Articles tagged with Drug Development
Researchers developed a new method to screen drugs for treating Alzheimer's disease, shedding light on why current treatments have been ineffective. The study identified new targets for drug development by analyzing disease mechanisms in human neurons.
A study found that 31.4% of trauma patients at Hospital das Clínicas in São Paulo, Brazil, tested positive for psychoactive substance use, including alcohol (23%), cocaine (12%), and marijuana (5%). The study contributes to the development of public policies to prevent accidents.
Researchers at Kumamoto University developed a novel 'supermolecular' material that binds to protein drugs, prolongs their effect without impairing activity, and improves overall drug performance. The material, called PEG-PRX, adds polyethylene glycol chains to proteins without compromising biological action.
Researchers at Hiroshima University discovered that a broccoli compound, DIM, induces controlled cell death and recycling of cellular components in fission yeast. The study suggests that targeting the nuclear envelope could be an early target for future anti-cancer treatments.
Roswell Biotechnologies has developed a molecular electronics sensor on a semiconductor chip, enabling real-time detection of single molecules for diverse applications including drug discovery, diagnostics, and DNA sequencing. The platform offers unlimited scalability in sensor pixel density and high resolution measurements.
A new review and meta-analysis found that drug companies are increasingly disclosing negative study findings for antidepressants. While progress has been made, full transparency remains an issue, with researchers emphasizing the need to report all trial results, both positive and negative, to inform patient treatment.
Researchers have created a new, simpler way to fabricate SERS nanostructures with superior stability and performance at low cost. By using a heat-resistant polymer called polyimide (PI), they can produce nanosurfaces with nanopillars that enhance signal intensity for efficient chemical detection. The new fabrication method has the pote...
A molecule of RNA called CARMN has been found to play a crucial role in maintaining healthy smooth muscle cells in the blood vessel wall, which can help prevent atherosclerosis and angioplasty-induced restenosis. Restoring healthy CARMN levels may lead to new approaches for treating heart disease.
Researchers developed a novel polymeric nanoparticle that selectively binds to fibrinogen in human plasma, offering a simpler and less expensive way to manufacture fibrinogen concentrate. This breakthrough could lead to the creation of more efficient fibrinogen-specific affinity reagents for drug development.
Researchers found that increasing the solution pH makes niclosamide effective against SARS-COV-2 virus replication. A lower dose of niclosamide can also positively affect airway cells without harming them. This could enable safe and effective nose and throat sprays with added protection.
Researchers devised a novel approach to unify quality assessment of generic drugs developed through different processes. The 'population pharmaceutical quality assessment' method uses computational modeling to evaluate process information, providing a scientific tool for objective quality consistency evaluation.
Researchers at Purdue University have identified a new pathway for producing the anti-cancer compound thymohydroquinone, found in plants like thyme and oregano. By understanding this process, plant scientists can engineer plants to produce higher levels of beneficial compounds or synthesize them in microorganisms.
Researchers used PET scans to quantify antibiotic levels in orthopaedic implants, discovering rifampin penetration is only about 14% as much as previously believed. A higher dose of rifampin achieved higher bacterial killing and fewer antibiotic-resistant strains, suggesting a shorter treatment regimen may be effective.
Researchers at Houston Methodist have discovered a new combination therapy that regresses tumor growth of triple negative breast cancer and prevents the cancer from spreading. The response rate using this therapy is about 50%, compared to 25-30% with older drugs, offering new hope for patients with hard-to-treat breast cancers.
Researchers have mapped the atomic structure of amphotericin B, a powerful but toxic antifungal agent. The detailed structure reveals how the drug kills fungal cells by robbing them of sterol molecules, providing a roadmap for synthesizing less-toxic derivatives.
Researchers developed an AI-powered system to model disease progression in patients as they age. The model assesses metabolic and cardiovascular biomarkers to calculate health status and disease risks across a patient's lifespan.
A research team at Lund University has successfully produced two molecules, glionitrin A and B, with unique properties useful in drug development. The breakthrough could pave the way for new types of drugs and improve existing ones.
Engineered biofilms made of E. coli bacteria exhibit emergent drug resistance properties when printed using the new technique. This study provides valuable insights into harnessing the beneficial aspects of biofilms while combating their negative effects, potentially leading to breakthroughs in medicine and materials science.
A research team has identified a bacterium responsible for producing palmerolide A, a melanoma-fighting compound found in Antarctic sea squirts. The discovery could lead to the development of naturally-derived treatments for skin cancer.
A new computational tool allows precise prediction of protein interfaces for COVID-19 and human interactions. This breakthrough enables researchers to better understand virus development, identify high-risk populations, and develop targeted drugs.
Researchers at University of Technology Sydney identified microRNA-21 as a potential therapeutic target for chronic obstructive pulmonary disease (COPD). Inhibition of microRNA-21 using antagomir-21 reduced inflammation and improved lung capacity in experimental models.
Researchers developed a predictive model that maps electric activity of mouse, rabbit, and human cardiac cells, allowing translation of findings across species. The model is expected to accelerate drug development and improve understanding of disease mechanisms.
Researchers at Vanderbilt University have identified a new target for rapid antidepressant drugs using ketamine's role in synaptic effects. This breakthrough could lead to new treatments for approximately half of patients whose current antidepressants are ineffective, significantly reducing the risk of suicide.
Researchers developed a compound that regulates a biological channel linked to pain, reducing the sensation of pain in rodents. The compound, dubbed 194, successfully targets sodium ion channels and promotes pain relief by activating the body's endogenous opioid system.
An international research team discovered that intestinal bacteria can distribute their metabolic products throughout the body via the bloodstream using membrane vesicles. The study found that these vesicles can overcome the blood-brain barrier and enter brain cells, suggesting a new method for delivering drugs or vaccines.
Scientists have engineered enzymes to manufacture molnupiravir, resulting in a shorter and higher-yielding synthesis. The new method reduces the risk of hospitalization and death from COVID-19 for newly diagnosed patients, showing promise as an antiviral treatment.
A team of experts from Tel Aviv University has identified 5 coronavirus proteins responsible for damaging blood vessels. The researchers hope that the identification will lead to the development of targeted drugs that reduce vascular damage in COVID-19 patients.
A therapeutic antibody has been shown to unblock and normalise blood vessels inside cancerous tumours, enabling the more effective delivery of targeted cancer treatments. The findings also suggest that inhibiting LRG1 protein production can enhance the effectiveness of immunotherapies, including checkpoint inhibitors and CAR T-cell the...
Researchers developed a molecular agent that can target lung and other cancer cells for imaging and treatment, distinguishing between healthy and cancerous cells. The new approach uses a unique chemistry method to tune the reactivity of the molecule, avoiding off-target effects.
Stem cell researchers have developed a new method to identify and develop personalized therapies for Cystic Fibrosis patients with rare mutations. By growing precursor lung cells from patients' own blood, they can screen for new drugs and validate responses in mature airway cells.
Researchers at UVA Health System found that fluoxetine, an antidepressant commonly known as Prozac, shows promise against age-related macular degeneration. Patients taking fluoxetine were less likely to develop dry AMD, a condition affecting nearly 200 million people worldwide.
A new, bacteria-based system can detect cancer cells and release therapeutic drugs directly into them, leaving healthy cells intact. The technology has shown promising results in preclinical tests on mice, particularly for liver cancer.
Researchers at the University of Oklahoma have contributed to a study on a new antibiotic that may cure Lyme disease and eradicate its occurrence from the environment. The antibiotic, hygromycin A, targets the ribosomes of the bacteria Borrelia burgdorferi and shows promise in treating the disease.
Scientists have developed a technique to sequence individual malaria parasites' genomes, allowing for the detection of new mutations. These mutations are often targeting a gene family controlling transcription in malaria, suggesting potential avenues for developing more effective treatments and vaccines.
The USC Stevens INI is partnering with Vanderbilt University Medical Center and the University of Miami to merge Alzheimer's disease data from over 30 datasets, producing a large-scale, standardized set of clearly defined data. This harmonization will enable large-scale machine learning analysis to better characterize the genetic basis...
A recent study suggests that targeting alpha-synuclein protein in Parkinson's disease may not be sufficient to cure most patients. Instead, resolving brain inflammation caused by dysfunctional interferon-beta receptor signaling may hold the key to developing more effective treatments.
Researchers found that psilocybin increased the emotional response to music by around 60% compared to ketanserin. The study implies that music should be an active component of psilocybin therapy for treating depression and other mental health conditions.
Researchers at GlaxoSmithKline and CCDC combined proprietary and published datasets to train machine learning models for predicting stable polymorphs in new drug candidates. The approach leverages the large volume and variety of data in the Cambridge Structural Database, resulting in more confident predictions and improved model accuracy.
A new study funded by FDA and HHS suggests that continuous manufacturing (CM) processes could make pharmaceutical production in the US more attractive than investing in China or India. The findings show that CM processes were more economical than current batch processing, particularly under current US corporate tax rates.
A new study in mice reveals that fragile X treatment can incur resistance, but also identifies potential strategies to overcome this. Administering mGluR5 inhibitors at a young age and then stopping may produce lasting benefits in cognitive ability.
Researchers identified five specific mutations prevalent in Delta Plus infections compared to Delta, highlighting the need for expanded antiviral tools. The findings provide clues on how the virus mutates and evade antibodies produced from previous COVID-19 infections or vaccinations.
Researchers have identified a molecule that slows cells' production of alpha-synuclein, a protein forming toxic aggregates in Parkinson's brains. The compound, A-443654, also reduces cell stress and may help degrade existing alpha-synuclein aggregates.
A team of researchers from IOCB Prague has discovered a new type of nanoparticles capable of safely transporting various types of nucleic acids used for therapeutic purposes into cells. The universal nature of their system sets it apart from existing solutions, allowing for efficient transport of mRNA and other RNA molecules into cells.
Researchers at Uppsala University developed a new method to track individual cancer cells and their offspring over time. The study found that brain tumour cells are hierarchically organised, but with some degree of flexibility, and that drug treatment influences cell organisation. This breakthrough may lead to the development of target...
The MONALEESA-2 trial found that adding a CDK 4/6 inhibitor to first-line hormonal treatment prolongs survival by one year for postmenopausal women with HR-positive, HER2-negative advanced breast cancer. The combination of endocrine therapy and the CDK 4/6 inhibitor ribociclib also extends progression-free survival.
Researchers at MIT developed a new way to grow pancreatic organoids using synthetic gel, allowing for study of interactions between tumors and environment. The gel can also be used to grow other types of tissue, including intestinal and endometrial tissue.
Researchers found that ribociclib achieved pharmacologically-relevant concentrations in tumor tissue, while everolimus showed minimal penetration. The combination is promising for brain cancer treatment and could lead to new therapeutic drug combinations.
A mechanical engineering faculty-researcher at RIT is developing a microfluidic device to improve the detection of drug-resistant bacteria in blood, which can cause severe infection and death. The goal is to detect these strains early, allowing for prompt treatment and recovery.
The Vilcek Foundation has awarded four prizes worth $250,000 to foreign-born scientists in the United States. The prizes recognize outstanding career contributions to biomedical science and innovative research. This year's recipients include Vishva M. Dixit, Markita del Carpio Landry, Hani Goodarzi, and Harris Wang.
A new study examines the similarities and differences among disease activity indices used to monitor rheumatoid arthritis. Researchers found that while there are high correlations among the indices, they were not interchangeable, highlighting the need for further analysis of RA in patients using various indices.
Researchers developed a pollen-based hybrid ink that can be used to fabricate parts useful for tissue engineering, toxicity testing and drug delivery. The ink is biocompatible, flexible and low in cost, allowing for the creation of customized flexible membranes tailored to human skin contours.
Scientists challenge existing thinking on opioid tolerance and respiratory depression, proposing a new balanced approach to developing safer analgesics. They found that arrestin-3 engagement limits tolerance development but does not exacerbate respiratory depression.
Researchers have identified a new potential treatment for neuroblastoma by targeting the ALT mechanism, which is responsible for chemotherapy resistance. The study found that activating ATM kinase at telomeres promotes chemotherapy resistance in ALT neuroblastoma and suggests a cancer-specific approach to treating this disease.
Researchers at UCLA developed brain organoids that mimic human brain structure and function, allowing for the study of neurological disorders like Rett syndrome. The organoids showed organized waves of activity similar to those found in living brains and responded to treatment with an experimental drug.
Researchers at SpheroFill are developing a unique oral drug delivery platform using microsphere technology, protecting drugs from degradation and enabling targeted release. This technology has the potential to improve medication compliance and delivery of sensitive biological drugs.
A new study developed a wearable technology-based method to assess myoclonus symptoms in the home environment. The method, which measures electrical neuromuscular function and movement, correlates well with assessments performed by experienced physicians.
Researchers have identified a promising therapeutic target, METTL1, to treat aggressive cancers by inhibiting an RNA-modifying protein. The study found that targeting METTL1 effectively destroys cancer cells in laboratory models and mice while leaving healthy cells unharmed.
Researchers from USC Stem Cell discovered a latent regenerative potential in the inner ear's sensory cells. They found that epigenetic modifications regulate hair cell development and identified a key histone decoration, H3K4me1, that keeps supporting cells primed for transdifferentiation.
The UNITE4TB partnership aims to develop new and highly active TB treatment regimens for drug-resistant and -sensitive TB. The 7-year project will utilize advanced clinical trials networks, adaptive trial designs, and machine learning techniques to accelerate the development of better treatment solutions.
The UNITE4TB partnership aims to develop new and highly active TB treatment regimens for drug-resistant and -sensitive TB. The consortium will accelerate the clinical evaluation of combinations of existing and novel drugs through advanced trial designs and AI-powered analysis.