Articles tagged with Gastroenterology
A study found that ERCP quality outcomes, including complication rates, compare favorably with those of academic centers in a community hospital setting. Technical success rates met or exceeded recommended levels, indicating competence among gastroenterologists performing ERCP.
A study published in Gastroenterology found that men with chronic hepatitis C undergoing antiviral therapy experience common sexual dysfunction, including impairment of desire, function, and satisfaction. The average onset of sexual dysfunction was within four weeks of starting therapy.
Researchers found that acid refluxing at night results in sleep arousal 89 percent of the time in participants with and without GERD. GERD patients experience longer acid reflux events, leading to increased risk for complicated disease and esophageal cancer. This association suggests a bi-directional link between sleep problems and GERD.
Researchers have discovered a potential therapeutic agent for treating hepatic fibrosis, a scarring condition that impairs liver function and can lead to organ failure. The CCN2 hammerhead ribozyme shows promise in reducing collagen production and cell proliferation, offering new hope for millions affected by liver fibrosis.
A study reinterpretated proximal colon polyps as hyperplastic in 2001 revealed a significant inter-observer variation among gastrointestinal pathologists. This discrepancy highlights the need for clarification on the pathologic interpretation of serrated colorectal polyps and their clinical significance.
Researchers found that acute transient hepatocellular injury occurs in patients with cholelithiasis and cholecystitis without evidence of CBD stones, resolving within weeks after surgery. Markers of liver damage are more severe in those with CBD stones or histologically less severe inflammation.
A rare case of duodenal obstruction after successful embolization for duodenal diverticular hemorrhage was reported. The study highlights the importance of thorough observation of resolving hematomas and conservative treatment before surgery to relieve duodenal fibrotic encasement.
The Eli and Edythe Broad Foundation has renewed its three-year grant to support high school students in gastroenterology research careers through the AGA Foundation's Student Research Fellowship Awards program. The program provides funding for students to conduct research under the supervision of an approved preceptor.
A randomized controlled trial found that low-dose imipramine improved global symptoms and quality of life in patients with IBS who had failed conventional therapy. The study, published in the World Journal of Gastroenterology, is the largest ever conducted on the use of tricyclic antidepressants (TCAs) in IBS patients.
Researchers found that perianal disease, current smoking, prior steroid use and early azathioprine or biological therapy are predictors of disease behavior change in CD patients. These findings may aid clinicians in choosing the treatment strategy for their patients.
Patients with primary sclerosing cholangitis (PSC) have significantly larger fasting and postprandial gallbladder volumes compared to healthy controls. However, there is no correlation between gallbladder size or emptying and the occurrence of abdominal pain in PSC patients.
Researchers investigated chronic acid-reflux esophagitis in a rat model, discovering epithelial thickening and inflammatory cell infiltration in the middle to lower esophagus. Ecabet sodium inhibited these changes, suggesting its potential role in preventing reflux esophagitis.
Research in cirrhosis patients reveals low bone formation and increased resorption leading to fragile bones. The study highlights the importance of correcting factors such as inadequate sunlight exposure, reduced physical activity, and vitamin D deficiency to improve bone health.
A study found that patients satisfied with their GERD treatment had better health-related quality of life and were more likely to be taken seriously by their physicians. The quality of patient-physician communication was also a key factor in patient satisfaction.
A study by the American Gastroenterological Association found that metformin reduces pancreatic cancer risk in diabetics by 60%. In contrast, insulin and other therapies may increase risk. The study's results suggest metformin could be a tool for primary prevention of pancreatic cancer.
Researchers successfully treated hydatid cysts with RTA, achieving a 100% success rate in necrosis of the endocyst and minimal host tissue damage. The technique also avoided post-RTA fistula occurrence and chemical cholangitis or pneumonia.
A study published in the World Journal of Gastroenterology found that fecal incontinence significantly impacts patients' quality of life, affecting lifestyle, coping behavior, depression, and embarrassment. The results show that over 22% of patients experience severe QOL effects due to FI.
A large abdominal wall lipoma caused bowel obstruction in a patient with Proteus syndrome. Excision of the lipoma improved bowel passage and reduced symptoms. The treatment was successful, allowing the patient to continue medical treatment on an outpatient basis.
Researchers found thermal hyperalgesia in IBS patients compared to controls, with higher sensitivity in those with high FBDSI scores. Controls were less sensitive than C-IBS and D-IBS, with no differences between the two IBS subtypes for pain threshold and tolerance.
Researchers found that adding simethicone to sodium phosphate bowel preparation improved visualization during colonoscopy by reducing air bubbles. However, simethicone did not demonstrate a significant impact on the adequacy of colon preparation.
The study found that molecular adsorbent recirculating system (MARS) treatment is effective in patients with acute liver failure. The etiology of liver failure and the grade of encephalopathy before MARS treatment were significant prognostic factors, while coagulation factor 5 levels were also predictive for unknown etiologies.
Research on Pluronic L-81, a synthetic copolymer, reveals its potential in alleviating obesity-induced insulin resistance and type 2 diabetes. The study found that L-81 significantly corrected body weight and plasma glucose levels in genetically diabetic mice.
A surgical procedure, palliative cardia resection with gastroesophageal reconstruction, was performed on a 82-year-old man with iatrogenic perforation of adenocarcinoma of the GE junction. The patient recovered quickly and showed no complaints after treatment.
A new study found that healthy volunteers who took proton pump inhibitors for eight weeks developed acid-related symptoms like heartburn and dyspepsia when the medication was stopped. The study suggests that long-term use of PPIs may lead to dependency due to rebound acid hypersecretion.
A Mayo Clinic study found celiac disease has become four times more common, with undiagnosed cases associated with a nearly quadrupled mortality risk. The study suggests increased awareness is needed among physicians and patients to diagnose the condition earlier.
A study comparing reflux esophagitis in African-Americans and non-Hispanic whites found similar frequencies of complications, except for Barrett's esophagus. Non-Hispanic whites had higher rates of endoscopic and histological Barrett's esophagus and heartburn-induced endoscopy.
A study of 115 young women with iron deficiency anemia found that serological screening for H. pylori and celiac disease increased gastroscopy compliance rates. The tests were confirmed by gastroscopy, which identified IDA-related GI causes in most cases.
A case of Meckel's diverticulum masked by intermittent recurrent subocclusive episodes is presented, highlighting the difficulty in diagnosing this condition due to overlapping symptoms. Laparoscopy proved to be a crucial diagnostic tool in establishing the final diagnosis and also therapeutic in nature.
The presence of multiple portal vein invasion (PVI) is a significantly poor prognostic factor for hepatocellular carcinoma. Anatomical resection is recommended for patients with HCC and PVI-M, while non-anatomical resection may lead to poorer disease-free survival.
A study published in the World Journal of Gastroenterology found that current alcohol drinking and a high body mass index (BMI) ≥ 24.0 kg/m2 are independent risk factors for colon and rectal cancer. Former alcohol consumption and a positive family history of cancer are also linked to an increased risk of colon cancer.
A case of cecal volvulus was reported in a 78-year-old woman with severe abdominal pain and fever. The patient underwent an emergent laparotomy and recovered after intensive care. A review of Japanese literature revealed an increase in aged patients with mental disabilities presenting with cecal volvulus, adoption of ileo-colectomy as ...
A study published in the World Journal of Gastroenterology found that type 2 diabetes mellitus is an independent risk factor for hepatocellular carcinoma. The research revealed a direct association between HCC and insulin/sulphanylureas treatment, as well as an inverse relationship with metformin therapy.
The study found that Ang-(1-7) levels predominate in the peripheral circulation in early stages of liver cirrhosis, contributing to reduced vascular resistance. In advanced stages, Ang 2 leads to extra-splanchnic vasoconstriction. The relationship between these peptides and hemodynamic changes was investigated.
The revised Vienna Classification enhances diagnosing colorectal polyps and lesions with improved sensitivity and specificity. However, it has limitations in predicting depth of invasion, and should be supplemented by endoscopic assessment.
A study published in the World Journal of Gastroenterology found that endoscopic ultrasonography (EUS) is unable to distinguish between malignant and benign gallbladder polyps smaller than 1 cm. The study suggests that EUS alone may not be sufficient for determining a treatment strategy for these small lesions.
Recent research found that Tribble 3 can block the insulin signaling pathway, contributing to insulin resistance and NAFLD. The study provides an experimental basis for future studies on the role of TRB3 in NAFLD.
Researchers found that two-channel GES with trains of pulses can entrain gastric slow waves and accelerate gastric emptying. This treatment approach may be applicable for treating gastroparesis and normalizing gastric dysrhythmia.
The American Gastroenterological Association honors individuals for their lifetime achievements and significant advancements in gastroenterology. This year's awardees include Dr. Daniel K. Podolsky, Dr. Warren Strober, and Dr. Judith M. Podskalny, among others.
Researchers presented data on the effectiveness of monoclonal antibodies in treating Crohn's disease and preventing C. difficile recurrence, showing improved clinical outcomes and safety profiles.
A study found that complex antithrombotic therapy is associated with a high risk of upper gastrointestinal events among vulnerable elders. The researchers also discovered that proton pump inhibitors may increase the risk of hip fractures in patients taking acid suppressors.
Dr. Daniel K. Podolsky receives the 2009 Julius Friedenwald Medal for his lifelong contributions to gastroenterology and groundbreaking scientific achievements. He credits his colleagues and mentors for his success, highlighting UT Southwestern's role in his career.
Recent studies have shown that patients under deep sedation during colonoscopy are more likely to have large polyps detected, which could lead to earlier detection of colon cancer. Additionally, research suggests that removing advanced pre-malignant polyps sooner than recommended may be beneficial in reducing the risk of colon cancer.
A new study published in Clinical Gastroenterology and Hepatology suggests that obesity is an independent predictor of inadequate bowel preparation at colonoscopy. Patients with a higher Body Mass Index (BMI) are more likely to require more rigorous bowel preparation regimens.
The AGA Institute will present exciting data on treatments for Clostridium difficile infection, hepatitis C, and Crohn's disease. The late-breaking session includes studies on optimized therapies and new technologies, which may become the standard of care in the near future.
A study examining COX2 and UGT1A6 genetic polymorphisms in colon cancer risk found no significant association. The protective effect of NSAIDs on colon cancer risk was not modified by these genetic variations.
The study found that estimated glomerular filtration rate (eGFR) equations, particularly eGFR5 and eGFR3, are reliable preoperative renal function tests for patients undergoing hepatectomy. These equations were compared to creatinine clearance (Ccr), with significant differences in postoperative serum creatinine levels
Researchers discovered a novel compound, ADFMChR, with potent anti-tumor activity against human liver carcinoma cells. The compound induces apoptosis and modulates key proteins, providing new insights into its potential as a cancer-preventive agent.
The study developed a molecular marker for Pi-deficiency in rats and evaluated the efficacy of Chinese materia medicas and probiotics. It found that middle doses of these recipes showed pronounced recovery activities, while higher doses did not.
A novel marker of TSPAN1 has been identified as a significant prognostic indicator for patients with colorectal adenocarcinoma. The protein's expression was found to correlate with histological grade, cell proliferation, lymph nodal metastasis, and TNM staging, leading to a shorter survival period in those with overexpression.
Researchers found that only 61.9% of patients assigned a billing diagnosis code for Barrett's esophagus actually had the condition after manual record review. A pathologic diagnosis was highly likely to be reproduced by separate reviews, but electronic coding confirmed only 61.9% of cases.
A case study reports a patient with chronic diarrhea responding to lansoprazole withdrawal, highlighting the drug's potential link to collagenous colitis. Withdrawal of lansoprazole promptly resolved both colonoscopic and histological abnormalities.
A study published in World Journal of Gastroenterology found that small colon polyps can be removed without interrupting anticoagulation therapy, resulting in an acceptable bleeding rate. The procedure was performed on 123 patients with lesions up to 1 cm in size.
Researchers used computer simulation to investigate the effects of duodenal stump geometry on gastric resection outcomes. The study found that certain geometric configurations can improve food transport and emptying, but may compromise pressure distribution.
Researchers characterized early-stage liver reperfusion injury mechanisms using rats with varying ischemia-reperfusion periods. Key findings include cell vacuolation, bleb formation, and apoptosis induction.
The study found that dephytinization significantly increased mineral cell uptake efficiency, retention, and transport efficiency of iron and zinc. Calcium bioavailability also showed a significant increase after phytate removal from most samples. This research provides valuable insights for infant nutrition and mineral absorption.
Research suggests that Rocket 'Eruca sativa' has potent gastric anti-ulcer properties, inhibiting acid secretion and reducing ulceration. The herb's extract also replenishes mucous and sulfhydryl levels, while reducing oxidative stress markers.
Two studies published in Gastroenterology found that statin use is associated with a significant reduction in the risk of hepatocellular carcinoma (HCC) among patients with diabetes. Additionally, statins appear to reduce the risk of cholecystectomy, surgical removal of the gallbladder, in women.
Researchers found that short-term calorie restriction with a low-carbohydrate diet caused greater changes in liver fat content and metabolic function compared to a high-carbohydrate diet. Long-term calorie restriction improved skeletal muscle insulin sensitivity, while cellular insulin signaling increased.
A study published in the World Journal of Gastroenterology has discovered a significant link between aryl hydrocarbon receptor (AhR) expression and gastric cancer. The research suggests that AhR may be a potential therapeutic target for gastric cancer treatment.
A study of 1970 patients found a strong association between gastroesophageal reflux disease and linked angina. Patients with GERD had a higher prevalence of linked angina than those without GERD symptoms, suggesting that GERD may be misclassified as non-GERD heartburn.