Researchers from Korea University Medicine have discovered a potential therapeutic target for overcoming cisplatin resistance and neuropathic pain in cervical cancer. By inhibiting TRPV1, they found that resistant tumors became vulnerable to cisplatin, improving the outlook for patients.
SourceKorea University College of Medicine·JournalNature Communications·TypeExperimental study·DateJul 20, 2023
A study published in Science reveals that ganglia in the neck region are responsible for disrupting melatonin production and causing sleep disturbances in people with heart conditions. Researchers found that macrophages accumulate in the ganglion, leading to inflammation and scarring, which can be treated with drugs.
SourceTechnical University of Munich (TUM)·JournalScience·TypeExperimental study·DateJul 20, 2023
Researchers at Tokyo University of Science successfully synthesized tanzawaic acid B in large amounts, paving the way for new antibiotic development. The breakthrough method could lead to creation of various compounds for pharmaceuticals, including new antibiotic candidates.
SourceTokyo University of Science·JournalACS Omega·TypeExperimental study·DateJul 19, 2023
Researchers from Osaka University identified ten blood proteins associated with mortality in severe burns, including HBA1, TTR, and SERPINF2. These proteins may serve as targets for developing new treatment methods for burns, offering a promising direction for future research.
SourceOsaka University·JournaliScience·TypeObservational study·DateJul 18, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
The latest Alzheimer's drug, donanemab, has shown encouraging results in slowing cognitive decline by 35% compared to placebo in patients with low-to-intermediate levels of tau. However, its effectiveness is limited for those with more advanced disease, and risks include serious side effects such as amyloid-related imaging abnormalities.
SourceUniversity of California - San Francisco·JournalJAMA·DateJul 17, 2023
Rice University chemist Han Xiao has won a $3.2 million research grant from the National Cancer Institute to develop an epigenetic inhibitor targeting bone metastasis. The drug, based on existing bisphosphonates, aims to prevent cancer cells from spreading to other organs without affecting normal tissues.
A new biomarker, MTBR-tau243, tracks Alzheimer's disease progression by measuring levels of a specific form of tau in cerebrospinal fluid. The finding has major implications for diagnosing and staging the disease, and could accelerate the development of effective treatments.
SourceWashU Medicine·JournalNature Medicine·TypeObservational study·DateJul 13, 2023
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A team from the University of Tokyo combines economic theory with biology to understand how natural systems respond to change. They use the Slutsky equation to discover that different metabolic systems share previously unknown universal properties, which can be understood using tools from other academic fields.
SourceUniversity of Tokyo·JournalPhysical Review Letters·TypeData/statistical analysis·DateJul 13, 2023
Researchers have identified a unique role for certain immune receptors in leprosy infections, which could lead to new treatments. The study found that targeting a specific glycolipid and its interaction with an immune receptor may offer an alternative approach to current antibiotic-heavy treatment.
SourceAmerican Chemical Society·JournalACS Central Science·DateJul 12, 2023
A new study published in Developmental Cell reveals that a signal produced by neurons is essential for the proper formation of the blood-brain barrier during embryonic development and helps maintain its integrity throughout adulthood. The findings could lead to more effective ways of delivering cancer or psychiatric medicines into the ...
SourceHarvard Medical School·JournalDevelopmental Cell·DateJul 12, 2023
The 'Fastball' test, a non-invasive EEG assessment, shows promise in detecting Alzheimer's disease earlier with a high success rate and minimal user interaction. With the new £1.5m funding, researchers aim to scale up testing and develop the technology for wider NHS rollout.
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers have discovered a new target for antibiotics that could treat multi-drug resistant superbugs. The antibiotic AMC-109 affects the cell membrane of bacteria by disordering its organization, leading to the death of the bacterium. This approach may also break down resistance to old-fashioned antibiotics.
SourceUniversity of Groningen·JournalNature Communications·TypeExperimental study·DateJul 11, 2023
Researchers at Nanyang Technological University discover ponatinib, an existing cancer drug, can block key steps in alternative lengthening of telomeres (ALT) mechanism. This could lead to new treatment options for ALT cancers, which currently lack targeted therapies.
SourceNanyang Technological University·JournalNature Communications·DateJul 10, 2023
Researchers at the University of Virginia Health System have identified a novel mechanism by which hair cells can repair themselves after damage. This breakthrough understanding has the potential to develop new treatments for age-related hearing loss and other conditions.
SourceUniversity of Virginia Health System·JournaleLife·DateJul 10, 2023
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A novel association of t(5;17) with t(8;21) has been reported in an acute myeloid leukemia (AML) patient, resulting in a RUNX1-RUNX1T1 rearrangement. The patient received chemotherapy and stem cell transplantation, highlighting the importance of this rare translocation.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeCase study·DateJul 7, 2023
Research leaders collaborate with organizations and regulators to develop digital tools for Parkinson's clinical trials. The Digital Drug Development Tools initiative accelerates the regulatory endorsement of these tools, enabling more objective and patient-centered measures.
SourceCritical Path Institute (C-Path)·JournalJournal of Parkinson’s Disease·DateJul 6, 2023
An international team of chemists has successfully used structural editing to insert a four-membered molecular ring into an aromatic ring, creating a complex bicyclic ring system. The new process utilizes visible-light photocatalysis, providing environmentally friendly and atom-economical conditions.
SourceUniversity of Münster·JournalScience·TypeExperimental study·DateJul 6, 2023
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers at Helmholtz Munich discovered that DHODH inhibitors sensitize cancer cells to ferroptosis by inhibiting ferroptosis suppressor protein-1 (FSP1), not DHODH itself. This finding confirms the crucial role of FSP1 in ferroptosis surveillance and opens up new avenues for developing effective cancer therapies.
SourceHelmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH))·JournalNature·DateJul 4, 2023
Researchers have developed a technology to capture and release cell-free DNA from urine using nanowire surfaces, successfully detecting IDH1 mutation in glioma patients. This method opens possibilities for the detection of other tumor mutations and could revolutionize cancer diagnosis.
SourceNagoya University·JournalBiosensors and Bioelectronics·DateJul 2, 2023
Researchers at UC San Diego found a novel combination of KRAS and ERBB drug inhibitors outperformed treatments in human and mouse models of pancreatic cancer. The combination reduced drug resistance and increased survival rates.
SourceUniversity of California - San Diego·JournalCancer Research·DateJun 28, 2023
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers explore pyroptosis as a potential therapeutic approach for lung cancer treatment. The review highlights the dual role of pyroptosis in tumor progression and negative impact on normal cells. It suggests balancing the contradictory effects of pyroptosis to optimize clinical applications.
SourceCactus Communications·JournalChinese Medical Journal - Pulmonary and Critical Care Medicine·TypeLiterature review·DateJun 28, 2023
Researchers investigate MCL-1i-induced Mcl-1 protein accumulation and its implications in B-cell malignancies. The study reveals a complex mechanism contributing to MCL-1 protein stability upon treatment with MCL-1 inhibitors.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateJun 28, 2023
A large international collaboration has identified a genetic variant associated with faster disease progression in multiple sclerosis, highlighting the need to focus on nervous system resilience and repair. The study found that individuals with two copies of the gene variant experience accelerated disability due to MS.
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers at Baylor College of Medicine have discovered a drug called DEQ that significantly reduces the ability of bacteria to develop antibiotic resistance. The study shows that DEQ works by slowing down genetic mutations in bacteria, thereby prolonging the effectiveness of antibiotics.
SourceBaylor College of Medicine·JournalScience Advances·TypeExperimental study·DateJun 23, 2023
The study found that drug-resistant Leishmania parasites have distinct protein production profiles compared to sensitive parasites, suggesting a global reprogramming of protein synthesis. This pre-emptive adaptation enables the parasite to quickly respond to the presence of the drug and survive when it is absent.
SourceTexas Tech University Health Sciences Center·JournalNature Communications·TypeExperimental study·DateJun 22, 2023
Recent studies in the New Journal of Pharmaceutical Analysis feature novel diagnostic tools, RNA sequencing-based workflows, and mechanical property evaluations to enhance cancer and cardiovascular disease treatment outcomes. These innovations aim to improve the therapeutic effect of drugs and promote personalized medicine.
SourceCactus Communications·JournalJournal of Pharmaceutical Analysis·TypeExperimental study·DateJun 21, 2023
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers developed a more accurate model of human cardiac fibrotic tissue, which could enable quicker drug testing and potentially lead to new therapies for heart failure. The model, built using an electrospinning technique, recreates the unique aspects of scarred cardiac tissue.
SourceAmerican Chemical Society·JournalACS Biomaterials Science & Engineering·DateJun 20, 2023
Researchers developed a new therapeutic molecule that activates WNT signaling to restore the blood-brain barrier's normal function. The treatment showed promise in treating conditions such as multiple sclerosis and ischemic stroke by reducing the severity of strokes and improving survival rates.
SourceStanford Medicine·JournalNature Communications·DateJun 20, 2023
Researchers have developed methods to produce polyphenolic compounds with improved solubility through microbial fermentation, enabling potential life-saving drugs. The process, called glycosylation, attaches sugar molecules to the compounds, making them more effective in preventing diseases such as cancer and heart disease.
SourceUtah State University·JournalBiotechnology Advances·TypeExperimental study·DateJun 14, 2023
The FDA has issued a Biomarker Letter of Support for four novel biomarkers identifying drug-induced pancreatic injury. These microRNAs will enhance the detection of acute drug-induced pancreatic injury (DIPI) in phase 1 clinical trials, improving safety and accuracy.
Researchers have made progress in generating stem cell-derived beta cells, but current methods are costly and labor-intense. A recent study has found a simple method to address these issues, enhancing maturation and functionality of sBCs.
SourceInternational Society for Stem Cell Research·JournalStem Cell Reports·DateJun 13, 2023
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Research by West Virginia University professor Sean Tu found that orphan drugs earn pharmaceutical companies almost as much as those marketed to the general public. The Orphan Drug Act incentivizes companies with tax credits, longer patent exclusivity, and easier FDA review for treating rare diseases.
SourceWest Virginia University·JournalJournal of the American Medical Association·DateJun 12, 2023
Researchers at Karolinska Institutet have developed a new method called single-particle profiling (SPP) to study bioparticles in health and disease. The SPP enables the measurement of thousands of particles between 5 and 200 nanometres in size, with potential applications in vaccine development and creating more effective nanocarriers.
SourceKarolinska Institutet·JournalNature Biotechnology·DateJun 12, 2023
Researchers have made a breakthrough in treating melanoma by adding an mRNA vaccine tailored to individual tumour genetics to common immunotherapy, significantly improving survival and disease recurrence rates. After two years, cancer-free survival increased to 78.6%, and the risk of death or cancer returning was reduced by 44%.
SourceEdith Cowan University·TypeRandomized controlled/clinical trial·DateJun 8, 2023
A team of Japanese researchers has successfully developed a recycling photoreactor that enables the synthesis of optically pure compounds with high yields, achieving an optical purity of 98-99%. The system uses a two-step rapid photoracemization process and can produce enantiomerically pure chiral sulfoxides in yields higher than 80%.
SourceTokyo University of Science·JournalThe Journal of Organic Chemistry·TypeExperimental study·DateJun 6, 2023
Researchers found that malaria parasites synchronize their gene expression with the host's internal clock, repeating every 24 hours. The study reveals a potential new target for anti-malarial drugs by 'jet-lagging' the parasites' clocks.
SourceDuke University·JournalProceedings of the National Academy of Sciences·TypeObservational study·DateJun 6, 2023
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
A study published in Brain Behavior and Immunity found autoantibodies against a synaptic adhesion protein, neurexin 1α, in patients with schizophrenia. In mice, these autoantibodies caused schizophrenia-related changes, including reduced social behavior and cognitive function.
SourceTokyo Medical and Dental University·JournalBrain Behavior and Immunity·DateMay 31, 2023
Researchers used AI to identify a compound that kills Acinetobacter baumannii, a bacterium responsible for many drug-resistant infections. The new antibiotic shows promise in combating this growing public health threat.
SourceMassachusetts Institute of Technology·JournalNature Chemical Biology·TypeComputational simulation/modeling·DateMay 25, 2023
Researchers have developed new methods to analyze dry-coated drug particles using 3D Raman mapping, which can effectively slow down dissolution rates. Another study introduces a novel technique for detecting complex traditional Chinese medicines, preventing adulteration and counterfeiting.
SourceCactus Communications·JournalJournal of Pharmaceutical Analysis·TypeExperimental study·DateMay 24, 2023
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers found that apoE4 poorly binds factor H, a regulatory factor of immunity, leading to amyloid-β oligomerization and neuroinflammation. This could be a potential solution to preventing Alzheimer's disease, with further research needed to find a bridging molecule.
SourceUniversity of Helsinki·JournalEMBO Reports·DateMay 23, 2023
Pharmaceutical scientists from the National University of Singapore have developed multi-functional synthetic peptide nanonets for relieving inflammation caused by bacterial infection. These nanonets trap bacterial endotoxins and pro-inflammatory cytokines, achieving anti-inflammatory activity through selective binding.
SourceNational University of Singapore·JournalAdvanced Healthcare Materials·TypeExperimental study·DateMay 23, 2023
Researchers from Rice University and Baylor College of Medicine are developing a new 'glyco-immune' checkpoint inhibitor to train the immune system to target and kill breast cancer metastasis in bones. The therapy has shown promise in preliminary tests, including eradicating cancer in some animals.
Researchers from China explore the mechanisms of action and clinical data of bispecific antibodies, which have shown promise in increasing cytotoxicity against cancerous cells and enhancing immune response towards tumor clearance. Several bsAbs are being evaluated in phase I-III clinical trials for lung cancer treatment.
SourceCactus Communications·JournalChinese Medical Journal·DateMay 16, 2023
Researchers at MIT's Picower Institute used a nematode worm to study serotonin's effects on behavior and brain activity. They identified three key receptors driving slowing behavior and found complex interactions between serotonin receptors modulating brain-wide activity.
SourcePicower Institute at MIT·JournalCell·TypeExperimental study·DateMay 15, 2023
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers at Dartmouth Cancer Center found that alternating estrogen stimulation and anti-estrogen therapy is an effective treatment for patients with metastatic or advanced ER+ breast cancer. The POLLY trial showed that 42% of patients experienced tumor stabilization, while no patients discontinued treatment due to side effects.
SourceDartmouth Health·JournalClinical Cancer Research·TypeRandomized controlled/clinical trial·DateMay 15, 2023
A team led by Professor Timo Betz has developed a 3D cell culture chamber to grow muscle and other tissue using high-resolution microscopy. The new system will enable scientists to mimic the mechanical situations that confront various living tissues in serious conditions, reducing animal testing and costs.
Clinical studies with children as participants often require more time, people, and resources than initially budgeted. The study found that pediatric clinical studies cost 59% more on average than the initial proposal, highlighting a need for accurate budgeting.
SourceUniversity of Gothenburg·JournalActa Paediatrica·TypeData/statistical analysis·DateMay 11, 2023
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
A research team at Hokkaido University has developed a system to deliver antioxidants to mitochondria in the liver, reducing oxidative stress and damaging caused by ROS. The system, called CoQ10-MITO-Porter, was found to be more effective when downsized particles were used.
SourceHokkaido University·JournalScientific Reports·TypeExperimental study·DateMay 10, 2023
A new advanced artificial intelligence system has been developed in the UK that can accurately identify protein patterns within individual cells. The HCPL system uses a deep-learning model to quickly and accurately determine subcellular structures where proteins are present.
SourceUniversity of Surrey·JournalCommunications Biology·DateMay 10, 2023
KNT-127 exhibits anti-stressing and anti-depressant effects in mice, improving social interaction and reducing stress-induced hormone levels. The agent suppresses neuronal inflammation and newborn death without affecting neurogenesis.
SourceTokyo University of Science·JournalNeuropharmacology·TypeExperimental study·DateMay 8, 2023
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
SourceXi'an Jiaotong-Liverpool University·JournalNano Letters·TypeExperimental study·DateMay 8, 2023
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A multi-institutional phase 3 clinical trial found that a cancer stem cell test can accurately decide more effective treatments and lead to increased survival for patients with recurrent glioblastoma. ChemoID, a CLIA-accredited diagnostic test, was used to select chemotherapy treatments, resulting in significantly lower risk of death a...
SourceUniversity of Cincinnati·JournalCell Reports Medicine·TypeRandomized controlled/clinical trial·DateMay 5, 2023
A major international study found that women taking certain epilepsy medicines during pregnancy are at a higher risk of having children develop severe psychiatric disorders. The study, which analyzed data from 38,000 children, highlights the importance of carefully weighing the risks and benefits of medication use during pregnancy.
SourceAarhus University·JournalJAMA Neurology·TypeData/statistical analysis·DateMay 4, 2023
Researchers have observed beta-arrestin molecules directly controlling receptor-mediated signals in living cells using advanced microscopy. The study reveals a new mechanism of how these proteins interact with receptors on the plasma membrane, enabling efficient control of signal flow and desensitization.
SourceUniversity of Birmingham·JournalCell·TypeImaging analysis·DateMay 4, 2023
Researchers at the University of Missouri identified occludin protein as a mediator for cell-to-cell transmission of coronavirus. The study found that damaged occludin protein enables virus replication and spread to neighboring cells, worsening symptoms.
SourceUniversity of Missouri-Columbia·JournalProceedings of the National Academy of Sciences·TypeImaging analysis·DateMay 1, 2023
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A team of researchers conducted the largest proteomic study on yeast cells to gain a detailed picture of previously unknown gene functions. The study revealed general principles governing protein expression and identified thousands of proteins with their biophysical properties.
SourceCharité - Universitätsmedizin Berlin·JournalCell·TypeExperimental study·DateApr 27, 2023
A new review paper highlights the potential of fungal biotechnology to advance various industries. By manipulating fungal genomes, researchers can develop bioinformatic tools and create sustainable biomaterials, such as machine learning algorithms for predicting mycological patterns or fungal batteries.
SourceOhio State University·JournalFrontiers in Fungal Biology·TypeLiterature review·DateApr 20, 2023
A new liposome-based method aims to kill periodontitis-causing leukotoxin while protecting immune cells, providing an alternative treatment for aggressive gum infections. The approach has potential applications against a range of bacteria and could help combat antibiotic resistance.
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
The collaboration between CiTOS Lab at ULiège and Mithra Pharmaceuticals enables the development of an efficient biosourced estetrol production process. The thermolysis reaction yields a key intermediate with unprecedented productivity, allowing for several million doses to be achieved with minimal global footprint.
SourceUniversity of Liège·JournalReaction Chemistry & Engineering·DateApr 20, 2023
A drug called teriflunomide has been found to delay the first symptoms of multiple sclerosis in people with radiologically isolated syndrome. In a preliminary study, researchers found that those taking teriflunomide had a 72% lower risk of experiencing first symptoms than those taking a placebo.