Articles tagged with Gastroenterology
A study of young age gastric cancer patients in Korea found that epidemiologic characteristics, risk factors, and treatment approaches differ by age and gender. Hormonal factors were more common in females, while environmental factors were more common in males, particularly in the older age group.
A Canadian study has found that younger age at diagnosis and more recent year of diagnosis are associated with more severe ulcerative colitis. These findings may help physicians identify patients at higher risk of severe disease and tailor their care accordingly.
A study analyzing 429 patients with intrahepatic cholangiocarcinoma found associations between hepatitis B infection, CA19-9 levels, and lymph node metastases. Radical resection is a key prognostic factor for ICC, and future research should focus on evaluating molecule-targeted therapy.
Patients with resectable esophageal adenocarcinoma benefit from neoadjuvant chemoradiotherapy, showing improved overall survival and complete resection rates. However, the treatment is connected to a higher mortality rate after surgery.
Researchers found distinct bacterial phylotypes associated with IBS subtypes, including diarrhea-predominant and constipation-predominant IBS. These findings suggest potential targets for diagnostic and therapeutic approaches to managing IBS.
Researchers report a rare diagnosis of superior mesenteric artery syndrome in a diabetic patient, causing similar symptoms to gastroparesis. Computed tomography and upper GI series are reliable diagnostic tools, while adequate nutrition supply and bodyweight gain aim to relieve symptoms.
Researchers from Taiwan evaluated 34 CT-guided biopsies in patients with pancreas masses, demonstrating a high success rate and minimal complications. The study suggests that transgastric biopsy using large needles is a feasible alternative method for pancreatic lesion sampling.
A phase II study found that adding ketoprofen to pegylated-interferon (PEG-IFN) with or without ribavirin improves viral kinetics and early activation of the IFNa signaling pathway. This combination therapy shows promise for treating genotype 1 chronic hepatitis C.
A study published in World Journal of Gastroenterology found that oral sodium phosphate (OSP) laxatives can induce hyperphosphatemia in low-risk patients, particularly those with lower weights. The research suggests that preoperative evaluation and adjusting OSP doses according to weight may help prevent this condition.
A novel and simple formula predicts treatment success for patients with chronic hepatitis C, outperforming viral kinetics. The formula, based on clinical data, is suitable for every cohort of patients and can help tailor treatment.
A study of mucosal biopsies from patients with ileal pouch-anal anastomosis reveals protein expression changes in pouchitis and antibiotic-induced remission. Proteomic analysis identifies novel biomarkers for disease activity, diagnosis, and prognosis.
Research by Dr. L Veijola and colleagues suggests H. pylori infection may trigger autoimmune gastritis, a condition that requires lifelong vitamin B12 supplementation. The study confirms previous findings that serum markers of autoimmune gastritis appear in patients with H. pylori, highlighting the potential for eradication therapy to ...
In a study published in World Journal of Gastroenterology, researchers found that MRI-enterography revealed incidental findings outside the small intestine in 25% of patients with suspected or known Crohn's disease. These extra-intestinal manifestations were rare and did not necessarily require additional examinations.
A prospective randomized clinical trial examined acupuncture's effect on preventing prolonged postoperative ileus (PPOI) after intraperitoneal surgery among patients with colon cancer. The study found no significant benefit of acupuncture, suggesting that standard postoperative care is sufficient to prevent PPOI in this population.
Two head-to-head studies found that Peginterferon alpha-2a (PegIFNα2a) plus ribavirin (RBV) produces a significantly higher sustained virological response (SVR) rate than peginterferon alpha-2b (PegIFNα2b) plus RBV for patients with chronic hepatitis C. The SVR rates were 66% and 54% for PegIFNα2a and PegIFNα2b, respectively.
Research suggests that high nicotinamide intake can lead to reactive oxygen species production, insulin resistance, and glucose intolerance. Sweating is identified as an effective way to expel excess nicotinamide from the body, offering a potential preventive and therapeutic intervention for type 2 diabetes.
A recent study published in World Journal of Gastroenterology found that shift work significantly increases the development of metabolic syndrome (MetS) among early-middle-aged males with elevated alanine aminotransferase (ALT). The researchers observed that workers with both baseline e-ALT and long-term rotating shift work exposures h...
A large-scale case-control study found no association between GSTM1 and GSTT1 null genotypes and increased risk of gastric and colorectal cancer in Koreans. Smoking, alcohol consumption, and age did not modify this association.
Researchers used EUS with contrast-enhanced harmonic imaging to diagnose small pancreatic carcinomas. Periodic follow-ups revealed accurate diagnosis of disease progression in patients with branch duct intraductal papillary mucinous neoplasm (IPMN).
Researchers investigated manometric measurements in patients with isolated distal reflux (IDR) to compare findings in those with erosive esophagitis and non-erosive esophagitis. IEM was observed only in patients with erosive disease, suggesting a potential pathophysiological link.
A study published in the World Journal of Gastroenterology found that PEG placement does not guarantee elimination of gastroesophageal reflux. The researchers identified factors contributing to GER persistence, including reflux esophagitis and altered gastroesophageal flap valve function.
Peliosis hepatis, a rare pathological entity, can lead to spontaneous liver rupture, a life-threatening condition that necessitates prompt medical intervention. The case report highlights the importance of considering PH in patients with risk factors, emphasizing the need for early diagnosis and treatment to prevent severe complications.
A new study published in Clinical Gastroenterology and Hepatology found that combining sigmoidoscopy and fecal immunochemical test (FIT) improves CRC detection by 10 percent. This combination is particularly useful for communities with limited colonoscopy access, as it allows for more effective screening of advanced proximal tumors.
Research in Taiwan found working after meals and H. pylori infection increase GCA risk, while healthy diet may reduce it. Healthy dietary habits and eradication of H. pylori are crucial for prevention.
A study found that fructose-sorbitol (F-S) ingestion provoked gastrointestinal symptoms in over half of female ED patients, with a significant difference in response between underweight and normal-weight individuals. The response was specific for F-S and more common in anorexia nervosa patients.
Patients with more bile duct visualization on imaging studies and fewer liver metastases had greater bile output after biliary drainage. However, daily observation of bile output and serum bilirubin reduction is crucial for determining procedure success.
A research team investigated a highly-selective EP4 agonist for treatment of gastric ulcers in mice. The EP4 agonist reduced acute hemorrhagic damage, promoted mucous epithelial regeneration, and accelerated ulcer healing. In vitro, it protected human gastric mucous cells from indomethacin-induced apoptosis.
Researchers developed a protocol to direct the hepatic specification of ES cells using valproic acid and cytokines, resulting in functional hepatocytes. This study may aid hepatocyte transplantation and provide an in vitro model for understanding liver development.
A large cohort study found that patients with type 2 diabetes mellitus have a threefold increased risk of pancreatic cancer and a twofold increased risk of gallbladder and extrahepatic biliary cancers compared to non-diabetic controls. This is the first comprehensive assessment of the risk for these cancers in type 2 DM patients.
A study published in the World Journal of Gastroenterology found that vardenafil has dose-dependent gastroprotective effects against NSAID-induced peptic ulcer. This suggests that vardenafil may be used as a potential therapeutic drug to prevent NSAID-induced gastric ulcer formation.
A new report from gastroenterology/hepatology societies emphasizes the importance of competency-based curriculum and disease-specific training in improving patient outcomes. The report recommends changes to GI training programs, including pairing of GI/hepatology training and enhanced training in specific disease areas.
Researchers investigated gastric mucosal changes prior to gastric cancer in Indonesian and Japanese patients with H. pylori infection. They found significant differences in the grade and activity of mucosal changes, suggesting a different host response between the two populations.
A study published in the World Journal of Gastroenterology investigated whether children can tolerate surgery without fasting. The results showed that children can handle the stress of surgery when fed up to 2 hours before surgery, indicating no significant difference between short and long periods of fasting.
A new study found that short-term Celecoxib intervention can effectively prevent gastric carcinogenesis in Mongolian gerbils. The research team suggests that COX-2 inhibitors may be used as chemoprevention for people older than 40 years old, especially those with refractory H. pylori infections at high risk of gastric cancer.
A 33-year-old woman accidentally swallowed a 15 cm long spoon while attempting to remove a fish bone from her pharynx. The spoon was found in the lower mid-abdomen on an urgent plain abdominal radiograph and successfully removed during exploratory laparotomy, revealing it had passed into the jejunum after 200 cm of the ligament of Treitz.
Researchers at the Mayo Clinic found that high-definition colonoscopy detected 29% more polyps than standard colonoscopy, with a 20% increase in detecting precancerous polyps. This study, conducted on 2,430 patients, marked the first comparison of these two methods in clinical practice.
A new Mayo Clinic study has found that video capsule endoscopy is safe for patients with heart devices, contradicting previous FDA contraindication. The study, involving 84 patients, showed no complications or interference between the procedure and implanted cardiac devices.
Researchers found a significant association between gastrointestinal disorders and exposure to infectious gastroenteritis, with the highest risk of functional diarrhea and irritable bowel syndrome. Long-term effects of high-stress occupations on GI health are being considered for novel solutions.
A new study reveals professional football players, particularly those in the larger weight classes, exhibit increased fasting glucose levels, body mass index, waist circumference, and other risk factors for cardiometabolic syndrome. This finding highlights the potential future health risks associated with large-scale exercise routines.
In a unique situation, gastroenterologists performed endoscopies on military dogs with gastrointestinal complications. The procedures involved putting their human skills to the test to care for canine heroes in the combat zone.
A large series of 91 patients found that performing capsule endoscopy did not interfere with images captured by devices like pacemakers. The study, presented at the American College of Gastroenterology meeting, suggests that capsule endoscopy can be safely used in elderly patients with implantable cardiac devices.
New studies suggest that adequate bowel preparation prior to colonoscopy can impact follow-up timetables. Researchers found that inadequate bowel preparation resulted in a recommended follow-up colonoscopy 17.1 months earlier than average.
Researchers found that Barrett's esophagus patients have comparable survival rates to the general population, with a 10-year overall survival rate of 68%. Esophageal cancer was not significantly more common among these patients.
A new study finds that a 7-day course of levofloxacin, omeprazole, nitazoxanide and doxycycline (LOAD) is more effective in eradicating Helicobacter pylori than a similar treatment with lansoprazole, amoxicillin and clarithromycin. The therapy is also found to be equally effective when reduced to 7 days.
A study found that high transglutaminase antibody levels can accurately diagnose mucosal atrophy in celiac disease, making duodenal biopsy unnecessary. The predictive value of tTG antibodies may vary by age, with higher accuracy in adults than children.
A study found that emodin reduces hepatic hydroxyproline content, serum AST and ALT activities, and inhibits HSC activation by down-regulating TGF-b1 and Smad4. Emodin may be an attractive therapeutic agent for treating fibrotic liver diseases.
A study published in World Journal of Gastroenterology found that long-term proton pump inhibitor (PPI) treatment can lead to weight gain in patients with gastroesophageal reflux disease (GERD). The research highlights the importance of lifestyle modifications, such as dietary changes and weight management, to mitigate this effect. By ...
Small-for-size graft dysfunction can occur in liver transplant patients with a graft-to-recipient body weight ratio above 0.8%. The study found that patients with a high GV/SLV ratio were more likely to develop early graft dysfunction, highlighting the importance of prompt recognition and timely treatment.
A study of 124 patients with advanced biliary tract cancer found EGFR overexpression in 39.3% of tumors, while HER2 overexpression and gene amplification were present in only 5% of cases. This suggests that targeting EGFR may be a promising therapeutic approach for BTC, while routine testing and targeting of HER2 is not recommended.
A case of post-gastrectomy acute pancreatitis was reported in a patient with gastric carcinoma and pancreas divisum. Early detection and aggressive treatment may improve prognosis for patients with this condition. The study highlights the importance of monitoring pancreatic function after gastrectomy.
Dr. Daniel K. Podolsky, UT Southwestern president, has been elected to the Institute of Medicine for his scientific and medical achievements. He joins 19 current UT Southwestern faculty members as a national member.
A new study published in the October 2009 issue of Gastroenterology found that patients with moderate-to-severe active ulcerative colitis had a 41 percent reduction in colectomy after one year when treated with infliximab. Treatment with infliximab reduced the incidence of colectomy through 54 weeks by 41 percent.
A new study by the American Gastroenterological Association found that antidepressant amitriptyline is as effective as a placebo in treating child pain-predominant gastrointestinal disorders. The study involved 83 children and showed that both amitriptyline and placebo were associated with excellent therapeutic response.
A recent study published in the World Journal of Gastroenterology investigated whether Helicobacter pylori eradication therapy prevents gastric cancer. The research team found that younger patients with successful eradication had significantly lower incidence rates, while no overall prevention was observed for all patients.
A study published in World Journal of Gastroenterology found that HBV genotypes B and C were the major genotypes in Indonesia, with genotype B being predominant. The study also identified associations between certain mutations and liver disease progression.
A study found that ERCP quality outcomes, including complication rates, compare favorably with those of academic centers in a community hospital setting. Technical success rates met or exceeded recommended levels, indicating competence among gastroenterologists performing ERCP.
A study published in the World Journal of Gastroenterology evaluated 76 cases of living donor liver transplantation and found that the Chengdu formula is reliable. The other formulas, such as Fan and Heinemann, underestimated liver volume, while Urata and Lee overestimated it.
A study published in the World Journal of Gastroenterology found that underlying malignancy, liver cirrhosis, and hematemesis are key predictors of rebleeding after negative angiographic findings. The research team analyzed 128 patients with acute non-variceal gastrointestinal bleeding who had negative initial angiography results.
The study investigates proficiency level in laparoscopic splenectomy using the learning curve method, finding a horizontal lazy S-shape with two distinct slopes. Surgeons can be accepted as proficient after performing at least 25 cases, contrary to the widely accepted 'L' shape.
Researchers found a positive correlation between Yes-associated protein (YAP) and survivin expression in gastric carcinoma, suggesting YAP's role in inducing cell proliferation and inhibiting apoptosis. The study suggests potential for YAP as an early diagnostic marker for gastric carcinoma.