease settings.
A new oral drug, selumetinib, has shown significant tumor shrinkage in children with neurofibromatosis type 1 (NF1) and plexiform neurofibromas. Most patients experienced partial responses, with tumor growth stopping in over 70% of cases.
A recent study has identified more than 2,000 genetic mutations in tissue samples of esophageal tumors, revealing the complexity of cancer cells within individual tumors. The findings demonstrate that different areas of a tumor have unique genetic patterns, making it difficult to target a specific genetic defect.
A major clinical trial has found that adding bortezomib to a standard two-drug regimen significantly prolongs the time before multiple myeloma cancer returns, giving patients about another year of remission. The study also shows that patients who receive this combination therapy live an average of six years after initial treatment.
Researchers developed iCAGES, a computational tool that integrates whole genome-based approach to identify individual cancer driver genes and select treatment options. The tool was found to be superior in predicting cancer drivers and identifying beneficial treatments compared to other computational tools.
Researchers developed a dual strategy combining biomimetic beads and anti-PD1 therapy to boost killer T cell immunity against skin cancer. The combination technique increased T cell activation by 35% compared to artificial beads alone and 72% compared to anti-PD1 alone.
Scientists have discovered a potential biomarker, GHRH-R, for gastric cancer, which can aid in earlier diagnoses and better staging. The team also found that the GHRH-R antagonist MIA-602 inhibited gastric cancer growth in cell lines and human xenografts.
Regular NSAID use associated with a 66% increased risk of dying from endometrial cancer, particularly among those who had used NSAIDs for over 10 years. However, the association did not apply to more aggressive Type 2 cancers.
Researchers found a strong correlation between circulating tumor DNA (ctDNA) and poor outcomes in pancreatic cancer patients. ctDNA levels were associated with disease stage, grade of differentiation, and overall survival. The study suggests that detecting ctDNA could help subclassify cancers and manage treatment.