Articles tagged with Drug Development
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers found that individuals with a diverse population of macrophage cells, which include M2 and regulatory macrophages, are better protected against severe COVID-19. The study suggests that a balance between pro-inflammatory and anti-inflammatory responses is key to preventing the worst symptoms.
Researchers developed a new software tool, called 'meta-transcriptome detector,' that integrates genetic sequencing analysis of hosts and their microbiomes. The tool enables analysis of gene expression activity in both microbes and hosts simultaneously, allowing researchers to spot relationships between them.
Researchers developed a deep learning-based model to predict drug-drug interactions using gene expression data. The DeSIDE-DDI model can identify potentially dangerous pairs and act as a drug safety monitoring system, helping establish the correct usage of drugs in the development phase.
A study at the University of Helsinki found that a strong saline solution can quadruple morphine concentration in the spinal cord, intensifying pain relief. The glymphatic system enables faster drug delivery when administered with hypertonic solutions.
The University at Buffalo is developing new treatments for ovarian cancer by targeting the apelin receptor. Ovarian cancer cells rely on lipids for energy and survival, making this a promising therapeutic target.
Researchers used single-molecule imaging to study GPCR activation, gaining insight into cellular signal relay and potential drug targets for various disorders. The findings show that the receptor tail plays an autoinhibitory role, controlled by agonist binding, which affects signaling intensity and duration.
Researchers developed a disposable electrochemical sensor using graphite-based molecularly imprinted polymers to detect theophylline levels. The sensor can identify low concentrations of theophylline (2.5 μg/mL) in whole blood within 3 seconds, enabling real-time monitoring and potential overdose prevention.
Researchers have developed a new ligand that promotes a direct nickel-photocatalyzed cross-coupling reaction. This novel tridentate pyridinophane ligand enables the discovery of key reaction steps and intermediate species in the catalytic cycle.
A new study estimates the national economic burden of PTSD at $232.2 billion for 2018, with civilians accounting for 82% of the total costs. The study calls for increased awareness, effective therapies, and expanded evidence-based strategies to reduce the clinical and economic burden of PTSD.
The ESMO Breast Cancer Congress 2022 event will present more than 200 studies on various aspects of breast cancer, including new treatments and innovative clinical practices. The congress will be held onsite in Berlin, Germany, and online, offering a platform for breast cancer specialists to share knowledge and improve patient outcomes.
A new study reveals a gene called KLF4 that normally suppresses tumor formation but is reprogrammed in acute promyelocytic leukemia, an aggressive type of blood cancer. Overexpressing KLF4 can suppress the growth of cancerous cells and reverse the effects of the disease.
A new University of Gothenburg study has found that a drug treatment can reduce the frequency of breathing pauses in sleep apnea by an average of over 20 per hour. The treatment, which involves carbonic anhydrase inhibition, showed promising results with minimal side effects.
Researchers at Tokyo University of Science discovered that disulfiram inhibits FROUNT protein and chemokine signaling pathways, reducing anxiety levels in mice. The study suggests a potential breakthrough anti-anxiety medication with safe and effective treatment for elderly patients suffering from anxiety and insomnia.
Researchers created edible tags with fluorescent silk proteins to track medications, providing a new way for consumers to verify authenticity. The codes are readable by a smartphone app and can be ingested without causing harm.
Researchers have found that treating prostate cancer cells with novel CDK8 and CDK19 inhibitors reduces their potential to migrate into surrounding structures. This suggests a promising approach to overcome resistance against anti-androgenic therapy, offering new therapeutic options for patients with advanced disease.
The TTUHSC's C. Patrick Reynolds has received a $1.34 million CPRIT grant to investigate updating the clinical risk stratification scale for neuroblastoma and rhabdomyosarcoma, two childhood cancers in need of improved therapies.
Researchers have developed a new 3D printing technique to fabricate microfluidic devices with precise channels at the microscale. This breakthrough allows for accurate creation of channels in clear resin, enabling applications such as COVID-19 detection and cancer research.
Researchers discovered that Viagra and a common over-the-counter drug TUDCA restored mitochondrial processes, which drive heart failure in HLHS patients. This could lead to new therapies for treating heart failure without relying on heart transplants.
Recent studies published in the Journal of Pharmaceutical Analysis have found applications of nanotechnology in medicine, drug research, and environmental protection. Researchers developed nanodots made of carbon using natural polysaccharides from mushrooms to detect chromium, and created nanozymes that could be used to detect drug con...
Researchers have developed a method to chart the first-ever map of allosteric sites in two common human proteins, revealing they are abundant and identifiable. This could lead to safer, smarter, and more effective medicines by targeting these 'secret doors'.
A study by University of Gothenburg researchers has identified two biomarkers that can distinguish between patients with subcortical small-vessel disease, Alzheimer's disease, and mixed dementia. The discovery opens up new possibilities for diagnosis, treatment, and medication development.
A new deep learning-based model called Highlights on Target Sequences (HoTS) predicts binding between drugs and target molecules, providing interpretable results. The model can predict target proteins' binding regions and interactions with drugs without a 3D complex.
A new study suggests that cardamonin, a compound from the cardamom spice, can kill triple-negative breast cancer cells and reduce PD-L1 expression. The findings hold promise for improving cancer therapy without severe side effects.
A new clinical trial found that the drug mavacamten alleviates shortness of breath in patients with obstructive hypertrophic cardiomyopathy. The treatment also improves symptoms and heart failure biomarkers.
Researchers at the University of Eastern Finland have developed a novel nuclear microRNA, miR-466c, that regulates vascular endothelial growth factor A (VEGFA) expression in response to hypoxia. The drug has commercial relevance for treating ischemic cardiovascular disease by increasing VEGFA levels.
Levi A. Garraway is being honored for his groundbreaking contributions to cancer research, including the identification of melanoma genes and development of precision oncology approaches. He has also championed parallel sequencing as a definitive approach to tumor genomic profiling, revolutionizing cancer treatment strategies.
Researchers at Massachusetts General Hospital have discovered a new class of biological factors that can be targeted by small molecule drugs, including noncoding RNAs. This breakthrough could lead to new therapies for genetic disorders such as Rett syndrome and Fragile X syndrome.
Behunin's project targets challenges in practical quantum computing by controlling noise and its impact on qubits. By manipulating sound waves, he hopes to quiet the noise that corrupts information stored in quantum computers.
Researchers have identified a new mechanism of action for extracellular vesicles in the development and progression of lymphomas. sPLA2 secreted by tumor-associated macrophages degrades EV-derived phospholipids, enhancing EV function and inducing vital phenomena. This discovery may lead to new drug targets for cancer treatment.
This year's Experimental Biology 2022 meeting features groundbreaking studies on COVID-19 vaccine-associated symptoms in non-menstruating people, a plant compound showing promise for alleviating food allergies, and the potential of omega-3s to boost immunotherapy's cancer-fighting power. Researchers also explore the safety of using CBD...
Researchers developed a method to identify aggressive early-stage lung cancers and target drugs to tumors likely to respond. They used genomics network models and identified signature genes associated with tumor invasiveness.
Researchers at TTUHSC will investigate common mechanisms of resistance and sensitivity in alternate telomere lengthening (ALT) cancers, with a focus on targeting ATM kinase inhibitors for therapy. The team aims to develop clinical trials for patients with ALT+ cancers.
Researchers developed a novel drug to reduce airway mucus that exacerbates common lung diseases. The treatment works by blocking the secretion of mucins, which can block airways and cause life-threatening symptoms.
Researchers have developed a robust and stretchable ECM hydrogel-based membrane with nanofiber scaffolds, mimicking native basement membranes. This membrane enables cyclic stretching motions and maintains stable structure over extended cell culture periods, contributing to fabricating sophisticated artificial organs.
The European Lung Cancer Congress 2022 focused on the latest advancements in lung cancer treatment, including personalized strategies for better patient care. The congress also explored emerging therapies and molecular sub-types to enhance precision medicine.
The National Comprehensive Cancer Network has published new consensus recommendations to improve the safety and efficiency of research studies involving investigational drugs. The recommendations focus on seven areas, including pharmacy workflows and collaboration with sponsors.
A team of scientists led by Karine Le Roch has identified two proteins, RAP01 and RAP21, crucial to the malaria parasite's survival. Knocking down these proteins can interrupt protein translation in the mitochondria, leading to the parasite's death.
The collaboration aims to accelerate addressing unmet needs in the neonatal population by applying quantitative modeling, biomarkers, and regulatory science. Patients and families will benefit from improved understanding of bronchopulmonary dysplasia and better patient enrollment for trials.
Researchers have identified a crucial nuclear transport mechanism essential for organ growth and development, involving the protein YAP. The study shows that YAP interacts with importin-7 to control its nuclear entry, regulating cell and tissue growth, and potentially targeting diseases such as atherosclerosis and cancer.
A team of UTSA researchers has developed an innovative inhibitor that blocks the effects of cytochrome P450 8B1, a key enzyme linked to cholesterol absorption and obesity. The treatment shows promise in reducing glucose levels without affecting body weight, offering potential relief from obesity-associated metabolic disorders.
A modeling study suggests that breast cancer overdiagnosis may occur in about 15% of screen-detected cases, rather than the estimated 30%. This could spare around 25,000 women unnecessary treatment. Researchers used data from the Breast Cancer Surveillance Consortium to estimate the rate of overdiagnosis.
Researchers found that bilobalide, an active ingredient in Ginkgo biloba extract, protects the heart from ischemic injuries by preserving ATP generation and enhancing metabolic flux. The study suggests that bilobalide may provide a new herbal therapy for treating myocardial ischemia.
A UC Riverside-led study has identified a potential antiviral therapy for SARS and SARS-like coronaviruses by targeting the papain-like protease enzyme. The research reveals that subgroup 2b PLpros selectively target specific host immune pathways, making them a promising target for future coronavirus therapeutics.
Researchers from Eötvös Loránd University have created a more efficient method for producing catalysts, which can speed up chemical transformations and reduce environmental impact. This breakthrough could lead to faster drug development and improved pesticide production.
Researchers at KTH Royal Institute of Technology created a 3D model of living brain cancer using cavitation molding technique. The model closely replicates human tissue and maintains cell viability, making it suitable for drug screening.
Scientists have devised a method to pinpoint active ingredients from traditional Chinese medicine formulations, revealing 4 analytes with significant anti-inflammatory activity. This breakthrough could improve quality control standards and lead to better herbal remedies.
Researchers at UC San Diego have made a groundbreaking discovery about the role of fibroblasts, or fat cells, in controlling bacteria and developing acne. These findings could lead to more targeted treatment options for acne, which affects up to 50 million Americans each year.
Researchers from Florida Atlantic University advise against prescribing ivermectin to treat or prevent COVID-19 due to the lack of reliable evidence. They emphasize the importance of relying on proven therapeutic innovations and vaccinations to combat the pandemic, citing the risks of unproven treatments like ivermectin.
Researchers at NTU Singapore have developed a new method to generate sulphur pharmacophores, which are crucial for drug discovery. The method uses a catalyst called pentanidium and can produce multiple variations of pharmacophores, making the process more efficient and fruitful.
A study by University of Pittsburgh researchers found that blood levels of seven out of ten commonly used anticonvulsant medications dropped dramatically during pregnancy, leading to breakthrough seizures. The study aims to improve outcomes in women with epilepsy by better managing their medications over the course of pregnancy.
Researchers have discovered a streamlined two-step synthesis strategy to produce neoechinulin B and its derivatives, exhibiting strong anti-HCV and anti-SARS-CoV-2 activities. The novel process utilizes a piperazine-2,5-dione derivative and tetra-n-butylammonium fluoride (TBAF) as key reagents.
A new study by Virginia Commonwealth University researchers finds that triplatin is effective against triple negative breast cancer with high sulfated glycosaminoglycans (sGAG) levels. The drug accumulates inside cancer cells, causing damage and slowing tumor growth.
A University of Nebraska-Lincoln researcher has developed a virtual immune system model that can simulate the complex interactions between different components of the human immune system. The goal is to identify more effective drug targets and accelerate the development of new treatments for immune-related diseases.
A groundbreaking genome-wide association study identified 123 genetic regions linked to migraine risk, including two specific genes targeted by recently developed drugs. The study provides insight into the biological basis of migraine and its subtypes, paving the way for new treatments.
A new generation of cholesterol-lowering drugs is being developed to target the PCSK9 protein, which regulates LDL receptor degradation on cells. These therapies have shown promise in reducing LDL levels with fewer side effects than statins.
A team of scientists has discovered that the enzyme DNA topoisomerase VI plays a critical role in removing chromosome tangles in plants, which may lead to new antimalarial drug targets. The study provides unprecedented insight into the mechanism of action of this enzyme and its potential applications in plant breeding.
A University of Oklahoma chemist is engineering a sustainable method for producing valuable compounds found in nature, such as cannabinoids and squalenes, using enzymes and E. coli. This approach avoids the environmental and economic challenges associated with traditional plant-based methods.
The collaboration aims to create an interoperable global data ecosystem for rare diseases, accelerating the development of new therapies. This partnership benefits patients, regulators, advocacy stakeholders, researchers, and industry, while expanding C-Path's global capabilities in collaborating on methodologies and technologies.
Localis-rex identifies 32 locale-specific sensor proteins sensing hydroxynonenal, a lipid-derived electrophilic-metabolite, revealing new information on electrophile signaling and its impact on biological processes. The study also highlights the potential for covalent drug design and profiling of drug-sensitive cells.