Articles tagged with Drug Development
A team of researchers at Aarhus University has discovered a protein that helps protect the body against blood clots in hibernating bears. The protein, HSP47, is found to be downregulated during winter months, allowing bears to avoid blood clots.
A recent study reveals the first high-quality nuclear genome sequence and assembly of Babesia duncani, a neglected species until now. The parasite's evolution and mechanism of virulence have been identified, providing leads for the development of effective therapies.
Researchers have developed a novel 3D printing strategy that preserves the folding structure and molecular function of various biopolymers, enabling precise control over size and geometry at submicron resolution. The technique allows for the production of 3D biopolymeric architectures with functional integrity and biofunctions.
Recent studies have highlighted the importance of tumor microenvironment in developing and controlling triple negative breast cancer progression. Researchers suggest that technological advancements like genomics and epigenomics hold promise for overcoming TNBC's current limitations.
Researchers developed a chelator-free-radiolabeled polymersome capable of long-term multiday PET imaging in vivo. The nanovesicle meets key requirements for targeted cancer therapy, including precision targeting, stable radiotracer binding, and biocompatibility.
New research at ECCMID 2023 presents 19 gold complexes effective against at least one hard-to-treat bacterium, including MRSA and Pseudomonas aeruginosa. The gold-based drugs use a multimodal mechanism to kill bacteria, preventing antimicrobial resistance from developing.
Scientists at RIKEN have developed a new technique for creating complex 3D organoids using a cube-like structure made of hydrogels. This innovation enables researchers to control the environment around cells, allowing for the creation of tissues with faithful reproduction of asymmetric genetic expression. The technology has the potenti...
Researchers at Simon Fraser University are studying the genes of superbugs to develop new and effective treatments for drug-resistant bacterial infections. The team has discovered new genes responsible for causing disease and infection symptoms in humans, which can be targeted by antivirulence drugs.
A new shape-shifting antibiotic has been developed by Cold Spring Harbor Laboratory researchers, offering a potential cure for deadly infections caused by drug-resistant bacteria. The innovative design uses click chemistry to create a molecule with multiple possible configurations, avoiding the development of resistance.
A major international study published in Nature Genetics has provided new insights into the genetics of preterm birth and pregnancy length. The research reveals a mutually antagonistic effect between the woman's and unborn child's genes, favoring earlier labor for the mother's survival and extending pregnancy for the child's weight gain.
A recent study published in PLOS ONE found that academic institutions receive significantly lower royalty rates, total payments, and pre-commercial payments for biotechnology licenses compared to commercial firms. The disparities were observed even after accounting for differences in product stage development.
Researchers have found lab-made antibodies that can strengthen the body's fight against yellow fever, a disease with no current treatment. The monoclonal antibody infusions were able to remove all signs of infection from research animals, offering potential hope for a cure.
Researchers have developed a cubic molecule platform that can improve the properties of hydrocarbons like cubane, which was previously overlooked due to limited synthesis. This breakthrough enables the incorporation of nitrogen atoms, facilitating biologically desirable interactions and expanding options for chemists.
Three pre-clinical studies published in Journal of Pharmaceutical Analysis explore the molecular mechanisms underlying cardiovascular and neurological diseases, providing new avenues for therapeutic strategies.
Researchers at the University of Surrey used a new technology called fluxomics to reveal how cells process nitrogen in TB-causing bacteria. The study identified glutamate as a crucial amino acid in the nitrogen metabolism, providing a target for new drug development.
A team of researchers from POSTECH and Georgia Tech developed a biohybrid 3D printed heart model with integrated sensors to monitor drug-induced cardiotoxicity. The platform enables real-time, continuous monitoring of heart contractions, facilitating the testing of acute and chronic pharmacological effects.
Researchers at the University of Helsinki have developed a nasal spray that is effective in preventing coronavirus infection, including the latest variants. The molecule, TriSb92, identifies a region in the spike protein common to all current variants and inhibits its functioning.
Researchers developed a small-molecule drug that limits magnesium transport into cellular power plants, resulting in skinny, healthy mice. The findings hold significant implications for preventing cardiometabolic diseases like heart attack and stroke, as well as reducing liver cancer risk.
A new study found that women with BRCA1 or BRCA2 mutations who are obese may experience higher rates of DNA damage in their breast tissue, which could contribute to breast cancer development. The researchers suggest that weight management and medications like metformin may be important for preventive care.
Researchers at Mayo Clinic have made significant progress in treating multiple myeloma using chimeric antigen receptor therapy (CAR-T cell therapy), which has shown a median progression-free survival of 13.3 months compared to 4.4 months for standard treatment regimens.
Researchers at NTU Singapore have found a way to spur brain immune cells to clear toxic waste linked to Alzheimer’s disease by targeting their metabolism. The study reveals a ‘metabolic switch’ in the brain’s immune cells that can be manipulated to improve their function.
Researchers at Rice University aim to create genetically encoded antibiotics that selectively kill pathogenic bacteria while sparing beneficial microbes. The goal is to develop targeted, tailored RNA antibiotics to combat antibiotic resistance and improve treatment outcomes.
Recent review article discusses clinical development in long-acting growth hormone (LAGH) therapy, which mimics natural GH release patterns. LAGH therapies reduce daily injection burden, improving patient compliance and treatment outcomes.
Scientists have developed a high-throughput genetic screening approach to identify viral proteins that target bacterial cell walls, leading to potential new antibiotics. The method uses a coded library of DNA fragments to investigate unknown genes in environmental samples, sidestepping the need for culturing bacteria.
Scientists from Tokyo Medical and Dental University find that antibody fragments encapsulated in nanomicelles can reduce toxic Aβ species in the brain of an Alzheimer's disease model mouse. This breakthrough delivers treatment to where it is needed most, potentially slowing AD progression.
A study by Washington University School of Medicine suggests targeting T cells to prevent neurodegeneration and treat Alzheimer's disease. The research indicates that microglia partner with T cells to cause brain damage in the disease, and blocking their entry can avoid most neurodegeneration.
Researchers have discovered that high-grade glioma brain tumors have LDL receptors, which could be targeted by drugs already in development. The study's findings pave the way for using nanoparticle-based therapies to starve the tumors of energy and cause disruptions to their growth and spread.
Researchers have identified a key cause of metastasis from aggressive brain cancer in children and found a potential new therapy. Medulloblastoma cells hijack neurodevelopmental signaling pathways to promote tumor cell spreading. Targeting these pathways with a drug called dasatinib has shown promise in killing metastatic tumors.
Researchers explore cellular senescence's complex relationship with growth stimulation and cell cycle arrest, revealing potential anti-aging drug targets. Understanding these mechanisms is crucial for developing new treatments for age-related diseases.
Researchers at University Hospitals Cleveland Medical Center discovered that S-nitrosohemoglobin senses areas with insufficient oxygen and restores blood flow for oxygenation. This breakthrough opens up a new line of drug development to correct poor tissue oxygenation, including peripheral artery disease and sickle cell disease.
MIT engineers develop a new purification method using bioconjugate-functionalized nanoparticles to rapidly crystallize proteins, reducing the cost of manufacturing protein drugs. The approach has shown promising results in isolating lysozyme and insulin, with faster crystallization times and increased nucleation rates.
A new study by WVU economist Zachary Porreca found that gentrification can displace organized criminal activity, leading to a surge in gun violence in nearby neighborhoods. The study analyzed data on shootings and real estate across Philadelphia neighborhoods between 2011-2020.
Researchers at Gladstone Institutes found that ApoE4 from neurons plays a critical role in Alzheimer's disease, contrary to previous focus on glial cells. The study shows that deleting ApoE4 from neurons reduces brain changes resembling Alzheimer's disease, offering new possibilities for treatment.
Researchers found that fasudil reversed reduced pyramidal neuron density and cognitive dysfunction associated with methamphetamine treatment in mice with ARHGAP10 gene mutations. Fasudil also restored the density of pyramidal neurons, improving visual discrimination tests performance.
Researchers have discovered a late-stage small molecule inhibitor called rebecsinib that reverses ADAR1-induced cancer stem cell cloning capacity. This breakthrough has significant implications for treating various types of cancers, including acute myeloid leukemia and chronic myeloid leukemia.
Scientists at the University of Illinois Chicago have found a way to selectively degrade disease-causing proteins in specific parts of cells. By studying the movement of enzymes inside cells, they discovered that attaching or detaching a fat molecule can direct where these enzymes go.
The 6th Annual Meeting of the Labroots Drug Discovery & Development Virtual Event Series will bring together specialists to discuss ongoing research in drug discovery and development. Keynote speaker Professor Kevin Pfleger will present novel pharmacology findings, while attendees can earn free CE credits.
The IMPACTIVE project aims to develop a sustainable alternative to traditional pharmaceutical production methods. By leveraging mechanochemistry, the team hopes to reduce waste and emissions in the industry. The initiative has already shown promising results, with potential cost savings of up to 12%.
Researchers at the University of Texas M. D. Anderson Cancer Center have identified CD70 as a novel therapeutic target for eliminating drug-resistant cancer cells in EGFR-mutant non-small cell lung cancer. CD70 targeting strategies showed significant anti-tumor activity, eliminating resistant cells in laboratory models.
Researchers from Tokyo University of Science discovered β-damascone, a natural aroma compound found in rose fragrance, modulates dendritic cell functions and reduces inflammatory cytokine production. The study showed β-damascone inhibits antigen-dependent activation and Th1 cell development, as well as ear inflammation in mice models.
The study uses artificial intelligence to generate new molecules with optimized properties, applicable to various industries. The method enables finding Pareto-optimal solutions, leading to more efficient materials for optoelectronics, solar energy, and other fields.
The NCI is funding a $587,000 research grant to improve KRAS treatment resistance in pancreatic cancer. Dr. Andrew Waters aims to develop personalized medicine approaches by studying unique resistance mechanisms.
Scientists at Tokyo Institute of Technology developed a new synthesis method that allows the introduction of multiple B- and Si-containing groups into aromatic nitrogen heterocycles. This breakthrough unlocks the creation of versatile platforms for organic compounds relevant to medicinal chemistry. The approach enables the production o...
Scientists have identified genes that play key roles in the development of coronary artery disease (CAD), a leading cause of death worldwide. The study found notable differences in gene activity between males and females, as well as between cells that were multiplying and those that were not.
Researchers report an updated analysis from a phase I study of mivavotinib, a spleen tyrosine kinase inhibitor, in patients with relapsed/refractory B-cell lymphoma. The study showed a 45% overall response rate and median duration of response of 28.1 months in the overall cohort.
Researchers have identified a new class of potent antimalarial compounds that target the parasite's sexual phase, preventing it from infecting mosquitoes and subsequently humans. The compounds inhibit the parasitic protein Pfs16, forming the strongest bond with the drug.
Bonn researchers create micropipette-based local perfusion of capillaries to analyze BBB transport at the cellular level, providing insights into epilepsy and drug development. The approach reveals the barrier's integrity remains largely intact, offering a tool for evaluating active ingredients' brain penetration.
A new antibacterial spray and coating can kill antibiotic-resistant bacteria, reducing the risk of infection in wounds and medical devices. The innovative material has been shown to be effective against MRSA and other resistant bacteria, offering a promising solution to combat antibiotic resistance.
A team of researchers from Korea and USA identified the importance of lipid homeostasis in overcoming brain cancer radioresistance. They found that regulating diacylglycerol kinase B and diacylglycerol acyltransferase 1 could potentially sensitize brain cancer cells to radiotherapy, offering a new treatment strategy.
In a mouse model of laser-induced CNV, RORα expression was highly increased in the choroidal/RPE complex post-laser, while loss or inhibition of RORα worsened CNV with increased lesion size and vascular leakage. RORα negatively regulates pathological CNV development by modulating angiogenic response and inflammatory environment.
Researchers found that inhibiting HSF1 signaling reduces hepatoblastoma growth and induces apoptosis, suggesting it as a viable pharmacologic target. The study also identified HSF1's role in tumor aggressiveness and its potential association with mortality.
Researchers have improved the FDA's equation for predicting drug interactions by addressing fundamental limitations and incorporating new models. The modified equation has shown a significantly increased accuracy of about 80%, which is expected to contribute to increasing the success rate of new drug development.
Researchers aim to develop a drug that enhances brown adipose tissue response to cold exposure, potentially treating hypothermia and arctic exploration challenges. The new screening method could also optimize drug development for diseases and infections, reducing costs and time.
Researchers at University of Nottingham have discovered a new mechanism to block the Mannose Receptor, which is present in key immune cells and can be hijacked by viruses and some cancers. Synthetic glycopolymers have been designed to trap the receptor within the cell, inhibiting its function.
Researchers have developed a novel portable and low-cost macroscopic mapping system for all-optical cardiac electrophysiology using optogenetics and machine vision cameras. The system can stimulate and image engineered networks of human heart cells, providing insights into cardiac wave function and stability.
Ceramides accumulate in aged muscle, impairing its function and affecting functional capacity in older adults. This finding encourages researchers to develop potential pharmaceutical agents to combat sarcopenia and age-related diseases.
Research suggests that frequent antibiotic use may heighten the risk of inflammatory bowel disease among older adults. The study found a cumulative risk, with the highest risk observed 1-2 years after antibiotic exposure, particularly for those targeting gut infections.
Researchers at Rice University have developed a multiplex base-editing platform that significantly improves the pace of new drug discovery by inducing fungi to produce more bioactive compounds. The technique has been deployed as a tool for mining fungal genomes for medically useful compounds, reducing research timeline by over 80%.
New research finds Filamin A positions GABA-B receptors to control brain activity and slow down electric impulses. This discovery could lead to new therapies for neurological disorders such as Multiple Sclerosis and epilepsy.
The INFLOW project has developed a unique state-of-the-art technology platform in Europe for the flow production of bio-degradable carrier materials and their efficient formulation. This technology enables companies to create new products with high potential for healthcare, food/feed, and cosmetics industries.