Articles tagged with Cancer Patients
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A study analyzing SWOG clinical trials found that cancer patients in the US have gained a cumulative 3.34 million years of life due to successful therapies. The analysis calculated that an NCI investment of $125 for each year of life saved was sufficient, making it a cost-effective approach.
A study analyzing SWOG treatment trials from 1965 to 2012 found positive trials resulted in substantial gains in patient survival, with estimates suggesting over 3.34 million life-years were saved through these trials.
A new study by Cleveland Clinic researchers found that delays in initiating cancer therapy are associated with a substantially increased risk of death. Patients who wait more than six weeks for treatment have significantly worse survival rates, with some cancers experiencing declines of up to 40% in five-year survival rates.
Early research suggests that immunotherapy may provide new hope to patients with relapsed mesothelioma. A phase II clinical trial found that the combination of nivolumab and ipilimumab slowed cancer growth by 44% and tumor shrinkage in 26% of patients.
A recent study found that cancer patients who reported their symptoms using a web-based survey lived five months longer than those who did not. The study, led by UNC Lineberger Comprehensive Cancer Center researcher Ethan Basch, showed a significant median overall survival benefit of 20 percent.
A study published in JAMA found that integrating electronic patient-reported outcomes into routine care led to a significant increase in survival among patients with metastatic cancer. The trial showed a median survival difference of 5 months between the electronic patient-reported symptom monitoring group and usual care.
A French study of 1,944 patients with advanced cancer found that comprehensive genomic profiling can guide treatment choices and lead to higher survival rates. The study's results suggest that routine genomic testing may not benefit all patients but offers hope for personalized medicine.
Olaparib has been shown to improve progression-free survival compared to chemotherapy in patients with BRCA-related advanced breast cancer. The phase III OlympiAD trial demonstrates the efficacy of olaparib as a treatment option for this patient population.
A web-based tool enables patients to report symptoms in real time, triggering alerts to clinicians, resulting in a median survival of 5 months longer. Patients experience improved quality of life and are able to tolerate chemotherapy longer.
A new cancer medicine, larotrectinib, has demonstrated compelling evidence for treating a range of advanced cancers. The therapy, which targets TRK fusion proteins, resulted in responses in 76% of patients across 17 different types of cancer. After 12 months of treatment, 79% of responding patients remained progression-free.
A randomized clinical trial of 305 patients with advanced cancer found that a brief psychological intervention called Managing Cancer And Living Meaningfully (CALM) significantly reduced depressive symptoms. CALM also improved psychological well-being and preparedness for the end of life, with greater benefits at six months.
A phase III clinical trial shows that a single radiation treatment is as effective as a full week of radiation in relieving spinal cord compression symptoms. This breakthrough finding could help patients with advanced cancer spend more time focusing on the things they enjoy, without compromising care.
A web-based stress management program improved quality of life and reduced distress in patients with cancer, according to a prospective study. The STREAM intervention showed significant clinical improvements after two months, with a greater improvement in quality of life compared to the control group.
A new analysis found that nearly three-quarters of patients with advanced cancer could be referred to a targeted treatment based on their tumor's genetic landscape. Genetic sequencing identified anomalies in 11% of patients, including hereditary variations that increase cancer risk.
The AACR Project GENIE initiative has published its first analysis of nearly 19,000 de-identified genomic records, showing that over 30% of samples had clinically actionable mutations. The data can be used to facilitate clinical research and improve patient care.
Researchers from Fred Hutch Cancer Center are showcasing promising new treatments for various types of cancer, including pancreatic cancer, Merkel cell carcinoma, and early-stage breast cancer. The findings suggest that experimental drugs, triple immunotherapy, and novel sarcoma vaccines may provide extended progression-free survival p...
Researchers at Queen's University Belfast have made a significant advance in treating bowel cancer by defining precise gene signatures within cells. This allows for the development of novel prognostic and predictive markers, enabling personalized medicine approaches.
A study by Penn State researchers suggests a possible link between the partial meltdown at Three Mile Island Nuclear Power Plant and thyroid cancer cases in nearby areas. The study found an increase in genetic mutations caused by low-dose radiation exposure in patients who developed thyroid cancer after living in at-risk regions.
Researchers at Moffitt Cancer Center have developed a test called the radiosensitivity index to determine how sensitive a patient's tumor is to radiation therapy. This allows them to select the optimum radiotherapy dose for each patient based on their individual tumor biology.
Researchers at German Cancer Research Center (DKFZ) found a substance that blocks cancer-promoting metabolic products in leukemia and brain tumors. The investigational compound BAY1436032 is effective against AML and glioblastomas, reducing stem-cell properties and tumor cell growth.
A new study at Penn Medicine identified several barriers to discussing cost transparency in cancer care, including patient fear of being 'profiled' based on socioeconomic status. Strong doctor-patient relationships, availability of financial expertise, and scalability are potential facilitators for improving cost transparency discussions.
A small clinical trial found that three out of four patients treated with a combination of T-cell therapy, avelumab, and either radiation or interferon achieved complete remission. The treatment approach may offer new hope for patients with Merkel cell carcinoma, a rare skin cancer with limited treatment options.
A study from Fred Hutchinson Cancer Center found that up to 53% of cancer patients' non-admission ED visits could be prevented with timely care in an outpatient setting. The most common reason for ED visits was pain, costing a median $1,127 per visit.
A new test based on a patient's epigenetics may accurately identify those at highest risk of anal cancer, minimizing painful procedures and over-treatment. This test has the potential to reduce costs, pain, and anxiety associated with diagnosis, particularly in high-risk groups such as men who have sex with men and people with HIV.
The Affordable Care Act has improved access to and affordability of cancer-related care, but critical gaps remain. The ACA has expanded insurance coverage, led to earlier diagnoses, and ensured access to cancer treatments.
Researchers at the Universities of Birmingham and Newcastle studied DNA of two types of acute myeloid leukemia to explain clinical prognosis differences. They discovered how oncogenes reprogram blood stem cells, leading to variable treatment responses.
A study analyzing 3,640,229 patients in the SEER database found that lung cancer diagnoses are associated with a nearly 420% higher suicide rate compared to the general population. The highest suicide risk was observed in lung cancer patients, particularly older individuals, widowed patients, and those with metastatic disease.
A large-scale study found that raised blood platelet counts are a strong predictor of cancer, with lung and colorectal cancers being more commonly diagnosed. The research suggests that substantial numbers of people could have their cancer diagnosed up to three months earlier if thrombocytosis prompted investigation.
Research shows that blood cancer patients are less likely to enroll in hospice care compared to solid cancer patients. However, a survey of hematologic oncologists found that 68% agree that hospice care is helpful for blood cancer patients, and most would refer patients if red blood cell transfusions were available.
According to a new report, rare cancers account for over one-fifth of all cancer diagnoses in the United States, with notable disparities in incidence rates among different ethnic groups. Rare cancers often present unique challenges, including limited research, delayed diagnosis, and limited treatment options.
A multi-institutional research team analyzed nearly 11,000 human cancers to identify molecular changes involved in cancer development. They confirmed previously known pathways and discovered new ones, such as IDH1 and VHL, which may be linked to targeted therapy.
A new study estimates that more than 150,000 US women are currently living with distant metastatic breast cancer, a form of the disease that has spread to distant sites in the body. Despite poor prognosis, survival rates for women diagnosed with MBC at younger ages have been increasing significantly.
Patients with stage III colon cancer who reported a healthy lifestyle had a 42% lower chance of death and a trend for lower cancer recurrence risk than those with less healthy lifestyles. A healthy diet, regular physical activity, and maintaining a healthy body weight were all important factors.
Patients with stage III colon cancer who consumed two ounces or more of tree nuts per week had a 42% lower chance of cancer recurrence and 57% lower chance of death than those who did not eat nuts. This benefit was consistent across known factors that can influence cancer recurrence.
The Emperor Science Award program recognizes 100 high school students who will conduct research in a lab or virtually on a multi-week cancer project, receiving a computer and $1,500 stipend. The program aims to inspire students to pursue careers in cancer research.
A new study found that younger colorectal cancer patients have a higher tumor mutation load, with significant differences in gene mutations related to DNA repair, and may benefit from immunotherapies
A phase III trial of 447 patients with biliary tract cancers showed that giving capecitabine after surgery extended survival by a median of 15 months compared to surgery alone. The treatment was associated with a 20% lower chance of death, but the difference was not statistically significant for the overall population.
A recent trial funded by Cancer Research UK found that patients who take capecitabine after surgery for bile duct cancer live for almost a year and a half longer than those not given the drug. Three-year survival improved by almost a quarter in these patients.
Researchers found tumor mutation load correlates with age and cancer type, potentially increasing immunotherapy effectiveness. High TML is seen in melanoma, non-small cell lung cancer, and tumors lacking specific genes.
Researchers have 'carbon dated' a patient's cancer for the first time, showing it can spread rapidly within a year of initial appearance. The study provides insights into genetic instability and its impact on cancer progression.
Researchers identified 22 genes-of-interest with mutation frequencies across the largest group of CCEC patients. They also uncovered mutations in the TAF1 gene and found similarities to serous endometrial cancer or endometrioid endometrial cancer in a substantial number of CCECs.
Researchers at MUSC found that using FDA-approved small molecules can improve the potency and function of T cells in adoptive T cell therapy, making them more effective against melanoma. The treatment reduces regulatory T cells in the tumor microenvironment and enhances antitumor activity.
Dr. Daniel Von Hoff, a world-renowned expert in cancer therapies, is honored by Columbia University with a gold medal for his outstanding accomplishments in clinical medicine. This recognition marks the 250th anniversary of P&S, one of the nation's most accomplished medical schools.
Research by the German Cancer Research Center found that vitamin A deficiency can lead to a loss of dormant stem cells in the bone marrow, impairing the immune system. The study suggests that understanding how vitamin A regulates these stem cells could lead to new cancer treatments.
Researchers found that platelets release TGF-beta to suppress T cells and promote immune tolerance to certain cancers. Adding antiplatelet drugs like aspirin may improve adoptive T cell therapy against melanoma and other cancers.
High tumor PD-L1 expression after radiation therapy is associated with increased risk of head and neck cancer recurrence in HPV-negative patients. Researchers identified PD-L1 as a biomarker of poor outcomes, suggesting that combining radiation and a PD-1/PD-L1 inhibitor could improve survival rates.
A study published in The Lancet Gastroenterology & Hepatology found that patients with rectal cancer who undergo chemotherapy and radiation have excellent survival rates and low rates of cancer recurrence. These 'complete responders' may not benefit from surgery, raising questions about the safety of a watch-and-wait approach.
Around half of women with locally advanced cervical cancer experience symptoms like fatigue, insomnia, and hot flushes after treatment. Younger women are more likely to be affected. Research highlights the need for better recognition and treatment of these under-recognised symptoms.
A new analysis reveals heart failure patients experience worse survival rates than prostate cancer and breast cancer survivors, but better outcomes compared to lung cancer and ovarian cancer. The study highlights the continued burden of heart failure as a major public health concern.
A new study conducted at The Ohio State University Comprehensive Cancer Center found that more than half of breast cancer patients undergoing mastectomy lack necessary medical knowledge for high-quality decision-making about reconstructive surgery. Researchers emphasize the need for shared decision-making tools and patient-doctor commu...
Researchers at Florida State University have developed a statistical model that ranks chemotherapy treatment options for patients based on the gene expression profile of their tumor. The model takes into account both effectiveness and potential side effects, predicting a higher complete response rate for some subtypes of breast cancer.
A study conducted by Ohio State University researchers found that over half of breast cancer patients undergoing mastectomy lack necessary medical knowledge to make informed decisions about reconstructive surgery. Only 43% of patients demonstrated adequate understanding of reconstruction facts and made choices aligned with their prefer...
A study found that a decrease in circulating tumor cells with increased ALK gene copies is associated with longer progression-free survival in patients with non-small cell lung cancer treated with crizotinib. This biomarker may help predict treatment response and tailor therapies for individual patients.
A large study of African-American women found that those who drank seven or more drinks per week were 33% more likely to develop breast cancer than moderate drinkers. The study suggests that black women may benefit from limiting alcohol to reduce their risk, similar to white women.
The WorldQuant Initiative combines advanced molecular profiling technologies with quantitative methods to analyze genomic data, enabling the prediction of disease risk and outcomes. Researchers will leverage predictive tools to improve diagnosis and treatment for various illnesses.
A newly-created prognostic tool reliably predicts the recurrence of parathyroid cancer, allowing physicians to identify patients at highest risk. The tool is based on three key indicators: serum calcium level, age over 65, and tumor invasion into blood vessels.
Researchers found that most patients with intermediate-risk adenomas benefit from follow-up colonoscopies, reducing the risk of bowel cancer. However, a subgroup of patients may not require additional surveillance, potentially leading to cost savings for healthcare services.
Researchers will test drug Selumetinib on patients after endoscopic removal of stage I gastric cancer. The goal is to reverse pre-cancerous metaplasia and prevent cancer recurrence.
A study found that only 18 out of 47 cancer indications approved by the NHS Cancer Drugs Fund showed statistically significant benefits, with a median overall survival benefit of 3.2 months. The majority of drugs failed to show meaningful clinical benefits when considering quality of life and toxic side effects.
A new study published in Oncoimmunology suggests that kidney dysfunction in cancer patients can be triggered by the immune system's response to the tumor. Researchers identified neutrophils as a key player in this process, which can lead to impaired blood flow and inflammation in organs like the kidneys.