Articles tagged with Psychiatry
Researchers developed a groundbreaking approach to prioritize schizophrenia-associated genes by analyzing genetic data from over 102,000 individuals. This study uncovered 641 previously unrecognized genes associated with schizophrenia, shedding light on the complex interactions between distant genetic variants.
Researchers found that pramipexole, a Parkinson's disease medication, improved symptoms of anhedonia in patients with treatment-resistant depression. The therapy was associated with positive effects on the brain's reward system and increased physical activity.
A new study suggests that lower baseline dopamine may drive teenage risk-taking behavior, such as substance experimentation, which tends to decrease with age. The research found that adolescents with lower dopamine levels were more likely to try substances, but their use declined after the college years.
The study analyzed polygenic scores and simulated expectations to understand changes in genetic contributions to ASD and ADHD diagnoses by year of diagnosis. Findings suggest broadening diagnostic criteria as a possible explanation for increasing rates, which has significant implications for risk factors and clinical practice.
Researchers propose using low-dose lithium orotate to slow dementia progression in mild cognitive impairment, leveraging established neuroprotective mechanisms. The approach aims to mitigate kidney and thyroid risks associated with higher-dose formulations, offering a potentially accessible and inexpensive treatment option.
Advanced Brain is an open access journal dedicated to publishing cutting-edge research across the brain-mind continuum. The journal aims to foster dialogue across life, medical, and behavioral sciences to accelerate fundamental and applied understanding of the human brain.
A new framework, criticome, integrates experience until age 25, reframing autism, schizophrenia, depression, and trauma as developmental disorders. The study suggests that screen-saturated childhoods may produce adult dysfunction, highlighting the importance of early experience in brain development.
The project aims to expand University Hospitals' collaborative care model from 26 practices to all 88 practices within the UH Primary Care Institute. It will also broaden services to include screening and treatment for conditions such as bipolar disorder and post-traumatic stress disorder (PTSD).
Researchers at UCLA Health have identified a brain region called the ventromedial prefrontal cortex (vmPFC) that regulates memory integration. The vmPFC acts as a quality control checkpoint, preventing memories from getting mixed up when they are significantly different or far apart in time.
Researchers found biomarkers for Alzheimer's disease that correlated with minor cognitive differences in midlife adults. These biomarkers, measuring tau and amyloid plaque, were associated with a greater chance of cognitive decline, particularly in processing speed and executive function.
A new viewpoint article highlights the risk of AI 'collusion' with unreliable human input in mental health settings. The author argues that clinical expertise should be included when designing training data and evaluating AI systems to strengthen safeguards.
Interleukin 6 is investigated as a treatment target for depression in this randomized clinical trial. The study highlights the therapeutic potential of IL-6 or IL-6 receptor inhibition and proposes suitable patient selection methods.
Researchers found that combining ketamine with low-dose buprenorphine treatment can prolong its antisuicidal effects for at least a month. Patients who received this combination treatment showed greater and longer-lasting reductions in suicidality compared to those given a placebo.
A new study found a steady rise in children's mental health concerns during routine primary care visits, with anxiety-related visits increasing by 300% over 10 years. The study highlights the growing role of pediatric primary care in addressing mental health needs and calls for more training and resources to support this shift.
A systematic review and meta-analysis found single and repeated intravenous ketamine infusions to be efficacious in reducing suicidal and depressive symptoms in acute major depressive episodes. Longer-term outcomes remain unclear.
This systematic review and meta-analysis found differences in efficacy and acceptability of adjunctive atypical antipsychotics for major depressive disorder. The study highlights the need for more well-controlled studies on maintenance efficacy of these medications.
A new study found that mental health clinicians prefer evolutionary explanations of anxiety over genetic approaches, believing they provide a more positive outlook and can improve patient willingness to seek help. This shift could lead to more hopeful and therapeutically empowering attitudes towards anxiety treatment.
A randomized clinical trial found that genotype-guided prescribing of SSRIs did not improve depression symptoms at 3 months but showed higher remission rates at 6 months. Future studies should focus on the long-term impact of this approach.
A study finds microplastics in the human brain associated with increased risk of stroke and dementia. Apheresis, a medical treatment, is proposed as a potential removal method for microplastics from the body.
Dr. Dilek Colak's journey began with a childhood observation of a boy with mental illness, which inspired her to pursue a career in neuroscience. Her current work focuses on understanding autism and schizophrenia through the study of human brain organoids.
The latest issues of APA journals feature new research on PTSD and substance use disorders. The American Journal of Psychiatry explores the understanding of these conditions, while Psychiatric Services discusses the future of the DSM. Focus journal delves into psychopharmacologic treatments with expert perspectives.
Researchers found significant loss of neurons in the locus coeruleus, a second critical region involved in arousal and muscle tone regulation. This finding suggests an immune-mediated process and challenges the prevailing explanation for narcolepsy with cataplexy.
A nationwide ecological study found a statistical correlation between fewer psychiatric beds and higher suicide rates in Sweden. The study suggests that investing in outpatient care may not be enough to prevent suicides, highlighting the need for further research into healthcare resource allocation.
A new study found that nearly 1,200 TBI respondents used psychedelics to treat or manage physical health conditions, with 208 participants using them to manage brain injury-related symptoms. Researchers reported a 90% self-reported symptom improvement rate.
Researchers are developing a new wearable technology to monitor babies' movements and detect early signs of autism. The study aims to improve early identification and intervention, which is crucial for optimal developmental outcomes in autistic individuals.
A recent study published in Frontiers in Pediatrics has found that preschool children born with heart defects are at a greater risk of developing behavioral problems, including ADHD and peer relationship issues. The study suggests that a cognitively stimulating home environment may help reduce this risk.
A new study reveals that electroconvulsive therapy (ECT) can lead to significant negative impacts on standard of living, personal relationships, and even brain damage. Relatives and friends of ECT patients report long-term effects including memory loss, emotional blunting, and loss of independence.
A survey of 286 relatives and friends found that 45% experienced improvement, while 42% saw worsening symptoms. Many reported memory loss, difficulty concentrating, and relationship problems after ECT.
Research found that gender-diverse teens reported higher rates of psychological stress and psychotic-like experiences, which can lead to depression, anxiety, and other serious mental health disorders. Bullying and unsupportive legislation drove these findings.
The report highlights a critical implementation gap in digital mental health tools, which struggle to reach the masses due to inadequate infrastructure. The industry has excelled in creating evidence-based tools and AI systems, but fails to deliver them at population scale without proper systems in place.
A cohort study found that individuals diagnosed with ADHD at a younger age tended to perform better academically, receiving more education and experiencing lower dropout rates compared to those diagnosed closer to age 16. This suggests that targeted support for early diagnoses could help prevent school dropout.
Current AI systems lack internal embodiment, a property that humans take for granted, which can lead to performance and behavior limitations. Researchers propose a dual-embodiment framework to guide future research in building safer and more aligned AI models.
In this randomized clinical trial, mirtazapine effectively reduced methamphetamine use in adults with methamphetamine use disorder. The study's findings have important implications for the treatment of this condition, which currently lacks approved pharmacotherapies.
A study published in Brain Medicine suggests autonomic dysfunction, particularly parasympathetic and sympathetic imbalances, contributes to depressive symptoms in patients unresponsive to conventional antidepressants. Low-dose medications targeting these imbalances may offer a new approach to treatment.
Researchers identified NOX-1 as a key molecular target to prolong ketamine's therapeutic benefits. Combining ketamine with NOX-1 inhibitors significantly extended its antidepressant-like effects. K-4, a novel AMPAR modulator, also showed rapid antidepressant effects that persisted for at least 2 weeks.
A new study published in JAMA Network Open reveals that fathers' mental health declines over time after the birth of their child, with increased risk of anxiety and substance abuse diagnoses returning to pre-pregnancy levels. However, depression and stress-related disorders continue to rise by over 30% one year after childbirth.
The European Psychiatric Association has launched an action plan to address unmet needs in psychiatric care, focusing on brain health, treatment delivery, stigma reduction, and preventive measures. The plan aims to improve diagnostic accuracy and precision care through its 80,000-psychiatrist network.
The study found that wildfire exposure and its socioeconomic consequences were associated with increased psychological distress beyond the burn zone. Integrating mental health care, housing stability, and economic recovery are crucial for disaster response and climate resilience strategies.
Emerging research across conceptual frameworks, biomarker science, digital phenotyping, and artificial intelligence synthesizes a translational pathway toward a more biologically grounded and clinically useful approach to psychiatric diagnosis. The current system falls short due to standardized clinical language and lack of biological ...
A new study by Brown University and Harvard Medical School found that telemedicine does not substantially increase access to mental health care for those in rural or underserved areas. Despite its convenience benefits for existing patients, telemedicine did not lead to a significant expansion of care access for these populations.
Researchers at the University of Toronto found that higher ultra-processed food consumption is associated with increased anxiety, fearfulness, aggression and hyperactivity in preschoolers. Replacing ultra-processed foods with minimally processed options may support healthier development and lower behavioural difficulties.
A massive Swedish study of over 2 million individuals reveals that genetic risk for mental illness is far less disorder-specific than clinicians have assumed. Schizophrenia shows the highest genetic specificity, while drug use disorder has a much lower specificity, scattering its genetic risk across multiple conditions.
The latest American Psychiatric Association journals feature new research on treating bipolar disorder, preventing PTSD symptoms, improving access to eating disorder care, and more. Journal highlights include advancements in schizophrenia treatment and a retrospective analysis of suicide deaths in U.S. immigration detention.
Benzodiazepine use decreased across the US from 2018 to 2022, with the greatest decline among older adults. Nearly half of patients receiving benzodiazepines also took other central nervous system depressants, increasing the risk of adverse effects.
A study found distinct inflammatory biomarkers and brain signatures for early-stage depression and psychosis, differing even in the earliest stages. These findings support customized therapies and may reduce risk of severe progression.
Researchers found that implanted cuff electrodes can trigger unintended nerve stimulation during MRI, causing discomfort or pain. The study recommends more refined guidelines and careful safety considerations to mitigate this risk.
A new study analyzing global Google Trends data reveals a sharp increase in online searches for crisis hotlines, particularly in recent years. The findings suggest that digital help-seeking signals can provide timely insight into population distress and demand for crisis resources.
Exercise mimetics aim to replicate the muscle-brain axis benefits of physical activity without requiring engagement in regular exercise. By activating key molecular pathways, these compounds may alleviate depressive symptoms without traditional therapy or medication.
A meta-analysis of 55 studies found a significant protective association between spirituality and hazardous alcohol and drug use. The study suggests that spiritual practices may be effective in preventing or reducing the risks associated with these substances.
A cross-sectional analysis found that nearly half of mental health visits and 29 million non-mental health telehealth visits occurred annually. The study suggests that telehealth has become an essential component of care for older and medically vulnerable adults, raising concerns about rolling back telehealth flexibilities.
Research finds that SSRIs during pregnancy increase gestational diabetes risk in newborns but lower preterm birth and low birth weight risks. SSRIs also associated with breathing problems and neonatal care needs in newborns.
A new online tool provides information and tools for clinicians to respond to emerging patient care needs, enhancing trauma-informed healthcare for individuals with C-PTSD. The resource was co-developed by researchers and survivors, aligning with best practices and patient-centered research.
Researchers discovered that brief intermittent intense exercise is a more effective treatment for panic disorder than relaxation therapy. The 12-week program showed significant reductions in Panic and Agoraphobia Scale scores, anxiety, depression, and panic attack frequency and severity.
Two Weill Cornell physician-scientists, Dr. Semra Etyemez and Dr. Jesse Platt, have been awarded prestigious early-career awards from the American Society for Clinical Investigation (ASCI) for their outstanding research in obstetrics and gynecology, psychiatry, and gastroenterology. The ASCI recognizes and supports the scientific effor...
A large-scale Japanese cohort study and mouse experiments reveal that maternal perinatal depression increases autistic-related traits in toddlers, with a particularly strong impact on girls. The findings suggest a sex-specific neurobiological pathway underlying these effects.
A ketogenic diet was found to have a modest effect in reducing depressive symptoms in patients with treatment-resistant depression. The study's results suggest that this dietary approach may be worth exploring as an adjunct therapy option.
Dr. Ronald C. Kessler's decades-long research transformed international understanding of psychiatric disorders and suicide prevention. His work exposes the global scope of mental health challenges and highlights key factors in prevention.