Researchers have developed a novel portable and low-cost macroscopic mapping system for all-optical cardiac electrophysiology using optogenetics and machine vision cameras. The system can stimulate and image engineered networks of human heart cells, providing insights into cardiac wave function and stability.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateJan 11, 2023
Researchers at University of Nottingham have discovered a new mechanism to block the Mannose Receptor, which is present in key immune cells and can be hijacked by viruses and some cancers. Synthetic glycopolymers have been designed to trap the receptor within the cell, inhibiting its function.
SourceUniversity of Nottingham·JournalJournal of the American Chemical Society·TypeExperimental study·DateJan 11, 2023
Ceramides accumulate in aged muscle, impairing its function and affecting functional capacity in older adults. This finding encourages researchers to develop potential pharmaceutical agents to combat sarcopenia and age-related diseases.
SourceUniversity of Helsinki·JournalNature Aging·DateJan 10, 2023
Research suggests that frequent antibiotic use may heighten the risk of inflammatory bowel disease among older adults. The study found a cumulative risk, with the highest risk observed 1-2 years after antibiotic exposure, particularly for those targeting gut infections.
SourceBMJ Group·JournalGut·TypeObservational study·DateJan 9, 2023
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers at Rice University have developed a multiplex base-editing platform that significantly improves the pace of new drug discovery by inducing fungi to produce more bioactive compounds. The technique has been deployed as a tool for mining fungal genomes for medically useful compounds, reducing research timeline by over 80%.
SourceRice University·JournalJournal of the American Chemical Society·TypeExperimental study·DateJan 6, 2023
New research finds Filamin A positions GABA-B receptors to control brain activity and slow down electric impulses. This discovery could lead to new therapies for neurological disorders such as Multiple Sclerosis and epilepsy.
SourceUniversity of Birmingham·JournalNature Communications·TypeObservational study·DateJan 4, 2023
Researchers at Hokkaido University have developed a new class of antibacterial compounds targeting MraY, effective against MRSA and VRE. The findings provide a promising lead for the development of more effective antibiotics against multidrug-resistant bacteria.
SourceHokkaido University·JournalNature Communications·TypeExperimental study·DateDec 20, 2022
The INFLOW project has developed a unique state-of-the-art technology platform in Europe for the flow production of bio-degradable carrier materials and their efficient formulation. This technology enables companies to create new products with high potential for healthcare, food/feed, and cosmetics industries.
The American Roentgen Ray Society has awarded the 2023 ARRS Gold Medal to Dr. Bernard F. King, Jr., MD, FACR, FSAR, in recognition of his distinguished service to radiology. Dr. King has made significant contributions to the field, including the development of contrast media recognition and treatment protocols.
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A recent study suggests that stimulating the intersection of two particular brain networks correlated with better patient outcomes than stimulating nearby sites for patients with Alzheimer's disease. Cognitive improvement was associated with DBS to the direct interface between the fornix and bed nucleus of the stria terminalis.
SourceBrigham and Women's Hospital·JournalNature Communications·TypeRandomized controlled/clinical trial·DateDec 14, 2022
Salk scientists have developed a new therapeutic compound called FexD, which reverses gut inflammation in mouse models of inflammatory bowel disease. By activating the master regulator protein FXR, FexD reduces inflammation and restores balance to the digestive system.
SourceSalk Institute·JournalProceedings of the National Academy of Sciences·DateDec 12, 2022
Scientists create an artificial brain in a petri dish to study the effects of the Zika virus. The study reveals that viral noncoding RNA helps the virus evade antiviral responses and cause cell death in developing brains.
SourceUniversity of Queensland·JournalScience Advances·DateDec 11, 2022
WEHI researchers have visualized how a non-insulin molecule can mimic the role of insulin, opening new avenues for an oral insulin pill. The study confirms alternative molecules can be used to turn on blood glucose uptake, bypassing insulin needs.
SourceWalter and Eliza Hall Institute·JournalNature Communications·TypeExperimental study·DateDec 11, 2022
A team of researchers at Tokyo Medical and Dental University has designed and synthesized novel compounds that have the potential to be effective drugs against COVID-19. The compounds target the main protease enzyme of the SARS-CoV-2 virus, which is essential for viral replication.
SourceTokyo Medical and Dental University·JournaliScience·DateDec 9, 2022
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A team from Tohoku University has developed an efficient synthesis of (-)-quinine, a key compound in malaria treatment, enabling further medication development. The new method uses organocatalyst-mediated reactions, reducing the number of steps and chemical waste.
SourceTohoku University·JournalNature Communications·DateDec 8, 2022
Researchers at USC developed a 'heart attack on a chip' device to study heart attacks and test new personalized medicines. The device replicates the effects of an oxygen gradient on cardiac tissue function, shedding light on the mysteries of heart cell communication and change after a heart attack.
SourceUniversity of Southern California·JournalScience Advances·TypeExperimental study·DateDec 7, 2022
A retrospective cohort study of 1,404 subjects with type 2 diabetes found that metformin use reduced the risk of delirium by 50% and decreased 3-year mortality rates. The study suggests that metformin may be a potential benefit for patients with diabetes, particularly in reducing age-related disorders such as dementia.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateDec 7, 2022
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers at Tokyo University of Science have developed a unique 3D COF with scu-c topology, exhibiting efficient gas adsorption and drug delivery capabilities. The material has been shown to exhibit excellent hydrogen and methane adsorption properties.
SourceTokyo University of Science·JournalACS Applied Materials & Interfaces·TypeExperimental study·DateDec 5, 2022
A team of scientists has identified three new biomarkers for detecting the consumption of emerging synthetic cannabinoids like OXIZID. These biomarkers will facilitate work by drug enforcement agencies worldwide in monitoring OXIZID abuse, enabling more accurate identification of abusers and potentially preventing overdoses.
SourceNational University of Singapore·JournalClinical Chemistry·TypeExperimental study·DateNov 30, 2022
A research team led by City University of Hong Kong neuroscientist Dr. Geoffrey Lau Chun-yue identified a new drug candidate, D4, that selectively blocks connexin hemichannels to suppress neuroinflammation and curbs TLE seizures in a mouse model. The findings suggest a promising new treatment strategy for epilepsy.
SourceCity University of Hong Kong·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateNov 23, 2022
A trial found that extending anti-clotting treatment after a blood clot in the lower leg reduced further clot risk up to two years. Rivaroxaban administered for three months effectively and safely reduced venous thromboembolism compared to six weeks of treatment.
SourceBMJ Group·JournalThe BMJ·TypeRandomized controlled/clinical trial·DateNov 23, 2022
A team from UNIGE has revealed the existence of a hidden 'pocket' on the surface of the non-structural protein Nsp1, which could be used to develop new treatments against Covid-19. This discovery paves the way for innovative therapies targeting the Nsp1 protein and its potential application against other coronaviruses.
SourceUniversité de Genève·JournaleLife·TypeNews article·DateNov 22, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A team of researchers developed a new strategy to functionalize the 'meta-position' of pyridines, which is extremely challenging and rare. They achieved high selectivity in introducing various functional groups into this position using temporary de-aromatization and radical/polar chemistry.
The FDA's investigation into its own oversight of clinical trials reveals a concerning lack of surveillance, leaving room for scientific misconduct. Experts argue that the agency should inspect sites more frequently to ensure data quality and integrity.
SourceBMJ Group·JournalThe BMJ·TypeNews article·DateNov 16, 2022
Researchers have found that gossypetin from hibiscus activates microglia in the brain, which scavenge amyloid-beta aggregates to prevent cognitive decline. The study suggests a potential treatment for Alzheimer's disease using this flavonoid compound.
SourcePohang University of Science & Technology (POSTECH)·JournalAlzheimer s Research & Therapy·DateNov 15, 2022
Researchers at Lund University have discovered that people with Alzheimer's disease can be identified before symptoms appear, using PET scans to visualize tau and amyloid proteins in the brain. Participants found to have these biomarkers were at a 20-40 times higher risk of developing cognitive decline in the next few years.
SourceLund University·JournalNature Medicine·DateNov 11, 2022
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers found that MK256 induced differentiation and maturation in leukemia stem cells, inhibiting proliferation of AML cell lines. The study also showed dose-dependent inhibition of the STAT pathway in both in vitro and in vivo studies.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateNov 10, 2022
The study reveals the structure of the 15-subunit IFT-B complex, a crucial component in cilia formation and maintenance. The complex's elongated and flexible nature is consistent with previous low-resolution reconstructions, and two configurations are identified that may drive bi-directional movement.
SourceAarhus University·JournalThe EMBO Journal·TypeExperimental study·DateNov 10, 2022
Researchers at OHSU discovered adenosine effectively acts as a brake to dopamine, promoting balance in neuronal signaling. This finding suggests new avenues for drug development to treat Parkinson's disease symptoms by targeting the push-pull dynamic between dopamine and adenosine.
SourceOregon Health & Science University·JournalNature·TypeExperimental study·DateNov 9, 2022
Researchers have developed a transport nanoparticle to deliver an anti-inflammatory drug, Necrosulfonamide (NSA), directly into macrophages to combat inflammatory overactivation. The mesoporous silica nanoparticle is fully biodegradable and non-toxic, showing remarkable efficacy in reducing inflammation.
SourceUniversité de Genève·JournalJournal of Controlled Release·TypeNews article·DateNov 8, 2022
Regular use of cholesterol-lowering and diabetes-control drugs may lessen the risk of age-related macular degeneration (AMD) in European populations. The pooled data analysis involved 38,694 participants and showed a 15% lower prevalence of any type of AMD with these medications.
SourceBMJ Group·JournalBritish Journal of Ophthalmology·TypeMeta-analysis·DateNov 7, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Letrozole, a breast cancer treatment drug, shows promise in suppressing liver fibrosis through inhibition of the CTGF pathway and reduction of Hsd17b13 expression. This repurposed approach may lead to new treatments for liver disease.
SourceNiigata University·JournalJournal of Gastroenterology·DateNov 7, 2022
Researchers from UCLA have developed a strategy to identify novel treatments for cognitive decline and neurodegenerative diseases by exploiting sex differences in the brain. The study provides a roadmap for disentangling the contribution of sex-specific factors, which can yield treatments optimized for each sex.
SourceUniversity of California - Los Angeles Health Sciences·JournalJournal of Experimental Medicine·DateNov 4, 2022
Researchers found that rapamycin treatment during developmental growth phase decelerates aging rate and extends lifespan in animals. A transient late-life treatment is not effective, but a transient early-life treatment can reprogram aging.
SourceImpact Journals LLC·JournalAging-US·TypeCommentary/editorial·DateNov 3, 2022
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers identified specific monkeypox mutations that contribute to its continued infectiousness. The virus is accumulating mutations where drugs and antibodies from vaccines are supposed to bind, making it smarter and more infectious.
SourceUniversity of Missouri-Columbia·JournalJournal of Autoimmunity·TypeExperimental study·DateNov 3, 2022
A recent study found worsening disparities in cancer drug trial participant diversity from 2000 to 2018, highlighting systemic biases and unequal access to new treatments. The findings underscore the need for increased diversity in phase 1 clinical trials to ensure equitable access to life-saving treatments.
SourceJAMA Network·JournalJAMA Network Open·DateNov 3, 2022
A study by CeMM researchers and the University of Dundee identifies mutations in E3 ligases that mediate resistances in cell cultures, but also finds that these mutations can be targeted by chemically modified degraders. This understanding has clinical relevance and enables further improvement of cancer therapy drugs.
SourceCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences·JournalNature Chemical Biology·DateNov 3, 2022
A new study found that only 12% of middle-aged adults are willing to participate in dementia prevention drug trials, citing concerns over the risks involved. The study suggests prioritizing those with a family history or perceived personal risk for dementia and communicating about trial safety could increase participation.
SourceMichigan Medicine - University of Michigan·JournalThe Journal of Prevention of Alzheimer s Disease·TypeSurvey·DateNov 2, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers mapped the detailed neural pathway of defensive responses from the gut to the brain in mice after detecting germs. The study could lead to better anti-nausea medications for cancer patients undergoing chemotherapy.
SourceCell Press·JournalCell·TypeExperimental study·DateNov 1, 2022
The research reveals PAPP-A's heart-shaped structure and its interaction with STC2, a key regulator of IGF conversion. The study suggests that complex formation between PAPP-A and STC2 is highly regulated, influencing height by up to 2.1 cm.
SourceAarhus University·JournalNature Communications·TypeExperimental study·DateOct 31, 2022
Researchers tracked COVID-19 symptoms in 158 untreated participants for 29 days and found that more than one-third experienced a return of symptoms after at least two consecutive days of being symptom-free. The most common relapsing symptoms were cough, fatigue, and headache.
SourceUniversity of California - San Diego·JournalJAMA Network Open·DateOct 31, 2022
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers at Kyoto University have developed a prodrug form of curcumin called TBP1901, which has shown anti-tumor effects without causing harm. The study found that TBP1901's conversion to active curcumin is dependent on the enzyme GUSB, suggesting its potential therapeutic targets.
SourceKyoto University·JournalEuropean Journal of Pharmacology·TypeExperimental study·DateOct 27, 2022
A phase I clinical trial found that Omomyc (OMO-103) has few side effects and can stabilize disease in some patients. The treatment showed stabilization of disease in 8 out of 17 evaluable patients, including one patient with pancreatic cancer who remained on the study for over six months.
Researchers at UC San Diego identified a new signaling process involving GPCRs, suggesting untapped potential for therapies, including for multiple forms of cancer. The study challenges traditional views on GPCR-mediated signaling, revealing a new mechanism that originates at endosomes and propagates into the nucleus.
SourceUniversity of California - San Diego·JournalNature·DateOct 26, 2022
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers at VCU Massey Cancer Center have identified a new therapeutic target for triple-negative breast cancer (TNBC), a more aggressive and deadly form of disease. Using CRISPR/CAS9 screening, scientists pinpointed the UBA1 enzyme as an ideal target, which can be inhibited by the novel drug TAK-243 to effectively kill cancer cells.
SourceVirginia Commonwealth University·JournalPNAS Nexus·DateOct 25, 2022
Researchers have found a drug that targets the key, cancer-causing gene MYC has been able to inhibit its function safely and effectively. Eight out of 12 patients showed stabilisation of disease after treatment with OMO-103, with one patient experiencing a reduction in tumour-derived DNA circulating in the blood stream.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeRandomized controlled/clinical trial·DateOct 25, 2022
A novel oxytocin derivative, PAS-CPPs-oxytocin, has been shown to improve cognitive function in mice with Alzheimer's-like symptoms. The derivative is delivered via intranasal administration and shows increased brain penetration compared to traditional intracerebroventricular delivery.
SourceTokyo University of Science·JournalNeuropsychopharmacology Reports·TypeExperimental study·DateOct 24, 2022
Researchers developed a new method to study membrane proteins in their native environment, the cell, using electron spin resonance spectroscopy. This technique allows for precise determination of protein properties and could lead to better understanding and targeting of membrane proteins involved in anti-cancer drug resistance.
SourceUniversité de Genève·JournalScience Advances·TypeNews article·DateOct 24, 2022
Researchers from Yokohama National University successfully generated hair follicles in cultures using organoid cultures. The study demonstrates the potential of hair follicle organoids for understanding hair follicle development and regeneration, as well as evaluating drugs for treating hair loss disorders.
SourceYokohama National University·JournalScience Advances·DateOct 21, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers have developed a novel method for antibiotic resistance testing that can analyze bacterial cells in real-time, allowing for faster identification of susceptible and resistant bacteria. This breakthrough technology has the potential to transform microbial screening in clinical and research labs.
SourceNara Institute of Science and Technology·JournalACS Sensors·DateOct 21, 2022
Researchers have successfully blocked the adhesion mechanism of Bartonella henselae bacteria, preventing cell infection. The discovery offers a promising new approach to combat highly resistant infectious agents like Acinetobacter baumannii.
SourceGoethe University Frankfurt·JournalMicrobiology Spectrum·TypeExperimental study·DateOct 19, 2022
Scientists are conducting a first-of-its-kind study to investigate the origin of psychedelic compounds in fungi, including psilocybin found in 'magic mushrooms'. The research aims to understand the evolution of these compounds and their potential applications in medicine and conservation.
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
The study reveals how the activating partner PI5P interacts with two different regions of regulatory protein UHRF1, showing its role in modulating complex proteins. This finding could breathe new life into the search for UHRF1-directed medicines.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalScience Advances·DateOct 9, 2022
The Critical Path Institute has launched a pre-consortium collaboration with the FDA's CBER and CDER to accelerate medical product development in alpha-1 antitrypsin deficiency. The collaboration aims to define unmet needs in drug development and lay the groundwork for specific solutions.
SourceCritical Path Institute (C-Path)·TypeData/statistical analysis·DateOct 6, 2022
Coskun's team has developed SpatialVizScore, a new method that visualizes tumor immunology in cancer tissues to identify patients more likely to respond to immunotherapy. The system looks at the interactions of multiple immune cells, including macrophages with subtypes M1 and M2.
SourceGeorgia Institute of Technology·Journalnpj Precision Oncology·TypeMeta-analysis·DateOct 6, 2022
A new study from Flinders University has shown that reboxetine, previously used to treat depression, can reduce obstructive sleep apnoea (OSA) severity. The study found that reboxetine alone reduces the number of sleep apnoea events per hour and improves oxygen levels.
SourceFlinders University·JournalJournal of Clinical Sleep Medicine·TypeRandomized controlled/clinical trial·DateOct 5, 2022
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A new drug capsule developed at MIT may be able to replace injections for biologic drugs by tunneling through the mucus barrier in the small intestine. The capsule's robotic cap spins and displaces mucus, allowing drugs to pass into cells lining the intestine.
SourceMassachusetts Institute of Technology·JournalScience Robotics·DateSep 28, 2022
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
SourceXi'an Jiaotong-Liverpool University·JournalMaterials Today Chemistry·TypeExperimental study·DateSep 28, 2022
Researchers at the University of Arizona have identified a protein called Ait1 that regulates cell growth in yeasts. This discovery presents new targets for developing antifungal drugs that can attack disease-causing yeasts while sparing human immune cells.
SourceUniversity of Arizona·JournaleLife·TypeExperimental study·DateSep 28, 2022
Researchers found no link between R&D costs and high drug prices in the US, contradicting industry claims. Despite $83 billion spent on R&D in 2019, drug prices are driven by market demand rather than investment costs.
SourceUniversity of California - San Diego·JournalJAMA Network Open·DateSep 26, 2022